scholarly journals ALGORITHM FOR STRATIFICATION OF CARDIOVASCULAR RISK IN MEN AGED 18-29 YEARS WITH ARTERIAL HYPERTENSION SYNDROME

2021 ◽  
Vol 19 (2) ◽  
pp. 224-228
Author(s):  
A. N. Zayats ◽  
◽  
V. I. Shyshko ◽  
Keyword(s):  
Cardiovascular Risk ◽  
Arterial Hypertension ◽  
Clinical Laboratory ◽  
Young Patients ◽  
Test Analysis ◽  
System Functioning ◽  
Complete Physical Examination ◽  
Instrumental Methods ◽  
Ergometry Test

Background: Arterial hypertension (AH) is a leading factor of cardiovascular risk (CVR), and stratification of CVR in young patients with AH is an important area of clinical research. Aim: to develop an algorithm for CVR stratification in men aged 18-29 years with AH syndrome (AHS). Materials and methods: 165 men underwent a complete physical examination, which included standard clinical, laboratory and instrumental methods, ergomtry test, analysis of heart rate variability, pulse wave velocity determination. Results: The clinical characteristics and features of the cardiovascular system functioning at rest and during ergometry test have been determined, depending on the nosological form of AHS and the established CVR. The algorithm has been developed based on the assessment of the type of hemodynamic response and determination of the probability of cardiovascular outcomes within 10 years. Conclusion: the proposed algorithm enables to optimize therapeutic, diagnostic and preventive measures in men aged 18-29 years with AHS.

scholarly journals Vascular Age Concept: Which Approach Is Preferable in Clinical Practice?

Kardiologiia ◽  
2019 ◽  
Vol 59 (2) ◽  
pp. 45-53 ◽  
Author(s):  
O. P. Rotar ◽  
A. S. Alieva ◽  
M. A. Boiarinova ◽  
K. M. Tolkunova ◽  
A. O. Konradi
Keyword(s):  
Cardiovascular Risk ◽  
Cardiovascular Events ◽  
Population Sample ◽  
Ankle Brachial Index ◽  
Young Patients ◽  
Instrumental Method ◽  
Vascular Aging ◽  
History Of ◽  
Vascular Age

Aim:to compare various approaches to estimation of vascular age in patients from sample of citizens of Saint-Petersburg (SPB) with arterial pressure (AP) above 130 / 80 mm Hg without history of cardiovascular events.Materials and methods.Examination of a population sample of SPB citizens (n=1600) was carried out within framework of the observational epidemiological study ESSE-RF (ЭССЕ-РФ) in 2012–2013. We selected from this sample 477 women and man aged 40–65 years without history of cardiovascular events, diabetes, or chronic kidney disease, and AP >130 / 80 mm Hg. Examination included anthropometry, sampling of fasting blood for measurement of lipids, glucose, creatinine levels, urine sampling for determination of albumin excretion, and AP measurement in ac-cordance with standard methods. The SCORE scale was used of evaluation of 10-year risk of fatal stroke and fatal myocardial infarction. Volume sphygmography (VaSera device) was applied for determination of cardio-ankle vascular index (CAVI) with calculation of vascular age, and ankle-brachial index. ASCORE scale was used for determination of сalculated vascular age was determined with help of the ASCORE scale.Results.Mean age of participants (182 men [38.2 %], 295 women [61.8 %]) was 52.5±6.2 years. Calculated and instrumental methods of determination of vascular age and early vascular aging had low concordance (κ = 0.099). With elevation of cardiovascular risk early vascular aging was more frequently detected by method of its calculation ASCORE than with instrumental method (VaSera). In the absence of achievement of target AP level signs of early vascular aging were significantly more often detected by the method of vascular age calculation than by the instrumental method VaSera.Conclusion.Application of the concept of vascular age and early vascular aging syndrome might be an effective tool for stratification of cardiovascular risk by a physician and improvement of adherence of a patient. This is especially actual for young patients with burdened heredity. One can assume that estimation of virtual risk factor load on blood vessels by the ASCORE method of calculation is more sensitive to detection of premature vascular aging, while requiring less financial and organizational efforts.

scholarly journals Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya

2019 ◽  
Vol 91 (1) ◽  
pp. 71-77
Author(s):  
T A Mulerova ◽  
E S Filimonov ◽  
S A Maksimov ◽  
V N Maksimov ◽  
M I Voevoda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Arterial Hypertension ◽  
Cardiovascular Risk Factors ◽  
Abdominal Obesity ◽  
Clinical Laboratory ◽  
Medical Society ◽  
High Density Lipoproteins ◽  
Russian Society ◽  
Lipid Metabolism Disorders

