scholarly journals Clinical prognostic factors of bilateral synchronous renal cancer

2018 ◽  
Vol 20 (3) ◽  
pp. 51-54
Author(s):  
M I Komarov ◽  
V B Matveev ◽  
M I Volkova ◽  
I G Komarov ◽  
V A Ridin
Keyword(s):  
Prognostic Factors ◽  
Survival Rate ◽  
Renal Cancer ◽  
Statistical Significance ◽  
Factors Affecting ◽  
National Medical ◽  
The Russian Federation ◽  
Main Factors ◽  
Type Of Surgery

The aim of the study is to assess the positive and negative prognostic factors of survival in patients with bilateral synchronous renal cancer (BRC). Materials and methods. The study was conducted on the basis of N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation. Cohort of patients with the synchronous BRC consisted of 160 patients between 1996 and 2014. All patients after finishing treatment were observed on an ambulatory basis during the period from 11 months to 12 years (median follow-up 81.05±46.7 months). We studied factors affecting 5-year survival rate, both positive and negative. Statistical analysis of the obtained results carried out using generally accepted statistical methods such as SPSS 23.0 - block of programs for Windows. Results. In case of synchronous BRC in 2/3 (65%) of patients the first kidney was operated on using organ-preserving surgery, in 1/4 of patients (n=21, 26.2%) both kidneys were operated on using organ-preserving surgery. In case of synchronous renal cancer the best results of survival, but without statistical significance (p=0.112) had patients with bilateral renal cancer who operated on using organ-preserving surgery. The 10-year overall survival in this group of patients was 90.5% in comparison with 62.5% - when nephrectomy was performed on the first stage and 76.4% in patients who had nephrectomy performed because of the renal cancer in the second kidney. Conclusions. The main factors affecting the 5-year survival rate of patients with synchronous BRC were: smoking, primary tumor size, age and type of surgery.

scholarly journals An empirical investigation of physical literacy-based adolescent health promotion

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Minmin Du ◽  
Yimin Liu ◽  
Lei Li
Keyword(s):  
Health Promotion ◽  
Adolescent Health ◽  
Panel Survey ◽  
Physical Literacy ◽  
Factors Affecting ◽  
Training Models ◽  
Study Results ◽  
Main Factors ◽  
Physical Elements

Abstract A reexamination of the health problems of Chinese adolescents based on the concept of physical literacy (PL) was necessary. Through the use of follow-up data collected from the China Education Panel Survey 2014–2015, the main factors affecting the health of adolescents were identified, and possible explanations were investigated after cluster and inductive analyses were conducted. The results showed that (1) the 10 main factors identified as affecting adolescent health promotion are in line with the four main elements of PL (emotional, cognitive, social and physical elements) and (2) the three major categories of influencing factors identified through a cluster analysis were aligned with the three main factors of PL (endogeneity, fundamentality and permeability). These findings suggest that the factors influencing adolescent health promotion are closely associated with PL. The study results can provide empirical evidence for adolescent health promotion research and a reference for the development of evidence-based PL training models.

FACTORS AND RESERVES FOR INCREASED EXPORTS OF WHEAT AND WHEAT PRODUCTS PROCESSING FROM THE RUSSIAN FEDERATION

2020 ◽  
Vol 13 (1) ◽  
pp. 160-169
Author(s):  
M.D. Magomedov ◽  
◽  
V.V. Stroyev ◽  
O.V. Karabanova ◽  
I.E. Domarev ◽  
...  
Keyword(s):  
Russian Federation ◽  
Factors Affecting ◽  
Wheat Products ◽  
The Russian Federation ◽  
Main Factors

The article proposes a classification of the main factors affecting the increase in wheat exports and processing products from the Russian Federation. They are grouped into external and internal. Each factor is disclosed in detail. Reserves are considered and recommendations on their use are given.

scholarly journals Efficacy and safety of selective internal radiation therapy with yttrium-90 for the treatment of unresectable hepatocellular carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nguyen Van Thai ◽  
Nguyen Tien Thinh ◽  
Thai Doan Ky ◽  
Mai Hong Bang ◽  
Dinh Truong Giang ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Proportional Hazards ◽  
Tumor Response ◽  
Complete Response ◽  
Tumor Burden ◽  
Cox Proportional Hazards ◽  
Factors Affecting ◽  
Kaplan Meier ◽  
Modified Recist

