scholarly journals Replacement of vitamin-mineral premix by Spirulina and its effect on the performance of broiler

2018 ◽  
Vol 2 ◽  
pp. 39
Author(s):  
Shahinur Nahar Moury ◽  
Md. Touhiduzzaman Sarker ◽  
Adhita Sri Prabakusuma ◽  
Md. Imrul Hasan Russel ◽  
Md. Shahidul Islam
Keyword(s):  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Feed Conversion ◽  
Final Body Weight ◽  
Group 4 ◽  
Group 6 ◽  
Group 5 ◽  
And Control ◽  
Group 1

The main purpose of this study was to explore the effects of Spirulina (Spirulina platensis) as a feed supplement by replacing Vitamin-Mineral Premix on the performance of broiler. The study explored that final body weight was 1039, 1070, 1044, 1065, 1117 and 893 g/bird in group 1, 2, 3, 4, 5 and 6 where significantly (p<0.5) higher weight observed in Spirulina group (5) but lower in negative control group (6). Feed intake observed more or less similar in all groups (1483±24g; p>0.5). Feed conversion ratio (kg FI/kg LWG) observed significantly different like 1.72, 1.65, 1.69, 1.62, 1.61 and 1.99 in group 1, 2, 3, 4, 5 and 6 respectively (p<0.5) where higher in negative group (6) and control group (1), but is lowest and similar in 75% Spirulina group (4) and highest (100%) Spirulina group (5). %Ash of different dietary groups were 46.35, 46.54, 48.93, 49.93, 55.07 and 46.92 of group 1, 2, 3, 4, 5 and 6 respectively. The %ash of bone was gradually increased among dietary groups and the best result was obtained in 100% Spirulina group 5 (55.07). It also revealed that diets containing no vitamin-mineral premix with 100% Spirulina improve the performance of broiler. The findings suggest that poultry farmer can use spirulina as a feed item for broiler for more yield.

scholarly journals Effect of using Spirulina platensis in place of vitamin mineral premix in feed on the performance of broiler

2021 ◽  
Vol 50 (1) ◽  
pp. 64-72
Author(s):  
KMS Islam ◽  
MR Debi ◽  
R Haque ◽  
SN Moury
Keyword(s):  
Control Diet ◽  
Negative Control ◽  
Poultry Feed ◽  
Control Group ◽  
Feed Conversion ◽  
Final Body Weight ◽  
Complete Replacement ◽  
Blue Green Algae ◽  
Group 5 ◽  
Group 1

Feed of commercial broiler fortified by the external sources of vitamin and minerals which is expensive and increase the cost of feed. Blue green algae (Spirulinaplatensis) would be an alternative to those synthetic micronutrients after production in laboratory scale was studied in broiler.Spirulinaplatensiswas cultured in inorganic media contained macronutrients NaHCO3, K2HPO4, NaNO3, K2SO4, NaCl, MgSO4.7H2O, CaCl2, and FeSO4.2H2O and micronutrient solution containing H3BO4, MnCl2.4H2O, ZnSO4.7H2O, CuSO4.5H2O, MoO3, CoCl2.6H2O. Media was autoclaved and Spirulinawas cultured for 12 hours lighting with continuous aeration for 15 days to use in poultry feed. Day old broiler chick (180) was reared offering starter mash diet for 7 days. Birds were divided into 6 groups having 30 birds in each (10 per cage). Birds were offered 1. Control diet, 2. 75% premix+25% Spirulina, 3. 50% premix+50% Spirulina, 4. 25% premix+75% Spirulina, 5. 0% premix+100% Spirulina and 6. 0% premix+0% Spirulina (negative control). Spirulinawas calculated on DM basis added minerals in the media. After 21 days (28 day old) final body weight was 1039, 1070, 1044, 1065, 1117 and 893 g/bird in group 1, 2, 3, 4, 5 and 6 where higher (P<0.5) weight observed in Spirulinagroup (5). Feed intake was observed more or less similar in all groups (1483±24g). Feed conversion ratio was 1.72, 1.65, 1.69, 1.62, 1.61 and 1.99 in group 1, 2, 3, 4, 5 and 6 respectively (P<0.5) where higher in negative control group (6) and control group (1), but was lowest in 75% Spirulinagroup (4) and highest (100%) Spirulina group (5). Ash% is also highest in 100% Spirulina group 5 (55.07) than any other group. Considering growth performance of broiler, complete replacement of vitamin-mineral premix could be possible by cultured Spirulinaalong with media in broiler diet. Bang. J. Anim. Sci. 2021. 50 (1):64-72

