scholarly journals The role of Toxoplasma gondii in concentration of some sex hormones in infertile individual: أثر الإصابة بطفيلي المقوسة القندية على تراكيز بعض الهرمونات الجنسية عند الأشخاص العقيمين

Author(s):  
Musafer H. Al-Ardi Musafer H. Al-Ardi

The main objective: Link the incidence of the Toxoplasma gondii present and manifestations of some sex hormones ‎ at ‎infertile persons.‎ Follicle-stimulating hormone (FSH), 17-β Estradiol (E2), and testosterone are key ‎regulators for the development ‎and progress of germline cells. Also affect many defensive ‎functions to the ‎immune system. Toxoplasma gondii attempts to manipulating these ‎Hormones concentration to their survive. ‎ ‎The study methodology‎‏:‏‎ since October 2018 tell 31th March 2019, 100 samples of the blood of ‎infertile ‎patients have been collected from both sexes from outpatient clinics in ‎different areas of ‎Qadisiyah governorate, Iraq. All there examined with Elisa test to detect IgM and IgG ‎antibodies against T. gondii and to estimate concentration of sex hormones. ‎ Results: ‎ 39 samples (39 %) were positive to T. gondii. IgM positive ‎samples were (6 and ‎‎10) with (12% and 20%) at male and female, Positive IgG samples for male ‎and female were (10 and 13) ‎with (20% and 26%).‎ In male, Testosterone ‎concentrations were increased in infected where were (5.4 and 5) ng/ ml with IgG and IgM ‎test. Also E2 were (33.6 and 35) pg/ ml with IgG and IgM infected men ‎. While FSH concentrations were decreased in (12.1 and 12.3) IU with IgG and ‎IgM. In female, FSH and E2 concentrations were increased in infected female, ‎where were (5.45 and 5.9)IU/ ml and (260 and 250)pg/ ml from both hormones with IgG ‎and IgM test. Testosterone concentration was decreased (0.98)ng/ ml with IgG, ‎but increased (1.35) ng/ ml with IgM in female. ‎ ‎The study has been showed that a significant difference in the concentrations ‎of hormones studied ‎between non-infected and infected samples in ‎the acute case, and did not register a ‎significant difference between ‎chronic infection and non-infection, a significant increase ‎in ‎hormones Testosterone and E2 in male and female while FSH in ‎female only, FSH ‎concentration was lower in male after infection.‎ Conclusion: in light the study results the author see that: Infection with the parasite is associated with significant changes ‎in the ‎concentrations of sex hormones in infertile peoples, therefore ‎it can be said that infection ‎with Toxoplasma gondii is one of the ‎main causes of infertility in both sexes.‎ ‎ ‎Suggestions:‎ ‎Conduct broader studies by examining more people and ‎determine the relationship ‎between infertility and sex hormone ‎concentration with infection by T. gondii in girls and ‎boys before ‎or after puberty.‎

2010 ◽  
Vol 9 (3) ◽  
pp. 128
Author(s):  
K. M. Al-Saad ◽  
Saad Hashim Al-Husseiny

The objective of this study was to investigate Toxoplasma gondii antibodies among sheep in different regions of Basrah province (including Al-Mdayna, Shatt Al-Arab, Al-Basrah, Al-Zubayr, and Abu Al-Khasib). The study was started in Oct. 2008 and was finished in May 2009, using latex agglutination test (LAT) and indirect enzyme linked immunosorbent assay (ELISA) IgG, 309 adult sheep were randomly selected from 15 herds among different ages and both sexes and used in this study, including 62 pregnant ewes, 185 non-pregnant ewes, 14 aborted ewes, and 48 rams. Results showed, that 60.84% were seropositive by LAT, whereas 51.11% were seropositive by ELISA IgG test, among animals used in this study, results detected that 79.03% pregnant ewes (highest value), 56.75% nonpregnant ewes,71.40% aborted ewes and 50% Rams (lowest value) were seropositive by LAT, whereas 56.52% pregnant ewes, 51.11% non-pregnant ewes, 83.33% aborted ewes (highest value), and 31.25% Rams (lowest value) were seropositive by indirect ELISA IgG. Moreover, among regions of Basrah province, the details of percentage of T.gondii antibodies were 54.54% in AL-Basrah , 71.43% in Abu Al-Khasib (highest value), 57.35% in Al- Mdayna, 47.83% in Shatt Al-Arab (lowest value), and 67.16% in Al-Zubayr by LAT, whereas 63.64% in AL-Basrah (highest value), 22.73% in Abu Al-Khasib (lowest value), 57.89% in Al-Mdayna, 50% in Shatt Al-Arab and 61.90% in Al-Zubayr by indirect ELISA test. Although the difference observed in the percentage of Toxoplasma gondii antibodies among different regions of Basrah, there was no significant difference P>0.05 detected LAT, whereas in the indirect ELISA IgG test there was significant difference P<0.05. Ewes showed high percentages 62.83%, 55.40% of toxoplasmosis than rams 50 %, 31.25% by LAT and ELISA test respectively. The highest titer was 1/4 28.57% were detected in pregnant ewes and lowest titers were 1/2, 1/8, and 1/256 0.0% were detected in aborted ewes and in ramsrespectively.


