Morphofunctional Characteristics of Individual Organs of the Human Digestive System

2021 ◽  
Vol 6 (5) ◽  
pp. 9-15
Author(s):  
V. H. Hryn ◽  
Keyword(s):  
Digestive System ◽  
Review Literature ◽  
The Body ◽  
Laboratory Animals ◽  
Morphological Aspect ◽  
Bibliographic Analysis ◽  
Theoretical Medicine ◽  
Domestic Literature ◽  
Morphological Studies ◽  
Human Digestive System

Today, the growing trend of the prevalence of diseases of the digestive system is a very important issue not only in Ukraine but also around the world. This problem applies not only to practical areas of health care, but also to theoretical medicine. The study of the anatomical structure and functional state of the digestive system is the theoretical basis for the extrapolation of various pathological conditions in laboratory animals. Analysis of scientific sources showed a lack of comprehensive morphological studies of the human digestive system. The purpose of the paper was to study the features of some organs of the human digestive system in the morphological aspect by bibliographic analysis of literature. Materials and methods. This bibliographic analysis is based on published peer-reviewed articles, books, textbooks, monographs, abstracts of dissertations. For the purposes of this systematic review, literature search (concerning the study of the structure of the human digestive system) was carried out on the Internet, domestic literature sources, scientific and electronic libraries of Poltava State Medical University by the following keywords: "digestive system", "morphology", "gastrointestinal tract", "colon", "cаecum", "embryonic development of the digestive system". Results and discussion. Digestive system (Latin «systema digestorium») is a system of organs of various structures and functions formed in phylogeny, the importance of which lies in the perception, mechanical and chemical (enzymatic) processing and absorption of nutrients needed to compensate for energy and material costs in the body. Conclusion. Significant progress has been made in understanding the development of the human digestive system over the past two decades. The human digestive system is formed in phylogeny community of similar in structure and function of organs, the importance of which is the digestion of food, mechanical and enzymatic breakdown, absorption of breakdown products into the internal environment of the body and their transport to the liver. The structure of the gastric mucosa is well thought out for secretion and protection against low pH of gastric contents, which is regulated by hydrochloric acid. The pancreas, like the gland of external secretion, produces many digestive enzymes in an inactive form. Activation usually occurs in the lumen of the small intestine. The liver receives most of the nutrients absorbed through the portal vein and then uses them to synthesize many larger molecules

scholarly journals The effectiveness of the use of oxymethyl uracil on the model of acute alcohol intoxication

2021 ◽  
Vol 100 (11) ◽  
pp. 1287-1291
Author(s):  
Ahat B. Bakirov ◽  
Elvira F. Repina ◽  
Denis O. Karimov ◽  
Samat S. Baigildin ◽  
Alfiya R. Gimadieva ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Effective Means ◽  
Experimental Models ◽  
The Body ◽  
Acute Exposure ◽  
Laboratory Animals ◽  
Acute Alcohol Intoxication ◽  
Genetic Studies ◽  
Morphological Studies ◽  
Corrective Effect

Introduction. Considering the prevalence of acute alcohol poisoning in Russia, it seems urgent to search for new effective means of correcting them. Along with taking measures to remove ethanol from the body, pathogenetic correction is effective. Oxymethyluracil and its derivatives have proven to be effective hepatoprotectors in various experimental models of liver damage. The aim of the research was the evaluation of the effectiveness of oxymethyl uracil on the model of acute alcohol intoxication. Material and methods. On the model of acute toxic liver injury of laboratory animals with ethanol, the efficiency of correction of pathological changes with oxymethyl uracil was studied compared to the drug “Mexidol”. A complex of biochemical, morphological and genetic studies was carried out. Results. The morphological studies showed that the correction with oxymethyluracil was more effective at both time points than the drug “Mexidol”, which was manifested in a lower intensity of damage to the liver parenchyma. In the group that received oxymethyluracil, a restoration of the frequency of expression of the Chek 1 gene was observed both after 24 and 72 hours. Upon acute exposure to ethanol, a slight decrease in the level of RIPK1 gene expression was observed. The level of expression of this gene decreased most significantly during the correction of oxy methyl uracil. A decrease in the frequency of expression of this gene can indicate a slowdown in necrosis processes and suppression of reactive oxygen species production in liver cells and, consequently, a curative effect of oxymethyluracil in this type of intoxication. Conclusion. Based on the complex biochemical, morphological and genetic studies carried out, it can be concluded that under acute exposure to ethanol, the corrective effect of oxymethyl uracil is more pronounced than Mexidol (ethylmethylhydroxypyridine succinate).

