COMPARISON OF ROUTINE HEMATOLOGY RESULTS BASED ON LOCAL LABORATORY REFERENCE VALUE AND SYSMEX KX-21 REFERENCE VALUE IN HASAN SADIKIN HOSPITAL BANDUNG

2015 ◽  
Vol 1 (2) ◽  
Author(s):  
Adrian Suhendra
Keyword(s):  
Reference Values ◽  
Japanese Population ◽  
Normal Population ◽  
Clinical Pathology ◽  
Reference Value ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Value Range ◽  
The Subject ◽  
Local Laboratory

Various factors contribute to the routine hematology values in a healthy-looking person. Variability in analysis methods can also influence the results. However, all of the factors above can be standardized. Those variables have to be considered in determining hematology reference values. The aim of this research is to compare routine hematology results based on local RSHS Clinical Pathology laboratory with Sysmex KX-21 reference values in Medical Check Up (MCU) patients. Another aim is to determine own reference values of RSHS Clinical Pathology Laboratory. The subject of research is MCU patients who came to RSHS Clinical Pathology laboratory, Bandung, for medical check-ups and declared healthy by the internist, and meet the inclusion criteria. The method used is diagnostic test research with cross-sectional descriptive design. The result shows that routine hematology values range that is not too different from reference value range used for KX-21 in Japanese population. Nevertheless, the value range acquired in this research is closer to reference values in Wintrobe reference book. In conclusion, this research shows that routine hematology results of normal population in RSHS are closer to Wintrobe reference values compared to Sysmex KX-21 reference value in Japanese population.  Keywords : reference value range, MCU, Wintrobe, Sysmex KX-21

Selection of Hormonal Reference Values for Undescended Testicle Case in 8-Year-Old Boy with Abnormal Chromosome

2021 ◽  
Vol 28 (1) ◽  
pp. 91
Author(s):  
Vina Corry ◽  
Merci M. Pasaribu
Keyword(s):  
Reference Values ◽  
Clinical Pathology ◽  
Tanner Stage ◽  
Chromosome Analysis ◽  
Reference Intervals ◽  
Undescended Testicle ◽  
Pediatric Endocrinology ◽  
Pathology Laboratory ◽  
Testosterone Levels ◽  
And Gender

Establishing the diagnosis of undescended testicles requires appropriate hormonal laboratory reference values basedon age and gender. An 8-year-old boy with an undescended testicle, mental retardation, and stunting had a blood test thatwas carried out at the Clinical Pathology Laboratory, dr. Cipto Mangunkusumo (RSCM) Hospital on February 6, 2020, withtestosterone levels of 0.69 nmol/L (N male: 4.94-32.01 nmol/L) indicating decreased testosterone levels. The patient wasconsulted from urological surgery to pediatric endocrinology to determine the presence or rudiment of the patient'stesticles. Using the reference range of testosterone values assists clinicians in determining the diagnosis, monitoringtherapy, and prognosis of a disease. There are some testosterone reference values, which are currently available, includingCanadian Laboratory Initiative on Pediatric Reference Intervals Database (CALIPER) and the Tanner stage reference value.Later is more applicable because it is based on chronological age and secondary sexual development in assessing pubertydevelopment. A case of an 8-year-old boy with a clinical diagnosis of an undescended testicle, the laboratory test resultsshowed normal-low testosterone levels using the CALIPER and Tanner stage ranges according to the patient's age. Noincrease of testosterone levels after the second HCG stimulation test might be due to differences in the HCG administrationprotocol; therefore, the diagnosis of anorchia had not been established, and chromosome abnormalities of 46 XY, +6 Mar,17 dmin on chromosome analysis suggested the suspected syndrome. These findings were consistent with the suspicion ofprimary hypogonadism in children with suspected syndrome caused by bilateral cryptorchidism with a suspectedseminiferous tubular defect.

