scholarly journals Clinical Application Significance of Nutritional Support Therapy in Patients with End-stage Malignant Tumor

2018 ◽  
Vol 2 (4) ◽  
Author(s):  
Tao Qin ◽  
Zonghui Jiang
Keyword(s):  
Nutritional Support ◽  
Malignant Tumors ◽  
Reference Group ◽  
Statistical Significance ◽  
Post Treatment ◽  
Double Blind ◽  
Fatigue Score ◽  
Superior Effect ◽  
End Stage ◽  
Experimental Group

【Abstract】Objective: To analyze the effect of nutritional support therapy on the clinical outcomes in patients with end-stage malignant tumors. Methods: Sample data collection was conducted from April 2015 to July 2018. Fifty-four patients with end-stage malignant tumors were enrolled in the study. They were divided into reference group (n=27) and experimental group (n= 27) by double-blind method. Conventional treatment was used in the reference group, while nutritional support therapy was used in the experimental group. The treatment effects of the two groups were compared. Results: Post-treatment effect of the experimental group and the reference group were compared using the parameters including total adverse reaction value, Cancer-Related Fatigue Score, quality of life, A/G, AS:AL, ALP, BUN, anorexia score, ALB, UA. The parameters such as A/G, AS:AL, ALP, BUN, anorexia score, ALB, UA were also used to compare between pre and post-treatment. The value of P <0.05 was used to indicate the statistical significance of the test. Conclusion: Nutritional support therapy had a superior effect in patients with end-stage malignant tumors.

scholarly journals Business English blended learning of non-linguistic students: the flipped classroom teaching model

2021 ◽  
Vol 49 (1) ◽  
pp. 265-275
Author(s):  
Olga A. Zharina ◽  
◽  
Alexandra D. Shulepova ◽  
Victoria A. Borisenko ◽  
Marina V. Samofalova ◽  
...  
Keyword(s):  
Educational Technology ◽  
Foreign Language ◽  
Blended Learning ◽  
Flipped Classroom ◽  
Reference Group ◽  
Statistical Significance ◽  
Teaching Model ◽  
Traditional Teaching ◽  
Learning Path ◽  
Experimental Group

The challenges faced by modern Russian education make require the transformation of traditional teaching models and the introduction of innovative ones. One solution is the use of blended learning. Despite the existing scientific works in this area, the issue of the effectiveness of such a learning model in the formation of foreign language communicative competence remains open. The purpose of this experimental study is to determine the effectiveness of using the "flipped classroom" blended model in teaching the 3rd year students of the College of Economics of the South Russian Institute of Management of the Russian Academy of National Economy and Public Administration under the President of the Russian Federation the discipline "Foreign language in business communication". The experiment was carried out from 2019 to 2020, the total number of participants was 81. Two groups were allocated during the study: experimental group (n = 40) and reference group (n = 41). The participants in the experimental group were trained using the new educational technology "flipped classroom". The members of the reference group were trained using traditional educational technology. To determine the effectiveness of the technologies used, as well as to determine the qualitative changes after the implementation of the pedagogical influence, the nonparametric Pearson χ2 criterion was applied. The critical level of statistical significance when testing the null hypothesis was taken equal to 0.05. In all cases, bilateral variants of the criteria were used. The results obtained (xemp2 = 8.095 > x0.052 = 7.815) led to the conclusion that the "flipped classroom" blended teaching model has an advantage in its effectiveness over traditional teaching in the formation of language competence. The experiment has shown that this format helps students to implement an individual learning path, which contributes to the improvement of educational performance.

scholarly journals The Efficacy of Different Interventional Chemoembolization Regiments Combined with Radiofrequency Ablation in the Treatment of Primary Liver Cancer and its Effects on Patients’ Immune Function

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Liangjin Liu ◽  
Lianglong Wu
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Cancer ◽  
Adverse Reactions ◽  
Reference Group ◽  
Primary Liver Cancer ◽  
Clinical Effects ◽  
Double Blind ◽  
Double Blind Method ◽  
Experimental Group ◽  
Target Data

