scholarly journals Cisplatin-Induced Peripheral Neuropathy: An Observational Descriptive Study

2020 ◽  
Vol 11 (3) ◽  
pp. 3585-3589
Author(s):  
Anjol Kurian ◽  
Bittu Babu ◽  
Benson Punnoose ◽  
Chinju Susan Chacko ◽  
Mallikarjuna Rao ◽  
...  

Peripheral neurotoxicity is a major adverse effect of cisplatin chemotherapy. A prospective observational study was conducted among 200 cancer patients who received cisplatin between October 2017 and March 2018 to evaluate the occurrence, causality and severity of cisplatin induced peripheral neuropathy. A suitable data collection form was used to record patient information required for the study. Peripheral neuropathy was assessed using the National Cancer Institute- Common Terminology Criteria for Adverse Events (NCI-CTCAE). As per the results, 19 (9.5%) patients developed peripheral neuropathy after receiving cisplatin therapy. Peripheral neuropathy was reported higher in males (84.2%) compared to females (15.7%) and more within the age group of 58-65 years (38.6%). Most of the patients developed Grade I neuropathy (84.2%), followed by Grade II neuropathy (15.7%). The study concluded that the severity of peripheral neuropathy increases with higher cumulative doses of cisplatin.

Author(s):  
Lakshmi R ◽  
Jithin Kc ◽  
Arya G ◽  
Lekshmi P Nair

ABSTRACTObjectives: The main objectives of this study were to estimate the demographic details of patients with the first incidence of stroke and to study thevarious risk factors for ischemic stroke.Methods: It was a retrospective, observational study carried out for 1 year at the Department of Stroke Medicine of a tertiary care teaching hospitalin Kerala, India. A total of 636 patients were admitted under stroke medicine during the period from July 1, 2014, to July 1, 2015, and who satisfiedthe inclusion and exclusion criteria were included in the study. A standardized data collection form was prepared and necessary data were collectedfrom patient’s medical records.Results: The maximum number of patients was in the age group of 60-69 years. 65.1% patients were residing in the rural area. 60.7% patients weremale. Most of them had hypertension as common comorbidity (21.35%) and the highest number of patients had diabetes mellitus and hypertension(21.7%). Majority of the patients were prescribed with antiplatelets (94.91%), followed by statins (93.8%).Conclusion: A strict control on the comorbid conditions and sticking on to the medications can prevent the occurrence of future stroke.Keywords: Stroke, Secondary prevention, Drugs, Prescribing pattern.


2019 ◽  
Vol 8 (2) ◽  
pp. 80-88
Author(s):  
Abdul Faqih ◽  
Mateus Sakundarno

Measles is a highly contagious disease caused by viruses and transmitted through coughing and sneezing. Symptoms of measles are high fever, spotting redness of the skin (rash) is accompanied by coughing and / or runny nose and / or conjunctivitis. In 2017 the highest measles incidence in the City of Kediri was the age group less than 15 years, namely 71.6 per 100.000 population. In addition to immunization coverage low in 2016, CBMS achievements in the last four years were also still below target, is a factor that is thought to affect the high incidence of measles in the City of Kediri. This study aims to describe the epidemiology of measles in Kediri City in the year 2014 - 2017. This research is an observational descriptive study. Population at this research is CBMS data in the City of Kediri Health Office in 2014 - 2017.


2021 ◽  
Vol 21 (4) ◽  
pp. 696-703
Author(s):  
Yeny Tejada-López ◽  
Evelyn del Socorro Goicochea-Ríos ◽  
Olga Y. Guzmán-Aybar

Introduction: the SARS-CoV-2 pandemic affected a large part of the population of La Libertad, among them, the population of Florencia de Mora whose hospital played an important role in the care of patients diagnosed with COVID-19. Objective: to determine the epidemiological clinical characteristics of patients diagnosed with SARS-CoV-2 treated at the care center. Methods: Retrospective observational descriptive study, with a population of 2622 patients treated in the COVID-19 triage, taking into account the molecular test and the rapid serology test for the detection of SARS-CoV-2. Results: SARS-CoV-2 was detected in 74.90% (1155) of patients. The months with the highest number of cases were June and July with 29.4% (340) and 37.4% (432), respectively. The predominant age group was 27- 59 years with 77.9% (900) and males with 57.5% (664). Regarding the clinical profile, the most frequent comorbidity was hypertension with 6.9% (80), obesity and overweight with 3.7% (43) and the most frequent symptoms were cough 62.9% (726) and odynophagia 55.7% (643). Conclusions: 75 out of 100 screened patients had SARS-CoV-2, predominantly males, the age group of 27-59 years, hypertension, obesity and overweight as comorbidity, cough and odynophagia as the most frequent symptoms.