scholarly journals ANALISIS LAMA WAKTU PELAYANAN LABORATORIUM DI RUMAH SAKIT UMUM DAERAH PASAMAN BARAT

2018 ◽  
Vol 5 (1) ◽  
pp. 114-121
Author(s):  
Betti Rosita ◽  
Ulfa Khairani
Keyword(s):  
Health Services ◽  
Waiting Time ◽  
Service Time ◽  
Clinical Chemistry ◽  
Clinical Pathology ◽  
Blood Chemistry ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Laboratory Service ◽  
Laboratory Services

Hospital laboratory services is one of the activities in hospitals that support quality health services. One indicator of the success of health services in the field of clinical pathology laboratory services is the waiting time for laboratory services. The standard set for laboratory service outcome waiting time is ≤ 140 minutes for blood chemistry and routine blood. This research analyzed the service time of outpatient laboratory that conducted hematology and clinical chemistry examination in the laboratory of Pasaman Barat Hospital. This research is a type of descriptive analytic research that is quantitative and supported by qualitative using cross sectional approach. The result of the research showed that laboratory service time at RSUD Pasaman Barat fulfilled the standard (≤ 140 minutes) for hematology examination 33.94 minutes, clinical chemistry 83.92 minutes, hematology and clinical chemistry 98 minutes. Based on the results of this study, the stages that contribute to the length of time laboratory services for hematological examination lies in the pre analytical stage, for clinical chemistry examination is located at the analytical stage, as well as for hematology and clinical chemistry examination lies in the analytic stage as well as the factors that affect the length of time laboratory services are human resources that is in the ability of officers and infrastructure facilities

ANGKA BANDING ALBUMIN KREATININ AIR KEMIH DAN HbA1C SERTA ESTIMASI LAJU FILTRASI GLOMERULUS PADA PASIEN DIABETES MELITUS TIPE 2

2016 ◽  
Vol 21 (3) ◽  
pp. 250
Author(s):  
Amiroh Kurniati ◽  
Tahono Tahono
Keyword(s):  
Glycemic Control ◽  
Clinical Pathology ◽  
Poor Glycemic Control ◽  
Control Group ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Chronic Hyperglycemia ◽  
Type 2 Dm ◽  
Spearman Correlation Test

Diabetes Mellitus (DM) type 2 is a metabolic disease that prevalence increasing. A chronic hyperglycemia with poor glycemic control can stimulate oxidative stress, which will continue to occurrence of complications in the kidneys characterized by the presenceof microalbuminuria can be measured by the ratio of urinary albumin creatinine ratio (UACR) and the change in estimated glomerular filtration rate (eGFR). The aims of this study was to know the correlation between the UACR with HbA1c value and eGFR in patients with type 2 DM by finding them out. This study used cross sectional research design. Subjects were patients with type 2 DM who attend control in Endocrinology Subdivision of Internal Medicine Departement and perform blood and urine tests in Clinical Pathology Laboratory in Dr. Moewardi Hospital Surakarta in August 2013. To determine the pattern of the data distribution, the researchers used KolmogorovSmirnov test, and to analyse the result used Spearman (r) correlation with p<0.05 and confidence interval 95%. Statistical analysis using Spearman correlation test (r), significant when p<0.05 with 95% confidence intervals. From 68 samples examined the mean age is 60.9 year old, with equal participants for male and female (34 subjects each). Most subjects were in poor glycemic control group (72.1%) and in the range of microalbuminuria (44.1%). There was a significant correlation between UACR with HbA1c and eGFR in type 2 DM patient (r=0.412, p=0.000; and r= -0.270, p=0.02, respectively). Based on this study it can be concluded that increased UACR were associated with worsened glycemic control and were characterized by higher levels of HbA1c and its eGFR value would be lower. Further analysis requires further research with a larger sample size and more attention to the factors that may affect the related examination

scholarly journals Normal Sudanese Spirometeric Values for Police Men

2020 ◽  
Author(s):  
Barakat Mohazab Bakhit ◽  
Omer Abd_elaziz Musa ◽  
Mohanad Hassan Malla
Keyword(s):  
Lung Function ◽  
Reference Values ◽  
Police Officers ◽  
Reference Value ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Anthropometric Measurements ◽  
Regression Equations ◽  
Continuous Training ◽  
Cross Sectional

