SOME ASPECTS OF ETHIOPATHOGENESIS OF NEUROLOGICAL MANIFESTATIONS IN CORONAVIRUS INFECTION AND STUDY OF THE EXPRESSION AND PREVALENCE OF SMELLAND TASTE IMPAIRMENTS IN PATIENTS WITH SARS-COV-2

2021 ◽  
Vol 2 (4) ◽  
pp. 55-61
Author(s):  
Markhamat Yakubova ◽  
◽  
Munis Fayzieva ◽  
Keyword(s):  
Nervous System ◽  
Respiratory System ◽  
Insufficient Data ◽  
Neurological Manifestations ◽  
Taste Disorders ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Smell Disorders ◽  
Taste And Smell ◽  
Systematic Database

The new coronavirus SARS-CoV-2 and the disease it causes, COVID-19, along with damage to the respiratory system, sometimes leads to nervous system disorders. The loss of smell and taste in COVID-19 is most likely of a perceptual nature. Because of the active accumulation of information about the symptomatology of this nosology, data appeared on the characteristic manifestations of thedisease in mild and moderate cases, in particular, on the violation of taste and smell. Although there is currently insufficient data to determine the exact mechanisms of anosmia and ageusia in patients diagnosed with COVID-19, there are studies that support certain theories. This paper presents the results of a systematic database review of COVID-19 taste and smell disorders. The article analyzes information on the etiopathogenic aspects of the neurological manifestations of COVID-19 and data on the severity and prevalence of smell and taste disorders in patients with coronavirus.Keywords: COVID-19, SARS-CoV-2, novel coronavirus infection, loss of smell and taste, anosmia, hypogeusia, ACE2 receptors

scholarly journals Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals

BJGP Open ◽  
2022 ◽  
pp. BJGPO.2021.0141
Author(s):  
Anna Ruiz-Comellas ◽  
Pere Roura Poch ◽  
Glòria Sauch Valmaña ◽  
Víctor Guadalupe-Fernández ◽  
Jacobo Mendioroz Peña ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Clinical Symptoms ◽  
Strong Predictor ◽  
Area Under The Curve ◽  
Low Grade ◽  
Predictive Values ◽  
Standard Value ◽  
Taste Disorders ◽  
Smell Disorders ◽  
Taste And Smell

Backgroundamong the manifestations of COVID-19 are Taste and Smell Disorders (TSDs).AimThe aim of the study is to evaluate the sensitivity and specificity of TSDs and other associated symptoms to estimate predictive values for determining SARS-CoV-2 infection.Design and settingRetrospective observational study.Methodsa study of the sensitivity and specificity of TSDs has been carried out using the Polymerase Chain Reaction (PCR) test for the diagnosis of SARS-CoV-2 as the Gold Standard value. Logistic regressions adjusted for age and sex were performed to identify additional symptoms that might be associated with COVID-19.Resultsthe results are based on 226 healthcare workers with clinical symptoms suggestive of COVID-19, 116 with positive PCR and 111 with negative PCR. TSDs had an OR of 12.43 (CI 0.95 6.33–26.19), sensitivity 60.34% and specificity 89.09%. In the logistic regression model, the association of TSD, fever or low-grade fever, shivering, dyspnoea, arthralgia and myalgia obtained an area under the curve of 85.7% (CI 0.95: 80.7 % - 90.7 %), sensitivity 82.8 %, specificity 80% and positive predictive values 81.4% and negative 81.5%.ConclusionsTSDs are a strong predictor of COVID-19. The association of TSD, fever, low-grade fever or shivering, dyspnoea, arthralgia and myalgia correctly predicts 85.7% of the results of the COVID-19 test.

scholarly journals Main symptoms in patients presenting in the COVID-19 period

2020 ◽  
Vol 65 (4) ◽  
pp. 127-132 ◽  
Author(s):  
Aylin Çalıca Utku ◽  
Gökçen Budak ◽  
Oğuz Karabay ◽  
Ertuğrul Güçlü ◽  
Hüseyin Doğuş Okan ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Negative Group ◽  
Positive Group ◽  
Taste Disorder ◽  
First Case ◽  
Training And Research ◽  
Novel Coronavirus ◽  
Smell Disorders ◽  
University Training ◽  
Taste And Smell