2021 ◽  
Vol 74 (4) ◽  
pp. 961-965
Author(s):  
Stepan O. Karabinyosh ◽  
Galina M. Koval

The aim: The overall aim of this project was to provide a comprehensive description of epidemiological and demographic features of SARS2 COVID19 outbreak among patients in Zakarpattya oblast during 2020 to define most vulnerable and susceptible groups of population. Materials and methods: We conducted a retrospective observational descriptive study of the 33 190 cases that tested RT-PCR positive for SARS 2 COVI19 in Zakarpattya oblast, studied their comorbidities and concomitant diseases, as well as their clinical and functional outcomes. Results: Among studied cases: females – 20 069 (60.47±0.27%) and males – 13 121 (39.53±0.27%). Geographical distribution showed that: 10 230 (30.8%) of cases were registered in district capital Uzhhorod and surrounding area, 3 646 (11%) were registered in Mukachevo district, Tyachivsky district 3 235 cases (9.7%), Vynohradisky district 2 627 (7.9%), other districts had less than 4 %. Most patients were within the age group 31 and 70 with a mean age of 47.76±17.57 years. Conclusions: the emergence of current outbreak of SARS-CoV-2 (COVID-19) pandemic is a reminder of how new pathogens can mutate, emerge and rapidly spread through large amount of human population, and cause severe burden to public health and healthcare system is general.


2021 ◽  
Vol 1 (3) ◽  
pp. 270-277
Author(s):  
Yunia Habsari ◽  
Roza Mulyana ◽  
Elmatris Elmatris

Abstrak Latar Belakang. Penurunan fungsi tubuh dan gangguan organ akan memengaruhi karakteristik pasien lansia dengan kanker. Beberapa karakteristik pasien memengaruhi pemberian kemoterapi pada pasien lansia. Objektif. Penelitian ini bertujuan untuk mengetahui karakteristik pasien lanjut usia yang akan menjalani kemoterapi pertama di RSUP M Djamil, Padang. Metode. Penelitian ini merupakan penelitian deskriptif observasional dengan desain cross sectional. Data penelitian didapatkan dari rekam medik. Sampel penelitian sebanyak 110 pasien lansia yang akan menjalani kemoterapi pertama di RSUP dr. M. Djamil Padang periode Januari 2017 – Juli 2018. Hasil. Sebagian besar pasien berada di kelompok usia 60 - 69 tahun (78,2%) serta memiliki kadar haemoglobin dan hematokrit dibawah batas normal (73,6% dan 70% secara berurutan). Kesimpulan. Sebagian besar pasien berada di kelompok usia lansia muda dan memiliki nilai hemoglobin dan kadar hematokrit dibawah batas normal, sedangkan karakteristik lainnya cenderung normal. Kata kunci: Lansia, Kanker, Kemoterapi Abstract Background. Decreased body function and organ dysfunction will affect the characteristic of elderly patients with cancer. Some characteristics will affect the chemotherapy given in elderly patients. Objective. This study discussed the characteristics of elderly patients who received the first chemotherapy in RSUP dr. M. Djamil Padang. This research is an observational descriptive study with a cross sectional design. Methods.The research data was obtained from the patient's medical record. The research sample consisted of one hundred and ten elderly patients who received first chemotherapy at RSUP dr. M. Djamil Padang period January 2017 - July 2018. Result. Most of the patients were in the age group 60 - 69 years (78.2%) and had hemoglobin levels and hematocrit below the normal limit (73.6% and 70% respectively). Conclusion. Most of patients were in the young elderly age group and had hemoglobin values ​​and hematocrit levels below the normal range, while other characteristics tend to be normal. Keywords: Elderly, Cancer, Chemotherapy


e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Ade M. Sitepu ◽  
Dewi U. Djafar ◽  
Agnes L. Panda

Abstract: Coronary heart disease (CHD) is the leading cause of death in the world and marked by the existence of atherosclerotic plaque at the coronary artery that progressively blocks the blood stream to myocardium resulting in myocardial infarction. Elevated of leukocyte count typically indicates an infection or inflammation, and has a role in vascular injury and atherogenesis that is a development of an atherosclerotic ruptured plaque and trombosis. This study was aimed to obtain the profile of leukocyte count in patient with acute myocardial infarction (AMI) at Prof. Dr. R. D. Kandou Hospital Manado from January to December 2015. This was an observational descriptive study with a retrospective approach using data of medical records of AMI patients who came to Prof. Dr. R. D. Kandou Hospital Manado from January to Desember 2015. The results showed that of totally 63 medical records of patients with AMI, there were 45 samples that fulfilled the inclusion criteria. The majority patients were in the age group 46-60 years, males, the risk factor was a combination of several major risks, and NSTEMI as the type of type of infarction. There were 57,77% of leukocyte count results ranged 10,000-14,900/mm3 and 8,88% were ≥15,000/mm3. Conclusion: There was an increase in the leukocytes count in more than half of the samples. Keywords: acute myocardial infarction, leukocyte, inflammation Abstrak: Penyakit jantung koroner (PJK) merupakan penyebab kematian tersering di dunia dan ditandai adanya plak aterosklerosis pada arteri koroner yang secara progresif menghalangi aliran darah ke miokardium yang berakibat terjadinya infark miokard. Peningkatan jumlah leukosit secara tipikal mengindikasikan adanya suatu infeksi dan peradangan, serta juga berperan pada cedera vaskular dan aterogenesis yang merupakan perkembangan dari suatu ruptur plak aterosklerosis dan trombosis. Penelitian ini bertujuan untuk mengetahui gambaran jumlah leukosit pada pasien IMA di RSUP Prof. Dr. R. D. Kandou periode Januari sampai Desember 2015. Jenis penelitian ialah deskriptif observasional dengan pendekatan retrospektif menggunakan data rekam medik pasien IMA yang berobat di RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2015 dengan eksklusi riwayat infeksi minimal 2 minggu sebelum masuk rumah sakit. Hasil penelitian mendapatlan 45 sampel dengan mayoritas kelompok usia 46-60 tahun, jenis kelamin laki-laki, faktor risiko kombinasi beberapa faktor risiko mayor, dan jenis infark NSTEMI. Sebanyak 57,77% hasil pemeriksaan leukosit berkisar 10.000-14.900/mm3 dan 8,88% pada ≥15.000/mm3. Simpulan: Lebih dari setengah jumlah sampel mengalami peningkatan jumlah leukosit.Kata kunci: infark miokard akut, leukosit, peradangan