Aim: to evaluate the association of a complex of cardiovascular risk factors and genetic markers with the development of high albuminuria among patients with arterial hypertension in the population of Mountain Shoriya, taking into account ethnicity. Materials and methods. A clinical epidemiological study of a compactly residing population in remote areas of Mountain Shoria was carried out. 1409 people were examined [901 people - representatives of the indigenous nationality (Shorians), 508 people - representatives of non-indigenous nationality (90% of them are Caucasians)]. Hypertension was diagnosed according to the National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). All patients underwent clinical, laboratory and instrumental investigation. To study the state of the kidneys, the concentration (the presence of elevated levels) of albumin (albuminuria) in the morning portion of urine by an immunoturbidimetric method was analyzed. Polymorphisms of genes ACE (I/D, rs4340), АGT (c.803T>C, rs699), AGTR1 (А1166С, rs5186), ADRB1 (с.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs28365031), MTHFR (c.677С>Т, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) were tested using PCR. Results. In the group of shors with arterial hypertension, high albuminuria was associated with polymorphisms of the ACE genes (OR=2.05), ADRA2B (OR=6.00), elevated triglyceride level (OR=2.86), decreased index of cholesterol of high density lipoproteins (OR=5.57) and increased index of low density lipoproteins (OR=2.49); in the new population - with polymorphisms of the AGTR1 genes (OR=8.66), ADRA2B (OR=6.53), MTHFR (OR=7.16), obesity (OR=2.72), and abdominal obesity (OR=3.14). Conclusion. The primary predictors determining the development of high albuminuria among patients with arterial hypertension in both ethnic groups were genetic ones. In addition to them, non-genetic risk factors also contributed to the development of this organ damage to the kidneys: age and lipid metabolism disorders in representatives of indigenous nationality; age and abdominal obesity in the examined patients non-indigenous nationality.

scholarly journals Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension

2019 ◽  
Vol 91 (9) ◽  
pp. 108-114 ◽  
Author(s):  
V I Podzolkov ◽  
T A Safronova ◽  
D U Natkina
Keyword(s):  
Comparative Analysis ◽  
Arterial Hypertension ◽  
Asymmetric Dimethylarginine ◽  
Clinical Laboratory ◽  
Uncontrolled Hypertension ◽  
Group I ◽  
Essential Arterial Hypertension ◽  
Group Ii ◽  
Adma Concentration

Aim. To conduct a comparative analysis of the level of asymmetric dimethylarginine (ADMA) in two groups of patients with a diagnosis of essential arterial hypertension (AH). Group I - patients with uncontrolled hypertension (UCAH) and group II - patients with controlled course of hypertension (CAH). Materials and methods. The study included 109 patients: group I - 73 patients with UCAH, group II - 36 patients with CAH. Groups were comparable. Clinical, laboratory and instrumental examination was performed, including determination of ADMA concentration in blood plasma. Results. The concentration of ADMA in patients with UCAH was significantly higher than in the group with CAH. In patients with UCAH, a pronounced positive correlation was found between the concentration of ADMA and creatinine level (r=0.615, p

scholarly journals GALLBLADDER SIZES IN PATIENTS WITH ARTERIAL HYPERTENSION, OBESITY AND HYPOTHYROIDISM: CORRELATION ANALYSIS

2020 ◽  
Vol 45 (2) ◽  
Author(s):  
L. M. Strilchuk ◽  
L. V. Olenych ◽  
O. M. Radchenko
Keyword(s):  
Cardiovascular Risk ◽  
Correlation Analysis ◽  
Arterial Hypertension ◽  
Clinical Laboratory ◽  
Rank Correlation ◽  
Correlation Method ◽  
Gallstone Formation ◽  
Gallbladder Ejection Fraction ◽  
Increased Risk ◽  
Rank Correlation Method

Abstract Our previous studies showed that patients with arterial hypertension and excessive weight or obesity presented with the significantly enlarged gallbladder, both fasting and after taking cholekinetic. The gallbladder ejection fraction was below the normal range, and poor blood pressure control was accompanied by further gallbladder over distension, reduction of its contractility and increased risk of gallstone formation. This needs further research, especially considering hypothyreoidism. The aim is to establish correlations of the sonographically estimated gallbladder sizes in patients with arterial hypertension, obesity and hypothyreoidism. Materials and methods. The cohort of 40 patients (females 90%, males 10%) with arterial hypertension, body overweight/obesity and h underlying hypothyroidism was examined; sonographically estimated gallbladder sizes are compared with clinical, laboratory and instrumental data. Kendall's rank correlation method was applied; significance threshold was taken as р < 0,05. Results. In patients with arterial hypertension and overweight/obesity, the sizes of GB are enlarged both in cases of hypothyreoidism 64,4 mm (56–87) and 25 mm (21,2–28) and without it 67 mm (60–72) and 24 mm (22–29) with a significantly larger interquartile range (31 vs 12 mm) for hypothyroidism. According to Kendall's rank correlation analysis, gallbladder was enlarged in the older patients with a higher body mass index, and this statistically correlated with the advancement of stage and degree of arterial hypertension, cardiovascular risk, neutrophilic inflammation activation and immune inflammation suppression, thinned renal parenchyma, increased echogenicity of the pancreas, and cardioselective aspartataminotransferase cytolysis. These connections can be based on the common spinal innervation of the heart and gallbladder, dysregulated beta 3-adrenoceptor activity and disturbed nitrite mediated vasorelaxation. Keywords: gallbladder, size, arterial hypertension, hypothyroidism, obesity, cardiovascular risk.