Objective: To study and compare the clinical effects of the combination of different interventional embolization chemotherapy and radiofrequency ablation in patients with primary liver cancer. Methods: In this paper, based on the target data validation of those 60 patients with primary liver cancer treated in the hospital during the period from May 2017 to May 2018, the double-blind method was used for the comparison between groups. Patients in the reference group were treated with the combination of cis-platinum interventional chemoembolization regimen and radiofrequency ablation, while those in the experimental group were treated with the combination of lobaplatin interventional chemoembolization regimen and radiofrequency ablation. Then, the efficacy of both groups was compared. Results: After the treatment, the clinically effective total value, the calculation value of adverse reactions, and the value of IgA, IgM, IgG and AFP of the experimental group were compared with those of the reference group. In addition, the value of IgA, IgM, IgG and AFP of both groups after and before the treatment were compared. The experimental results showed that the data was statistically significant (P<0.05). Conclusion: The combination of lobaplatin and cisplatin interventional embolization chemotherapy and radiofrequency ablation has some effects in patients with primary liver cancer, but the former one showed more significant effects.

scholarly journals Application Effect of Clinical Pathway Teaching Method in Clinical Teaching of Cardiology

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Xiaopeng Wu ◽  
Hongmei Shangguan ◽  
Leisen Han ◽  
Tongchao Xing
Keyword(s):  
Clinical Pathway ◽  
Clinical Teaching ◽  
Teaching Method ◽  
Reference Group ◽  
Teaching Quality ◽  
Double Blind ◽  
Satisfaction Degree ◽  
Examination Result ◽  
Experimental Group ◽  
Assessment Results

Objective: To study the clinical effect of applying clinical pathway teaching method in clinical teaching of cardiology. Methods: This paper verifies and calculates that 50 interns working in cardiology department in our hospital from October 2016 to October 2019 are divided into groups and compared in the form of double-blind method. The reference group (N=25) uses traditional teaching methods, and the experimental group (N=25) uses clinical pathway teaching method. The satisfaction degree, teaching quality, theoretical assessment results, operation assessment and comprehensive assessment results of interns in the experimental group and the reference group are compared. Results: The satisfaction degree, theoretical examination result, operation examination, comprehensive examination result, improvement of team spirit, professional quality, improvement of professional ethics, standardized diagnosis and treatment, improvement of clinical problem handling ability, stimulation of learning interest and cultivation of clinical thinking of the interns in the experimental group were compared with those of the reference group(P<0.05), showing the value of statistical comparison and demonstration between data indexes. Conclusion: The application of clinical path-teaching method in clinical teaching of cardiology can improve the clinical teaching effect and teaching quality.

scholarly journals Effect of cryotherapy in preventing mucositis associated with the use of 5-fluorouracil

2020 ◽  
Vol 28 ◽  
Author(s):  
Andrea Bezerra Rodrigues ◽  
Maria Isis Freire De Aguiar ◽  
Patrícia Peres De Oliveira ◽  
Naiana Pacifico Alves ◽  
Renan Alves Silva ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Antineoplastic Agent ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Physiological Serum ◽  
Significant Difference ◽  
Oral Cryotherapy ◽  
And Control ◽  
Experimental Group

Objective: to evaluate the effect of oral cryotherapy compared to physiological serum on the development of oral mucositis in outpatient cancer patients using the 5-fluorouracil antineoplastic agent. Method: this is a controlled, randomized, double-blind, and multi-center clinical trial, conducted with 60 patients undergoing chemotherapy. The experimental group (n=30) used oral cryotherapy during the infusion of the 5-FU antineoplastic agent, while the control group (n=30) performed mouthwash with physiological serum at their homes. The oral cavity of the participants was assessed at three times: before randomization, and on the 7th and 14th days after using 5-FU. For data analysis, descriptive analyses and the ANOVA, paired t, and McNemar tests were used. Results: there was no statistically significant difference between the experimental and control groups in the assessments regarding the grade of mucositis. However, cryotherapy presented the chance to reduce the presence of intragroup mucositis, between the first and second assessments (p=0.000126). Conclusion: cryotherapy did not obtain statistical significance in relation to oral hygiene with serum, but it proved to be effective intragroup. Record number: RBR-4k7zh3

scholarly journals Discussion on Nursing Mode of Ecmo in Treating Severe Patients