MORPHOLOGICAL STUDIES OF THE MALE NYGOLAIMUS AQUATICUS THORNE, 1930

1963 ◽  
Vol 41 (5) ◽  
pp. 725-732
Author(s):  
V. M. Das
Keyword(s):  
Nervous System ◽  
Digestive System ◽  
Reproductive Organs ◽  
The Body ◽  
Excretory System ◽  
Serial Sections ◽  
Morphological Studies ◽  
Organ Systems ◽  
Cuticular Structure ◽  
Whole Mounts

The anatomy of males of Nygolaimus aquaticus Thorne, 1930, collected from Blackburn, Ontario, is described. Descriptions are based on whole mounts and also on serial sections. Specimens embedded in paraffin were cut in sections 9 μ in thickness and stained with haematoxylin and eosin.Special emphasis is given to cuticular structure, such as median pores, lateral pores, hemizonid, and transverse and longitudinal striations, which are described and illustrated. Besides these structures, other organ systems of the body, such as digestive system, excretory system, nervous system, and reproductive organs, have also been described and illustrated.

scholarly journals MORPHOLOGICAL STUDIES IN EXPERIMENTAL CRETINISM

1913 ◽  
Vol 17 (6) ◽  
pp. 636-652 ◽  
Author(s):  
Arthur L. Tatum
Keyword(s):  
Adrenal Glands ◽  
The Body ◽  
The Other ◽  
Degenerative Changes ◽  
Morphological Studies ◽  
Cellular Changes ◽  
Anatomical Basis ◽  
Parenchymatous Organ ◽  
Islands Of Langerhans

In summarizing the findings of this paper it may be said that degenerative changes have been noted in practically every parenchymatous organ. Among these the most striking has been that of serous imbibition by the most active cells of these organs. In regard to the changes in the glands of internal secretion, the findings corroborate the statements of Cushing in regard to hypophysectomy, that removal of one gland of internal secretion results in changes in all the other glands. In this case, degenerative changes predominate in the hypophysis, thymus, ovary, and testis, while hyperplasia is seen in the islands of Langerhans and the medullas of the adrenal glands. Finally, in the rabbit athyroidism is responsible for grave degenerative changes in practically all organs and tissues of the body, and many of the symptoms of cretinism have an anatomical basis in organic cellular changes.

Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia

2010 ◽  
Vol 30 (7) ◽  
pp. 725-735 ◽  
Author(s):  
Bernard D Goldstein
Keyword(s):  
Bone Marrow ◽  
Chromosomal Abnormalities ◽  
Species Difference ◽  
The Body ◽  
Myelogenous Leukemia ◽  
Laboratory Animals ◽  
Human Leukemia ◽  
Toxicological Evaluation ◽  
Hematopoietic Stem ◽  
Hematological Cancers

Epidemiological findings suggesting that formaldehyde exposure is associated with a higher risk of acute myelogenous leukemia (AML) and other hematological cancers have led to consideration of the potential mechanism of action by which inhalation of this rapidly reactive agent can cause bone marrow cancer. Two major mechanism-based arguments against formaldehyde as a leukemogen have been the difficulty in envisioning how inhaled formaldehyde might penetrate to the bone marrow; and the lack of similarity of non-cancer effects to other known human myeloleukemogens, particularly the absence of pancytopenia in humans or laboratory animals exposed to high levels. However, both of these arguments have been addressed by the recent finding of a pancytopenic effect and chromosomal abnormalities in heavily exposed Chinese workers which, if replicated, are indicative of a genotoxic effect of formaldehyde on hematopoietic stem cells that is in keeping with other known human leukemogens. Review of the body of evidence suggests an apparent discrepancy between studies in laboratory animals, which generally fail to show evidence of penetration of formaldehyde into the blood or evidence of blood or bone marrow genotoxicity, and studies of exposed humans in which there tends to be evidence of genotoxicity in circulating blood cells. One possible explanation for this discrepancy is species difference. Another possible explanation is that myeloid precursors within the nasal mucosa may be the site for leukemogenesis. However, chloromas, which are local collections of myeloid tumor cells, are rarely if ever found in the nose. Other proposed mechanisms for formaldehyde leukemogenesis are reviewed, and dose issues at the interface between the epidemiological and hematotoxicological findings are explored.

