Breast self-examination practice and its impact on breast cancer diagnosis in Alexandria, Egypt

This study estimated the frequency of breast-self examination practice and its possible relation to the stage of the disease at diagnosis and patient-related delay in diagnosis among newly diagnosed breast cancer patients. Breast self-examination was practised in 10.4% of cases. It was performed by patients from higher socioeconomic levels and those with a positive family history of breast cancer or benign breast mass. There was significant association between failure to practise breast self-examination and diagnostic delay. We emphasize the need for breast self-examination awareness campaigns as a key measure for ensuring earlier diagnosis and hence better prognoses for breast cancer patients in our community

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Breast self-examination among diagnosed breast cancer patients

Cancer ◽

10.1002/1097-0142(19841201)54:11<2528::aid-cncr2820541136>3.0.co;2-u ◽

1984 ◽

Vol 54 (11) ◽

pp. 2528-2532 ◽

Cited By ~ 14

Author(s):

Shelley E. Taylor ◽

Rosemary R. Lichtman ◽

Joanne V. Wood ◽

Avrum Z. Bluming ◽

Gary M. Dosik ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Breast Self Examination ◽

Self Examination

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Usefulness of Breast Self-Examination for an Early Detection of Breast Cancer. Results of a Study on 500 Breast Cancer Patients and 652 Controls

Tumori Journal ◽

10.1177/030089168106700310 ◽

1981 ◽

Vol 67 (3) ◽

pp. 219-224 ◽

Cited By ~ 20

Author(s):

Marcello Tamburini ◽

Giovanna Massara ◽

Lucio Bertario ◽

Alberto Re ◽

Sergio Di Pietro

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Cancer Patients ◽

Age Groups ◽

Axillary Lymph Nodes ◽

Tumor Diameter ◽

Axillary Lymph ◽

Breast Cancer Patients ◽

Breast Self Examination ◽

Self Examination

The knowledge and practice of breast self-examination (BSE) was investigated among 500 women with operable breast tumors between 35 and 64 years of age (all successively operated) and 652 healthy women, matched with the previous group for 5-year age groups from 35 to 54 years. Only 39.9 % of breast cancer women and 34.5 % of the controls practiced BSE, and only a third of these did it monthly. Such practice tends to progressively decrease, starting from 45 years, and it is used less frequently by the women with a poor education and those in a lower economic bracket. Among the 500 breast cancer patients, those who practiced the self-examination had a higher number of tumors with a diameter no greater than 2 cm and a lower number with a diameter larger than 4 cm. In addition, in this group the percentage of unaffected axillary lymph nodes (N–) was 58.8 % compared to 48.8 % for the group that did not practice self-examination, and the percentage of the cases with more than 3 metastatic lymph nodes (N+ > 3) was 20.0 % in the first group and 27.3 % of the second one. These differences are statistically significant. The correlation between tumor diameter and the histologic lymph node stage is equally evident, since there is a progressive reduction in N– cases and a contemporary progressive increase in N+ (> 3) cases with increasing breast tumor diameter. Therefore, we can infer that the lack of practice of BSE causes a diagnostic and therapeutic delay, which is responsible for aggravation of the prognosis.

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The impact of a brief coping skills intervention on adherence to breast self-examination among first-degree relatives of newly diagnosed breast cancer patients

Psycho-Oncology ◽

10.1002/(sici)1099-1611(199905/06)8:3<220::aid-pon370>3.0.co;2-c ◽

1999 ◽

Vol 8 (3) ◽

pp. 220-229 ◽

Cited By ~ 41

Author(s):

Janet Audrain ◽

Barbara Rimer ◽

David Cella ◽

Michael Stefanek ◽

Judy Garber ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Coping Skills ◽

Newly Diagnosed ◽

Breast Cancer Patients ◽

Breast Self Examination ◽

First Degree Relatives ◽

Self Examination ◽

The Impact

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First-Degree Relatives of Breast-Cancer Patients: Cognitive Perceptions, Coping, and Adherence to Breast Self-Examination

Behavioral Medicine ◽

10.1080/08964280209596394 ◽

2002 ◽

Vol 28 (1) ◽

pp. 15-22 ◽

Cited By ~ 40

Author(s):

Miri Cohen

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Breast Self Examination ◽

First Degree Relatives ◽

Self Examination

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Excessive Breast Self-Examination Among First-Degree Relatives of Newly Diagnosed Breast Cancer Patients

Psychosomatics ◽

10.1016/s0033-3182(97)71462-2 ◽

1997 ◽

Vol 38 (3) ◽

pp. 253-261 ◽

Cited By ~ 45

Author(s):

Steven A. Epstein ◽

Ting Hsiang Lin ◽

Janet Audrain ◽

Michael Stefanek ◽

Barbara Rimer ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Newly Diagnosed ◽

Breast Cancer Patients ◽

Breast Self Examination ◽

First Degree Relatives ◽

Self Examination

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Delay in diagnosis of breast cancer in a developing country: a single centre observational study in a tertiary care hospital in North Kerala, India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20174605 ◽

2017 ◽

Vol 5 (10) ◽

pp. 4604

Author(s):

Manikandan Lakshmanan ◽

Ramesan Chayampurath ◽

Ramalingam Trivikraman ◽

Selvam Paramasivam ◽

Sasi M. P.

