scholarly journals The prevalence of Rheumatoid arthritis on female patients of child-bearing age at University of Port Harcourt Teaching Hospital, Rivers State, Nigeria

2021 ◽  
Vol 8 (2) ◽  
pp. 001-007
Author(s):  
Henrrietta Ogadimma Asuzu-Samuel
Keyword(s):  
Rheumatoid Arthritis ◽  
Qualitative Analysis ◽  
Teaching Hospital ◽  
Negative Control ◽  
The Body ◽  
Female Patients ◽  
Port Harcourt ◽  
Child Bearing ◽  
Systemic Inflammatory Disease ◽  
Test Control

Rheumatoid arthritis (RA) is the most commonly diagnosed systemic inflammatory disease that can affect multiple joints of the body. RA affects women 2-3 times more than men. Pregnancy has been reported to have an ameliorating effect on the course of existing RA and the flare-up of disease activity in the postpartum period. This study was carried out on two hundred and forty (240) female patients of child bearing age after obtaining an ethical approval from the Ethical Committee of University of Port Harcourt Teaching Hospital. 5ml of blood samples were drawn from the ante-cubital fossa of each woman with 5ml syringe and needle, between 8am to 11am each day. The samples were sent to the laboratory for analysis. The Latex Slide Test kit used for the serological analysis contains both the positive and negative control. The result obtained was compared with both the positive and negative control. Twelve (12) of the samples tested positive for the Rheumatoid Factor during the qualitative analysis, while the remaining two hundred and twenty-eight (228) tested negative. All positive results from the qualitative analysis tested positive when the test control was carried out, likewise the negative results which were all negative for the test control. The prevalence of rheumatoid arthritis in female patients of child bearing age for this study was calculated to be 5% which was 4% higher than the world prevalence, estimated to be 1%. The relevance of this study was to ascertain the occurrence of rheumatoid arthritis in female patients of child bearing age, which would serve as a useful tool in other rheumatoid arthritis prevalence studies that could be directed towards a better understanding of the flare of the disease and for the development of a more effective preventive and curative therapy.

scholarly journals Prevalence of systemic lupus erythematosus amongst child-bearing female patients attending University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria

2021 ◽  
Vol 14 (3) ◽  
pp. 090-097
Author(s):  
Asuzu-Samuel Henrrietta Ogadimma ◽  
Oluwatayo, Beatrice Olatundun
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Teaching Hospital ◽  
Lupus Erythematosus ◽  
Antinuclear Antibody ◽  
Systemic Lupus ◽  
Female Patients ◽  
Port Harcourt ◽  
Child Bearing ◽  
The University ◽  
Rivers State

Systemic lupus erythematosus (SLE), a chronic and progressive multisystem autoimmune disorder is chiefly mediated by immune complexes in which the body’s immune system produce antibody (mostly antinuclear antibody) against normal cells and organs leading to inflammatory injuries. Several studies on this disease have been done in different parts of the world but very little exist in Nigeria, particularly in Port Harcourt. The study aim to determine the prevalence of systemic lupus erythematosus in Child-bearing female patients between the age ranges of 15 – 45 years, attending University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. Ethical approval was sought for and obtained from the Ethical committee of the University of Port Harcourt Teaching Hospital. A total sample size of 207 was used. 5ml of blood samples were collected with 5ml syringe and needle into non-heparinized bottle from the antecubital fossa of recruited study group between 8am and 11am each day and was taken to the laboratory for analysis. De-fibrination method was used with the aid of centrifuge and microscope for detection of LE cell. Using an SLE latex reagent, the serum was analyzed for the presence of antinuclear antibody after centrifuging for 10mins. The SLE test kit used contained positive and negative controls to which the results were compared. Results gotten were all negative for the test group. This indicates a zero (0) prevalence level of systemic lupus erythematosus amongst child-bearing female patients attending the University of Port Harcourt Teaching Hospital.

scholarly journals An observational study to evaluate the efficacy Pachana Poorvaka Shodhana i.e. Agnilepa Chikitsa followed by Virechana Karma in the management of Amavata w.s.r. to Rheumatoid Arthritis