Abstract Background This retrospective analysis was undertaken to evaluate the efficiency of SIRT with Y-90 microspheres and determined prognostic factors affecting patients with unresectable HCC. Methods A total of 97 patients diagnosed with unresectable HCC who underwent SIRT with Y-90 microspheres. Patient survival was assessed using the Kaplan–Meier method, and prognostic factors affecting survival were assessed using log-rank tests and Cox proportional hazards regression. Results Among the 97 patients (90 males, mean age 60.4 ± 12.3 years) who underwent SIRT, the median clinical follow-up was 16.4 (1.8–62) months. The median overall survival (OS) was 23.9 ± 2.4 months. Tumor response according to the Modified RECIST in patients followed up beyond 6 months included a complete response (CR) to treatment in 12 patients (18.8%), partial response (PR) in 23 (35.8%), stable disease (SD) in 8 (12.5%), and progressive disease (PD) in 21 (32.8%). Factors associated with longer OS included age > 65 years, BCLC stage B, tumor size < 5 cm, tumor burden < 25%, and tumor response (CR/PR). In multivariate analysis, unilobar disease and objective tumor response (CR/PR) were predictors of longer OS. Conclusion SIRT was an effective treatment for unresectable HCC. Unilobar disease before SIRT and tumor response (CR/PR) were positive prognostic factors.

Analysis of prognostic factors after 16 years of follow-up in a randomized phase II trial of neoadjuvant FAC compared with CMF in stage III breast cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 11118-11118
Author(s):  
Julieta Leone ◽  
Jose Pablo Leone ◽  
Carlos Teodoro Vallejo ◽  
Juan Eduardo Perez ◽  
Alberto Omar Romero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Neoadjuvant Chemotherapy ◽  
Phase Ii ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Disease Free Survival ◽  
Stage Iii ◽  
Stage Iii Breast Cancer

11118 Background: Neoadjuvant chemotherapy is a standard treatment in stage III breast cancer. Prognostic factors can help to identify patients (pts) with high risk of recurrence. The aim of this study was to assess several prognostic factors after a long follow-up, in stage III breast cancer pts, treated with neoadjuvant chemotherapy. Methods: We evaluated 126 pts with stage III breast cancer that participated in a phase-II randomized trial of neoadjuvant 5-fluorouracil, doxorubicin and cyclophosphamide (FAC every 21 days) compared with cyclophosphamide, methotrexate and 5-fluorouracil (CMF days 1 and 8 every 28). Chemotherapy was administered for three cycles prior to definitive surgery and radiotherapy, and then for six cycles as adjuvant. Response was assessed by WHO criteria. Results: The median age was 52 years (range 24-75). Median follow-up was 4.5 years (range 0.2-16.4), disease free survival (DFS) 4.8 years and overall survival (OS) 6.4 years. Results of the phase-II study showed no difference in efficacy between groups. Univariate analysis showed that the number of pathologically involved lymph nodes (pLN), pathologic response and estrogen and progesterone receptor status correlated with DFS and OS. Number of pLN was the only prognostic factor with statistical significance in Cox regression test for both, DFS and OS (P=0.0004 and P=0.0006, respectively). In a subgroup analysis of pts with pLN, we found no difference in survival when we compared FAC with CMF. Conclusions: The prolonged follow-up of this study provides a unique opportunity to evaluate factors that predict long-term outcomes. After 16 years of follow-up, the number of pLN remains the most powerful predictor of survival. The subset of pts with pLN had similar survival regardless of the regimen used. Clinical trial information: NCT00002696.

Prognostic Factors Affecting the Clinical Outcome of Septic Arthritis of the Shoulder

2016 ◽  
Vol 21 (03) ◽  
pp. 339-344 ◽  
Author(s):  
Chul-Hyun Cho ◽  
Geon-Myeong Oh
Keyword(s):  
Prognostic Factors ◽  
Los Angeles ◽  
Clinical Outcome ◽  
Septic Arthritis ◽  
Clinical Outcomes ◽  
Open Surgery ◽  
Positive Culture ◽  
Factors Affecting ◽  
The Mean

Background: The objective of this study was to determine prognostic factors affecting the clinical outcome of septic arthritis of the shoulder. Methods: We retrospectively reviewed 34 shoulders from 32 patients, two of which had bilateral involvement. Arthroscopic (22 shoulders) or open surgery (12 shoulders) was performed by a single surgeon. The mean follow-up period was 32.4 ± 17.0 months. Clinical outcomes according to the University of California at Los Angeles (UCLA) score, American Shoulder and Elbow Surgeons (ASES) score, and Subjective Shoulder Value (SSV) were assessed at the final follow-up period. Various factors were included for statistical analysis. Results: The mean UCLA, ASES scores, and SSV were 28.9 ± 7.2, 81.3 ± 21.0, 79.7 ± 2.5%, respectively. Positive culture was observed in only 13 shoulders (38.2%) and the most common organism was Staphylococcus aureus (seven shoulders). Five shoulders (14.7%) required two or three operations. Age and comorbidity were negatively correlated with the UCLA, ASES score, and/or SSV (p < 0.05). There was no correlation between clinical outcome and various parameters, including gender, location of lesion, history of previous steroid injection, interval between onset of symptoms and surgical intervention, bacterial organisms, operative method, and presence of rotator cuff tear and reoperation (p > 0.05). Conclusions: Both arthroscopic and open surgery for septic shoulders showed satisfactory clinical outcomes. Old age and comorbidity were poor prognostic factors of clinical outcomes after treatment.

