scholarly journals Computer-Aided Drug Designing of Ocimum Basilicum Compounds as Therapeutic Agents Against RdRp of SARS-CoV2

2021 ◽  
Author(s):  
Mehwish Shafiq ◽  
Rashid Saif ◽  
Laraib Ali ◽  
Tuba Ahmad ◽  
Anood Sohail
Keyword(s):  
Therapeutic Agents ◽  
Ocimum Basilicum ◽  
Binding Energies ◽  
Geranyl Acetate ◽  
Effective Vaccine ◽  
Treatment And Prevention ◽  
The World ◽  
Computer Aided ◽  
Drug Designing ◽  
High Binding Affinity

<div>The prevailing situation of the world is challenging due to COVID-19 pandemic that is caused by SARS-CoV2. To combat with this emerging pandemic by reducing disease severity and infection, the need of hour is to develop an effective vaccine and antiviral candidates as therapeutic agents against SARS-CoV2. This study was developed for the identification of potential anti-viral agents, from Ocimum basilicum against RdRp of SARS-CoV2. In this concern, nevadensin, ursolic acid, β-Sesquiphellandren, apigenin, nerolidol, nonyl acetate and geranyl acetate were screened out of fifty-seven compounds from Ocimum basilicum based on their best docking scores. The docking results were also compared with already clinically used drugs (Remdesivir and Ribavirin) against RdRp of SARS-CoV2. Molecular docking was performed using MOE software. The ADMET analysis and drug likeliness were also performed for all screened compounds by using admetSAR, pkCSM and SwissADME. Cumulatively, the optimum binding energies of screened compounds indicated their potential for drug development against SARS-CoV2. It appears promising that nevadensin exhibited a good docking score and high binding affinity towards RdRp of SARS-CoV2. Therefore, it may represent the potential to inhibit COVID-19. Hence, Ocimum basilicum nutraceuticals could be effective therapeutic candidates for the treatment and prevention of COVID-19. </div><div><br></div>

scholarly journals Computer-Aided Drug Designing of Ocimum Basilicum Compounds as Therapeutic Agents Against RdRp of SARS-CoV2

2021 ◽  
Author(s):  
Mehwish Shafiq ◽  
Rashid Saif ◽  
Laraib Ali ◽  
Tuba Ahmad ◽  
Anood Sohail
Keyword(s):  
Therapeutic Agents ◽  
Ocimum Basilicum ◽  
Binding Energies ◽  
Geranyl Acetate ◽  
Effective Vaccine ◽  
Treatment And Prevention ◽  
The World ◽  
Computer Aided ◽  
Drug Designing ◽  
High Binding Affinity

<div>The prevailing situation of the world is challenging due to COVID-19 pandemic that is caused by SARS-CoV2. To combat with this emerging pandemic by reducing disease severity and infection, the need of hour is to develop an effective vaccine and antiviral candidates as therapeutic agents against SARS-CoV2. This study was developed for the identification of potential anti-viral agents, from Ocimum basilicum against RdRp of SARS-CoV2. In this concern, nevadensin, ursolic acid, β-Sesquiphellandren, apigenin, nerolidol, nonyl acetate and geranyl acetate were screened out of fifty-seven compounds from Ocimum basilicum based on their best docking scores. The docking results were also compared with already clinically used drugs (Remdesivir and Ribavirin) against RdRp of SARS-CoV2. Molecular docking was performed using MOE software. The ADMET analysis and drug likeliness were also performed for all screened compounds by using admetSAR, pkCSM and SwissADME. Cumulatively, the optimum binding energies of screened compounds indicated their potential for drug development against SARS-CoV2. It appears promising that nevadensin exhibited a good docking score and high binding affinity towards RdRp of SARS-CoV2. Therefore, it may represent the potential to inhibit COVID-19. Hence, Ocimum basilicum nutraceuticals could be effective therapeutic candidates for the treatment and prevention of COVID-19. </div><div><br></div>