2020 ◽  
Vol 4 (1) ◽  
pp. 86-102
Author(s):  
Tasnim Rehna ◽  
Rubina Hanif ◽  
Muhammad Aqeel

Background: Widespread social paradigms on which the status variances are grounded in any society, gender plays pivotal role in manifestation of mental health problems (Rutter, 2007). A hefty volume of research has addressed the issue in adults nonetheless, little is vividly known about the role of gender in adolescent psychopathology. Sample: A sample of 240 adolescents (125 boys, 115 girls) aging 12-18 years was amassed from various secondary schools of Islamabad with the approval of the Federal Directorate of Education (FDE), relevant authorities of the schools and the adolescents themselves. Instruments: Taylor Manifest Anxiety Scale (Taylor & Spence, 1953) and Children’s Negative Cognitive Errors Questionnaire (CNCEQ) by Leitenberg et al., (1986) were applied in present study. Results: Multiple regression analysis revealed that cognitive errors jointly accounted for 78% of variance in predicting anxiety among adolescents. Findings also exhibited that gender significantly moderated the relationship between cognitive errors and adolescent anxiety. Implications of the findings are discoursed for future research and clinical practice.


Author(s):  
Mirosław Śnit ◽  
Maciej Misiołek ◽  
Wojciech Ścierski ◽  
Anna Koniewska ◽  
Grażyna Stryjewska-Makuch ◽  
...  

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.


2021 ◽  
pp. 135910452110058
Author(s):  
Sayyeda Taskeen Zahra ◽  
Sadia Saleem ◽  
Halima Khurshid

This research aims to determine the mediating role of social deficits in self-criticism and aggression using a sample of 695 adolescents (girls = 49%, boys = 51%), aged 12 to 19 years ( M = 14.97, SD = 1.30) from an urbanized city of Pakistan. Interpersonal Difficulties Scale, Self-Criticism Scale, and Aggressive Behavior Scale were used in the present study. Results indicated a significant positive association of social deficits with self-criticism and aggression ( p < .001). Furthermore, findings also suggested a significant positive association between self-criticism and aggression. Mediation analysis revealed that self-criticism partially mediated the relationship between social deficits and aggression. Findings are discussed in terms of the expression and manifestation of self-criticism, social deficits, and aggression in adolescents in collectivistic cultures.


1987 ◽  
Vol 17 (4) ◽  
pp. 160-164 ◽  
Author(s):  
Stephen D. Bluen ◽  
Caroline van Zwam

The relationship between union membership and job satisfaction, and the moderating role of race and sex is considered in this study. Results show that both race and sex interact with union membership in predicting job satisfaction. A significant 2 × 2 × 2 (union membership × race × sex) interaction showed that white, non-unionized females were less satisfied with their work than black, non-unionized females. In addition, sex moderated the relationship between union membership and co-worker satisfaction: Whereas unionized males were more satisfied with their co-workers than unionized females, the opposite was true for the non-unionized subjects. Finally, union members and non-members differed regarding promotion opportunities: Union members were more satisfied with their promotion opportunities than non-union members. On the basis of the findings, implications and future research priorities are discussed.


