An Impact of Intima Media Thickness of Carotids in Cardiovascular Profile

Author(s):  
Talluri Jagadeesh ◽  
Potlacheruvu Anusha ◽  
Reddyboyina Haripriya

Low blood pressure indeed includes a worse prognosis than excessive blood strain. This mechanism, bills for the "reverse causation "seen within the ’ patients, the company of conventional risk elements, such as high blood pressure, , and obesity, appear to be the worst diagnosis. Exogenous products can growth blood strain and requirement of tablets.30 Chronic ECFV overload secondary to activation of axis and disturbances inside the stability of and the contributes to high blood pressure. Improvement in blood pressure can be introduced out with oral sodium restriction, diuretics, and fluid elimination with dialysis. Some patients will continue to be hypertensive notwithstanding of the careful attention to ECFV reputation.LVH is related to reduced endurance of sufferers on /peritoneal dialysis. Lower five-year survival charge in ESRD patients with LVH has a 30%than people missing LVH. This has a look at produces the mean carotid artery thickness turned into higher in sufferers with superior CKD. However, it did now not attain statistical significance, probable due to the smaller sample size. It was also observed that carotid medial thickness did not correlate with . Even though the patients had maintained significantly healthy cholesterol and high HDL levels, there was an increase in CIMT. in CKD patients, CIMT cannot be predicted based on the traditional atherosclerotic risk factors like serum cholesterol and HDL.

2020 ◽  
Vol 10 (2) ◽  
pp. 48-52
Author(s):  
Jeevitha M ◽  
Kalaichandar M ◽  
Kirubakaran K ◽  
Baskaran V ◽  
Kokila K ◽  
...  

Low blood pressure truly includes a worse prognosis than the excessive blood strain. This mechanism,bills for the "reverse causation "seen within the haemodialysis’ patients, the company of conventional risk elements, such as high blood pressure, hyperlipidemia, and obesity, appear to be a worst diagnosis.Exogenous erythropoietic products can growth blood strain and requirement of antihypertensive tablets.30 Chronic ECFV overload secondary to activation of renin-angiotensin-aldosterone axisand disturbances inside the stability of vasoconstrictors and the vasodilators make a contribution to high blood pressure. Improvement in blood pressure can be introduced out with oral sodium restriction, diuretics, and fluid elimination with dialysis. Some patients will continue to be hypertensive notwithstanding of the careful attention to ECFV reputation. LVH is related with reduced endurance of sufferers on hemo/peritoneal dialysis .Lower five year survival charge in ESRD patients with LVH have a 30% than people missing LVH. This have a look at produces the mean carotid artery intima-medial thickness turned into higher in sufferers with superior CKD although it did now not attain statistical significance, probable due to smaller sample size.It was also observed that carotid intima medial thickness had no correlation with dyslipidemia. Even though the patients had maintained significantly normal cholesterol and high HDL levels, there was an increase in CIMT. Therefore, CKD patients, CIMT cannot be predicted based on the traditional atherosclerotic risk factors like serum cholesterol and HDL.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Long Zhang ◽  
Fangfang Fan ◽  
Litong Qi ◽  
Jia Jia ◽  
Ying Yang ◽  
...  

Abstract Background Hypertension and arterial vasculopathy may be mutual causes and effects. It is unknown whether carotid intima-media thickness (cIMT) is reliably predictive of the presence of newly developed hypertension in the Chinese population. This study evaluated the impacts of cIMT on new-onset hypertension in a community-based population without hypertension at baseline in China. Methods A total of 672 Chinese subjects who had complete data for demographics, baseline and follow-up blood pressure measurements, and cIMT measurements at baseline were included in our study. Baseline cIMT was obtained under standardized procedures using the GE Vivid 7 ultrasound system equipped with an 8-MHz linear array vascular probe (GE Medical Systems, Milwaukee, Wl, USA). The outcome was the incidence of hypertension at follow-up. Multivariate regression models were used to access the association between baseline cIMT and the risk of new-onset hypertension. Results Subjects were 51.5 ± 4.7 years old, and 32.0% were male. The mean baseline systolic blood pressure (SBP) was 122.5 ± 10.0 mmHg. The mean baseline diastolic blood pressure (DBP) was 72.4 ± 7.5 mmHg. The number of subjects with thickened cIMT (maximum ≥0.9 mm) at baseline was 198 (29.5%). After 2.3 years of follow-up, the rate of new-onset hypertension was 12.6%. The incidence rates of hypertension in the groups with thickened cIMT and normal cIMT were 19.2 and 9.9%, respectively. In the multivariable logistic regression analyses, both the average (OR = 1.69, 95% CI: 1.30–2.19, P = 0.0001) and maximum (OR = 1.55, 95% CI: 1.23–1.95, P = 0.0002) cIMT were significantly associated with new-onset hypertension after adjustment for various confounders. The group with thickened cIMT showed a higher risk for the incidence of hypertension, with an OR of 1.82 (95% CI: 1.07–3.10, P = 0.0270), compared to the normal group. Conclusion Thickened cIMT has a strong association with incident hypertension risk in a community-based population without hypertension at baseline in China.