Clinical and pathologic prognostic factors in adult granulosa cell tumors of the ovary

2008 ◽  
Vol 18 (5) ◽  
pp. 929-933 ◽  
Author(s):  
R. Ranganath ◽  
V. Sridevi ◽  
S. S. Shirley ◽  
V. Shantha
Keyword(s):  
Prognostic Factors ◽  
Granulosa Cell ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Disease Free Survival ◽  
Optimal Cytoreduction ◽  
Free Survival ◽  
Nuclear Atypia ◽  
Granulosa Cell Tumors

The objective of this study was to determine the clinicopathologic prognostic factors in adult granulosa cell tumors of the ovary. A retrospective review of the records of patients of granulosa tumors who were treated at our institute over a period of 10 years (1995–2005) was done. Clinical, pathologic, and follow-up data were collected. A total of 34 patients who were treated during this period were subjected to analysis. Cox univariate analysis and Wilcoxon's test for multivariate analysis were used as part of the SPSS software for examining the data. It was found that optimal cytoreduction (P= 0.02), presence of nuclear atypia (P< 0.001), and increased mitoses (P= 0.03) were the three factors that impacted significantly on survival. Age, stage of the tumor, parity, and size of the tumor had no significant effect on survival. Patients who received chemotherapy had a better median disease-free survival than those who did not (60 vs 48 months), but this did not reach statistical significance (P= 0.08). Optimal cytoreduction, nuclear atypia, and increased mitoses are the statistically significant prognostic factors and may be used for selecting patients for adjuvant therapy.

scholarly journals Prognostic factors and clinical outcome in a rare form of spastic paraplegia (Spoan syndrome): a 10-year follow-up

2019 ◽  
Author(s):  
Cláudia R. C. Galvão ◽  
Priscilla M. A. Cavalcante ◽  
Ricardo Olinda ◽  
Zodja Graciani ◽  
Mayana Zatz ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Clinical Outcome ◽  
Statistical Significance ◽  
Hand Function ◽  
Age At Onset ◽  
Spastic Paraplegia ◽  
Prospective Longitudinal Study ◽  
The Mean ◽  
Prospective Longitudinal

Abstract Background: Spastic paraplegia, optic atrophy and neuropathy (Spoan syndrome) is an autosomal recessive disease with approximately 70 cases recorded in Brazil and Egypt. Methods: This is a prospective longitudinal study performed with 47 patients affected with Spoan syndrome of seven communities of Rio Grande do Norte (Brazil) to investigate prognostic factors and clinical outcome based on comparative data obtained from a 10-year follow-up. Results: The mean age of the participants was 47.21±12.42 years old, and the mean ages at loss of ambulation and hand function were 10.78±5.55 and 33.58±17.47 years old, respectively. Spearman’s correlation analysis between the score on the Modified Barthel Index and the investigated variables evidenced statistical significance for age (p<0.001) and right- and left-hand grip strength (p=0.042 and p=0.021, respectively). Statistical significance was not evidenced for the remainder of the variables, including age at onset of symptoms (p=0.634), age at loss of ambulation (p=0.664) and age at loss of hand function (p=0.118). Conclusions: Our analysis allows asserting that the participants exhibited slight dependence until age 35. The greatest losses occurred from ages 35 to 41, and starting at 50, practically all patients become completely dependent. In fact, age is the main prognostic factor of impaired motor function among Spoan syndrome patients.

scholarly journals Survival analysis of surgically treated laryngeal cancer in Hospital Tengku Ampuan Afzan, Kuantan, Pahang from January 2002 to June 2013

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Kahairi Abdullah ◽  
Raja Ahmad ◽  
Jamalludin Abdul Rahman ◽  
Zamzil Amin Asha'ari ◽  
Mohd Sayuti Razali ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Survival Rate ◽  
Laryngeal Cancer ◽  
Histopathological Examination ◽  
Early Stage ◽  
Treated Patient ◽  
Statistical Significance ◽  
Rank Test ◽  
P Value ◽  
Poor Outcomes