2021 ◽  
Vol 4 (2) ◽  
pp. 12
Author(s):  
Fang Xie
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Reference Group ◽  
Statistical Significance ◽  
Carbon Dioxide Partial Pressure ◽  
Correlation Index ◽  
Experimental Group ◽  
Ecmo Treatment

Objective: To evaluate the nursing effect of Ecmo treatment for severe patients.Methods :66 patients treated with extracorporeal membrane pulmonary oxygenation were included in the experimental data. From August 2018 to August 2019, the patients were divided into experimental group and reference group by random digital table method, each group was 33 cases. Routine nursing and targeted nursing were performed to compare the complications of the two groups.Results :(1) The correlation index of extracorporeal membrane pulmonary oxygenation treatment before treatment was consistent, P>0.05, the oxygen saturation and oxygen partial pressure of 2 h、4h after treatment in the experimental group were higher than those in the reference group, compared with the reference group, the carbon dioxide partial pressure of 2 h、4h after treatment in the experimental group was lower, showing statistical significance of data test (PP>0.05). (2) The incidence of infection, bleeding, coagulation, embolism and hypotension in the experimental group (12.12%) was lower than that in the reference group (45.45%), showing statistical significance (P<0.05).Conclusion: the specific nursing effect of extracorporeal membrane pulmonary oxygenation in severe patients can effectively improve the success rate of treatment, and the possibility of complications during treatment is low.

scholarly journals The Effect of Dutasteride in Peri-Operative Blood Loss During Transurethral Resection of Prostate (Turp)

2020 ◽  
Vol 22 (2) ◽  
pp. 177-181
Author(s):  
Md Mostafizur Rahaman ◽  
Md Habibur Rahman ◽  
Muhammad Hossain ◽  
Md Saiful Islam ◽  
Mohammad Shafiqur Rahman
Keyword(s):  
Blood Loss ◽  
Transurethral Resection ◽  
Statistical Significance ◽  
Control Group ◽  
Transurethral Resection Of Prostate ◽  
Double Blind ◽  
Significant Difference ◽  
Group B ◽  
Group Control Group ◽  
Experimental Group

This prospective double blind comparative study was designed to compare the effect of Dutasteride on the perioperative blood loss in Transurethral Resection of Prostate (TURP).Sixty patients with BPH underwent TURP were divided into 2 groups. Patients belong to the group B (Control) and group A (Experimental). Experimental group patients were given Cap. A (dutasteride 0.5 mg) before two weeks of TURP and group B (control) were given Cap. B (placebo). Postoperative comparison between two groups showed that there were no significant difference between the weight of resected prostatic tissue (control =22.41±6.83 gm, and experimental = 25.38±7.22 gm; p=0.107). Postoperative hemoglobin level of both group (Control group = 10.78±0.64 gm/dL and experimental group = 10.83±.51 gm/dL) revealed no significant difference (p=0.774). The mean hemoglobin loss per gram of prostate tissue in both groups (control = 1.81±0.81 gm/gm and experimental = 1.79±0.88 gm/gm) did not show any statistical difference (p=0.938). In this the study it was found that if the BPH patients are subjected with dutasteride 0.5mg before 2 weeks of TURP, bleeding decrease slightly (Control group = 20.35±7.99 ml/gm and Experimental groups = 17.41±7.70 ml/gm). However, these data of bleeding loss did not show any statistical significance. Bangladesh Journal of Urology, Vol. 22, No. 2, July 2019 p.177-181