2019 ◽  
Vol 30 (6) ◽  
pp. 920-936 ◽  
Author(s):  
Manjeet Kharub ◽  
Rahul S. Mor ◽  
Rajiv Sharma

Purpose The purpose of this paper is to examine the cost leadership competitive strategy’s (CLCS) impact on firm performances and the mediating role of quality management (QM) practices in the context of micro, small and medium enterprises (MSMEs). Design/methodology/approach A structures questionnaire data collected from 245 ISO 9000 certified MSMEs in India (65.1 per cent of response rate) have been utilised to understand the CLCS’s impact on firm performances. In the first step, the data adequacy tests were performed to check the reliability and validity of the questionnaire and survey data. After that, the partial mediating model (direct, indirect and total effect) along with structural equation modelling approach was employed to test the research hypotheses. Findings The study results revealed that no direct relationship exists between the CLCS and firm performances (0.12<β<0.13; p>0.05); however, QM practices entirely mediated their relationship (β=0.73, p<0.01). Among eight model parameters, with highest total effects on product quality improvement (β=0.6264) and process improvement (β=0.6028), the continuous improvement secured the rank 1, followed by information and analysis (β=0.2334) and supplier management (0.1839), respectively, at p<0.05. Based on the empirical results, it can be concluded that the continuous improvement via proper information and data analysis is the key to achieve CLCS’s goal in the MSMEs. Research limitations/implications The study results’ generalisation towards the large organisations is limited. The survey result findings applicability to other developing countries should also be treated with caution because the Indian Government subsidised the MSMEs selected for this study. The study results will help managers in implementing CLCS at the organisational level. The successful implementation will facilitate a competitive advantage in the local market and will motivate them to think globally. Originality/value The research observation and findings are expected to contribute to the strategic management in manufacturing industries. The study also confirms the existence of strategic management in MSMEs in a developing country. Furthermore, the major contribution is to understand the mediating role of QM practices, especially continuous improvement effect on the relationship between CLCS and firm performances in a developing country. The results indicated that the CLCS is only possible when the managers in the manufacturing sectors emphasis on the QM practices in their firms.


2020 ◽  
Vol 34 ◽  
pp. 205873842092917
Author(s):  
Virginia Corazzi ◽  
Andrea Ciorba ◽  
Piotr Henryk Skarżyński ◽  
Magdalena B Skarżyńska ◽  
Chiara Bianchini ◽  
...  

In the last years, the attention to the role of gender in physiopathology and pharmacology of diseases in several medical disciplines is rising; however, the data on the relationship between gender and audio-vestibular disorders are still inconclusive and sometimes confusing. With this letter to the editor, we would like to review the role of gender in audio-vestibular disorders. Literature data show that anatomic variances of the inner ear do exist in men and women and that the different physiology and/or hormonal influence between genders could produce different clinical outcome of routine audiological and vestibular tests. Beyond the epidemiological gender-related differences, the clinical data suggest that the gender has a potential role as an etiopathogenetic factor in audio-vestibular disorders and it is probably responsible for the different clinical features observed between male and female subjects.


2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Maricela C. Arellano ◽  
Cristina Sancha ◽  
Torbjørn Netland ◽  
Cristina Gimenez Thomsen

PurposeIn pursuit of increased competitiveness, global manufacturers often seek tighter integration among the plants in their production networks. However, this is a challenging task because plants are dispersed across multiple institutional environments. Although the literature provides abundant evidence of how formal institutional environments affect the integration among plants, little is known about the role of the informal institutional environment – such as culture. In this study, the authors investigate the relationship between different dimensions of culture and manufacturing network integration.Design/methodology/approachThe authors combine survey data from the most recent International Manufacturing Strategy Survey with secondary data that capture cultural dimensions. They then analyze the responses from 581 assembly plants in 21 countries obtained from the survey using a multilevel regression model.FindingsThe study results show that plants located in masculine and long-term-oriented national cultures are associated with lower levels of integration with other plants. The results for the other four Hofstede dimensions of national culture were not statistically significant. At the level of organizational culture, the authors found that a collaborative plant environment positively relates to higher levels of network integration. They did not find statistically significant evidence for the relationship between cultural or geographical distance and network integration.Practical implicationsThis research provides managers with practical insights into the types and combinations of cultural environments that affect the integration of plants in a global network. This knowledge is useful for informing effective integration strategies and tactics.OriginalityThe authors provide new, empirical evidence of the relation between the informal institutional environments of a plant and its integration in a manufacturing network. Drawing on an institution-based view, they contribute to the literature on manufacturing networks by discussing and testing empirically the role of national and organizational culture in network integration.