2019 ◽  
Vol 4 (06) ◽  
Author(s):  
Deepanjali T ◽  
Kiran M. Goud ◽  
Prerana Singhal
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
Statistical Analysis ◽  
Food Habits ◽  
The Body ◽  
P Value ◽  
Human Race ◽  
Systemic Inflammatory Disease ◽  
Joint Disorder ◽  
Almost All

The change in life style, food habits have contributed to a number of new diseases which have become a challenge for the human race, one among such diseases is Rheumatoid arthritis which is the commonest joint disorder. It is a systemic inflammatory disease of undetermined aetiology involving primarily the synovial membrane and articular structures of multiple joint. The disease is often progressive and result in pain, stiffness and swelling of joint. In India the prevalence rate is 0.1-0.4%. The symptoms of Rheumatoid arthritis are parallel with Amavata, as the name suggests Amavata is comprise of two terms, Ama and Vata. The Nidanas such as Viruddhaahara, Viruddhacheshta, Mandagni, Nischalatva etc. due to consumption of Viruddahara and indulging in Viruddhacheshta the Ama will be manifested. The manifested ama is carried by vata and circulates throughout the body and takes ashraya in Sandhis. Commonly affecting the joints of Hasta, Pada, Shira, Gulpha, Trika, Janu and Uru and characterized by pain similar to vrischika damshtra. In this present clinical trial, 10 diagnosed patients of Amavata / Rheumatoid arthritis were selected randomly to evaluate the efficacy of Pachana Poorvaka Shodhana that is Agnilepa Chikitsa followed by Virechana Karma in Amavata w.s.r. to Rheumatoid Arthritis. Statistical analysis showed highly significant results p value (less than 0.0001) in almost all subjective and objective parameters of Amavata.

scholarly journals Rheumatoid Arthritis with Avascular Necrosis of Femur Head (AVN): A Case Report

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
Rani Khushboo ◽  
Umesh Kumar Sapra ◽  
Vidula Gujjarwar
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Inflammatory Disease ◽  
Clinical Symptoms ◽  
Visual Analogue Score ◽  
The Body ◽  
Femur Head ◽  
Remarkable Improvement ◽  
Systemic Inflammatory Disease ◽  
The Status

 Rheumatoid arthritis is a chronic systemic inflammatory disease whichinvolve multiple joints  of the body.The clinical symptoms of the Rheumatoid Arthritisresemble with Amavata described in Ayurvedic literature. In thisdisease, the vitiated Vatadosha and Ama spread all along the body and  localisein kaphasthana likejoints and producing symptoms like pain, stiffness, swelling, tendernessetc.Treatment principle recommended are to correct the status of the digestive fireof the bodyand balance of Vata in the body. In this case, a male patient of 28 years old presented with the symptoms of inabilityto walk and stand without support associated with pain, swelling and  stiffnessover multiple jointsalong with deformity of hands. Pain was assessed by Visual analogue score(VAS).The patient was admitted in IPD of the hospital andtreatedwith Ayurvedic  medicines and Panchakarma therapy for 28 days. Remarkable improvement was seen in pain, swelling and stiffness after the treatment.

scholarly journals Predominant Bacterial Diversity in Rheumatoid Arthritis Rat After Treated with Caprine CSN1S2 Protein

2021 ◽  
Vol 11 (2) ◽  
pp. 121-131
Author(s):  
Eko Suyanto ◽  
◽  
Fatchiyah Fatchiyah ◽  
◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bacterial Diversity ◽  
Dna Sequences ◽  
Pathogenic Bacteria ◽  
Bacillus Coagulans ◽  
The Body ◽  
Bacterial Composition ◽  
Cultivable Bacteria ◽  
Rheumatoid Arthritis Disease ◽  
Systemic Inflammatory Disease