2020 ◽  
Vol 10 (9) ◽  
pp. 3214
Author(s):  
Muhammad Tahir ◽  
Muhammad Usman ◽  
Fazal Muhammad ◽  
Shams ur Rehman ◽  
Imran Khan ◽  
...  

High Blood Pressure (BP) is a vital factor in the development of cardiovascular diseases worldwide. For more than a decade now, patients search for quality and easy-to-read Online Health Information (OHI) for symptoms, preventions, therapy and other medical conditions. In this paper, we evaluate the quality and readability of OHI about high BP. In order that the first 20 clicks of three top-rated search engines have been used to collect the pertinent data. Using the exclusion criteria, 25 unique websites are selected for evaluation. The quality of all included links is evaluated through DISCERN checklist, a questionnaire for assessing the quality of written information for a health problem. To enhance the reliability of evaluation, all links are separately assessed by two different groups—a group of Health Professional (HPs) and a group of Lay Subjects (LS). A readability test is performed using Flesch-Kincaid tool. Fleiss’ kappa has been calculated before considering average value of each group. After evaluation, the average DISCERN value of HPs is 49.43 ± 14.0 (fair quality) while for LS, it is 48.7 ± 12.2; the mean Flesch-Reading Ease Score (FRES) is 58.5 ± 11.1, which is fairly difficult to read and the Average Grade Level (AGL) is 8.8 ± 1.9. None of the websites scored more than 73 (90%). In both groups, only 4 (16%) websites achieved DISCERN score over 80%. Mann-Whitney and Cronbach’s alpha have been computed to check the statistical significance of the difference between two groups and internal consistency of DISCERN checklist, respectively. Normality and homoscedasticity tests have been performed to check the distribution of scores of both evaluating groups. In both groups, information category websites achieved high DISCERN score but their readability level is worse. Highest scoring websites have clear aim, succinct source and high quality of information on treatment options. High BP is a pervasive disease, yet most of the websites did not produce precise or high-quality information on treatment options.


2020 ◽  
Author(s):  
Jorge Salvador Marín ◽  
Francisco Javier Ferrández Martínez ◽  
Jose Miguel Seguí Ripoll ◽  
José Antoio Quesada Rico ◽  
Domingo Orozco Beltrán ◽  
...  

Abstract Objectives : This study aimed to determine the risk factors that increase the risk of in-hospital mortality and/or prolonged hospital stay in hip fracture patients aged over 65 years. Methods : We conducted a retrospective study of patients aged over 65 years who underwent hip fracture surgery in the period from January 2015 to December 2017. Our analysis included 54 variables related to medical, psychological, functional and laboratory comorbidities present at admission; treatment, complications and laboratory follow-up during the hospital stay; and functional status and destination on discharge. We performed a bivariate analysis and a multivariate analysis with a composite endpoint combining in-hospital mortality and hospital stay lasting more than 10 days. Results : We included 360 patients with an average age of 84 years. Women accounted for 75% of the sample, and 53.5% of all patients had a pertrochanteric fracture. The mean number of comorbidities per patient was 2.72, and the most common comorbidities were high blood pressure, dementia and diabetes. The rate of in-hospital mortality was 3.6% (n 13) and the mean length of hospital stay was 8.48 days, with 16.4% of patients staying in hospital for more than 10 days. Medical complications, lower hemoglobin on admission, high blood pressure, obesity and Parkinson’s disease were significantly associated with our endpoint in the multivariate analysis Conclusions : Patients who suffer medical complications during hospitalization, and those with lower hemoglobin on admission, high blood pressure, obesity or Parkinson’s disease, have an increased risk of in-hospital mortality or prolonged hospital stay


2022 ◽  
Vol 35 (1) ◽  
pp. 111-111
Author(s):  
Hong-yi Wang ◽  
Fang Wu ◽  
Ji-hua Wang ◽  
Qing-chun Ma ◽  
Fan Yang ◽  
...  