scholarly journals PENGARUH PEMBERIAN SUSU BEKATUL TERHADAP KONSENTRASI KOLESTEROL DAN TRIGLISERIDAPADA TIKUS PUTIH WISTAR DIABETES

2019 ◽  
Vol 12 (02) ◽  
Author(s):  
Husnul Khatimah ◽  
Saifuddin Sirajuddin ◽  
Zainal Zainal
Keyword(s):  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Cholesterol Concentration ◽  
Control Group ◽  
Group 4 ◽  
White Rats ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT In diabetics there is usually an increase in free fatty acids in the blood and increases the concentration of cholecerols and triglycerides, this condition is called diabetes dyshidemia. This study aimed to find out at the effect of bran milk treatment on the changes of the concetration of cholesterol and triglycerides in diabetetic white wistar rats. Conducted on May 15 until 15 August 2018. Experimental research pre-post test with control design. Subjects of twenty wistar white rats were made diabetic by injecting alloxan 140mg / kg. After being declared diabetic, the rats were divided into four groups, namely group 1 (negative control), group 2 (positive control), group 3 (bran milk 0.54g / 200 gr) and group 4 (bran milk 1.08g / 200gr). The intervention was given for fourteen days. The data analysis used the paired T-test to test the subject before and afterthe treatment and the One-Way ANOVA test was used to test the difference between the groups. The research results indicated that  the treatment with bran milk there were no significant differences in cholesterol and triglyceride concentrations in the four groups. But when viewed from changes before and after the intervention showed that group 4 (bran milk 1.08g / 200gr) decreased cholesterol concentration and in group 3 (bran milk 0.54g / 200gr) a decrease in triglycerides was better than group 1 (control negative) and group 2 (positive control). It was concluded that the administration of bran milk can reduce the concentration of cholesterol and triglycerides in wistar diabetic white rats.Keywords : Bran milk, Cholesterol, Triglycerides, Rats, Diabetic

scholarly journals Effect of dietary supplementation of ginger extract on growth, carcass characteristics and haematological parameters in broilers

2017 ◽  
Vol 3 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Sudipta Talukder ◽  
Md Mehedi Hasan ◽  
Zakaria Al Noman ◽  
Yousuf Ali Sarker ◽  
Torun Kumar Paul ◽  
...  
Keyword(s):  
Body Weight ◽  
Broiler Chickens ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Growth Promoter ◽  
Feed Conversion ◽  
Ginger Extract ◽  
Final Body Weight

This study evaluated the effect of ginger on the growth performance, carcass quality of broiler chickens. 20 broiler chickens were randomly selected into two treatment groups identified as T1 and T2 with a positive control and a negative control group. Each treatment contained with five birds. Birds on T1 were treated with 1% ginger extract and T2 was treated with 2% ginger extract via drinking water. Significant variations (p<0.05) existed between the control and other treatments in mean final body weight, dressed weight, daily feed intake and feed conversion ratio. At the end of experiment (35th day) for 1% ginger extraction treatment the live body weight is 1746gm (p<0.05), dressing weight 1106.4 (p<0.05) and FCR is 1.67(p<0.05). The usage of the test ingredients had a significant effect (p<0.05) on dressing percentage. Supplementation of ginger improves the performance of broilers when added at the rate of 1% of broiler ration and can be a possible alternative to antibiotic growth promoter in the feeding of broiler chicken.Asian J. Med. Biol. Res. June 2017, 3(2): 211-215

scholarly journals Antibacterial Effects of a 940 nm Diode Laser With/ Without Silver Nanoparticles Against Enterococcus faecalis