Abstract BackgroundSpirometric values for police officers in the police hospital, Khartoum, Sudan were observed to show higher values than predicted.1 Reference values are important for diagnosis of asthma and chronic bronchitisMethodsFor deriving a new reference value for adult police men, a cross- sectional study was performed on 161 adult male police officers, aged 20–50 years in (June- December 2012) in Khartoum state in different police units. Data were obtained through a questionnaire, pulmonary function testing and taking anthropometric measurements, forced vital capacity (FVC), forced expiratory volume in first second (FEV1) and peak expiratory flow rate (PEFR) were measured using a microplus spirometer and a peak flow meter. Lung function values and anthropometric measurements were correlated and regression equations were derivedResultsAdult police males had a significantly higher FVC, FEV1and PEFR [3.96 ± 0.56 L , 3.61 ± 0.52 L and 564.1 ± 70.4 L/min respectively] than those of normal adult Sudanese males [3.68 ± 0.22 L , 3.35 ± 0.23 L and 505.9 ± 19.1L/min respectively]. A positive correlation was found between lung function and height and a negative correlation with age. Regression equations of normal predicted values were derived for police officer FVC (L) [0.027 X (cm) – 0.039 X A (years) +0.345], FEV1 (L) [0.0264 X (cm) – 0.036 X A (years) +0.0105] and PEFR (L/min) [1.599 X (cm) – 4.207 X A (years) + 329.349.Conclusionsit seems that the continuous training of police officers produced higher lung volumes and a separate reference values tables should be used for them

scholarly journals DETERMINATION OF GRAY ZONE RANGE IN HBsAg TEST AND ITS IMPLICATION FOR HBsAg CONFIRMATION TEST

2018 ◽  
Vol 24 (2) ◽  
pp. 127
Author(s):  
Vina Zakiah Latuconsina ◽  
Irda Handayani ◽  
Asvin Nurulita ◽  
Uleng Bahrun Uleng Bahrun
Keyword(s):  
False Positive ◽  
False Negative ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Gray Zone ◽  
Chi Square ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Confirmation Test ◽  
Chi Square Test

Hepatitis is an inflammation of liver cells caused by infection (virus, bacteria, paracytes), medication, alcohol consumption, excessive lipid and autoimmune disease. Increasing method (sensitivity) of HBsAg test is often followed by a lot of false positive test results, which need a confirmation test which takes a longer time and higher cost so that it is needed to determine an optimal gray zone range for a confirmation test. This analytical cross-sectional study was held at the Clinical Pathology Laboratory of the Dr.Wahidin Sudirohusodo Hospital Makassar. The subjects were specimens which HBsAg value was within 0.06-1 COI. Specimens were examined using HBsAg confirmation test. Over 49 samples collected there were 32 reactive and 17 non-reactive. 14 out of 32 reactive samples (43.8%) were confirmed as negative (false positive) by HBsAg confirmation test and 3 out of 17 non-reactive samples (17.6%) were confirmed as positive (false negative). Chi-square test showed a significant correlation between HBsAg value and HBsAg confirmation test value (p=0.009). Chi-square test with some intervals with α=1% showed that the interval of HBsAg value 0.13-0.17 COI was the interval with the lowest significant value (p=0.004). This subsequent interval was recommended as the gray zone range. The range 0.13-0.17 was most optimal as HBsAg gray zone to determine the need for a confirmation test. A further study with larger samples is suggested. 

scholarly journals ANALISIS CAIRAN DARAH (TRANSUDAT) DAN SERUM CAMPURAN (EKSUDAT) DI PENDERITA DENGAN REMBESAN SELAPUT PARU (EFUSI PLEURA)

2018 ◽  
Vol 15 (2) ◽  
pp. 57
Author(s):  
Didi Irwadi ◽  
Sulina Y. Wibawa ◽  
Hardjoeno Hardjoeno
Keyword(s):  
Pleural Effusion ◽  
Leukocyte Count ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
T Test ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Old Patients ◽  
Acinetobacter Spp ◽  
Staphylococcus Spp

