scholarly journals DRUG INDUCED HEPATITIS

2014 ◽  
Vol 21 (01) ◽  
pp. 049-054
Author(s):  
Shuaib Ansari ◽  
Muhammad Adnan Bawany ◽  
Atif Sitwat Hayat ◽  
Akram Munir ◽  
Adnan Ali Khahro ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Control Group ◽  
Drug Induced ◽  
Short Course ◽  
Increased Risk ◽  
Observational Cohort ◽  
Study Population ◽  
Group 2

Aims and Objectives: We evaluated whether HBV +ve and HCV +ve patients areat high risk for developing drug induced hepatitis than control subjects during treatment fortuberculosis with standard short course regimens. Study design: Observational cohort study.Place and duration: This study was conducted at Department of Medicine, Liaquat University ofMedical and Health Sciences Jamshoro from May 2008 to May 2011. Material and Methods: Allnewly diagnosed active tuberculosis patients were included in the study population and theywere further screened for hepatitis B surface antigen and HCV antibodies. All patients weredivided into three groups. One having no co-infection with hepatitis B and Hepatitis C and wastaken as control group, second group was co-infected with hepatitis B and third was co-infectedwith hepatitis C. short course anti tuberculous regimen was started and patients were followed forsix months. Results: One hundred and twenty eight tuberculous patients were divided into threegroups. 92 in control groups without any co-infection with hepatitis B and C, 10 were HBV +veand 26 were HCV +ve. During follow up 24 developed drug induced hepatitis, 8(38.33%, n = 24)in control group, 2(8.33%, n = 24) in hepatitis B group and 14(58.33%, n = 24) in hepatitis Cgroup. Conclusions: These findings suggest that treatment for tuberculosis in HCV seropositivepatients is a risk factor for the development of hepatitis exacerbation and HBV seropositivepatients shows no any increased risk of hepatitis exacerbation.

scholarly journals Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia

2017 ◽  
Vol 57 (4) ◽  
pp. 176
Author(s):  
Pustika Amalia Wahidiyat ◽  
Felix Liauw ◽  
Nitish Basant Adnani ◽  
Siti Ayu Putriasih
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Early Detection ◽  
Serum Ferritin ◽  
Hepatitis B Surface Antigen ◽  
Thalassemia Major ◽  
Moderate Correlation ◽  
Sectional Study ◽  
Early Management ◽  
Increased Risk

Background Thalassemia major patients who undergo routine transfusion have an increased risk of acquiring transfusion-transmitted infections (TTI), including hepatitis B and C. These diseases have serious implications and may affect the serum ferritin and aminotransferase levels of thalassemia major patients.Objectives To identify the prevalence of hepatitis B and/or C infections among thalassemia major patients and to evaluate its correlation with serum ferritin and aminotransferase levels.Methods This was across-sectional study conducted at the Thalassemia Center of Dr. Cipto Mangunkusumo Hospital in Jakarta, Indonesia. The subjects were screened for hepatitis B and C infections, and their serum ferritin and aminotransferase levels were also measured.Results In total, 621 subjects were included in the study, among which 5 subjects tested positive for hepatitis B surface antigen (HBsAg) (0.8%), 111 subjects tested positive for anti-HCV (17.8%), and 5 subjects tested positive for both HBsAg and anti-HCV (0.8%). The subjects who tested positive for hepatitis B, hepatitis C, or both showed significantly higher values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum ferritin compared to their negative counterparts. Moreover, serum ferritin showed a positive, moderate correlation with both AST and ALT.Conclusion This study shows a significant association between hepatitis and serum ferritin as well as aminotransferase levels. Early detection and early management of hepatitis B and C infections is warranted to minimize the occurrence of liver damage in thalassemia major patients. 

scholarly journals Faktor Risiko Terjadinya Hepatotoksisitas Imbas Obat Antituberkulosis pada Pasien HIV/AIDS

2017 ◽  
Vol 4 (1) ◽  
pp. 23
Author(s):  
Lies Luthariana ◽  
Teguh H. Karjadi ◽  
Irsan Hasan ◽  
C. Martin Rumende
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Control Group ◽  
Case Group ◽  
Antituberculosis Drug ◽  
Aids Patients ◽  
Drug Induced ◽  
Hiv Aids