SARS-COV-2 CORONAVIRUS: NOMENCLATURE, CLASSIFICATION, STRUCTURE, HISTORY, SYMPTOMS EPIDEMIOLOGY, PATHOGENESIS, ETIOLOGY, DIAGNOSES, TREATMENT, AND PREVENTION

2021 ◽  
Author(s):  
Hanan Al-Khalaifah ◽  
Mohammad Al-Otaibi ◽  
Abdulaziz Al-Ateeqi
Keyword(s):  
Food Security ◽  
Social Economic ◽  
Animal Production ◽  
Effective Vaccine ◽  
Poultry Production ◽  
Treatment And Prevention ◽  
The World ◽  
Economic Health ◽  
Production Industry ◽  
Classification Structure

With the onset of the coronavirus pandemic in December 2019 in China, and the alarming rate at which it has spread across the world has unleashed not only fear, but has taken a toll on social, economic, health, and governing capabilities of the various countries infected with the virus. The pandemic is affecting all aspects of life, including industries such as the animal production industry all over the world. This includes plant, livestock and poultry production. Food security is accordingly impacted, as these industries are vital elements that are contributing to securing food to populations worldwide. In this review, light is shed on the origin of coronaviruses with special emphasis on COVID-19. It also includes introduction of symptoms, epidemiology and pathogenesis, etiology, and prevention. As the disease progresses, scientists are working around the clock in the hope of an effective vaccine, and they managed to introduce some to the worldwide populations. The world faces challenges on a day-to-day basis until most people are vaccinated.

Phytochemicals as Therapeutics Against COVID-19: An In-Silico Study

2020 ◽  
Author(s):  
Debraj Koiri ◽  
Ditam Chakraborty ◽  
Pranotosh Das ◽  
Rajkumar Rana ◽  
Soumyanil Chatterjee ◽  
...  
Keyword(s):  
In Silico ◽  
Therapeutic Agents ◽  
Binding Energies ◽  
Daily Lives ◽  
Lab Experiments ◽  
In Silico Studies ◽  
In Silico Study ◽  
The World ◽  
Wet Lab ◽  
Low Costs

Since December 2019, the worldwide spread of COVID-19 has brought the majority of the world to a standstill, affecting daily lives as well as economy. Under these conditions, it is imperative to develop a cure as soon as possible. On account of some of the adverse side effects of the existing conventional drugs, researchers all around the world are screening natural antiviral phytochemicals as potential therapeutic agents against COVID-19. This paper aims to review interactions of some specific phytochemicals with the receptor binding domain (RBD) of the Spike glycoprotein of SARS-CoV-2 and suggest their possible therapeutic applications. Literature search was done based on the wide array of in-silico studies conducted using broad spectrum phytochemicals against SARS-CoV-2 and other viruses. We shortlisted 26 such phytochemicals specifically targeting the S protein and its interactions with host receptors. To validate the previously published results, we also conducted molecular docking using the AutoDockVina application and identified 6 high potential phytochemicals for therapeutic use based on their binding energies. Besides this, availability of these compounds, their mode of action, toxicity data and cost-effectiveness were also taken into consideration. Our review specifically identifies 6 phytochemicals that can be used as potential treatments for COVID-19 based on their availability, toxicology results and low costs of production. However, all these compounds need to be further validated by wet lab experiments and should be approved for clinical use only after appropriate trials.

scholarly journals Coronavirus disease 2019 drug discovery through molecular docking

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 502 ◽  
Author(s):  
Sweta Singh ◽  
Hector Florez
Keyword(s):  
Molecular Docking ◽  
Communicable Disease ◽  
Therapeutic Agents ◽  
World Health ◽  
Effective Vaccine ◽  
Glycyrrhetic Acid ◽  
The World ◽  
Antiparasitic Drugs ◽  
Health Organization ◽  
Inhibitory Drug