Keyword(s):

Breast Cancer ◽

Observational Study ◽

Tertiary Care ◽

Diagnostic Delay ◽

Care Hospital ◽

Breast Cancer Patients ◽

Economic Implications ◽

Delay In Diagnosis ◽

Factors Influencing ◽

Self Examination

Background: Around the world breast cancer is the most common cancer in women. In India, peak incidence is between 45-50 years of age. Early diagnosis improves survival, hence reducing diagnostic delay in breast cancer will have major social and economic implications besides improving the quality of life. This observational study aims to decipher various factors influencing diagnostic delay so that early treatment can be instituted.Methods: We interviewed 212 consecutive patients who attended the twice weekly breast clinic conducted by Department of general surgery and department of radiotherapy, government medical college, Kozhikode between September 2014 and February 2015. All patients with primary breast cancer were included in the study. Exclusion criteria included recurrence, second primaries, history of partial treatment and incomplete records. Finally, we interviewed 202 patients with the help of a pretested semi-structured questionnaire.Results: In present study, the commonest age group was 40-50 years with 62.4% participants presenting with early breast cancer and 37.6% having advanced breast cancer. Most of present study subjects were educated up to high school and unemployed. Awareness about breast cancer was 74.25% but many were ignorant of its symptomatology. Practice of breast self-examination (BSE) was low at 32.1%. Side and quadrant were statistically significant factor.Conclusions: In present study religion, educational status, marital status, breast cancer awareness, practice of BSE and location of tumor were statistically significant factors influencing delay in diagnosis. There was a general lack of knowledge about the importance of self-examination in breast cancer which needs health education and need for active social propaganda in print and electronic media regarding its importance. In future institution of a screening programme will hasten diagnosis and improve survival of breast cancer patients.

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Serum Long Non-Coding RNAs PVT1, HOTAIR, and NEAT1 as Potential Biomarkers in Egyptian Women with Breast Cancer

Biomolecules ◽

10.3390/biom11020301 ◽

2021 ◽

Vol 11 (2) ◽

pp. 301

Author(s):

Amal Ahmed Abd El-Fattah ◽

Nermin Abdel Hamid Sadik ◽

Olfat Gamil Shaker ◽

Amal Mohamed Kamal ◽

Nancy Nabil Shahin

Keyword(s):

Breast Cancer ◽

Logistic Regression ◽

Cancer Patients ◽

Breast Cancer Diagnosis ◽

Serum Levels ◽

Breast Cancer Patients ◽

Multivariate Logistic Regression ◽

Expression Levels ◽

Non Coding Rnas ◽

Pai 1

Long non-coding RNAs play an important role in tumor growth, angiogenesis, and metastasis in several types of cancer. However, the clinical significance of using lncRNAs as biomarkers for breast cancer diagnosis and prognosis is still poorly investigated. In this study, we analyzed the serum expression levels of lncRNAs PVT1, HOTAIR, NEAT1, and MALAT1, and their associated proteins, PAI-1, and OPN, in breast cancer patients compared to fibroadenoma patients and healthy subjects. Using quantitative real-time PCR (qRT-PCR), we compared the serum expression levels of the four circulating lncRNAs in patients with breast cancer (n = 50), fibroadenoma (n = 25), and healthy controls (n = 25). The serum levels of PAI-1 and OPN were measured using ELISA. Receiveroperating-characteristic (ROC) analysis and multivariate logistic regression were used to evaluate the diagnostic value of the selected parameters. The serum levels of HOTAIR, PAI-1, and OPN were significantly higher in breast cancer patients compared to controls and fibroadenoma patients. The serum level of PVT1 was significantly higher in breast cancer patients than in the controls, while that of NEAT1 was significantly lower in breast cancer patients compared to controls and fibroadenoma patients. Both ROC and multivariate logistic regression analyses revealed that PAI-1 has the greatest power in discriminating breast cancer from the control, whereas HOTAIR, PAI-1, and OPN have the greatest power in discriminating breast cancer from fibroadenoma patients. In conclusion, our data suggest that the serum levels of PVT1, HOTAIR, NEAT1, PAI-1, and OPN could serve as promising diagnostic biomarkers for breast cancer.