Adhesive Platelet Count and Blood Coagulability in Myocardial Infarction and Cerebral Thrombosis

1970 ◽  
Vol 24 (03/04) ◽  
pp. 450-460 ◽  
Author(s):  
H Yamazaki ◽  
T Odakura ◽  
K Takeuchi ◽  
T Sano
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
Malignant Tumors ◽  
Total Cholesterol Level ◽  
Statistical Significance ◽  
Acute Stage ◽  
Cerebral Thrombosis ◽  
Prothrombin Activity ◽  
Recovery Stage ◽  
Blood Coagulability

SummaryIn 382 patients, aged 21 to 76 years, including 39 healthy volunteers, a platelet count by Olef’s method, an adhesive platelet count by Moolten-Vroman’s method, prothrombin activity due to one-stage prothrombin time and calcium clotting time were measured. In 39 cases of myocardial infarction and 40 cases of cerebral thrombosis, both in acute stage, a marked decrease in the adhesive platelet count and adhesive index and an increase of prothrombin activity were observed with statistical significance compared to the healthy group (P < 0.01). In the recovery stage of myocardial infarction, cerebral thrombosis and other diseases, except for malignant tumors, acute infectious diseases, diabetes mellitus and blood or liver diseases, the above observations were absent or reduced. In the case of thrombosis, a negative correlation was seen between the adhesive platelet count and prothrombin activity (r — —0.238, P < 0.01). There is no correlation between the changes in platelet adhesiveness or blood coagulability and total cholesterol level in serum.

scholarly journals A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christophe Lay ◽  
Collins Wenhan Chu ◽  
Rikky Wenang Purbojati ◽  
Enzo Acerbi ◽  
Daniela I. Drautz-Moses ◽  
...  
Keyword(s):  
Risk Factor ◽  
Gut Microbiome ◽  
Reference Group ◽  
Mode Of Delivery ◽  
Controlled Study ◽  
Double Blind ◽  
Lipopolysaccharide Biosynthesis ◽  
Infant Gut Microbiome ◽  
Stool Samples ◽  
The Impact

Abstract Background The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either synbiotic, prebiotics, or unsupplemented from birth until 4 months old. Vaginally born infants were included as a reference group. Stool samples were collected from day 3 till week 22. Multi-omics were deployed to investigate the impact of mode of delivery and nutrition on the development of the infant gut microbiome, and uncover putative biological mechanisms underlying the role of a compromised microbiome as a risk factor for NCD. Results As early as day 3, infants born vaginally presented a hypoxic and acidic gut environment characterized by an enrichment of strict anaerobes (Bifidobacteriaceae). Infants born by C-section presented the hallmark of a compromised microbiome driven by an enrichment of Enterobacteriaceae. This was associated with meta-omics signatures characteristic of a microbiome adapted to a more oxygen-rich gut environment, enriched with genes associated with reactive oxygen species metabolism and lipopolysaccharide biosynthesis, and depleted in genes involved in the metabolism of milk carbohydrates. The synbiotic formula modulated expression of microbial genes involved in (oligo)saccharide metabolism, which emulates the eco-physiological gut environment observed in vaginally born infants. The resulting hypoxic and acidic milieu prevented the establishment of a compromised microbiome. Conclusions This study deciphers the putative functional hallmarks of a compromised microbiome acquired during C-section birth, and the impact of nutrition that may counteract disturbed microbiome development. Trial registration The study was registered in the Dutch Trial Register (Number: 2838) on 4th April 2011.

scholarly journals EXPRESS: Efficacy and Safety of Tadalafil in a Pediatric Population with Pulmonary Arterial Hypertension: Phase 3 randomized, Double Blind Placebo-Controlled Study

2021 ◽  
pp. 204589402110249
Author(s):  
David D Ivy ◽  
Damien Bonnet ◽  
Rolf MF Berger ◽  
Gisela Meyer ◽  
Simin Baygani ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Statistical Significance ◽  
Significance Testing ◽  
Efficacy And Safety ◽  
Phase 3 ◽  
Statistical Significance Testing ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Treatment Groups ◽  
Pulmonary Arterial