2021 ◽  
Vol 12 (1) ◽  
pp. e73-e73
Author(s):  
Seyedeh Sareh Hendi ◽  
Maryam Shiri ◽  
Banafsheh Poormoradi ◽  
Mohammad Yousef Alikhani ◽  
Saeid Afshar ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Diode Laser ◽  
Sodium Hypochlorite ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
P Value ◽  
Antibacterial Effects ◽  
Group 4 ◽  
Group 1

Introduction: The final goal of root canal therapy is to remove of the most bacteria from the root canal. This study aimed at comparing the antibacterial effects of a diode laser with a wavelength of 940nm and silver nanoparticles and the synergic effects of both techniques on Enterococcus faecalis. Methods: Ninety single-rooted human teeth were decoronated and prepared with rotary files. The samples were irrigated with sodium hypochlorite and EDTA17%. Then they were autoclaved and contaminated with E. faecalis suspension (1.5 × 108 CFU/mL) for 21 days. The samples were fixed in a microtube and were randomly divided into 4 experimental (n=20) groups and a negative control group (n=10) as follows: Group 1: hypochlorite sodium 5%, Group 2: silver nanoparticle, Group 3: diode laser, and Group 4: diode laser and silver nanoparticle. The samples were obtained from dentin chips before and after the intervention. The data were analysed using the Kruskal-Wallis nonparametric test. Furthermore, alterations in bacterial colonies were entered using the Wilcoxon signed ranks test (α=0.05). Results: There was a significant decrease in colony counts for all groups after interventions (P value<0.05). Also, all groups showed more reductions in colony counts compared with the negative control group (P value <0.004). There was a significant reduction for group 1 in comparison with other groups (P value <0.001) and this group had an extreme decrease of colony counts (RCC=100%). There was an important differential between silver nanoparticles and diode laser groups in bacterial counts (P value<0.001) and silver nanoparticles (RCC=83.15%) had more efficiency than the diode laser (RCC=41/33%). RCC of group 4 was 68/52%. Conclusion: Followed by sodium hypochlorite 5%, silver nanoparticles were the most effective antibacterial substances. The 940 nm laser diode had less antibacterial effect compared to its use with silver nanoparticles.

Effects of Different Surface Conditioning Methods on the Bond Strength of Composite Resin to Amalgam

2011 ◽  
Vol 36 (3) ◽  
pp. 318-325 ◽  
Author(s):  
M Özcan ◽  
C Koolman ◽  
A Aladag ◽  
M Dündar
Keyword(s):  
Bond Strength ◽  
Composite Resins ◽  
Control Group ◽  
Surface Conditioning ◽  
Specimen Diameter ◽  
Group 4 ◽  
Group 6 ◽  
Bond Strengths ◽  
Group 5 ◽  
Group 1

SUMMARY Repairing amalgam restorations with composite resins using surface conditioning methods is a conservative treatment approach. This study investigated the effects of different conditioning methods that could be used for repair of amalgam fractures. Amalgam (N=96) was condensed into cavities within autopolymerizing polymethylmethacrylate (PMMA), and the exposed surface of each specimen (diameter, 6 mm; thickness, 2 mm) was ground finished. The specimens were randomly divided into nine experimental groups (n=12 per group), depending on the conditioning method used. The control group had natural central incisors with amalgam (n=12). The combination of the following conditioning methods was tested: silicacoating (Sc), sandblasting (Sb), metal primers, coupling agents, fiber (Fb) application, and opaquers (O). Five types of silanes, metal primers, or adhesives (Visiobond [V], Porcelain Photobond [PP], Alloy Primer [AP], Unibond sealer [Us], ESPE-Sil [ES]), and four opaquers, namely, Clearfil St Opaquer (CstO), Sinfony (S), Miris (M), and an experimental Opaquer (EO-Cavex), were used. The groups were as follows: group 1, Sc+ES+S+V; group 2, Sc+ES+CstO+V; group 3, Sc+ES+M+V; group 4, Sc+ES+EO+V; group 5, Sb+AP+S; group 6, Sb+AP+PP+CstO; group 7, Sc+ES+S+Fb+V+Fb; group 8-control, SC+ES+V; and group 9, Etch+Sc+ES+S+Us. One repair composite was used for all groups (Clearfil Photo Bond Posterior, Kuraray, Tokyo, Japan). Shear bond strengths (SBSs) (MPa ± SD) were evaluated after 5 weeks of water storage (analysis of variance [ANOVA], Tukey honestly significant differences [HSD], α=0.05). Group 1 exhibited significantly higher values (35.5 ± 4.1) than were seen in group 4 (19.4 ± 8.9), group 6 (19.1 ± 7.8), and group 8 (20.1 ± 4.1) (p&lt;0.05). Group 9 exhibited significantly lower values (8.3 ± 3.4) than were noted in groups 1 to 3 (35.5 ± 4.1; 27 ± 12.5; 24.4 ± 5.1, respectively) (p&lt;0.05). Group 7 (16.4 ± 5.9) showed significantly lower values than were observed in group 1 (35.5 ± 4.1) (p&lt;0.05). Surface conditioning techniques affected the bond strengths of composite adhesion to amalgam. Experimental opaquer exhibited lower values. Leaving a small border of enamel around the restoration decreased the bond strength.