Rheumatoid arthritis (RA) is an autoimmune and systemic inflammatory disease that is affected to microbial abnormalities in the gut and altered the metabolism and immune system. Bioactive peptides have many functions in the body that related to health. This study aimed to investigate the effect of caprine CSN1S2 protein and to identify the predominant bacterial diversity in rheumatoid arthritis rats through fecal analysis based on PCR-DGGE and phylogenetic analysis. The animals were divided into 6 groups with 2 types of the rat model, namely control rats (untreated (C), treated with caprine CSN1S2 protein from milk (CM), and treated with caprine CSN1S2 protein from yogurt (CY)) and rheumatoid arthritis rats (rheumatoid arthritis (RA), treated with caprine CSN1S2 protein from milk (RAM), and treated with caprine CSN1S2 protein from yogurt (RAY). Predominant cultivable bacteria were obtained by direct culture and analyzed using PCR-DGGE with several specific primers. The DNA sequences were analyzed and aligned using bioinformatics software to construct the phylogenetic tree. The results showed that bacterial composition in all control groups was dominated by Lactobacillus group but in the rheumatoid arthritis rat (RA) group was dominated by Enterococcus group, particularly Enterococcus faecium and Enterococcus faecalis. Meanwhile, Bacillus coagulans dominated in rheumatoid arthritis rats after treated with caprine CSN1S2 protein. The caprine CSN1S2 protein has effects in rheumatoid arthritis rats with the emergence of predominant bacteria that can promote the growth of B. coagulans and it might be suppressed pathogenic bacteria in the development of rheumatoid arthritis disease.

Pattern of Otorhinolaryngological Disorders in HIV Positive Paediatric Patients at the University of Port Harcourt Teaching Hospital (UPTH)

2019 ◽  
pp. 1-9
Author(s):  
C. M. Vincent ◽  
O. B. da Lilly-Tariah ◽  
L. O. Onotai ◽  
N. I. Paul
Keyword(s):  
Teaching Hospital ◽  
Cervical Lymphadenopathy ◽  
The Body ◽  
Clinical Staging ◽  
Systematic Sampling ◽  
Hiv Positive ◽  
Paediatric Patients ◽  
Port Harcourt ◽  
The University ◽  
Hiv Negative

Background: HIV is a worldwide disease and affects all systems of the body. Despite the high burden of Paediatric HIV in Nigeria, few studies have been done on Otolaryngological disorders in children living with HIV. This study aimed to determine the pattern and prevalence of Otorhinolaryngological disorders among HIV positive paediatric patients and to compare them with age and sex-matched control. Methods: This was a descriptive cross-sectional case-control study carried out among 130 HIV positive and 130 HIV negative children aged 6 to 15 years at the University of Port Harcourt Teaching Hospital (UPTH). Eligible patients were recruited via a systematic sampling method and matched with HIV negative controls and an interviewer-administered questionnaire was used to extract relevant information. All patients had Otorhinolaryngological examination and CD4 count determination, while children with tonsillar enlargement underwent X-ray of the post nasal space. HIV patients were graded for severity using WHO clinical Staging. Results: A higher proportion of the HIV positive patients had allergic rhinitis (66.9% vs.30.8%, p=0.01), pharyngitis (40.8% vs.18.5%, p=0.01), tonsillitis (34.6% vs.20.8%, p=0.013), adenotonsilar disease (24.6% vs. 13.8%, p=0.028), cervical lymphadenopathy (15.4% vs. 5.4%, p=0.001) and otitis media (5.4% vs. 0.8%, p=0.031). There was a significantly higher prevalence of ORL disorders among HIV positive children (95.4%) compared to HIV negative children (78.5%). (P=0.001). Conclusion: Pattern of ORL disorder appeared similar in both HIV-positive and -negative children. However, the overall high prevalence of the findings among the HIV-positive children required regular ORL assessment in these children.

scholarly journals SAT0084 SERUM ADIPOKINES PROFILE IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TNF-INHIBITORS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 976.2-976
Author(s):  
M. Novella-Navarro ◽  
B. Hernández-Breijo ◽  
F. Genre ◽  
L. Lera-Gómez ◽  
V. Pulito-Cueto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Remission Rate ◽  
Binary Logistic Regression ◽  
Negative Influence ◽  
Normal Weight ◽  
The Body ◽  
Response To Treatment ◽  
Bivariate Analysis ◽  
Tnf Inhibitor ◽  
Serum Leptin

