Polysaccharides as wound healing agent: a mini review

Medicinal eukaryotes, such as plants and fungi, have prompted researchers to conduct extensive studies on their medicinal values for drug discovery. Current trends focus on bioactive compounds of medicinal plants to produce inventions in the medical and health fields. Among many bioactive compounds, polysaccharides attract attention because they are non-toxic and have no side effects. Polysaccharides have been widely used in food and pharmaceutical industries as a secondary ingredient for several decades. This paper reviewed the applications of polysaccharides as wound healing agents. Wounds can affect the patient’s well-being, self-image, working capacity and independence. Research studies on different sources of polysaccharides by in vitro and in vivo model have been investigated. Based on the scientific evidence related to polysaccharides, this work will be a baseline study for future investigations in different fields. All literature was accessed through available electronic databases

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Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

Pharmaceutics ◽

10.3390/pharmaceutics11090447 ◽

2019 ◽

Vol 11 (9) ◽

pp. 447 ◽

Cited By ~ 7

Author(s):

Fabian Ávila-Salas ◽

Adolfo Marican ◽

Soledad Pinochet ◽

Gustavo Carreño ◽

Oscar Valdés ◽

...

Keyword(s):

Wound Healing ◽

Sustained Release ◽

Bioactive Compounds ◽

Target Therapy ◽

Dicarboxylic Acids ◽

Skin Wound ◽

Dynamics Simulation ◽

Skin Wound Healing

This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-target therapy in wound healing. Interaction energy calculations and molecular dynamics simulation studies allowed evaluating the intermolecular affinity of the above bioactive compounds by hydrogels crosslinked with the different dicarboxylic acids. According to the computational results, the hydrogels crosslinked with succinic, aspartic, maleic and malic acids were selected as the best candidates to be synthesized and evaluated experimentally. These four crosslinked hydrogels were prepared and characterized by FTIR, mechanical properties, SEM and equilibrium swelling ratio. The sustained release of the bioactive compounds from the film dressing was investigated in vitro and in vivo. The in vitro results indicate a good release profile for all four analyzed bioactive compounds. More importantly, in vivo experiments suggest that prepared formulations could considerably accelerate the healing rate of artificial wounds in rats. The histological studies show that these formulations help to successfully reconstruct and thicken epidermis during 14 days of wound healing. Moreover, the four film dressings developed and exhibited excellent biocompatibility. In conclusion, the novel film dressings based on hydrogels rationally designed with combinatorial and sustained release therapy could have significant promise as dressing materials for skin wound healing.

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Wound Healing Potential of Rhodomyrtus tomentosa and its Bioactive Compounds- Rhodomyrtone

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i40a32243 ◽

2021 ◽

pp. 262-273

Author(s):

Evana Kamarudin ◽

Hasseri Halim ◽

Tengku Shahrul Anuar ◽

Roslinah Hussain

Keyword(s):