scholarly journals Experimental mouse model of bronchial asthma induced by house dust mite Dermatophagoides pteronyssinus allergenic extract

2015 ◽  
Vol 12 (6) ◽  
pp. 25-33
Author(s):  
A A Babakhin ◽  
A A Laskin ◽  
O Yu Kamishnikov ◽  
N N Shershakova ◽  
I P Shilovskiy ◽  
...  
Keyword(s):  
Allergic Inflammation ◽  
Inflammatory Cells ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Dust Mite ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

The purpose of this study was to develop a mouse model of asthma (MMA) using house dust mite Dermatophagoides pteronyssinus (Der p) extract. Methods. BALB/c mice were i.p. immunized with different doses of Der p lyophilized extract three times in three week interval in the mixture with Al(OH)3. 8 weeks after the final immunization mice were challenged with Der p during five consecutive days by intranasal applications (INA) or aerosol administration (AA). All mice were divided into 5 experimental groups: group 1 was immunized with 50 ^g/mouse of Der p (in protein equivalent) in the mixture with 2 mg/mouse Al(OH)3 and challenged by INA; group 2 was immunized in the same way and challenged by AA; group 3 was immunized with 100 ^g/mouse Der p in the mixture with 2 mg/mouse of Al(OH)3 and challenged by INA; group was immunized in the same way and challenged by AA; group 5 (negative control) was immunized and challenged with saline. 24 hours after the last challenge airway hyperresponsiveness (AHR) to different concentrations of metha-choline was evaluated in all groups by whole-body plethysmography. 48 hours after the last challenge in all groups blood was collected for differential cell count, brochoalveolar lavage fluid (BALF) was sampled for the determination of inflammatory cells and lungs were removed for histological analysis. Histopathological changes in lungs (allergic inflammation) were graded according to semi-quantitative scoring system. Anti-Der p IgE, IgG1 and IgG2a antibodies in individual sera samples were detected by ELISA seven days after the last immunization and 48 hours after the challenge. Results. The levels of anti-Der p IgE antibodies in groups 1-4 before as well as after the challenge were substantially higher than that of in the group 5 (negative control). The highest level of serum Der p-specific IgE antibodies was observed in the group 2. The levels of anti-Der p IgG1 and IgG2a antibodies in the groups 1-4 during all periods of observation were higher than that of group 5 (negative control). At the same time the maximal levels of anti-Der p IgG1 and IgG2a antibodies were observed in group 3 both after immunization and after challenge. The maximum of AHR was observed in the groups 1 and 3 challenged by INA. Analysis of cell composition in BALF demonstrated significant elevated number of eosinophils in group 3 in comparison with group 5 (negative control) and other experimental groups. Regarding peripheral blood leukocyte count we observed decreasing of band neutrophils in group 4 and increasing of segmented neutrophils in groups 1 and 3 in compare to group 5 (negative control). In group 1 we found statistically significant decreasing of lymphocytes and increasing of eosinophils in compare to negative control group 5. Histological picture of general allergic inflammation in lungs as well as peribronchial and perivascular infiltration with inflammatory cells were the most noticeable (according to score system) in group 3 in comparison with negative control group and other experimental groups. Conclusion. Data obtained indicate that immunization (sensitization) of mice with Der p in a dose 100 μg/mouse together with Al(OH)3 and challenge with Der p by mean of intranasal applications is a suitable approach for modeling of mouse allergic asthma.