Introduction: Laryngeal cancers are one of the most prevalent head and neck cancer in Malaysia. However, little information is available on survival rate for larynx cancer in Malaysia has been reported. The purpose of the present study was to evaluate the survival and the prognostic factors in surgically treated patient with laryngeal cancer in Hospital Tengku Ampuan Afzan, Kuantan, Pahang. Methods: Retrospective analysis of surgically treated patient of laryngeal cancer treated in Hospital Tengku Ampuan Afzan during January 2002 to June 2013 was analyzed. The overall survival rate was measured using the Kaplan Meier method. Prognostic factor was identified by log rank test taking p value <0.05 as statistical significance. Results: A total 36 cases were analyzed. Two-thirds (86.1%) of the cases were at an advanced stage (stage III & IV) at presentation. The 2, 5 and 10 year overall survivals for the laryngeal cancer were 62%, 34% and 22% respectively. The histopathological examination result was the strongest prognostic factors in laryngeal cancer. Conclusions: The results revealed remarkably poor outcomes of the patients in the series, indicating a strong need to increase the proportion of early stage presentations and maximize the treatment efficacy to improving outcomes.

scholarly journals FORMATION OF FORECAST ON THE INFLATION LEVEL IN SFD TAKING INTO ACCOUNT DYNAMICS OF DEVELOPMENT OF REGIONAL ECONOMY

2020 ◽  
pp. 223-231
Author(s):  
Olga S. Sivash ◽  
Roman S. Usenko
Keyword(s):  
Russian Federation ◽  
Inflation Rate ◽  
Negative Impact ◽  
Statistical Significance ◽  
Pair Correlation ◽  
Federal District ◽  
Statistical Dependence ◽  
Factors Affecting ◽  
The Russian Federation ◽  
The Impact

Inflation is a complex multilateral process, which, in general, has a negative impact on the economy, reduces the level of economic activity of the population and leads to a decrease in the level of real income. The article studies the main constituent elements of the inflation category, reveals the parameters of the impact on the economy of the inflation process, studies the dynamics of factors affecting the forecast inflation rate in the Southern Federal District, develops a regional multifactor inflation model, and based on the approximated data, a forecast of the annual inflation rate is constructed in the Southern Federal District at the end of 2020. The most significant factors affecting the inflation rate in the Russian Federation were identified from the position of the direction of their influence: acceleration or deceleration of inflation, as well as from the point of view of their degree of influence on the inflation rate. At the same time, the influence of the coronavirus pandemic and fluctuations in the oil market on the economic parameters in the Russian Federation in 2020, on the price level of individual food and non-food products was examined. The analyzed indicator of the inflation rate is defined as an indicator of the state of the economic situation in the country, it is revealed that this variable will be dependent. Using the methods of correlation and regression analysis, a mathematical expression is found in the form of a regression model and its adequacy and statistical significance are evaluated. The coefficient of pair correlation, which characterizes the degree of statistical dependence between two variables, without taking into account the influence of other variables, was adopted as the main indicator characterizing the relationship between the analyzed variables. As a result of the calculations, a model of multiple linear regression of the inflation rate was built, the average monthly nominal accrued wages of the employees of the organizations were approximated, and approximation equations were obtained, which made it possible to build an inflation rate forecast for the Southern Federal District for 2019-2020.

THE MAIN DIRECTIONS OF PERSPECTIVE DEVELOPMENT OF BEEKEEPING IN THE RUSSIAN FEDERATION TAKING INTO ACCOUNT REQUIREMENTS OF INTERNATIONAL LEGISLATION

2019 ◽  
Vol 1 (3) ◽  
pp. 266-271
Author(s):  
L.P. Satyukova ◽  
◽  
M.I. Shopinskaya ◽  
Y.M. Subbotina ◽  
P.V. Kulach ◽  
...  
Keyword(s):  
Amino Acids ◽  
Chemical Composition ◽  
Russian Federation ◽  
Healthy Lifestyle ◽  
Foreign Markets ◽  
Factors Affecting ◽  
Honey Production ◽  
Medicinal Properties ◽  
The Russian Federation ◽  
Main Factors

Recently, more and more people are paying attention to healthy lifestyle, including nutrition, giving preference to natural products. One of these products is honey. The chemical composition of honey is represented by a large number of nutrients: easily digestible carbohydrates, amino acids, enzymes, minerals, vitamins, organic acids, causing its nutritional, dietary¬, and medicinal properties. In the article, the authors analyzed the state of honey production in the country, reflected the share of imports in the market and the share of exports in production, the main factors affecting the honey market are investigated. Based on the results of studies of honey from different regions of the Russian Federation and the requirements of international legislation on product safety, the authors have developed proposals to improve the competitiveness of hive products, both in domestic and foreign markets.

Sign in / Sign up

Export Citation Format

Share Document