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What mediates the racial/ethnic disparity in psychosocial stress among breast cancer patients?

Cancer Causes & Control ◽

10.1007/s10552-021-01392-7 ◽

2021 ◽

Author(s):

C. T. Sánchez-Díaz ◽

S. Strayhorn ◽

S. Tejeda ◽

G. Vijayasiri ◽

G. H. Rauscher ◽

...

Keyword(s):

Breast Cancer ◽

Social Support ◽

Cancer Patients ◽

Cancer Diagnosis ◽

Psychosocial Stress ◽

Breast Cancer Diagnosis ◽

Support Needs ◽

Breast Cancer Patients ◽

Hispanic Patients ◽

Racial Ethnic

Abstract Background Prior studies have observed greater levels of psychosocial stress (PSS) among non-Hispanic (nH) African American and Hispanic women when compared to nH White patients after a breast cancer diagnosis. We aimed to determine the independent and interdependent roles of socioeconomic position (SEP) and unmet support in the racial disparity in PSS among breast cancer patients. Methods Participants were recruited from the Breast Cancer Care in Chicago study (n = 989). For all recently diagnosed breast cancer patients, aged 25–79, income, education, and tract-level disadvantage and affluence were summed to create a standardized socioeconomic position (SEP) score. Three measures of PSS related to loneliness, perceived stress, and psychological consequences of a breast cancer diagnosis were defined based on previously validated scales. Five domains of unmet social support needs (emotional, spiritual, informational, financial, and practical) were defined from interviews. We conducted path models in MPlus to estimate the extent to which PSS disparities were mediated by SEP and unmet social support needs. Results Black and Hispanic patients reported greater PSS compared to white patients and greater unmet social support needs (p = 0.001 for all domains). Virtually all of the disparity in PSS could be explained by SEP. A substantial portion of the mediating influence of SEP was further transmitted by unmet financial and practical needs among Black patients and by unmet emotional needs for Hispanic patients. Conclusions SEP appeared to be a root cause of the racial/ethnic disparities in PSS within our sample. Our findings further suggest that different interventions may be necessary to alleviate the burden of SEP for nH AA (i.e., more financial support) and Hispanic patients (i.e., more emotional support).

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Knowledge towards breast cancer, and breast self-examination practices and its barriers among university female students in Bangladesh: Findings from a cross-sectional study

10.1101/2021.10.20.21265262 ◽

2021 ◽

Author(s):

Rumpa Sarker ◽

Md. Saiful Islam ◽

Mst. Sabrina Moonajilin ◽

Mahmudur Rahman ◽

Hailay Abrha Gesesew ◽

...

Keyword(s):

Breast Cancer ◽

University Students ◽

Positive Family History ◽

Cross Sectional Study ◽

Female Students ◽

Sectional Study ◽

Cross Sectional ◽

Breast Self Examination ◽

The Mean ◽

Self Examination

Early diagnosis of breast cancer is the best approach towards its control that may result in alleviating related mortality and morbidity. This study aimed to evaluate knowledge about breast cancer and both practices and perceived barriers to breast self-examination among female university students in Bangladesh. A cross-sectional study was carried out with 400 female students of Jahangirnagar University, Bangladesh. Participants were sampled from female dormitories at the university from January to April 2020. Proportionate stratified random sampling was conducted to calculate the study sample from each dormitory. A pre-tested, semi-structured self-reported questionnaire was employed to collect data from participants during the survey periods. The questionnaire consists of demographic variables, items about knowledge about breast cancer, breast self-examination practices and its barriers. We applied descriptive and inferential statistics, and data were analyzed using SPSS. Participants aged between 18-26 years and comprised university students of 1st year (20%), 2nd year (24%), 3rd year (22%), 4th year (21%) and Masters (14.%). 18% of them had reported positive family history (mother, aunt, sister/cousin, grandmother) of breast cancer. The overall mean score of total knowledge items was 15 (SD = 3) out of 43, with an overall correct rate of 34%. The mean score of total knowledge items was significantly higher (p<0.001) among Masters students and students with family members who have breast cancer. Only one in five students (21%) ever practiced breast self-examination. The mean score of practice towards breast self-examination was significantly higher (p<0.001) among participants who reported having family member of breast cancer. It is noted that the total knowledge score about breast cancer and practice towards breast self-examination are significantly correlated with each other (r = 0.54; p<0.001). About 33% participants had reported that lack of knowledge as the main barrier to practicing breast self-examination followed by I do not have the symptoms (22%), and shyness/ uncomfortable feelings (17%). The study revealed low levels of knowledge about breast cancer and low breast self-examination practices. This implies the need of promotion and implementation of educational interventions programs that are social and culturally appropriate and suitable for specific age groups.

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