Background:In recent years, the relationship between obesity and autoimmune diseases has taken interest, since adipose tissue has been identified as an endocrine organ that secretes cytokines (adipokines), among which leptin stands out as a soluble pro-inflammatory mediator associated with the body mass index (BMI).Objectives:The main objectives of this study are: i) to analyse the influence of BMI on clinical response in Rheumatoid Arthritis (RA) patients who initiate TNF-inhibitor (TNFi) therapy; ii) to analyse the differences in the serum profile of adipokines (leptin and adiponectin) according to BMI and their association with response to treatment.Methods:Observational study of a prospective cohort of 73 RA patients who initiated biological treatment with TNFi from the Complex Therapy Unit (CTU) of our Hospital. Patients were classified according to their BMI in normal-weight (BMI<25) and overweight/obesity (O/O) (IMC≥25). Demographic, clinical and laboratory variables were collected at baseline and at 6 months. Our outcome measures were DAS28-VSG remission (DAS28<2.6) at 6 months after TNFi initiation. Serum leptin and adiponectin levels were measured by Enzyme-Linked Immuno Sorbent Assay (ELISA) at baseline and 6 months. A descriptive sample analysis comparing the characteristics of both patient subgroups was performed using Chi-square, T-test for independent samples and U-Mann Whitney. Likewise, a bivariate analysis was carried out by means of binary logistic regression to assess the probable association of the parameters studied with remission.Results:Of the 73 patients studied, 51% were classified in O/O group. The O/O patients presented higher levels of baseline CRP (16.69±6.16 vs 8.74±3.81, p=0.01). No statistically significant differences were observed in the remaining variables (sex, age at the beginning of the TNFi, disease duration, baseline DAS-28), as well as therapeutic variables (use of previous DMARDs and doses of methotrexate and/or steroids). Patients with overweight/obesity presented higher DAS28-ESR values at 6 months of treatment (3.59±1.14 vs 2.93±1.27, p=0.02) and achieved remission less frequently (18.9% vs 48.6%, p=0.007). Serum leptin levels were significantly higher in O/O patients, both baseline (29.39±21.50 vs 13.49±8.78, p<0.001) and 6 months (33.06±22.03 vs 14.77±9.50, p<0.001) after TNFi initiation. In addition, O/O patients were less likely to reach remission at 6 months than normal-weight patients. [OR= 4.04 IC95% (1.40-11.64); p=0.009]. Lower frequency of remission was associated to greater leptin levels at 6 months [OR=0.94 CI95% (0.90-098); p=0.012]. No differences in serum adiponectin were found between both subgroups of patients.Conclusion:In this RA patient cohort, overweight/obesity is associated with i) a reduced response to TNFi therapy and ii) a lower short-term remission rate. Within the adipokine profile, leptin seems to play a relevant role in the maintenance of pro-inflammatory activity with a negative influence on the response to TNFi therapy in O/O patients.References:[1] Versini M. et al. Autoimmun Rev. 2014; 13, 981-1000[2] Toussirot E et al. Life Sci. 2015;140: 29-36.Disclosure of Interests:Marta Novella-Navarro: None declared, Borja Hernández-Breijo: None declared, Fernanda Genre: None declared, Leticia Lera-Gómez: None declared, Verónica Pulito-Cueto: None declared, Laura Nuño: None declared, Alejandro Villalba: None declared, Alejandro Balsa Grant/research support from: BMS, Roche, Consultant of: AbbVie, Gilead, Lilly, Pfizer, UCB, Sanofi, Sandoz, Speakers bureau: AbbVie, Lilly, Sanofi, Novartis, Pfizer, UCB, Roche, Nordic, Sandoz, Chamaida Plasencia: None declared