scholarly journals ASSOCIATION BETWEEN OF ANTIOXIDANT PROTECTION WITH CHRONOLOGICAL AND BIOLOGICAL AGE IN PATIENTS WITH ARTERIAL HYPERTENSION

2021 ◽  
Vol 17 (2) ◽  
pp. 53-58
Author(s):  
A.O. Radchenko ◽  
O.V. Kolesnikova
Keyword(s):  
Arterial Hypertension ◽  
Young Patients ◽  
Diagnostic Value ◽  
Main Group ◽  
Biological Age ◽  
Antioxidant Protection ◽  
Significant Difference ◽  
Total Antioxidant ◽  
Relationship Of

Relevance. The study is relevant due to the increase in the prevalence of arterial hypertension (AH) with age, as well as the presence of common developmental mechanism with aging processes, that is a violation of antioxidant protection. Given the changes in the antioxidant state with age, studying their relationship with biological age (BA) may be useful in this category of patients. Objective: to study changes in antioxidant status in AH patients of various age categories and their relationship with calendar age (CA) and BA, calculated using two outpatient methods. Materials and methods. The study included 96 patients with an average age of 50.8 ± 14.3 years (53.1% of women), who were divided into 2 groups: the main group (n=71) – patients with AH degrees 1-2 stages 1-2 with low and moderate cardiovascular risk, controls (n=25) – healthy patients randomized by age and sex. Patients of the main group were divided into subgroups depending on age: 25-44 years (n=21), 45-59 years (n=25) and over 60 years (n=25). Markers of antioxidant protection: total antioxidant capacity (TAC) and total antioxidant activity (TAA) were determined in all patients. BA was calculated using the method of A. G. Gorelkin and B. B. Pinkhasov (BA1) and V.P. Voitenko’s method (BA2 ). Results. Patients of the main group had higher BA1 (p=0.024), BV2 (p=0.004), greater weight (p=0.010), body mass index (p=0.008), waist circumference (p=0.003). Also, there were tendencies towards an increase in TAC and a decrease in TAA in AH patients, compared with controls, although the differences were not significant. Correlation was found between CA and TAC (r=0.422; p=0.032) in the controls, and in the main group there was an association between CA and TAA (r=-0.357; p=0.003), the strength of which increased in young patients (r=-0.412; p=0.037). When comparing the levels of antioxidant state markers in AH patients depending on CA and BA, there was no significant difference in TAC levels, while TAA levels were the lowest in the group of patients aged 25-44 (p<0.05). After grouping patients depending on BA, there was an even more noticeable decrease in TAA in patients over 60 years old compared to controls. Conclusions. The associations between CA and the level of TAC in the controls and TAA in the main group were demonstrated. The relationship of these parameters with BA was observed only in patients with AH, which may indicate the effectiveness of BA evaluating using the methods of A. G. Gorelkin, B. B. Pinkhasov, and V. P. Voitenko for assessing the aging rate in AH patients. In young and elderly patients, the determination of TAA levels may be of greater diagnostic value than the determination of TAC. The nature of TAA changes in AH patients of the middle age, is different from patients of young and old age, which requires further study, taking into account other possible factors.

scholarly journals TECHNICAL, CLINICAL AND PROGNOSTIC ASPECTS OF HYPERTENSIVE RETINOPATHY

2020 ◽  
Vol 18 (5) ◽  
pp. 624-631
Author(s):  
N. Ya. Dotsenko ◽  
◽  
S. S. Boev ◽  
L. V. Нerasymenko ◽  
I. A. Shekhunova ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cardiovascular Risk ◽  
Patient Management ◽  
Moderate Hypertension ◽  
Young Patients ◽  
Routine Clinical Practice ◽  
Hypertensive Retinopathy ◽  
Prognostic Role