2018 ◽  
Vol 15 (2) ◽  
pp. 799
Author(s):  
Türkan Meryem Erer ◽  
Selim Kadıoğlu ◽  
Gülhan Orekici

The aim of this descriptive study is to determine a group of patients' awareness of patient rights, significance of patients’ rights for them and how they utilize these rights. The study was carried out with 100 of the patients who were admitted to the blood-taking unit of the outpatient services department of Mersin University Health Research and Application Center between September 1, - October 15, 2009, and agreed to participate in the study. The participants were asked to state whether they were knowledgeable about each of these rights, and whether they had ever benefited from them. Of the participants, 53% were knowledgeable about the 14 patients’ rights listed in the data collection form and 28% benefited from these rights.Although the study participants generally attached importance to patients' rights, they neither were knowledgeable about these rights nor benefited from them sufficiently.


Author(s):  
Zakarea Abdullah Yaseen Al-Khayat ◽  
Nabaz Fisal Shakir Agha ◽  
Kawthar Ibrahim Fatah Alharmni ◽  
Yousef Jafar Khudhur

<p class="abstract"><strong>Background:</strong> The objective of the study was to determine the incidence of cutaneous leishmaniasis (CL) in Makhmur District (Erbil Province).</p><p class="abstract"><strong>Methods:</strong> A cross-sectional, observational, descriptive study was performed in the outpatient clinic of Makhmur General Health Center. All the patients who presented at the dermatology clinic during the period from January 2015 to January 2017 were included in the study. The provisional diagnosis was dependent mainly on clinical examination in addition to Giemsa stain.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 1264 cutaneous leishmaniasis cases were diagnosed during the study period with males representing 54.6% of the cases. The study participants ranged from 10 months to 61 years. Age group &lt;15 years were 53.5%. Clinically, 49.3% of patients had one lesion, 51.5% of patients had wet type. Most lesions were found on both limbs (48.8%). The highest number of cases was recorded during February (29.1%) and November (21.8%), while the lowest rate of cases was recorded in July (0.2%). According to stain results, 70.6% of the cases were positive to giemsa stain.</p><p><strong>Conclusions:</strong> CL is endemic in Makhmur district. Males were infected in higher percent than females and this may be due to cultural, occupational and social factors.</p>


2020 ◽  
Vol 11 (4) ◽  
pp. 5828-5835
Author(s):  
Sanija P ◽  
Nandakumar U P ◽  
Jayaram Shetty K ◽  
Bharath Raj K C ◽  
Vinay B C ◽  
...  

Adverse Drug Reactions () are the problem that adds extra burden in the global scenario. Anticancer drugs can lead to severe negative consequences due to these . This study was conducted to assess the causality, severity and preventability of the identified of chemotherapeutic drugs among hospitalized patients diagnosed with cancer and also to analyze its management. A prospective observational study was conducted among cancer patients for a period of eight months. A total of 120 hospitalized patients who developed at least one ADR due to chemotherapy were included in this study. Data were collected and documented in a well-designed data collection form. A total of 166 were detected in 120 patients. 33(19.8%), was found as the most commonly identified ADR. Patients administered with as were found to be reported with the highest number of (36). According to Naranjo’s scale and WHO causality assessment, 110(66.2%) and 105(63.2%) were found probable. &amp; scale of severity showed that 97(58.4%) were moderate and Modified and Thornton scale revealed that 129(77.7%) were not preventable. The patients prescribed with , , regimen should be strictly and continuously monitored for the symptoms of ADR. Early detection of ADR can decrease morbidity and mortality.


Sign in / Sign up

Export Citation Format

Share Document