Pleural effusion is a fluid excess into pleural cavity due to transudation or exudation processes. The fluid deposited in the cavity canthreat the patient’s life. The pleural effusion could be produced in a patient with tuberculosis, cancer, cardiac failure, renal failure orviral/bacterial infection. The study is aimed to analyze the patterns of substance in the pleural effusion fluids produced by differentdiseases. A cross sectional study was performed from June 2006 to June 2007 at Clinical Pathology Laboratory of Dr. WahidinSudirohusodo Hospital, Makassar. The fluids were tested for glucose, total protein, LDH, and leukocyte count. Of 87 pleural effusion fluidsamples from 14–80 years old patients, 34.5% were transudates and 65.5% were exudates. Glucose value was higher (one tail T test,p < 0.01) in transudates group, whereas protein, LDH and leukocyte count were higher (one tail T test, p < 0.01) in exudates group.There were no significant differences of glucose, protein, LDH and leukocyte count among diseases within transudates group, as well aswithin exudates group. Staphylococcus spp., Klebsiella spp., and Acinetobacter spp., were the predominant bacteria revealed from thefluid cultures. Values of glucose, protein, LDH and leukocyte count have a different pattern between transudates and exudates groups.However, no special patterns were found among diseases within groups.

scholarly journals NILAI RUJUKAN FREE LIGHT CHAIN SERUM DENGAN IMUNOTURBIDIMETRI

2018 ◽  
Vol 18 (2) ◽  
pp. 92
Author(s):  
Lidya Utami ◽  
Riadi Wirawan ◽  
Alida R Harahap ◽  
Abdul Muthalib ◽  
Harny Edward
Keyword(s):  
Light Chain ◽  
Healthy Subjects ◽  
Clinical Pathology ◽  
Reference Value ◽  
Free Light Chain ◽  
Pathology Laboratory ◽  
Medical Checkup ◽  
Heavy Chains ◽  
Normal Reference ◽  
Normal Ranges

The light chains of immunoglobulin are produced in larger quantity rather than heavy chains, therefore small amount of free lightchains (FLC) can be found in the blood of healthy individuals. Free light chain production is increased in the clone’s proliferation ofmalignant B cells, i.e. in myeloma. Therefore the FLC level measurement can be used for diagnosis aid of myeloma and related B cellsdisorders. The aim of this study is to establish reference range of serum FLC κ, FLC λ, and κ/λ ratio in population ≥40 year’s old usingimmunoturbidimetry assay. Serum FLC κ, FLC λ and κ/λ ratio were measured in 240 healthy male and female attending medical checkup in MMC hospital. Healthy subjects were determined by anamnesis and physical examination, with routine haematology, ESR, andserum creatinine level within normal ranges. The serum FLC assays were performed in the Clinical Pathology Laboratory, RSCM, usingHitachi 912 with immunoturbidimetry method. The results were analyzed by SPSS 11.5 program. Serum FLC normal reference valuein 40-84 years old healthy subjects are: FLC κ 11.7–30.6 mg/L, FLC λ 9.7–25.0 mg/L, and κ/λ ratio 0.79–1.75. This research is thefirst study for finding serum FLC values in the Indonesian population. The normal reference value found is similar with another studyusing the same platform analyzer.

Normal Reference Values of Fetal Atrioventricular (AV) and Ventriculoatrial (VA) Time Intervals and VA:AV Ratio Assessed by Pulse Wave Doppler

2021 ◽  
Vol 104 (5) ◽  
pp. 781-786
Keyword(s):  
Reference Values ◽  
Pulse Wave ◽  
Rank Correlation ◽  
Reference Value ◽  
Cross Sectional Study ◽  
Time Interval ◽  
Reference Ranges ◽  
Time Intervals ◽  
Cross Sectional ◽  
Normal Reference