Abstract Background To primarily evaluate the effects and safety of a selective angiotensin II type 1 (AT1) receptor blocker (ARB) allisartan isoproxil combined with amlodipine or indapamide in the treatment of patients with essential hypertension who failed allisartan monotherapy. Methods Patients aged 18–75 years with mild-to-moderate essential hypertension [office systolic blood pressure (SBP) 140 to <180 and/or office diastolic blood pressure (DBP) 90 to <110 mm Hg] in 44 study centers between 2016 and 2018 were recruited. Allisartan isoproxil tablet 240 mg was administered per day for 4 weeks, and continued for 8 weeks if office blood pressure (BP) achieved the target of SBP/DBP <140/90 mm Hg. The nonachievers were 1:1 randomly divided into allisartan isoproxil 240 mg + indapamide sustained-release tablet 1.5 mg, or allisartan isoproxil 240 mg + amlodipine besylate 5 mg groups for further 8 weeks of combined therapy. The BP target achieving rate, reduction of sitting BP from baseline, safety and compliance were evaluated as the primary efficacy endpoint. Results A total of 2,212 patients were enrolled, among them 2,126 patients were included in the efficacy analysis, with an average age of 55.1 ± 10.2 years. A total of 1,463 cases (68.8%) were effective after 4 weeks allisartan treatment, and the mean SBP and DBP were significantly decreased by 14.7 ± 12.2 and 8.0 ± 8.4 mm Hg compared with the baseline levels (all P < 0.001). In nonachievers, allisartan combined with indapamide for 8 weeks significantly lowered the sitting BP (SBP/DBP) by 14.0 ± 12.2/8.3 ± 9.2 mm Hg, respectively, compared with 4 weeks monotherapy with allisartan with a BP targeting rate of 57.7% (169/293). In the allisartan + amlodipine group, the SBP/DBP were significantly decreased by (14.4 ± 12.1/8.2 ± 8.2) mm Hg, respectively, with a BP targeting rate of 62.8% (181/288). There was no statistical significance in BP reduction, targeting rate, or adverse reactions between the 2 combined therapies. Conclusions Allisartan isoproxil combined with indapamide or amlodipine can further improve the BP targeting rate when allisartan monotherapy failed in essential hypertension. The 2 combined therapies have similar efficacy and safety.


Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Victor J Del Brutto ◽  
Jose G Romano ◽  
Robertino M Mera ◽  
Jonathan P Amodio ◽  
Tatjana Rundek ◽  
...  

Background: Epidemiological information on extracranial carotid atherosclerosis (ECA) among Amerindians is limited. We aim to determine the prevalence of subclinical ECA and its correlation with cardiovascular risk factors in community-dwelling adults of Amerindian ancestry living in a rural Ecuadorian village. Methods: Utilizing a population-based design, stroke-free individuals aged ≥40 years were invited to undergo carotid ultrasound. Subclinical ECA was defined as an intima-media thickness (cIMT) >1mm and/or the presence of carotid plaques (focal intima thickening >1.5mm that protrudes into the lumen). Degree of luminal stenosis was calculated and considered significant if >50%. We investigated the association between these biomarkers and cardiovascular risk factors. Results: Of 728 candidates, 559 (77%) stroke-free individuals underwent carotid sonographic evaluation and were included. The mean age was 62.3 ±12.5 and 238 (43%) were men. The mean value of the cIMT was 0.85 ± 0.17mm (median cIMT: 0.83mm; IQ range: 0.74-0.92 mm). The prevalence of increased cIMT, carotid plaques, and increased cIMT and/or carotid plaques were 14%, 23.8%, and 26.1%, respectively. Table depicts the association of these biomarkers with cardiovascular risk factors. A multinomial logistic regression model, using individuals with normal carotids as the referent category, showed significant associations of ECA with increasing age, male gender, smoking and high blood pressure. Significant carotid stenosis was found in 19 subjects (3.4%). Conclusions: About one-fourth of Amerindians living in a rural setting have subclinical ECA. Increasing age, male gender, smoking and high blood pressure were independent determinants of the burden of ECA, while elevated glucose and total cholesterol showed no significant association. Obesity was inversely associated with ECA in univariate analysis, but such association disappeared in the multivariate model.