scholarly journals Evaluación de tres levaduras provenientes de ecosistemas colombianos en la alimentación de pollos de engorde

2009 ◽  
Vol 10 (1) ◽  
pp. 102 ◽  
Author(s):  
Natalia López Hernández ◽  
Germán Afanador Téllez ◽  
Claudia Janeth Ariza Nieto
Keyword(s):  
Negative Control Group ◽  
Negative Control ◽  
Feed Additives ◽  
Feed Additive ◽  
Control Group ◽  
Feed Conversion ◽  
Final Body Weight ◽  
Broiler Performance ◽  
Functional Additives ◽  
Los Grupos

<p>Una estrategia para mejorar la salud del tracto gastrointestinal en pollos de engorde es incluir productos novedosos como los aditivos funcionales entre los que se encuentran las levaduras, caracterizadas por su papel beneficioso en la salud animal. En este estudio se evaluó el valor nutricional de tres cepas nativas de levaduras, aisladas de frutales de Colombia. Se utilizaron 240 pollos machos para evaluar los efectos de levaduras en el desempeño, calidad de la canal, parámetros hematológicos y del corazón. Los pollos se distribuyeron al azar en seis tratamientos: tres diferentes levaduras nativas (0,5% inclusión en la dieta), dos controles positivos (inclusión de dos levaduras comerciales) y un grupo control negativo sin levaduras. Las aves que fueron alimentadas con las levaduras comerciales presentaron menor consumo de alimento total (-73,7 g) comparado con los grupos a los que se les suministró levaduras nativas. Por consiguiente, el peso corporal final fue más alto para los grupos de levaduras nativas comparado con las levaduras comerciales (98,9 g/ave, <em>p </em>&lt; 0,01). Los pollos alimentados con levaduras presentaron mejor conversión comparados con el grupo control. El peso de la canal y la pechuga fueron más altos para los grupos alimentados con levaduras (<em>p </em>&lt; 0,05). Se concluye que las levaduras nativas pueden tener un efecto beneficioso en el desempeño de pollos de engorde, y algunas levaduras nativas podrían mejorar las características de calidad de carne como la terneza. Aunque se requiere mayor investigación, pueden considerarse las levaduras nativas como aditivos funcionales prometedores para los pollos de engorde.  </p><p> </p><p><strong>Evaluation of three native Colombian yeasts as feed additives for broilers</strong>  </p><p>A strategy to improve the health of the gastrointestinal tract in broilers is to include novel products such as functional feed additives. Among these, yeasts have been recently reported to play a beneficial role as a feed additive. The objective of this study was to evaluate the nutritional value of three strains of yeasts, isolated from native fruits in Colombia. A total of 240 male broilers were used, and the effects of yeasts on performance, carcass quality, blood and heart parameters were evaluated. Chicks were randomly distributed in six treatments: three different native yeasts (0.5% of inclusion in the diet), two positive controls added with commercial yeasts and a negative control group without yeasts. Chicks fed with yeasts commercial had lower total feed intake (-73.7 g) compared with the native yeast groups. Therefore, final body weight was higher for the native yeast groups compared with the commercial yeasts (98.9 g/bird, <em>p </em>&lt; 0.01). Chicks fed native yeasts tended to have better feed conversion ratio (intake/gain) compared with the control group. Carcass and breast weights were higher for the yeasts groups (<em>p </em>&lt; 0.05). It is concluded that native yeasts can have a beneficial effect on broiler performance, and some native yeasts could also improve meat quality traits such as shear force. Although more research is required, native yeasts should be regarded as relevant and promising functional additives for broilers. </p>

Antiurolithiatic effect of Cymbopogon Proximus, Alhagi Maurorum, on Sulfadimidine induced urolithiasis in male New Zealand rabbits