Objective: To identify the normal reference ranges of the atrioventricular (AV) time interval, ventriculoatrial (VA) time interval, and VA:AV ratio in fetuses between 18 and 37 weeks of gestational age (GA) and to establish the relationship between AV and VA time intervals and VA:AV ratio with GA and fetal heart rate (FHR). Materials and Methods: A prospective cross-sectional study was conducted at Rajavithi Hospital between December 2019 and June 2020. AV and VA time intervals and VA:AV ratio were obtained by pulse wave Doppler over inflow and outflow tract of left ventricle. The correlation of the measurement values with GA and FHR were analyzed by Spearman’s rank correlation. Results: Three hundred seventy pregnant women were enrolled in the present study with 343 participants included in the analysis. The average values of AV and VA time intervals and VA:AV ratio, along with their 5th, 10th, 50th, 90th, and 95th percentiles were calculated from the measurement values. A correlation between each measurement value and GA was demonstrated to be linear [AV time intervals = 91.74+1×GA(weeks) (R²=0.516, p<0.001); VA time intervals = 2.58E2+1.39×GA(weeks) (R²=0.151, p<0.001); and VA:AV ratio = 2.74–8.99E–3×GA(weeks) (R²=0.063, p<0.001)]. A correlation between each measurement value and FHR was also linear [AV time intervals = 1.79E2–0.41×FHR (R²=0.181, p<0.001); VA time intervals = 6.21E2–2.23×FHR (R²=0.811, p<0.001); and VA:AV ratio = 3.9–9.64E-3×FHR (R²=0.150, p<0.001)]. Conclusion: Both AV and VA time intervals are positively correlated with GA but VA:AV ratio is negatively correlated with GA. All measurement values have negative correlation with FHR. The normal reference values of AV, VA time intervals, and VA:AV ratio from the present study may be useful for diagnosis of fetal arrhythmia. Keywords: normal reference value, atrioventricular time intervals, ventriculoatrial time intervals, VA:AV ratio

scholarly journals Comparison of PPT and APTT in Pre and Post-Hemodialysis Patients as the Heparin-Exposed Effect

2019 ◽  
Vol 55 (3) ◽  
pp. 166
Author(s):  
Yetti Hernaningsih ◽  
Widodo Widodo ◽  
Koko Aprianto
Keyword(s):  
Clinical Pathology ◽  
Coagulation Factors ◽  
Hemodialysis Patients ◽  
Rank Test ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Coagulation Study ◽  
Ckd Stage ◽  
Significant Difference ◽  
The Mean

Evaluations on Plasma Prothrombin Time (PPT) and Activated Partial Thromboplastin Time (APTT) are required in patients with Chronic Kidney Disease (CKD) stage V to determine the risk of bleeding after hemodialysis (HD) using heparin as the anticoagulant. This study aimed to compare the results of PPT and APTT in pre and post-hemodialysis patients with minimum dose of heparin. This was an observational-analytical study with cross-sectional design. The samples were collected in HD wards of Dr. Soetomo Hospital, Surabaya. There were 50 PPT and APTT samples collected from June to August 2017. The samples were evaluated using the tool CoaDATA 501. The examination of coagulation study was conducted in Clinical Pathology Laboratory of Dr. Soetomo Hospital, Surabaya. Paired t-test and Wilcoxon signed-rank test were performed in this study. In the 50 samples, pre-hemodialysis PPT ranged between 10.2-17.6 with the mean of 12.6±2.03 seconds, while for post-hemodialysis, the range was 10.1-20.9 with the mean of 13.41±2.43 seconds. Pre-hemodialysis APPT ranged between 19.5-75.2 with the mean of 30.32±10.43 seconds, while in post hemodialysis the range was 22.21-175 with the mean of 37.52±26.40 seconds. The results of PTT evaluation in pre and post-HD showed no significant difference (p=0.083), while those of APTT showed a significant difference (p=0.035 or p<0.05). Prolongation of APTT in post-HD is due to the use of heparin as an anticoagulant that increases PPT and APTT by inhibiting antithrombin III. HD procedures cause decreased activity of coagulation factors II, IX, X, XII leading to APTT prolongation in post-HD. A significant APTT prolongation was found in post-HD patients with CKD V.

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