2020 ◽  
Author(s):  
Yuan Zhao ◽  
Guang Yang ◽  
Suwen Niu ◽  
Min Zhang ◽  
Fengyan Gao ◽  
...  

Abstract Background: The newborn babies require multiple physical of adjustment hemodynamic changes after birth, Perfusion index (PI) c an help to evaluate peripheral tissue perfusion . Objective: T o investigate the tissue perfusion status and circadian rhythm in moderately premature infants.Methods: As a prospective study, it monitored indicators including perfusion index(PI), blood pressure(BP) (systolic BP and diastolic BP ) , pulse rate(PR), respiratory rate(RR), oxygen saturation(SpO 2 ) and body temperature of moderately preterm infants of hemodynamical stability in the morning and night within 8 days after birth from July 2019 to October 2019. Results: The mean PI values of moderately preterm infants within 8 days after birth were(1.1±0.5) on Day 1, (1.1±0.5) on Day 2, (1.3±0.5) on Day 3, (1.3±0.5) on Day 4, (1.4±0.6) on Day 5, (1.4±0.5) on Day 6, (1.5±0.6) on Day 7,and (1.5±0.5) on Day 8. There was no difference of statistical significance between PI values in the morning and night ( P >0.05). PR from Day 6 to 8 after birth were higher than those from Day 1 to 3 ( P <0.05). PR increased significantly on Day 7 and 8 compared with those on Day 4 and 5 ( P <0.05). BP from Day 3 to 8 was significantly higher than that on Day 1 ( P <0.05), and BP from Day 4 to 8 were higher than that on Day 2. There was a weak positive correlation between PI values and gestational age (GA) ( r =0.097), PR( r =0.067) and T ime (day) ( r =0.284) , and a negative correlat ion with SpO 2 ( r =-0.113)(P<0.01). The calculation of PI value under non-standardized regression is represented by the following equation: PI = 2.253 + 0.057 × GA ( week ) +0.062 × Time ( d ay) - 0.03 × SpO 2 (%). Conclusions: PI and PR of moderately preterm infants were growing within 8 days after birth, while BP was relatively lower after birth and gradually increased to a stable level on Day 3 to 4. PI and BP circadian rhythms associated w ith tissue perfusion weren’t established on Day 8 after birth.


2021 ◽  
Vol 8 (4) ◽  
pp. 264-268
Author(s):  
K Ranjith Babu ◽  
Malika Noorjehan Samozai ◽  
Rajashree Devarapalli

Hypertension(HTN) is the most common and significant cardiovascular disease because of its prevalence and severity of the damage to the mankind globally. Hyperuricemia, a condition of increased levels of Serum Uric acid (UA) has been proposed to have an association with hypertension in various studies. In certain studies, serum uric acid levels has been found to be an independent predictor for developing hypertension. On the basis of the above observations, we have proposed to the present study to compare the relationship between serum UA and hypertension in a single cohort with adjustment of all possible confounding factors.A total of 245 subjects were enrolled in this study during a regular routine health checkup. All subjects were informed about the study aims Individuals having a known history of gout and cardiac or severe renal diseases and patients who are already under medication for anti-hyperuricemic were excluded from the study. General information like Name, Age, Sex, Occupation, Address along with history of any drug intake and anthropometric indices - body weight (BW), body height (BH), hip circumference (HC), waist circumference (WC), and lifestyle information have been obtained. The data has been arranged in tables with mean ± SD for further analysis. The data is analyzed using IBM SPSS version 23. The difference between the groups for baseline variables was done by independent sample t-test (two-tailed). Pearson’s correlation coefficient test was performed to assess the interrelationships between baseline variables and SUA concentrations. The differences for the variables among the groups was determined by using One-way ANOVA.Of the 245 subjects, mean age of the participants was 42.4 ± 8.4 years (range 18–70 years). There was no significant difference in the mean levels of Height, Weight and BMI between the two groups. Mean levels of WC, HC were significantly different between two group (p &#60; 0.05) subjects. The mean levels of SBP and DBP were also significantly more in the hypertensive subjects (p &#60; 0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP. In this study, we have observed comparatively a stronger relationship for SUA concentration with hypertension and prehypertension in the participants. The extended mechanism for the effect of SUA on hypertension is yet to be elucidated. There are some hypotheses partly explain the association between SUA and high blood pressure. One of the possible mechanism might be uric acid deposition on the blood vessels walls activates the renin-angiotensin system, suppress the liberate of carbon monoxide, enhance inflammation, and leads to vasoconstriction on later stage, which consequently leads to hyperplasia and incidence of hypertension. Another possibility involving oxidative stress and endothelial dysfunction associated with high SUA levels may contribute to high blood pressure.