The internal anatomy of the woodlouse, Metoponorthus pruinosus (Brandt), (Porcellionidae, Peracarida)

1968 ◽  
Vol 46 (3) ◽  
pp. 321-327 ◽  
Author(s):  
M. A. Alikhan
Keyword(s):  
Nervous System ◽  
Digestive System ◽  
Circulatory System ◽  
Reproductive Organs ◽  
The Body ◽  
Internal Anatomy ◽  
Suboesophageal Ganglion ◽  
Digestive Tube ◽  
Thoracic Ganglia ◽  
Digestive Glands

Tbe circulatory system, lying in the mid-dorsal line of the body, consists of an oval heart, the opthalmic artery, and a dorsal abdominal artery.The digestive system comprises a wide, large alimentary tube and two pairs of digestive glands. An oesophagus, a proventriculus, midgut, and a short proctodacum or hindgut form the digestive tube. The digestive glands are very well developed and are beaded in form; each pair lies on either side of the alimentary canal.The reproductive organs are well developed in both sexes: in the male they consist of paired testes and their vas deferentia, and in the female paired bilobed ovaries and oviducts.A cerebral or supraoesophageal ganglion, a suboesophageal ganglion, and seven thoracic ganglia form the nervous system. The supraoesophageal ganglion is united with the suboesophageal ganglion by means of the circumoesophageal commissures, whereas the thoracic ganglia and suboesophageal ganglia are linked with each other by paired connectives.The gills and the tracheae are the organs of respiration. The gills are borne of the bases of the pleopods and are enclosed in the branchial chamber. The tracheae are located on the lateral lobes of the first two pleopods only.

The Tomato Pip's Story: Creative Narratives as Bridging Cultural and Science Discourses for Indigenous Students

2017 ◽  
Vol 47 (2) ◽  
pp. 171-184
Author(s):  
Lorrin Ruihi Shortland ◽  
Terry Locke
Keyword(s):  
Digestive System ◽  
Indigenous Education ◽  
Disciplinary Literacy ◽  
Word Count ◽  
Indigenous Students ◽  
Science Discourse ◽  
Group Data ◽  
Focus Group Data ◽  
Human Digestive System

This article reports on what happened when a Rumaki pūtaiao kaiako (Science) teacher at a New Zealand high school trialled the use of creative narratives with her Year-10 students as a way of developing their understanding of the human digestive system. These students were members of the school's Māori immersion unit, and creative narratives were in part utilised as a bridge between science discourse and the cultural knowledges these students brought to their learning. In this case study, students developed ‘Tomato Pip’ narratives through four versions, which told the story of a tomato pip travelling through the human digestive system. Word-count data based on these versions and from a summative test were analysed and correlations found between test scores and three categories of word-count total (total words, total science words and total discrete science words). A discourse analysis of one student's narratives identified two distinct voices in these texts: the personal narrator and the emerging biologist. Questionnaire and focus-group data indicated that the use of creative narratives was both motivational to these students and effective as a bridge into science discourse mastery. It is argued that the findings have implications for disciplinary literacy theory, Indigenous education and science instruction.

MICROSCOPIC CHANGES IN THE INTERNAL ORGANS OF WHITE MICE DURING EXPERIMENTAL IRON (IV) CLATHROCHELATE TOXICOSIS

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
B. V. Borysevych ◽  
◽  
V. V. Lisova ◽  
I. M. Derkach ◽  
S. S. Derkach ◽  
...  
Keyword(s):  
Biological Response ◽  
Organ Damage ◽  
The Body ◽  
New Drugs ◽  
Laboratory Animals ◽  
Internal Organs ◽  
Experimental Drug ◽  
Liver And Kidney ◽  
Preclinical And Clinical Studies ◽  
First Time

Iron (IV) clathrochelate based on a macrobicyclic ligand of the hexahydrazide type is a unique compound that contains iron in a rare high valence IV. Preclinical and clinical studies of this complex, which were started for the first time in Ukraine, have an important theoretical and practical consequence as this complex can be recommended as an active substance in iron-containing drugs with antianemic action. In conducting preclinical studies of new drugs, pathomorphological studies are important because they are a necessary step in studying the biological response of animals to the action of test substances. It was found that some pathological changes develop in the body of white mice under conditions of experimental acute and chronic iron (IV) clathrochelate intoxication. They correlated with the dose of the test compound. During chronic intoxication, the microscopic changes in the liver and kidney of white mice treated with iron (IV) clathrochelate at a dose of 1/10 DL50 were similar to the microscopic changes in the liver and kidney of mice treated with the experimental drug at a dose of 1/5 DL50. However, the severity of these changes was lower, reflecting a lower degree of organ damage. In the myocardium of mice treated with iron (IV) clathrochelate at a dose of 1/5 DL50 on the 10th day, as in acute iron (IV) clathrochelate poisoning, only edema was recorded. The prospects for further research are the study of microscopic changes in the organs of laboratory animals of other species during experimental iron (IV) clathrochelate toxicosis.