Background The first case of a novel coronavirus (COVID-19) infection was detected in Wuhan, fever and respiratory symptoms have been frequently reported in patients infected with this virus. Aim It was aimed to compare the symptoms of patients with COVID-19 positivity and patients without COVID-19 positivity hospitalized with suspicion of COVID-19. Methods Patients presenting to the Sakarya University Training and Research Hospital with suspicion of COVID-19 were included in the study. Samples were obtained from the patients and PCR tests were performed; the patients were grouped as COVID-19 positive and COVID-19 negative; these two groups were questioned for 15 symptoms and the results were compared. Results A total of 297 patients with suspicion of COVID-19 were included in the study. COVID-19 was positive in 143 patients and negative in 154 patients. The most common symptoms in the COVID-19 positive group were: cough (56.6%), weakness (56.6%), taste disorder (35.7%), myalgia (34.3%), and fever (33.6%); and in the COVID-19 negative group: cough (63%), weakness (45.5%), dyspnea (29.9%), headache (27.3%) and fever (24.7%). When these two groups were compared, taste disorder, smell disorder and diarrhea were significantly higher in the COVID-19 positive group (p = <0,00001, p = 0,00001 and p = 0,02). Conclusion Our study showed that taste and smell disorders and diarrhea were important markers in COVID-19 infection.

scholarly journals Heterogeneous Neurological Disorders Associated with the SARS-CoV-2 Infection: A Case Report

2021 ◽  
Vol 11 (1) ◽  
pp. 61-64
Author(s):  
Vyacheslav A. Kutashov Vyacheslav A. Kutashov ◽  
Olga Ulyanova ◽  
Igor Protasov ◽  
Oleg Zolotaryov ◽  
Elena Ananyeva ◽  
...  
Keyword(s):  
Nervous System ◽  
Case Report ◽  
Peripheral Nervous System ◽  
Respiratory System ◽  
Neurological Disorders ◽  
The Novel ◽  
Muscular System ◽  
Novel Coronavirus

The novel coronavirus SARS-CoV-2 and the disease it causes, COVID-19, along with damage to the respiratory system, can lead to disorders of the central and peripheral nervous system, as well as the muscular system. The article presents literature data and the authors’ observations of the course of neurological disorders in a patient with COVID-19. This study found that there is a link between the severity of COVID-19 and the intensity and frequency of neurological disorders.

scholarly journals Neurological manifestations and complications in patients with covid-19

2020 ◽  
Vol 7 (3) ◽  
pp. 21-29
Author(s):  
I. K. Ternovyh ◽  
M. P. Topuzova ◽  
A. D. Chaykovskaya ◽  
P. Sh. Isabekova ◽  
T. M. Alekseeva
Keyword(s):  
Nervous System ◽  
Neurological Diseases ◽  
Neurological Complications ◽  
Epidemiological Studies ◽  
Neurological Manifestations ◽  
Long Time ◽  
The Central Nervous System ◽  
Coronavirus Infection ◽  
Mechanisms Of Development ◽  
Large Groups

It becomes apparent that the neurological complications of COVID-19 are significantly common, but in some cases, establishing a causal relationship is difficult. For example, a stroke can occur for reasons unrelated to coronavirus infection, while Guillain–Barré syndrome and meningoencephalitis are likely to be a parainfection. Only long-term epidemiological studies in large groups of patients can clarify some of these issues. This will help to better understand the mechanisms of development of complications and develop schemes for their treatment and subsequent rehabilitation. The article presents the mechanisms of penetration of the coronavirus into the nervous system and systematizes the neurological manifestations and complications of COVID-19, which were described in the first 3 months of the pandemic. Particular attention is paid to the consideration of the complications of COVID-19 from the central and peripheral nervous system, the most interesting clinical examples are considered. Summing up the analysis of the literature, we can say that the clinical picture of neurological diseases and syndromes caused by coronavirus infection corresponds to the usual notions. Also considered is the assumption that SARS-CoV-2 can persist for a long time in the central nervous system in the form of inactive fragments, which means that it can recur in predisposed individuals when appropriate conditions arise. This suggestion is alarming regarding distant neurological complications in infected and cured patients.

