scholarly journals Methods for assessment of the course of wound process

2019 ◽  
Keyword(s):  
Clinical Medicine ◽  
Objective Assessment ◽  
Bacterial Flora ◽  
Healing Process ◽  
Experimental Studies ◽  
Infectious Agent ◽  
The State ◽  
Wound Healing Process ◽  
Tissue Destruction

Summary: The article is devoted to the analysis of methods for evaluation of the course of wound process. The problem of the treatment of wounds of various etiology is one of the complex sections of clinical medicine. Currently, there is an increase in the proportion of traumatic injuries that can cause wounds. Also common are vascular diseases and endocrine pathology, associated with the development of complications with the formation of tissue defects. The presence of tissue destruction and an infectious agent in the wound determine the development of purulent-inflammatory process in it. The current direction is determination of the criteria for diagnosis and methods of prevention of general and local complications. The purpose of the study was to determine the clinical and laboratory parameters used to reveal the stage of the wound process and to predict the development of complications. The factors that determine the wound healing process and the appropriate techniques for assessing the wound process were studied. Subjective and objective methods are identified among the control methods. The article describes techniques that reflect the condition of tissues forming the wound walls or wound surface; techniques enabling to characterize bacterial flora by qualitative and quantitative indicators; methods allowing to determine the state of local and general body resistance. A brief description of standard techniques – cytological examination of wound exudate, assessment of cytograms, planimetric and bacteriological tests – is given. The data on determination of pH of wound medium and liquid volumetric vulnerometry, estimation of the state of granulation tissue are given. The value of the use of computerized diagnostics and computerized monitoring of the wound process was studied. The importance of methods for objective assessment of the course of the wound process for control of the treatment efficacy and in experimental studies during preclinical trials of medicinal products and medical devices has been demonstrated.

scholarly journals Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications

Cosmetics ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 16 ◽  
Author(s):  
Anton Shabunin ◽  
Vladimir Yudin ◽  
Irina Dobrovolskaya ◽  
Evgeny Zinovyev ◽  
Viktor Zubov ◽  
...  
Keyword(s):  
Wound Dressing ◽  
High Efficiency ◽  
Healing Process ◽  
Experimental Studies ◽  
Scar Tissue ◽  
Wound Dressings ◽  
Control Group ◽  
Wound Healing Process ◽  
Electrospinning Technique

An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.

Improvement Of Curvilinear Diagrams Of Concrete Deformation

2019 ◽  
pp. 99-104
Keyword(s):  
Reinforced Concrete ◽  
Peak Load ◽  
Experimental Studies ◽  
Concrete Structures ◽  
Deformation Model ◽  
Reinforced Concrete Structures ◽  
Significant Difference ◽  
Deformation Diagrams

Problems when calculating reinforced concrete structures based on the concrete deformation under compression diagram, which is presented both in Russian and foreign regulatory documents on the design of concrete and reinforced concrete structures are considered. The correctness of their compliance for all classes of concrete remains very approximate, especially a significant difference occurs when using Euronorm due to the different shape and sizes of the samples. At present, there are no methodical recommendations for determining the ultimate relative deformations of concrete under axial compression and the construction of curvilinear deformation diagrams, which leads to limited experimental data and, as a result, does not make it possible to enter more detailed ultimate strain values into domestic standards. The results of experimental studies to determine the ultimate relative deformations of concrete under compression for different classes of concrete, which allowed to make analytical dependences for the evaluation of the ultimate relative deformations and description of curvilinear deformation diagrams, are presented. The article discusses various options for using the deformation model to assess the stress-strain state of the structure, it is concluded that it is necessary to use not only the finite values of the ultimate deformations, but also their intermediate values. This requires reliable diagrams "s–e” for all classes of concrete. The difficulties of measuring deformations in concrete subjected to peak load, corresponding to the prismatic strength, as well as main cracks that appeared under conditions of long-term step loading are highlighted. Variants of more accurate measurements are proposed. Development and implementation of the new standard GOST "Concretes. Methods for determination of complete diagrams" on the basis of the developed method for obtaining complete diagrams of concrete deformation under compression for the evaluation of ultimate deformability of concrete under compression are necessary.