Pendahuluan. Hepatotoksisitas imbas antituberkulosis (OAT) banyak didapatkan pada pasien HIV/AIDS. Beberapa faktor risiko terjadinya hepatotoksisitas imbas obat seperti alkoholisme, infeksi hepatitis B maupun C, abnormalitas transaminase, status gizi kurang, penggunaan beberapa obat hepatotoksik secara bersamaan, banyak didapatkan pada pasien-pasien tersebut. Dengan karakteristik pasien HIV/AIDS yang berbeda dengan di negara lain maka diperlukan penelitian tersendiri tentang risiko terjadinya hepatotoksisitas imbas OAT pada pasien tersebut di Indonesia. Penelitian ini dilakukan untuk mengetahui faktor risiko terjadinya hepatotoksisitas imbas OAT pada pasien HIV.Metode. Desain penelitian ini adalah studi retrospektif kasus-kontrol dengan matching usia, jenis kelamin, regimen OAT dan konsumsi alkohol. Faktor risiko yang diteliti adalah koinfeksi hepatitis C, hepatitis B, konsumsi obat hepatotoksik lainnya, dan abnormalitas nilai awal SGPT dan atau billirubin total.Hasil. Pada penelitian ini diperoleh 33 kasus dan 33 kontrol. Proporsi subjek dengan koinfeksi hepatitis C sebesar 82% pada kasus dan 76% pada kontrol, sedangkan proporsi subjek dengan koinfeksi hepatitis B sebesar 18% pada kasus dan 6% pada kontrol. Subjek dengan nilai SGPT awal meningkat didapatkan pada kelompok kasus sebesar 51,5% dan pada kontrol sebesar 12%. Sementara itu, proporsi subjek yang menggunakan obat hepatotoksik lainnya sebesar 54,5% pada kasus dan 42,4% pada kontrol. Pada analisis bivariat, hanya nilai SGPT awal yang meningkat yang berhubungan dengan kejadian hepatotoksisitas imbas OAT (OR=7,5; IK95% 1,72-32,80; p < 0,05).Simpulan. Nilai SGPT awal yang meningkat dapat meningkatkan risiko terjadinya hepatotoksisitas imbas OAT pada pasien HIV/AIDS sebesar 7,5 kali. Tidak didapatkan hubungan koinfeksi hepatitis C, hepatitis B dan penggunaan obat hepatotoksik lainnya dengan kejadian hepatotoksisitas imbas OAT pada pasien HIV/AIDS.Kata Kunci: hepatotoksisitas imbas OAT, HIV/AIDS, tuberkulosis Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS PatientsIntroduction. Antituberculosis (ATT) induced hepatotoxicity is commonly found among HIV/AIDS patients. Several risk factor related to drug-induced hepatotoxicity such as alcoholism, hepatitis B or hepatitis C infection, abnormal baseline aminotransferase/bilirubin, poor nutritional status and concomitant hepatotoxic drugs consumption, are usually found in these patients. This study was conducted to evaluate risk factor of ATT-induced hepatotoxicity in HIV/AIDS patients. Methods. This is a case control retrospective study with matching of age, sex, antituberculosis regimen, and alcohol consumption. Risk factors evaluated are hepatitis C and hepatitis B coinfection, concomitant hepatotoxic drugs consumption, abnormal baseline aminotransferase and or bilirubin.Results. We collected data of 33 cases and 33 controls We found 82% subjects in case group and 76% subjects in control group have hepatitis C coinfection; 18% subjects in case group and 6% subjects in control group have hepatitis B coinfection. Fifty four point five percent (54.5%) subjects in case group and 42.4% subjects in control group consume other hepatotoxic drugs. Elevated baseline ALT level was found in 51.5% subjects in case group and 12% subject in control group. Bivariate analysis showed that the risk of hepatotoxicity was higher in patients with elevated baseline ALT level (OR=7.5; 95% CI 1,7232,80; p < 0,05).Conclusions. Elevated baseline ALT level will increase antituberculosis drug induce hepatotoxicity risk up to 7.5 times. There were no association between hepatitis C, hepatitis B, concomitant hepatotoxic drugs consumption and antituberculosis drug-induced hepatotoxicity in HIV/AIDS patients.

scholarly journals Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia

2017 ◽  
Vol 57 (4) ◽  
pp. 176
Author(s):  
Pustika Amalia Wahidiyat ◽  
Felix Liauw ◽  
Nitish Basant Adnani ◽  
Siti Ayu Putriasih
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Early Detection ◽  
Serum Ferritin ◽  
Hepatitis B Surface Antigen ◽  
Thalassemia Major ◽  
Moderate Correlation ◽  
Sectional Study ◽  
Early Management ◽  
Increased Risk