COVID-associated coagulopathy and its consequences

2021 ◽  
pp. 56-71
Author(s):  
Larisa Vladimirovna Bychkova ◽  
Pavel Evgen’evich Shmaevskii ◽  
\Mihail Grigor’evich Rodoman ◽  
Ekaterina Vasil’evna Mukovnikova ◽  
Dar’ya Andreevna Tsigura ◽  
...  
Keyword(s):  
Literature Review ◽  
Respiratory System ◽  
Organ Damage ◽  
Hematopoietic System ◽  
Treatment Methods ◽  
Comprehensive Literature Review ◽  
Target Organs ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Novel coronavirus disease has been known for about a year and a half. Medical scientists worldwide have been united to fight it. 2019 novel coronavirus infection, COVID-19, can harm the heart, kidneys, hematopoietic system, and brain, in addition to the respiratory system. At present, there is a large amount of data on the pathogenetic mechanisms of damage to target organs and systems. Both prevention and treatment methods are getting improved. Many countries started widespread COVID-19 vaccination. Still, there is a lot of problems to be solved by medical scientists and healthcare institutions. This article provides a comprehensive literature review on COVID related organ damage and its effect on multiple body systems.

scholarly journals Neurological involvement of COVID-19: from neuroinvasion and neuroimmune crosstalk to long-term consequences

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Dian Eurike Septyaningtrias ◽  
Rina Susilowati
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Responses ◽  
Nerve Degeneration ◽  
Neurological Involvement ◽  
Neurological Manifestations ◽  
The Central Nervous System ◽  
Coronavirus Infection ◽  
Long Term Consequences

Abstract As the coronavirus disease 2019 (COVID-19) pandemic continues to be a multidimensional threat to humanity, more evidence of neurological involvement associated with it has emerged. Neuroimmune interaction may prove to be important not only in the pathogenesis of neurological manifestations but also to prevent systemic hyperinflammation. In this review, we summarize reports of COVID-19 cases with neurological involvement, followed by discussion of possible routes of entry, immune responses against coronavirus infection in the central nervous system and mechanisms of nerve degeneration due to viral infection and immune responses. Possible mechanisms for neuroprotection and virus-associated neurological consequences are also discussed.

scholarly journals Ophthalmological aspects of coronavirus infections

2021 ◽  
Vol 14 (1) ◽  
pp. 7-14
Author(s):  
V. V. Neroev ◽  
T. N. Kiseleva ◽  
E. K. Eliseeva
Keyword(s):  
Respiratory System ◽  
Early Stage ◽  
Clinical Sample ◽  
Virus Transmission ◽  
Detection Methods ◽  
The Novel ◽  
Molecular Tests ◽  
Ocular Disorders ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The novel coronavirus infection (COVID-19) caused by SARS-CоV-2 virus, may lead to ocular diseases besides affecting the respiratory system. Cororonavirus infection may be transmitted not only through the respiratory system but also through the conjunctiva. The review article summarizes the data on the origin and variants of coronaviruses that infect humans, as well as on SARS-CоV-2 structures. Literature data on prospects of molecular diagnostics of the disease, coronavirus type detection methods, clinical sample types and duration of the disease before it is diagnosed are discussed. The data on the relationship between the coronavirus infection and conjunctivitis are given. Molecular tests of the tear and conjunctival swabs were used to diagnose the coronavirus infection independently of whether symptoms of ocular disorders were present. The real-time reverse-transcription of RNA polymerase chain reaction (PCR) was the most informative method for diagnosis of SARS-CоV-2 in the early stage of COVID-19 (until the 9th day). The presence of SARS-CоV-2 in the tear fluid and conjunctival swabs indicates the need for safety measures to prevent virus transmission through the ocular surface, including protective goggles to be worn by healthcare workers. Since side effects in the eye may appear, COVID-19 patients with visual impairment who received etiotropic or pathogenetic treatment are advised to consult an ophthalmologist.

Epidemic risks during endoscopic examinations in the conditions of a specialized COVID-19 hospital in the pandemic of the novel coronavirus infection

2021 ◽  
pp. 12-25
Author(s):  
Sergey Anatolievich Babanov ◽  
Mikhail Lvovich Shteiner ◽  
Yuriy Iskhakovich Biktagirov ◽  
Aleksandr Viktorovich Zhestkov ◽  
Leonid Aleksandrovich Strizhakov ◽  
...  
Keyword(s):  
High Risk ◽  
Respiratory System ◽  
Scientific Community ◽  
Respiratory Diseases ◽  
The Novel ◽  
Daily Work ◽  
The World ◽  
Epidemiological Risk ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The pandemic of the novel coronavirus infection has posed additional challenges for endoscopy services. Endoscopy departments face a high risk of spreading airborne respiratory diseases in their daily work. This is especially true for endoscopic departments and offices that perform bronchoscopic examinations. The world scientific community recognizes the highest epidemiological risk of personnel infection during any interventional manipulations and operations related to the respiratory system, including bronchoscopic interventions.

Sign in / Sign up

Export Citation Format

Share Document