Energetic properties of peat saturated with petroleum products

2020 ◽  
Vol 13 (2) ◽  
pp. 105-109
Author(s):  
E. S. Dremicheva
Keyword(s):  
Crude Oil ◽  
Diesel Fuel ◽  
Energy Use ◽  
Experimental Studies ◽  
Calorific Value ◽  
Petroleum Products ◽  
Ash Content ◽  
Motor Oil ◽  
Initial Sample

This paper presents a method of sorption using peat for elimination of emergency spills of crude oil and petroleum products and the possibility of energy use of oil-saturated peat. The results of assessment of the sorbent capacity of peat are presented, with waste motor oil and diesel fuel chosen as petroleum products. Natural peat has been found to possess sorption properties in relation to petroleum products. The sorbent capacity of peat can be observed from the first minutes of contact with motor oil and diesel fuel, and significantly depends on their viscosity. For the evaluation of thermal properties of peat saturated with petroleum products, experimental studies have been conducted on determination of moisture and ash content of as-fired fuel. It is shown that adsorbed oil increases the moisture and ash content of peat in comparison with the initial sample. Therefore, when intended for energy use, peat saturated with petroleum products is to be subjected to additional drying. Simulation of net calorific value has been performed based on the calorific values of peat and petroleum products with different ratios of petroleum product content in peat and for a saturated peat sample. The obtained results are compared with those of experiments conducted in a calorimetric bomb and recalculated for net calorific value. A satisfactory discrepancy is obtained, which amounts to about 12%. Options have been considered providing for combustion of saturated peat as fuel (burnt per se and combined with a solid fuel) and processing it to produce liquid, gaseous and solid fuels. Peat can be used to solve environmental problems of elimination of emergency spills of crude oil and petroleum products and as an additional resource in solving the problem of finding affordable energy.

EXPERIMENTAL STUDIES OF REINFORCED CONCRETE STRUCTURES WITH CROSS-SHAPED SPATIAL CRACK UNDER TORSION WITH BENDING

2020 ◽  
Vol 92 (6) ◽  
pp. 13-25
Author(s):  
Vl.I. KOLCHUNOV ◽  
◽  
A.I. DEMYANOV ◽  
M.M. MIHAILOV ◽  
◽  
...  
Keyword(s):  
Reinforced Concrete ◽  
Experimental Determination ◽  
Calculation Method ◽  
Experimental Studies ◽  
Concrete Structures ◽  
Design Parameters ◽  
Reinforced Concrete Structures ◽  
Experimental Scheme

The article offers a method and program for experimental studies of reinforced concrete structures with cross-shaped spatial crack under torsion with bending, the main purpose of which is to check the design assumptions and experimental determination of the design parameters of the proposed calculation method. The conducted experimental studies provide an opportunity to test the proposed calculation apparatus and clarify the regularities for determining deflections, angles of rotation of extreme sections, and stresses in the compressed zone of concrete. For analysis, the article presents a typical experimental scheme for the formation and development of cracks in the form of a sweep, as well as characteristic graphs of the dependence of the angles of rotation of end sections.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hydrogels: A Versatile Drug Delivery Carrier Systems

1970 ◽  
Vol 5 (3) ◽  
pp. 1745-1756
Author(s):  
L H Baldaniya ◽  
Sarkhejiya N A
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Structural Integrity ◽  
Healing Process ◽  
Polymer Chains ◽  
Wound Healing Process ◽  
Aqueous Environment ◽  
Preparation Methods ◽  
Control Drug

Hydrogels are the material of choice for many applications in regenerative medicine due to their unique properties including biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics. Hydrogel (also called Aquagel) is a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. Hydrogels are highly absorbent (contain ~99.9% water), natural or synthetic polymers. Hydrogel also possess a degree of flexibility very similar to natural tissue, due to its significant water content. It can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures. Also serve as adhesives or barriers between tissue and material surfaces. The positive effect of hydrogels on wounds and enhanced wound healing process has been proven. Hydrogels provide a warm, moist environment for wound that makes it heal faster in addition to its useful mucoadhesive properties. Moreover, hydrogels can be used as carriers for liposomes containing variety of drugs, such as antimicrobial drugs. Hydrogels are water swollen polymer matrices, with a tendency to imbibe water when placed in aqueous environment. This ability to swell, under biological conditions, makes it an ideal material for use in drug delivery and immobilization of proteins, peptides, and other biological compounds. Hydrogels have been extensively investigated for use as constructs to engineer tissues in vitro. This review describes the properties, classification, preparation methods, applications, various monomer used in formulation and development of hydrogel products.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

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