scholarly journals Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10001
Author(s):  
Shanshan Lu ◽  
Qin Liang ◽  
Yanqing Huang ◽  
Fanming Meng ◽  
Junwen Liu
Keyword(s):  
Noncoding Rnas ◽  
Circulatory System ◽  
Modern Society ◽  
Apoptotic Bodies ◽  
Non Invasive ◽  
Physiological Processes ◽  
Non Coding Rna ◽  
Definition Of ◽  
Long Non Coding Rna ◽  
Potential Biomarkers

Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed.

scholarly journals Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1

2020 ◽  
Vol 6 (27) ◽  
pp. eaaz9072 ◽  
Author(s):  
Jasmine Barra ◽  
Gabriel S. Gaidosh ◽  
Ezra Blumenthal ◽  
Felipe Beckedorff ◽  
Mina M. Tayari ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Cancer Biology ◽  
Nuclear Bodies ◽  
Physiological Processes ◽  
Polyadenylated Rna ◽  
Non Coding Rna ◽  
Isoform Switching ◽  
Low Levels ◽  
Lncrna Neat1 ◽  
Long Non Coding Rna

RNA 3′ end processing provides a source of transcriptome diversification which affects various (patho)-physiological processes. A prime example is the transcript isoform switch that leads to the read-through expression of the long non-coding RNA NEAT1_2, at the expense of the shorter polyadenylated transcript NEAT1_1. NEAT1_2 is required for assembly of paraspeckles (PS), nuclear bodies that protect cancer cells from oncogene-induced replication stress and chemotherapy. Searching for proteins that modulate this event, we identified factors involved in the 3′ end processing of polyadenylated RNA and components of the Integrator complex. Perturbation experiments established that, by promoting the cleavage of NEAT1_2, Integrator forces NEAT1_2 to NEAT1_1 isoform switching and, thereby, restrains PS assembly. Consistently, low levels of Integrator subunits correlated with poorer prognosis of cancer patients exposed to chemotherapeutics. Our study establishes that Integrator regulates PS biogenesis and a link between Integrator, cancer biology, and chemosensitivity, which may be exploited therapeutically.

scholarly journals NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants

2020 ◽  
Vol 49 (D1) ◽  
pp. D165-D171
Author(s):  
Lianhe Zhao ◽  
Jiajia Wang ◽  
Yanyan Li ◽  
Tingrui Song ◽  
Yang Wu ◽  
...  
Keyword(s):  
Transcriptome Sequencing ◽  
Expression Profiles ◽  
Noncoding Rnas ◽  
Transcript Level ◽  
Tissue Expression ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
The Relationship ◽  
Long Non Coding Rna ◽  
Predicted Function

Abstract NONCODE (http://www.noncode.org/) is a comprehensive database of collection and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals. NONCODEV6 is dedicated to providing the full scope of lncRNAs across plants and animals. The number of lncRNAs in NONCODEV6 has increased from 548 640 to 644 510 since the last update in 2017. The number of human lncRNAs has increased from 172 216 to 173 112. The number of mouse lncRNAs increased from 131 697 to 131 974. The number of plant lncRNAs is 94 697. The relationship between lncRNAs in human and cancer were updated with transcriptome sequencing profiles. Three important new features were also introduced in NONCODEV6: (i) updated human lncRNA-disease relationships, especially cancer; (ii) lncRNA annotations with tissue expression profiles and predicted function in five common plants; iii) lncRNAs conservation annotation at transcript level for 23 plant species. NONCODEV6 is accessible through http://www.noncode.org/.

scholarly journals A „szabad” nukleinsavak jelentősége a noninvazív diagnosztikában

2016 ◽  
Vol 157 (48) ◽  
pp. 1900-1909 ◽  
Author(s):  
Bálint Nagy ◽  
Zoltán Csanádi ◽  
Róbert Póka
Keyword(s):  
Physiological Role ◽  
Clinical Diagnostics ◽  
The Body ◽  
Rna Molecules ◽  
Non Invasive ◽  
Physiological Processes ◽  
Specificity And Sensitivity ◽  
Non Coding Rna ◽  
Diagnosis And Classification ◽  
New Generation

There is a great interest to determine the physiological role of “free” nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiological processes is still in the focus of the research, while their use in the diagnostics is becoming more and more important. The use of „free” DNA in the non-invasive prenatal diagnosis is the first clinical application of the new generation sequencers, these methods are able to reach 99.9% specificity and sensitivity for the detection of the most common trisomies. There are promising results in their use in the diagnosis and classification of heart and cardiovascular diseases. In oncology the possibility to use the “liquid biopsy” captured the attention of not only researchers and clinicians, but the whole community. There is not enough data until today for the clinical utility and applicability of these methods. Orv. Hetil., 2016, 157(48), 1900–1909.

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