Background Thalassemia major patients who undergo routine transfusion have an increased risk of acquiring transfusion-transmitted infections (TTI), including hepatitis B and C. These diseases have serious implications and may affect the serum ferritin and aminotransferase levels of thalassemia major patients.Objectives To identify the prevalence of hepatitis B and/or C infections among thalassemia major patients and to evaluate its correlation with serum ferritin and aminotransferase levels.Methods This was across-sectional study conducted at the Thalassemia Center of Dr. Cipto Mangunkusumo Hospital in Jakarta, Indonesia. The subjects were screened for hepatitis B and C infections, and their serum ferritin and aminotransferase levels were also measured.Results In total, 621 subjects were included in the study, among which 5 subjects tested positive for hepatitis B surface antigen (HBsAg) (0.8%), 111 subjects tested positive for anti-HCV (17.8%), and 5 subjects tested positive for both HBsAg and anti-HCV (0.8%). The subjects who tested positive for hepatitis B, hepatitis C, or both showed significantly higher values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum ferritin compared to their negative counterparts. Moreover, serum ferritin showed a positive, moderate correlation with both AST and ALT.Conclusion This study shows a significant association between hepatitis and serum ferritin as well as aminotransferase levels. Early detection and early management of hepatitis B and C infections is warranted to minimize the occurrence of liver damage in thalassemia major patients. 

The prevalence of hepatitis B and C co-infections among people with HIV-1 in Bulgaria: 2010–2015

2019 ◽  
Vol 14 (12) ◽  
pp. 791-798
Author(s):  
Ivailo Alexiev ◽  
Elitsa Golkocheva-Markova ◽  
Asya Kostadinova ◽  
Reneta Dimitrova ◽  
Lora Nikolova ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Hcv Rna ◽  
B Virus ◽  
Sex With Men ◽  
Multiple Risk Behavior ◽  
Hiv 1 ◽  
Hiv Aids

Aim: To evaluate hepatitis B virus (HBV) and hepatitis C virus (HCV) among individuals with HIV/AIDS in Bulgaria diagnosed between 2010 and 2015. Materials & methods: A total of 1158 individuals were diagnosed with HIV/AIDS during the study period. Different transmission groups were tested with ELISA and real-time PCR for HBV and HCV markers. Results: Hepatitis B surface antigen and hepatitis C virus antiboby were found in 9.3 and 23.2% of the tested. HBV DNA and HCV RNA has been found in 47.4 and 69.6%. Hepatitis B and C co-infections were predominant in multiple risk behavior groups, including people who inject drugs, men who have sex with men, prisoners and Roma individuals. Conclusion: HIV prevalence in Bulgaria is low but the rates of hepatitis B and C co-infections among these patients fall within the upper range reported in Europe.

Short- and long-term outcomes of preterm spontaneous twin anemia-polycythemia sequence

2020 ◽  
Vol 48 (4) ◽  
pp. 329-334
Author(s):  
Soo Jin Han ◽  
Seung Mi Lee ◽  
Sohee Oh ◽  
Subeen Hong ◽  
Jeong Won Oh ◽  
...  
Keyword(s):  
Cord Blood ◽  
Neonatal Morbidity ◽  
Adverse Outcomes ◽  
Control Group ◽  
Long Term Outcomes ◽  
Neurodevelopmental Outcomes ◽  
Monochorionic Twin ◽  
Increased Risk ◽  
Study Population

AbstractBackgroundIn monochorionic twin pregnancy, placental anastomosis and inter-twin blood transfusion can result in specific complications, such as twin-twin transfusion syndrome (TTTS) and twin anemia-polycythemia sequence (TAPS). It is well established that adverse outcomes are increased in TTTS, but reports on the neonatal and long-term outcomes of TAPS are lacking. The objective of this study was to evaluate the neonatal and neurodevelopmental outcomes in spontaneous TAPS.MethodsThe study population consisted of monochorionic twin pregnancies with preterm birth (24–37 weeks of gestation) between November 2003 and December 2016 and in which cord blood was taken at the time of delivery. According to the result of hemoglobin in cord blood, the study population was divided into two groups: a spontaneous TAPS group and a control group. Neonatal and neurodevelopmental outcomes were compared between the two groups.ResultsDuring the study period, 11 cases were diagnosed as spontaneous TAPS (6.4%). The TAPS group had lower gestational age at delivery and had a higher risk for cesarean delivery. However, neonates with TAPS were not at an increased risk for neonatal mortality and significant neonatal morbidity. In addition, the frequency of severe cerebral lesion during the neonatal period and the risk of cerebral palsy at 2 years of age were not different between the two groups.ConclusionThe spontaneous TAPS diagnosed by postnatal diagnostic criteria was not associated with the increased risk of adverse neonatal and neurodevelopmental outcomes. Further studies are needed to evaluate the morbidity of antenatally diagnosed TAPS.