Wound Healing ◽

Bioactive Compounds ◽

Human Fibroblast ◽

Ethanolic Extract ◽

Fibroblast Cells ◽

Human Fibroblast Cells ◽

Healing Agent ◽

Wound Healing Activity ◽

Rhodomyrtus Tomentosa

Aims: The present work was aimed to study the phytochemical composition of a crude ethanolic extract of Rhodomyrtus tomentosa [SERT], and the presence of rhodomyrtone and SERT's in vitro wound healing activity. Introduction: Rhodomyrtus tomentosa is native plant to southern and southeastern Asia, India, east to southern China, Taiwan, Philippines, and south to Malaysia. In the traditional Vietnamese, Chinese and Malaysia, all its part, including leaves, roots, buds, and fruits have been used. A need for a new source of wound healing agent is the call for the investigation of the potential of R. tomentosa as the source of health-promoting agent, specifically as a natural wound healing agent. Methodology: SERT was screen for its phytochemicals and the detection of rhodomyrtone using liquid chromatography–mass spectrometry, /Quadrupole time-of-flight [LC-MS/QTOF] analysis. Cell viability, cell proliferation, and migration assay were performed to examine the SERT effect's in vitro wound healing activity on human fibroblast cells [CRL-2522]. Results: The phytochemical study showed the presence of saponins, flavonoids, tannins and steroid in the crude ethanolic extract. The LC-MS analysis of crude ethanolic extract of SERT showed presents of rhodomyrtone which is one of the major compounds in the extract. SERT exhibit proliferative and migratory rate in human fibroblast cells [CRL 2522] in dose-dependent manner, which supports wound healing process. Its bioactive compounds presented wound healing activities at 0.325 up to 2.5 µg/mL. Conclusion: Both SERT and rhodomyrtone portrayed in vitro wound healing activities. Further studies to elucidate the mechanism of action of SERT and rhodomyrtone is recommended.

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Differences among Branded Hyaluronic Acids in Italy, Part 1: Data from In Vitro and Animal Studies and Instructions for Use

Clinical Medicine Insights Arthritis and Musculoskeletal Disorders ◽

10.4137/cmamd.s38857 ◽

2016 ◽

Vol 9 ◽

pp. CMAMD.S38857 ◽

Cited By ~ 2

Author(s):

A. Migliore ◽

E. Bizzi ◽

O. De Lucia ◽

A. Delle Sedie ◽

M. Bentivegna ◽

...

Keyword(s):

Animal Studies ◽

Scientific Evidence ◽

In Vivo Studies ◽

In Vivo Model ◽

Extensive Literature ◽

Model Studies ◽

Extensive Literature Search ◽

Instructions For Use

Background The use of hyaluronic acid (HA) for intra-articular (IA) injection is widespread around the world for patients affected by osteoarthritis. AIM The aim of this study is to identify scientific evidence from in vitro and in vivo studies supporting the use of IA HAs marketed in Italy We also evaluated the accuracy of indications and contraindications reported in the leaflets of such HAs compared with the available scientific evidence. Materials and Methods An extensive literature search was performed to identify all in vitro and in vivo model studies reporting on the effects of various HAs marketed in Italy for IA use. Data reported in the leaflets of different HA-based products for IA use were extracted and analyzed alongside evidence from in vitro and in vivo model studies. Results Nine in vitro studies and 11 studies on animal models were examined. Comparing results with what is reported in the leaflets of HAs marketed in Italy, it was observed that many branded formulations are introduced in the market without any reporting of basic scientific evidence. Only 12.82% and 17.95% of branded products had been shown to be effective with scientific evidence from in vitro and in vivo studies, respectively. The rationale of use of these products is based on their nature, as if a class effect existed such that all HAs would yield similar effects. Conclusions Data on HAs deriving from in vitro and in vivo studies are scarce and relate to only a small percentage of products marketed in Italy. Many indications and contraindications are arbitrarily reported in Italian HA leaflets without the support of scientific evidence. Larger and brand-specific studies are necessary and should be reported in the leaflets to guide clinicians in making an appropriate choice regarding HA-based IA therapy.

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In Vivo and In Vitro Evaluation of the Therapeutic Potential of Some Turkish Scorzonera Species as Wound Healing Agent

Current Pharmaceutical Design ◽

10.2174/138161212799504867 ◽

2012 ◽

Vol 18 (10) ◽

pp. 1421-1433 ◽

Cited By ~ 6

Author(s):

Ipek Sutar ◽

Ozlem Bahadir Acikara ◽

Gulcin Saltan Citoglu ◽

Hikmet Keles ◽

Burcin Ergene ◽

...

Keyword(s):

Wound Healing ◽

Therapeutic Potential ◽

In Vitro Evaluation ◽

Healing Agent

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Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties, and In Vitro Bioaccessibility

Foods ◽

10.3390/foods9101483 ◽

2020 ◽

Vol 9 (10) ◽

pp. 1483 ◽

Cited By ~ 1

Author(s):

Nieves Baenas ◽

Jenny Ruales ◽

Diego A. Moreno ◽

Daniel Alejandro Barrio ◽

Carla M. Stinco ◽

...