Objective: This study evaluated the efficacy and safety of tadalafil in pediatric patients with pulmonary arterial hypertension (PAH). Methods: This phase-3, international, randomized, multicenter (24 weeks double-blind placebo controlled period; 2-year, open-labelled extension period), add-on (patient’s current endothelin receptor antagonist therapy) study included pediatric patients aged <18 years with PAH. Patients received tadalafil 20 mg or 40 mg based on their weight (Heavy-weight: ≥40 kg; Middle-weight: ≥25—<40 kg) or placebo orally QD for 24 weeks. Primary endpoint was change from baseline in 6-minute walk (6MW) distance in patients aged ≥6 years at Week 24. Sample size was amended from 134 to ≥34 patients, due to serious recruitment challenges. Therefore, statistical significance testing was not performed between treatment groups. Results: Patient demographics and baseline characteristics (N=35; tadalafil=17; placebo=18) were comparable between treatment groups; median age was 14.2 years (6.2 to 17.9 years) and majority (71.4%, n=25) of patients were in HW cohort. Least square mean (SE) changes from baseline in 6MW distance at Week 24 was numerically greater with tadalafil versus placebo (60.48 [20.41] vs 36.60 [20.78] meters; placebo-adjusted mean difference [SD] 23.88 [29.11]). Safety of tadalafil treatment was as expected without any new safety concerns. During study period 1, two patients (1 in each group) discontinued due to investigator’s reported clinical worsening, and no deaths were reported. Conclusions: The statistical significance testing was not performed between the treatment groups due to low sample size, however, the study results show positive trend in improvement in non invasive measurements, commonly utilized by clinicians to evaluate the disease status for children with PAH. Safety of tadalafil treatment was as expected without any new safety signals.

Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program

2021 ◽  
pp. 1-12
Author(s):  
Alexandra Martini Oliveira ◽  
Marcia Radanovic ◽  
Patricia Cotting Homem de Mello ◽  
Patricia Cardoso Buchain ◽  
Adriana Dias Barbosa Vizzotto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sleep Disturbances ◽  
Rating Scale ◽  
Neuropsychiatric Symptoms ◽  
Caregiver Training ◽  
Controlled Clinical Trial ◽  
Post Intervention ◽  
Double Blind ◽  
Activity Program ◽  
Experimental Group

Background: Neuropsychiatric symptoms (NPS) such as aggression, apathy, agitation, and wandering may occur in up to 90%of dementia cases. International guidelines have suggested that non-pharmacological interventions are as effective as pharmacological treatments, however without the side effects and risks of medications. An occupational therapy method, called Tailored Activity Program (TAP), was developed with the objective to treat NPS in the elderly with dementia and has been shown to be effective. Objective: Evaluate the efficacy of the TAP method (outpatient version) in the treatment of NPS in individuals with dementia and in the burden reduction of their caregivers. Methods: This is a randomized, double-blind, controlled clinical trial for the treatment of NPS in dementia. Outcome measures consisted of assessing the NPS of individuals with dementia, through the Neuropsychiatric Inventory-Clinician rating scale (NPI-C), and assessing the burden on their caregivers, using the Zarit Scale. All the participants were evaluated pre-and post-intervention. Results: 54 individuals with dementia and caregivers were allocated to the experimental (n = 28) and control (n = 26) groups. There was improvement of the following NPS in the experimental group: delusions, agitation, aggressiveness, depression, anxiety, euphoria, apathy, disinhibition, irritability, motor disturbance, and aberrant vocalization. No improvement was observed in hallucinations, sleep disturbances, and appetite disorders. The TAP method for outpatient settings was also clinically effective in reducing burden between caregivers of the experimental group. Conclusion: The use of personalized prescribed activities, coupled with the caregiver training, may be a clinically effective approach to reduce NPS and caregiver burden of individuals with dementia.

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