scholarly journals The relationship between neopterin and hepatitis B surface antigen positivity

Pteridines ◽  
2018 ◽  
Vol 29 (1) ◽  
pp. 1-5
Author(s):  
Songül Ü Ünüvar ◽  
Hamza Aslanhan ◽  
Zübeyde Tanrıverdi ◽  
Fuat Karakuş
Keyword(s):  
Immune System ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Normal Liver ◽  
Predictive Biomarker ◽  
Control Group ◽  
Hepatitis B Infection ◽  
Cellular Immune System ◽  
Cellular Immune

Abstract Hepatitis B is a life-threatening viral liver infection caused by the hepatitis B virus. Neopterin is regarded as an immunologic biomarker of several diseases related to activation of the cellular immune system. Hepatitis B infection is associated with increased production of cellular immune system markers. We aimed to investigate whether there is a relationship between hepatitis B surface antigen-positivity (HBsAg +) and neopterin to determine the role of neopterin in the early diagnosis of hepatitis B infections. Seventy-two HBsAg (+) patients with normal liver function tests and forty-three controls were included in the study. Neopterin levels were 17.6 ± 0.13 nmol/L in HBsAg (+) patients; and 9.12 ± 0.09 nmol/L in infection-free controls, respectively. Compared to the control group, a statistically significant increase (p < 0.001) in the serum neopterin levels of the patients was observed. No significant relationship was determined between neopterin levels and age/sex (both, p > 0.05). With overstimulation of interferon-gamma, the production of neopterin increases by monocytes/macrophages. Likewise with other diseases associated with an activated cellular immune system, this study shows that neopterin can be a predictive biomarker for persistent carriers of hepatitis B infection.

scholarly journals Cytokine profile during occult hepatitis B virus infection in chronic hepatitis C patients

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Camilla Rodrigues de Almeida Ribeiro ◽  
Nathalia Alves Araújo de Almeida ◽  
Katrini Guidolini Martinelli ◽  
Marcia Amendola Pires ◽  
Carlos Eduardo Brandao Mello ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Control Group ◽  
Occult Hepatitis ◽  
Tnf Α ◽  
B Virus ◽  
Occult Hepatitis B

Abstract Background The hepatitis B virus (HBV) is one of the leading causes of acute, chronic and occult hepatitis (OBI) representing a serious public health threat. Cytokines are known to be important chemical mediators that regulate the differentiation, proliferation and function of immune cells. Accumulating evidence indicate that the inadequate immune responses are responsible for HBV persistency. The aim of this study were to investigate the cytokines IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 and IL-17A in patients with OBI and verify if there is an association between the levels of these cytokines with the determination of clinical courses during HBV occult infection. Methods 114 patients with chronic hepatitis C were investigated through serological and molecular tests, the OBI coinfected patients were subjected to the test for cytokines using the commercial human CBA kit. As controls, ten healthy donors with no history of liver disease and 10 chronic HBV monoinfected patients of similar age to OBI patients were selected. Results Among 114 HCV patients investigated, 11 individuals had occult hepatitis B. The levels of cytokines were heterogeneous between the groups, most of the cytokines showed higher levels of production detection among OBI/HCV individuals when compared to control group and HBV monoinfected pacients. We found a high level of IL-17A in the HBV monoinfected group, high levels of TNF-α, IL-10, IL-6, IL-4 and IL-2 in OBI/HCV patients. Conclusion These cytokines could be involved in the persistence of HBV DNA in hepatocytes triggers a constant immune response, inducing continuous liver inflammation, which can accelerate liver damage and favor the development of liver cirrhosis in other chronic liver diseases.

scholarly journals Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

2014 ◽  
Vol 25 (6) ◽  
pp. 461-465
Author(s):  
João Paulo De Carli ◽  
Soluete Oliveira da Silva ◽  
Maria Salete Sandini Linden ◽  
Carmen Silvia Busin ◽  
Luiz Renato Paranhos ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Clinical Signs ◽  
Hcv Infection ◽  
Control Group ◽  
Proliferative Potential ◽  
Group 2 ◽  
Oral Lichen

The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection - Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment - Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV - Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool(tm) software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

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