2020 ◽  
Vol 6 (2) ◽  
pp. 107-124
Author(s):  
Agus Darmaji

Research on the Roleof Santri Middle Class in Democratization Process in Indonesia was conducted in three cities in Java, i.e. the Cities of East Jakarta, Yogyakarta, and Surabaya. The research was conducted by using quantitative approach and survey method. The data collection method used in this research is direct interview technique, by using questionnaire instrument that was asked to the respondents directly through face to face.There are two types of hypotheses to be proved through this survey research, they are associative and comparativehypotheses.The associative hypothesis verification aims to prove whether there is significant relationship between dependent variable (Y) and independent variable (X) as predictor or not. Inthis research context, the relationship between role in the democratization process as the dependent variable (Y) with predictor independent variables(X) will be tested, which are the literacy of political and economic information(X1), satisfaction to public services (X2), trust in democratic institutions (X3), access to political resources (X4), ideology (X5), and relative deprivation (X6).The comparative hypothesisverificationaims to prove whether there is significant difference between two or more different respondent groups or not. Based on this research purpose, the differences of two respondent groups will be proved comparatively related to their role in the democratization process; they are (1) santrimiddle-class group and (2) groups of santrinon-middle class.There are two types of hypotheses to be proved through this survey research, they are associative and comparative hypotheses. The associative hypothesis verification aims to prove whether there is significant relationship between dependent variable (Y) and independent variable (X) as predictor or not. In this research context, the relationship between role in the democratization process as the dependent variable (Y) with predictor independent variables (X) will be tested, which are the literacy of political and economic information (X1), satisfaction to public services (X2), trust in democratic institutions (X3), access to political resources (X4), ideology (X5), and relative deprivation (X6). The comparative hypothesis verification aims to prove whether there is significant difference between two or more different respondent groups or not. Based on this research purpose, the differences of two respondent groups will be proved comparatively related to their role in the democratization process; they are (1) santri middle-class group and (2) groups of santri non-middle class.From the result of hypothesis associative verification, it is proved that all variables X correlated positively and significantly to variable Y. With this result, then the literacy of political and economic information (X1), satisfaction to public services (X2), trust in democratic institutions (X3), access to political resources (X4), ideology (X5), and relative deprivation (X6) are proved to correlate positively and significantly to the role in democratization (Y).From the result of comparative hypothesis verification, the X2 value of 1363.44 is obtained. This value is greater than the X2 value of table at 88 degrees of freedom and significance level of 0.5. With this result, then the null hypothesis which stated that there is no significant difference between santri middle class and other class groups is rejected. This means the alternative hypothesis that stated otherwise is received. Conclusion based on this examination result is that there are significant differences between the role of santri middle class and other group samples in the democratization process.


Author(s):  
Mohtaram Zabihi ◽  
Ghahraman Mahmoudi ◽  
Ghassem Abedi

Background and purpose: The concepts of work and life have the strongest and most effective relationship with individuals and society, and making a balance between them can have a direct impact on the achievement of organizational goals. The purpose of this study was to compare the relationship between quality of public life and quality dedicated to working life in the presence of the mediator role of work conflict.Materials and Methods: This applied study was conducted by implementing a descriptive-analytical method in 2017. The study population consisted of 351 working women in the health sector of Mazandaran University of Medical Sciences, who were selected using stratified sampling method. The survey tool was a standard questionnaire which was used to collect the data, and then the collected data was analyzed by SPSS 24 and AMOS 22.Results: The relationship between quality of public life and quality dedicated to work life in the job groups of women’s healthcare providers (P=0.0009,t=3.592), nurses and midwives' job group (P=0.009,t=2.595), and women’s technician/health expert working in health sector was significant (P=0.002, t=3.104). Whereas, there was no significant difference between the average quality of public life (P=0.117, F=1.788) and the quality dedicated to working life among the employees with different job titles (P=0.592, F=0.742). At the same time, the average of work conflicts was significantly different among different occupations (p = 0.009, F=3.152).Conclusion: The results showed that the relationship between quality of public life and the quality dedicated to work life varies from one job group to another. As a result, with proper planning aiming at increasing the quality of public life, an increase in the quality dedicated to work life and a reduction in their work conflicts can be seen.


Sign in / Sign up

Export Citation Format

Share Document