Background: The dawn of the year 2020 witnessed the spread of the highly infectious and communicable disease coronavirus disease 2019 (COVID-19) globally since it was first reported in 2019. Severe acute respiratory syndrome coronavirus-2 is the main causative agent. In total, 3,096,626 cases and 217,896 deaths owing to COVID-19 were reported by 30th April, 2020 by the World Health Organization. This means infection and deaths show an exponential growth globally. In order to tackle this pandemic, it is necessary to find possible easily accessible therapeutic agents till an effective vaccine is developed. Methods: In this study, we present the results of molecular docking processes through high throughput virtual screening to analyze drugs recommended for the treatment of COVID-19. Results: Atovaquone, fexofenadine acetate (Allegra), ethamidindole, baicalin, glycyrrhetic acid, justicidin D, euphol, and curine are few of the lead molecules found after docking 129 known antivirals, antimalarial, antiparasitic drugs and 992 natural products. Conclusions: These molecules could act as an effective inhibitory drug against COVID-19.

COVID-19: The Unprecedented Malady-A Holistic Review

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Viney Chawla ◽  
Pooja A Chawla
Keyword(s):  
Virus Disease ◽  
Drug Repurposing ◽  
Signs And Symptoms ◽  
Effective Vaccine ◽  
Runny Nose ◽  
Difficult Time ◽  
Holistic Review ◽  
The World ◽  
Spanish Flu ◽  
Corona Viruses

Background: Corona virus disease (COVID-19) is spreading rapidly at an unprecedented scale across continents and has emerged as the single biggest risk the world has faced in modern times. Some scientists are comparing it to Spanish flu that created havoc around a century ago. The fear of death by COVID-19 looms large at the world today. The disease has reached devastating proportions since its first reports in December 2019. Doctors are having a difficult time dealing with this challenge and the microbiologists are having sleepless nights to bring about an effective vaccine for this disease. Methods: A number of research and review articles have been exhaustively reviewed. The collected data was meticulously analysed and documented. Conclusion: This paper reviews the different types of corona viruses, the structure of SARS-CoV-2 responsible for COVID19, its transmission, virulence. Further, the article discusses the diagnosis, signs and symptoms like fever, breathlessness, cough, potential loss of taste or smell, sneezing, runny nose, fatigue, headache, sore throat and different treatment approaches including drug repurposing being tried by doctors around the globe that may come handy in the management of disease symptoms. The article describes the use of remdesivir, ribavarin, lopinavir, favipiravir, hydoxychloroquine, chloroquine, tocilizumab among others in treating COVID-19.

Critical Insight into the Attributes of Emerging Novel Coronavirus (COVID-19) in India and Across the World

Coronaviruses ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Gaurav M. Doshi ◽  
Hemen S. Ved ◽  
Ami P. Thakkar
Keyword(s):  
Review Article ◽  
World Health ◽  
Effective Vaccine ◽  
Human Contact ◽  
The World ◽  
Critical Insight ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Insight Into ◽  
Old Drugs

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.

scholarly journals SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Nikolaos C. Kyriakidis ◽  
Andrés López-Cortés ◽  
Eduardo Vásconez González ◽  
Alejandra Barreto Grimaldos ◽  
Esteban Ortiz Prado
Keyword(s):  
Neutralizing Antibodies ◽  
Large Scale ◽  
Vaccine Development ◽  
Rna Virus ◽  
Protein S ◽  
Effective Vaccine ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Advantages And Disadvantages ◽  
The World

AbstractThe new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

Clinical Management Updates for Novel Corona Virus (COVID-19)

2021 ◽  
Vol 14 (3) ◽  
pp. 5449-5456
Author(s):  
Yogesh Chand Yadav ◽  
Ramakant Yadav ◽  
Sushant Kumar
Keyword(s):  
Clinical Management ◽  
Respiratory Illness ◽  
Symptomatic Treatment ◽  
Structural Features ◽  
Therapeutic Agents ◽  
Human Coronavirus ◽  
Transmission Potential ◽  
The World ◽  
Severe Respiratory Illness ◽  
Droplet Transmission