2019 ◽  
Vol 20 (1) ◽  
pp. 12-18
Author(s):  
Sameh El-Nabtity
Keyword(s):  
New Zealand ◽  
Intramuscular Injection ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Aqueous Extracts ◽  
Blood And Urine Samples ◽  
Group 2 ◽  
New Zealand Rabbits ◽  
Group 1

The present study aimed to investigate the prophylactic effect of Cymbopogon proximus and Alhagi maurorum on Sulfadimidine induced urolithiasis in rabbits . Thirty New Zealand male rabbits were allocated into six equal groups (each of five): Group (1) was used as a negative control. Group(2) were administered sulfadimidine (200mg/kg) by intramuscular injection.Groups(3) and (4) were administered sulfadimidine(200mg/kg) by intramuscular injection and 330mg/kg of Cymbopogon proximus alcoholic and aqueous extracts respectively orally.Groups(5) and (6) were administered sulfadimidine(200mg/kg) by intramuscular injection and 400mg/kg of Alhagi maurorum alcoholic and aqueous extracts respectively orally. The period of experiment was 10 days. Blood and urine samples were collected from rabbits on the 10th day. The results recorded a significant decrease in serum creatinine, urea, uric acid and crystalluria in Cymbopogon proximus and Alhagi maurorum groups compared to sulfadimidine treated group.We conclude that Cymbopogon proximus and Alhagi maurorum have a nephroprotective and antiurolithiatic effects against sulfadimidine induced crystalluria.

scholarly journals Association between serum oestradiol level on the hCG administration day and neonatal birthweight after IVF-ET among 3659 singleton live births

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu Liu ◽  
Jing Li ◽  
Wanyu Zhang ◽  
Yihong Guo
Keyword(s):  
Birth Weight ◽  
Ovarian Stimulation ◽  
Group 4 ◽  
Group 6 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
The Impact ◽  
Ivf Et ◽  
Group 1

AbstractOestradiol, an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization-embryo transfer (IVF-ET) cycles. A supraphysiologic E2 level is inevitable during controlled ovarian hyper-stimulation (COH), and its effect on the outcome of IVF-ET is controversial. The aim of this retrospective study is to evaluate the association between elevated serum oestradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and neonatal birthweight after IVF-ET cycles. The data of 3659 infertile patients with fresh IVF-ET cycles were analysed retrospectively between August 2009 and February 2017 in First Hospital of Zhengzhou University. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels ≤ 1000 pg/mL, n = 230), group 2 (serum E2 levels between 1001 and 2000 pg/mL, n = 524), group 3 (serum E2 levels between 2001 and 3000 pg/mL, n = 783), group 4 (serum E2 levels between 3001 and 4000 pg/mL, n = 721), group 5 (serum E2 levels between 4001 and 5000 pg/mL, n = 548 ), and group 6 (serum E2 levels > 5000 pg/mL, n = 852). Univariate linear regression was used to evaluate the independent correlation between each factor and outcome index. Multiple logistic regression was used to adjust for confounding factors. The LBW rates were as follows: 3.0% (group 1), 2.9% (group 2), 1.9% (group 3), 2.9% (group 4), 2.9% (group 5), and 2.0% (group 6) (P = 0.629), respectively. There were no statistically significant differences in the incidences of neonatal LBW among the six groups. We did not detect an association between peak serum E2 level during ovarian stimulation and neonatal birthweight after IVF-ET. The results of this retrospective cohort study showed that serum E2 peak levels during ovarian stimulation were not associated with birth weight during IVF cycles. In addition, no association was found between higher E2 levels and increased LBW risk. Our observations suggest that the hyper-oestrogenic milieu during COS does not seem to have adverse effects on the birthweight of offspring after IVF. Although this study provides some reference, the obstetric-related factors were not included due to historical reasons. The impact of the high estrogen environment during COS on the birth weight of IVF offspring still needs future research.

scholarly journals Zingerone Ameliorates Hepatotoxicity

2020 ◽  
Vol 11 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Julietpoornamathy J ◽  
Parameswari C.S.
Keyword(s):  
The Body ◽  
Control Group ◽  
Medical Sciences ◽  
Toxic Compounds ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Insight Into ◽  
Group 1

In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats.  A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

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