Keyword(s):

Antioxidant Capacity ◽

Bioactive Compounds ◽

Biological Properties ◽

Functional Ingredient ◽

Capacity Evaluation ◽

Interesting Candidate ◽

In Vitro Bioaccessibility ◽

Pharmaceutical Industries

The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.

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Anti-atherosclerotic effects of fruit bioactive compounds: A review of current scientific evidence

Canadian Journal of Plant Science ◽

10.4141/cjps2011-090 ◽

2012 ◽

Vol 92 (3) ◽

pp. 407-419 ◽

Cited By ~ 36

Author(s):

Surangi H. Thilakarathna ◽

H. P. Vasantha Rupasinghe

Keyword(s):

Bioactive Compounds ◽

Antioxidant Activities ◽

Scientific Evidence ◽

Experimental Models ◽

Lipid Lowering ◽

Experimental Conditions ◽

Beneficial Effects ◽

Positive Effects

Thilakarathna, S. H. and Rupasinghe, H. P. V. 2012. Anti-atherosclerotic effects of fruit bioactive compounds: A review of current scientific evidence. Can. J. Plant Sci. 92: 407–419. Atherosclerosis is a condition which leads to a cascade of processes involved in thickening of arterial walls as a result of fatty deposition, which can increase the risk of cardiovascular diseases. Among numerous remedies, the consumption of fruits is believed to have beneficial effects on atherosclerosis development. Various bioactive compounds are present in fruits and they have been found to be responsible for exerting these beneficial effects. Fruit flavonoids and certain terpenoids are among the most efficacious fruit bioactive compounds that have shown positive effects on different in vitro as well as in vivo research models of atherosclerosis. The mechanisms of actions of these compounds vary from exerting antioxidant activities to anti-atherogenic and lipid lowering activities, based on different experimental models. This review article briefly explains how some of the fruit bioactive compounds have affected atherosclerosis under experimental conditions.

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Natural Bioactive Compounds with Small-Bowel Glucose/Antiabsorption and Sugar Digestion Enzymes’ Inhibition Actions: New Strategy to Relieve Hyperglycemia and Diabetes

Recent Advances in Biology and Medicine ◽

10.18639/rabm.2019.879443 ◽

2019 ◽

Vol 5 ◽

pp. 1

Author(s):

Kais Rtibi ◽

Slimen Selmi ◽

Rafik Balti ◽

Lamjed Marzouki ◽

Hichem Sebai ◽

...

Keyword(s):

Small Bowel ◽

Bioactive Compounds ◽

Glucose Transporter ◽

Scientific Evidence ◽

Postprandial Glucose ◽

Glucose Absorption ◽

Glucose Levels ◽

New Strategy

Intestinal glucose absorption/inhibition activity by natural bioactive compounds is considered a new strategy for prevention/treatment of uncontrolled hyperglycemia and diabetes as well as chronic human metabolic disorders. This mini review provides scientific evidence of the contribution of natural bioactive nutrients to inhibit glucose absorption in the small bowel. Many studies were realized on intestinal glucose transport in vitro and on postprandial glucose levels in vivo. In this context, the main designated constituents are (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, epicatechingallate, tannic acid, resveratrol, and chlorogenic acid. The therapeutic approaches are to retard the absorption of glucose by inhibition of carbohydrate-hydrolyzing enzymes such as intestinal glycosidases (α-amylase and α-glycosidase) and the inhibition of intestinal Na+-dependent glucose absorption mediated by reduced expression of glucose transporter (SGLT1). These studies revealed that natural bioactive compounds, as potential candidates, can be designed as natural products for the development of novel functional foods or nutraceuticals to relieve hyperglycemia/diabetes.

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