The SARS-CoV-2 virus was first detected in Wuhan, China in December 2019 and was known to produce acute severe respiratory illness in humans which rapidly spread almost throughout the world within a few months. This human coronavirus has seven strains and they commonly produce illness in the nervous system, respiratory system and hepato- intestinal systems. This present review is an attempt to illustrate recent reports pertaining to the management of SARS-CoV-2. Further, it also highlights the diagnosis and clinical management of COVID-19. Various search engines like Scopus, Pubmed and WHO databases were accessed and literature on current advances about COVID-19 including structural features, replication, possible pathogenic, symptoms, diagnosis, prognosis, methods of prevention and possible therapeutic agents used for treatment of patients was reviewed. Current studies indicate that COVID-19 is very infectious with droplet transmission potential. The key modalities to prevent the infection is by keeping social distancing, respiratory/hand hygiene, detection of infection and subsequent quarantine of the infected persons. Presently, either no vaccine for prevention or specific treatments available, however, COVID-19 patients may be managed by using some repositioned drugs and symptomatic treatment.

Síndrome Respiratória Aguda Grave e a COVID-19 (SARS-Cov-2): uma revisão narrativa

2020 ◽  
Vol 11 (2.ESP) ◽  
Author(s):  
Maria Soraya Pereira Franco Adriano ◽  
Betânia Maria Pereira Santos ◽  
Carmem Gabriela Gomes de Figueiredo Figueiredo ◽  
Ana Carolina Bernardes Dulgheroff ◽  
Ronaldo Rodrigues Sarmento ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Health Professionals ◽  
Scientific Community ◽  
Scientific Production ◽  
Diagnosis And Treatment ◽  
Effective Vaccine ◽  
Disease Clinic ◽  
The World ◽  
Different Parts ◽  
Coronavirus Infections

Objetivo: Analisar a produção científica acerca da atual pandemia do novo coronavírus, destacando aspectos referentes às características do vírus, bem como a epidemiologia, o diagnóstico e tratamento da COVID-19 no intuito de fornecer informações aos profissionais de saúde e à comunidade científica. Método: Revisão narrativa, com busca nas bases de dados Scielo, Medline, Lilacs e Pubmed, referente ao período de fevereiro a maio de 2020, utilizando os descritores: “infecções por coronavírus” or “coronavirus infections”, “COVID-19”, “betacoronavirus”, “Síndrome Respiratória Aguda Grave”, “SARS-Cov-2”, “diagnóstico”, “diagnosis”. Resultados: Foram evidenciadas três categorias temáticas: aspectos referentes ao vírus; a epidemiologia e a clínica da doença; e aspectos do diagnóstico e tratamento. Conclusão: O Coronavírus sofreu mutações desde o início da pandemia, mas não se sabe se estas mutações afetaram seu poder de infecciosidade. Em diferentes partes do mundo a epidemiologia da COVID-19 foi diferente. Com relação ao tratamento, a droga que tem se mostrado mais promissora até o momento é o remdesivir. Sem uma vacina eficaz, a maior arma que dispomos é o isolamento social.Descritores: Infecções por Coronavírus; COVID-19; Síndrome Respiratória Aguda Grave. SEVERE ACUTE RESPIRATORY SYNDROME AND COVID-19 (SARS-COV-2): A NARRATIVE REVIEWObjective: To analyze a scientific production on the current pandemic of new coronaviruses, highlighting aspects related to virus resources, as well as the epidemiology, diagnosis and treatment of COVID-19 in order to provide information to health professionals and the scientific community. Method: Narrative review, searching the Scielo, Medline, Lilacs and Pubmed databases, for the period from February to May 2020, using the keywords: "coronavirus infections" or "coronavirus infections", "COVID-19", "Betacoronavirus", "Severe Acute Respiratory Syndrome", "SARS-Cov-2", "diagnosis", "diagnosis". Results: Three thematic categories were highlighted: aspects related to the virus; an epidemiology and disease clinic; and aspects of diagnosis and treatment. Conclusion: The Coronavirus has mutated since the beginning of the pandemic, but it is not known whether these mutations have affected its infectiousness. In different parts of the world the epidemiology of COVID-19 was different. Regarding treatment, a drug that has been shown to be more promising until recovery is needed. Without an effective vaccine, the biggest weapon that affects social isolation.Descriptors: Coronavirus Infections; COVID-19; Severe Acute Respiratory Syndrome. SÍNDROME RESPIRATORIO AGUDO GRAVE Y COVID-19 (SARS-COV-2): UNA REVISIÓN NARRATIVAObjetivo: analizar una producción científica sobre la pandemia actual de nuevos coronavirus, destacando aspectos relacionados con los recursos del virus, así como la epidemiología, diagnóstico y tratamiento de COVID-19 para proporcionar información a los profesionales de la salud y la comunidad científica. Método: Revisión narrativa, buscando en las bases de datos Scielo, Medline, Lilacs y Pubmed, para el período de febrero a mayo de 2020, utilizando los descriptores: "infecciones por coronavirus" o "infecciones por coronavirus", "COVID-19", "Betacoronavirus", "Síndrome respiratorio agudo severo", "SARS-Cov-2", "diagnóstico", "diagnóstico". Resultados: se destacaron tres categorías temáticas: aspectos relacionados con el virus; una clínica de epidemiología y enfermedad; y aspectos de diagnóstico y tratamiento. Conclusión: el coronavirus ha mutado desde el comienzo de la pandemia, pero no se sabe si estas mutaciones han afectado su infecciosidad. En diferentes partes del mundo, la epidemiología de COVID-19 fue diferente. Con respecto al tratamiento, un medicamento que ha demostrado ser más prometedor hasta que se necesita recuperación. Sin una vacuna efectiva, el arma más grande que afecta el aislamiento social.Descriptores: Infecciones por Coronavirus; COVID-19; Síndrome Respiratorio Agudo Severo.

