Long Non-Coding Rna Profiling Reveal Potential Biomarkers Associated With Metastatic Progression In Rectal Cancer

2020 ◽  
Author(s):  
MINUTENTAG I W ◽  
SOUZA C P ◽  
MORAES M P T ◽  
CARVALHO M ◽  
REIS R M V ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Metastatic Progression ◽  
Rna Profiling ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Potential Biomarkers

scholarly journals Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis

2019 ◽  
Vol 25 (8) ◽  
pp. 491-502
Author(s):  
Ling Guo ◽  
Linna Li ◽  
Yang Zhang ◽  
Shulin Fu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Immune Response ◽  
Target Genes ◽  
Intestinal Inflammation ◽  
Ileal Mucosa ◽  
Rna Profiling ◽  
Lps Challenge ◽  
Non Coding Rna ◽  
Inflammatory Immune Response ◽  
Novel Target ◽  
Long Non Coding Rna

LPS can induce an inflammatory immune response in the intestine, and long non-coding RNA (lncRNA) is involved in the process of inflammatory disease. However, the biological role of lncRNA in the intestinal inflammation of piglets remains unclear. In this study, the lncRNA expression profile of the ileal mucosa of piglets challenged by LPS was analysed using lncRNA sequencing. In total, 112 novel lncRNAs were predicted, of which 58 were up-regulated and 54 down-regulated following LPS challenge. Expression of 15 selected lncRNAs was validated by quantitative PCR. We further investigated the target genes of lncRNA that were enriched in the signalling pathways involved in the inflammatory immune response by utilising Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes analysis, with cell adhesion molecules and mTOR signalling pathway identified. In addition, the co-expression networks between the differentially expressed lncRNAs and the target mRNAs were constructed, with seven core lncRNAs identified, which also demonstrated that the relationship between lncRNAs and the target genes was highly correlated. Our study offers important information about the lncRNAs of the mucosal immune system in piglets and provides new insights into the inflammatory mechanism of LPS challenge, which might serve as a novel target to control intestinal inflammation.

scholarly journals Long non-coding RNA profiling of pediatric Medulloblastoma

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Varun Kesherwani ◽  
Mamta Shukla ◽  
Don W. Coulter ◽  
J. Graham Sharp ◽  
Shantaram S. Joshi ◽  
...  
Keyword(s):  
Rna Profiling ◽  
Pediatric Medulloblastoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Potential Biomarkers for Therapeutic Monitoring and Clinical Outcome in Breast Cancer

2021 ◽  
Author(s):  
Yuki Yamamoto ◽  
Sabrina La Salvia ◽  
Sahoo Susmita ◽  
Hidetoshi Tahara
Keyword(s):  
Expression Profiles ◽  
Therapeutic Targets ◽  
Transfer Rna ◽  
Therapeutic Monitoring ◽  
Transfer Rnas ◽  
Non Coding Rna ◽  
Tumor Tissues ◽  
Non Coding Rnas ◽  
Long Non Coding Rna ◽  
Potential Biomarkers

Non-coding RNAs are a species of RNA that are not translated to proteins. These include transfer RNAs and ribosomal RNAs, microRNAs, transfer RNA-derived fragments, and long non-coding RNA. It is known that expression levels of some non-coding RNAs included microRNAs are altered in cancer cells or tumor tissues. Moreover, expression profiles of such non-coding RNAs correlate between tissues and body fluids. Therefore, several non-coding RNAs are being used as diagnostic/prognosis biomarkers or therapeutic targets in cancer. In this chapter, we review about representative non-coding RNAs and introduce especially microRNA as diagnosis/prognosis biomarkers and therapeutic targets.

scholarly journals Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10001
Author(s):  
Shanshan Lu ◽  
Qin Liang ◽  
Yanqing Huang ◽  
Fanming Meng ◽  
Junwen Liu
Keyword(s):  
Noncoding Rnas ◽  
Circulatory System ◽  
Modern Society ◽  
Apoptotic Bodies ◽  
Non Invasive ◽  
Physiological Processes ◽  
Non Coding Rna ◽  
Definition Of ◽  
Long Non Coding Rna ◽  
Potential Biomarkers

Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed.

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