2018 ◽  
Vol 8 (1) ◽  
pp. 101 ◽  
Author(s):  
Hamidreza Abdolsamadi ◽  
Mohammad vahedi ◽  
Farnaz Fariba ◽  
Alireza Soltanian ◽  
Meghdad Zakavati Avval ◽  
...  

Introduction: Vitamin D deficiency is a major public health problem. Low vitamin D levels associated with adverse health consequences such as musculoskeletal health, cognitive decline and progression of cancer and death. The lack of vitamin D associated with major risk factors for cardiovascular disease (CVD) includes hypertension is considered. The ability to assess the general health, disease and treatment outcomes through saliva as a non-invasive, inexpensive and simple method of interest is located. The aim of this study was a comparative study of salivary and serum levels of vitamin D3 in patients with a history of developing high blood pressure and a healthy person.Methods: This study was a case - control survey, in which 40 patients with high blood pressure were examined. The control group including 40 healthy subjects. Both groups were matched in terms of age and gender. After collecting samples of serum and saliva, the amount of vitamin D level samples were measured using ELISA method by electrochemiluminescence (ELC), and then analyzed the results using software SPSS 16 and statistical test including Chi Square Test, Independent-Samples, linear regression model, the Mann-Whitney Test and Spearman correlation coefficient.Results: There was no significant difference in the mean serum levels of vitamin D among patients and healthy subjects (p= 0.588). In addition, there was no significant difference in the mean salivary levels of vitamin D between patients and healthy subjects (p= 0.833). There was no significant relationship between salivary and serum level of vitamin D in healthy individuals (p= 0.095). As well as there was no significant correlation between salivary and serum level of vitamin D in patients (p= 0.5).Conclusions: This study showed that vitamin D is a measurable marker in saliva, but its analysis in saliva, may not be a reliable tool for determining the vitamin D levels.


Vascular ◽  
2020 ◽  
Vol 28 (4) ◽  
pp. 405-412
Author(s):  
Oscar H Del Brutto ◽  
Victor J Del Brutto ◽  
Robertino M Mera ◽  
Aldo F Costa ◽  
Rubén Peñaherrera ◽  
...  

Objective Information on the associations among arterial stiffness, carotid intima-media thickness (cIMT) and carotid plaques as biomarkers of atherosclerosis is limited in diverse populations. We aimed to assess whether aortic pulse wave velocity (aPWV) – as a surrogate of arterial stiffness – is associated with increased cIMT and the presence of carotid plaques in a cohort of older adults of Amerindian ancestry. Methods Atahualpa residents aged ≥60 years ( n = 320) underwent aPWV determinations, and carotid ultrasounds for cIMT and plaque assessment. Multivariate models were fitted to assess the independent association between the aPWV, and cIMT and carotid plaques, after adjusting for relevant confounders. Differences in risk factors across these biomarkers were investigated. Results Mean values of aPWV were 10.3 ± 1.8 m/s, and those of cIMT were 0.91 ± 0.21 mm (24% had a cIMT >1 mm). Carotid plaques were observed in 118 (37%) subjects. In univariate analyses, risk factors associated with an increased aPWV included age, female gender, poor physical activity and high blood pressure. An increased cIMT was associated with age, male gender, a poor diet, high blood pressure and severe tooth loss. The presence of carotid plaques was associated with increasing age, poor physical activity and high blood pressure. Multivariate models showed a significant association between aPWV and cIMT (β: 0.028; 95% C.I.: 0.001–0.056; p =  0.047) but not between aPWV and carotid plaques (OR: 1.14; 95% C.I.: 0.83–1.56; p =  0.423). Conclusions This study shows an independent association between aPWV and cIMT but not with carotid plaques. These biomarkers may indicate distinct phenotypes for atherosclerosis.


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