scholarly journals Pharmacotherapeutic management of chronic viral hepatitis

2021 ◽  
Vol 2 (4) ◽  
pp. 1-8
Author(s):  
Gabriela Mitea ◽  
Marius Daniel Radu ◽  
Ana Maria Ionescu ◽  
Nicoleta Blebea
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
World Health Organization ◽  
Geographical Area ◽  
Chronic Viral Hepatitis ◽  
World Health ◽  
Effective Vaccine ◽  
Special Importance ◽  
The World ◽  
Health Organization

In infectious diseases, viral hepatitis has an increased incidence, being an important cause of morbidity and mortality, being a "sentinel" indicator of the socio-economic and hygienic-cultural standard of a geographical area. The World Health Organization (WHO) admits the following types of hepatitis viruses: A, B, B + D, C, E, F and G. Among the viral entities recognized by the WHO, a special importance in terms of incidence, evolution over time with the risk of chronicity and the therapeutic options are presented by hepatitis B and C. There is currently an effective vaccine as well as treatment for hepatitis B. There is no vaccine for hepatitis C, but in recent years considerable progress has been made in treating this disease. Also, the introduction of drugs known as direct-acting antivirals makes it possible to cure over 90% of patients within 2-3 months. But in many countries, current drug policies, regulations and prices keep treatment out of the reach of most people with hepatitis. Eradication of viral hepatitis is possible if greater emphasis is placed on prevention, diagnosis and treatment. Vaccination is very important, as it is possible for types A and B of hepatitis. Early diagnosis is also extremely important, given that there are currently very effective drugs that can prevent the development of liver cancer. The WHO also noted that about two million people worldwide become ill each year due to the reuse of syringes and stressed the importance of checking blood donors to see if they are not carriers of hepatitis B or C viruses. Therefore, the purpose of this article is to highlight the pharmacological treatment and the main therapeutic and prevention schemes currently used for patients with these liver diseases. The paper was based on the most popular methods of identification of the latest international information about the treatment of hepatitis (by electronic search using Pubmed, SciFinder, Scirus, GoogleScholar and Web of Science). We also consulted the global literature cited in the hepatitis database of the World Health Organization (WHO) updated frequent from the current literature on this topic.

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