THE PHYSILOGICAL CONCEPT OF AGNI AND TRIDOSH WITH REFERENCE TO GRAHANI, A LITERARY REVIEW

2020 ◽  
Vol 8 (02) ◽  
Author(s):  
Vrushali P. Kale Vrushali Purushottam Kale
Keyword(s):  
Gastrointestinal Tract ◽  
Life Style ◽  
Food Habits ◽  
Digestive System ◽  
The Body ◽  
Main Role ◽  
Classical Literature ◽  
Root Cause ◽  
Digestion Process ◽  
Physiological Analysis

According to Ayurveda, Jatharagni plays main role in the digestion process. Jatharagni carries its functions through Pachaka pitta. Grahani is an organ of gastrointestinal tract located between Amashaya and Pakwashaya, where digestion takes place. According to classical literature Pitta is same as Agni. Tridosha also plays very important role in the digestion process. In the recent days, irregular life style affects the digestive system and Jatharagni very badly. Whenever Agni gets (Vikrut) unbalanced due to wrong food habits and lifestyle, it should be understood that along with Agni, Pachaka Pitta will also get disturbed. Agnimandya is the root cause of most of the disorders like Grahani. Grahani organ is the main location of Jatharagni. Grahani is the organ where Pachak Pitta and Samanvayu carry out digestion. The most important function of Grahani is digestion of food with the help of Jatharagni, Pachakpitta, Pittadhara Kala and Samnvayu. Agni inside the body, digest the food give strength and maintain health. Samanvayu regulates the movements of the Grahani and helps in digestion. Hence, in this article we attempt to analyze and correlate patho-physiology of Grahani with respect to Physiological analysis of Agni and disturbed doshas. Etiological factors induces imbalance in Jatharagni, Pachak Pitta and Samanvayu and prolonged imbalance state weakens the Pittadhara Kala, which results in disease Grahani. Health of Grahani entirely depends on balanced state of Jatharagni, Pachaka Pitta, Pittadhara Kala and Samanvayu. The irregular life style, incompatible food habits creates Ama causes Grahani, affecting the digestive system and Jatharagni very badly.

Classification of diseases of the gastrointestinal tract in the practice of a family doctor

2021 ◽  
pp. 8-13
Author(s):  
Aleksey Borisovich Petrukhin
Keyword(s):  
Gastrointestinal Tract ◽  
Digestive System ◽  
Family Doctor ◽  
The Body ◽  
Internal Organs ◽  
Important Place ◽  
High Prevalence ◽  
Classification Of Diseases ◽  
Diagnosis Of Diseases

Gastroenterology belongs to one of the leading branches of therapy. In the structure of diseases of the internal organs, diseases of the digestive system occupy a particularly important place due to their high prevalence, which increases with age. As a rule, these diseases have a chronic, progressive, recurrent course, which ultimately leads to severe disorders of the activity of many organs and systems of the body. The article presents the basic requirements for the formation of a clinical diagnosis of diseases of the gastrointestinal tract, which are most common in the practice of a family doctor.

scholarly journals Aquaporin Channels in the Heart—Physiology and Pathophysiology

2019 ◽  
Vol 20 (8) ◽  
pp. 2039 ◽  
Author(s):  
Arie O. Verkerk ◽  
Elisabeth M. Lodder ◽  
Ronald Wilders
Keyword(s):  
Cardiac Function ◽  
Digestive System ◽  
The Body ◽  
Monovalent Cations ◽  
Biological Functions ◽  
Specific Distribution ◽  
Transmembrane Channels ◽  
Heart Physiology ◽  
Aquaporin Channels ◽  
Coupling Processes

Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of cells and tissues throughout the body. They are known as water channels, but they also facilitate the transport of small solutes, gasses, and monovalent cations. To date, 13 different AQPs, encoded by the genes AQP0–AQP12, have been identified in mammals, which regulate various important biological functions in kidney, brain, lung, digestive system, eye, and skin. Consequently, dysfunction of AQPs is involved in a wide variety of disorders. AQPs are also present in the heart, even with a specific distribution pattern in cardiomyocytes, but whether their presence is essential for proper (electro)physiological cardiac function has not intensively been studied. This review summarizes recent findings and highlights the involvement of AQPs in normal and pathological cardiac function. We conclude that AQPs are at least implicated in proper cardiac water homeostasis and energy balance as well as heart failure and arsenic cardiotoxicity. However, this review also demonstrates that many effects of cardiac AQPs, especially on excitation-contraction coupling processes, are virtually unexplored.

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