Changing approaches to the management of patients with arterial hypertension, reflected in international recommendations regarding, including diagnosis, determination of a cardiovascular risk, required to return to the issue of the place of fundoscopy in routine clinical practice. Recent studies have clarified the prevalence of various retinopathy options using new, highly accurate instruments. A large number of works are devoted to the study of the prognostic role of fundoscopy, and here the opinions of researchers are unequivocal: the detection of signs of the initial stages of retinopathy has a very little effect on patient management. It should be agreed with the opinion of experts from the European Cardiology Society that fundoscopy is indicated mainly in patients with difficult to control or resistant hypertension, and is not recommended for people with mild to moderate hypertension, not suffering from diabetes, with the exception of young patients.

scholarly journals Association of polimorphism rs1801282 with different components of the metabolic syndrome

2018 ◽  
Vol 10 (3) ◽  
pp. 60-64
Author(s):  
Tatiana V. Eremenko
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Clinical Laboratory ◽  
High Density Lipoproteins ◽  
Newly Diagnosed ◽  
Wild Type ◽  
The Metabolic Syndrome ◽  
Instrumental Methods ◽  
Pparγ Gene

Objective. To study the association of polymorphism rs1801282 of the PPARγ gene with different components of metabolic syndrome (MS). Materials and methods. 145 subjects with newly diagnosed MS were examined. All subjects underwent a clinical examination, including general clinical, laboratory and instrumental methods; presence of polymorphism rs1801282 of the PPARγ gene was also determined. Results. In the group of subjects with rs1801282 polymorphism, hyperglycemia was observed less frequently compared with the rest of subjects the incidence was 53.8% and 79.8% cases respectively (p = 0.005). A decrease in the risk of arterial hypertension was also observed in subjects with polymorphic allele: an increase in blood pressure was noted in 70.6% of rs1801282 group and 96.2% for wild type PPARγ (p < 0.001). When analyzing levels of triglycerides and high-density lipoproteins, an increase in these parameters was noted in the group of subjects with rs1801282 polymorphism. Conclusion. The results of the study indicate the association of rs1801282 polymorphism in subjects with metabolic syndrome with a number of clinical features of the disease, dyslipidemia and a reduction of the risk of hyperglycemia and hypertension.

Association of plaque echostructure and cardiovascular risk factors with symptomatic carotid artery disease

VASA ◽  
2009 ◽  
Vol 38 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Giannoukas ◽  
Sfyroeras ◽  
Griffin ◽  
Saleptsis ◽  
Antoniou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Cardiovascular Risk Factors ◽  
Carotid Plaque ◽  
Young Patients ◽  
Symptomatic Disease ◽  
Age Related ◽  
Ica Stenosis

Background: Severity of stenosis remains the main factor for assessing risk of stroke in patients with internal carotid artery (ICA) disease. This study was conducted to investigate the association of plaque echostructure and other established and emerging cardiovascular risk factors with symptomatic ICA disease. Design: Cross-sectional study of consecutive patients with significant (> 50 %) ICA stenosis. Patients and methods: Carotid plaque echostructure, smoking, hypertension, diabetes mellitus, serum lipoprotein (a), homocysteine, vitamin B12, folate, cholesterol to high-density lipoprotein ratio, triglycerides, C-reactive protein, and the Framingham risk score were assessed in 124 consecutive patients (70 asymptomatic; 54 symptomatic) with significant (> 50 %) ICA stenosis. Results: The asymptomatic and symptomatic groups did not differ in terms of gender distribution (p = 0.76) and severity of stenosis (p = 0.62). Echolucent plaques (type 1 and 2) were more predominant in patients with symptomatic disease (p = 0.004, OR = 2.13, 95 % CI = 1.26-3.6). Patients with plaques type 1 were relatively younger than those with type 4 (p = 0.02). None of the other factors assessed had any significant association with symptomatic disease and any type of carotid plaque. Conclusions: Besides the severity of carotid stenosis, the presence of an echolucent plaque appears as an important factor associated with symptomatic ICA disease. Also, young patients are more likely to have an echolucent plaque suggesting an age-related association with plaque maturation.

DETERMINATION OF WHITE BLOOD CELLS USING FOLDSCOPE WITH SMARTPHONE

2019 ◽  
pp. 10-13
Author(s):  
Ranu Kumar ◽  
Prasad Kapildeo
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Blood Smear ◽  
Clinical Laboratory ◽  
White Blood Cells ◽  
Healthcare Services ◽  
Field Level ◽  
Morphology Analysis

We are traditionally used Microscope in clinical laboratory for determination of white blood cells of human blood smear. Now, in this study we were used Foldscope with Smartphone in the place of Microscope and examine many samples of human blood smear which was collected from local diagnostic centers. We were very easily quantity & morphology analysis of all types of WBC cells such as Neutrophils, Lymphocytes, Monocytes, Eosionophils, Basophils in blood smear with the help of Foldscope & image taken by Smartphone. The main objective of this study is to use Foldscope for quantity & morphology analysis of human WBCs at field level especially poor resource area where healthcare services or centers is not available & where carry of microscope is not possible.

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