scholarly journals AB1326-HPR TOBACCO ADDICTION IN PEOPLE WITH RHEUMATOID ARTHRITIS – FROM THE PERSPECTIVE OF PATIENTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1952.2-1952
Author(s):  
B. A. Esbensen ◽  
I. K. Roelsgaard ◽  
S. K. Larsen ◽  
T. Thomsen
Keyword(s):  
Rheumatoid Arthritis ◽  
Smoking Cessation ◽  
Tobacco Smoking ◽  
Physical Dependence ◽  
The Body ◽  
Controlled Study ◽  
Structured Interviews ◽  
Background Population ◽  
Increased Risk ◽  
Tobacco Addiction

Background:Smoking is one of the most significant modifiable exosomes risk factors for rheumatoid arthritis (RA) (1). Studies suggest that 25-30% of people with RA in Denmark smoke (2). This is almost twice as many as in the background population in Denmark. People with RA have a significant increased risk of severe comorbidity including cardiovascular disease. In addition, there are indications that smokers with RA have a poorer effect of the medical inflammatory treatment compared to non-smokers, and consequently more difficult to achieve remission of the disease activity (3). Tobacco addiction is complex and can be a challenge in smoking cessation. In addition to physiological dependence, habits and social and environmental factors may influence addiction. Tobacco smoking is associated with an addiction to nicotine and it is unexplored how this addiction appears in people with RA.Objectives:The aim of this study was to examine from the patient’s perspective how tobacco addiction appears in people with rheumatoid arthritis.Methods:We conducted a qualitative study based on a hermeneutics approach. People with RA who previously had participated in a randomized controlled study (4) about smoking cessation conducted at the Center for Rheumatology and Spine Diseases at Rigshospitalet, Denmark were recruited for semi-structured interviews.Results:In total, 12 people with RA (50% female) were included in the study. The median age was 62 years and median RA disease duration was 12 years. The degree of physical dependence measured by Fagerströms Test for Nicotine dependence (FTND) was on average: 4.9 (score: 0-10, 0=nonphysical dependence).Three categories of how tobacco addiction appeared emerged during the analysis: 1)It develops into ingrown habitsreferring to the fact that smoking already in adolescence contributes to the development of specific physical, mental and social smoking behavior. Not all individuals considered themselves addicted to nicotine as they did not necessarily connect the nicotine to the ingrown habits. 2)The body craves for nicotinereferring to nicotine proved calming, while a lacking or insufficient dose caused withdrawal symptoms. Furthermore, smoking became a habit where a craving for smoking occurred in certain situations. 3)Ambivalence – for and againstreferring to the physical dependence and smoking habits making a smoking cessation difficult. Dependency to nicotine and challenges to quit smoking led to a feeling of ambivalence and a lack of control.Conclusion:Tobacco addiction appeared as a physical dependence and a habit, which, during a smoking cessation, led to ambivalent feelings. Therefore, based on this study, there is still a need for health professionals to talk to patients about smoking. But also, a need to articulate the complexity of addiction in order to support for smoking cessations. Information should be strengthened in the clinical practice in relation to nicotine’s implication in tobacco addiction as well as the consequences of tobacco smoking for individuals with RA.References:[1]Scott DL, Wolfe F, Huizinga TW. Lancet. 2010 ###[2]Loppenthin K, Esbensen BA, Jennum P, Ostergaard M, Tolver A, Thomsen T, et al. Clin Rheumatol. 2015. ###[3]Roelsgaard IK, Ikdahl E, Rollefstad S, Wibetoe G, Esbensen BA, Kitas GD, et al. Rheumatology (Oxford). 2019. ###[4]Roelsgaard IK, Thomsen T, Ostergaard M, Christensen R, Hetland ML, Jacobsen S, et al. Trials. 2017;18(1):570.###Disclosure of Interests:None declared

scholarly journals From Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid Arthritis

2021 ◽  
Vol 22 (2) ◽  
pp. 686
Author(s):  
Chao-Yi Wu ◽  
Huang-Yu Yang ◽  
Shue-Fen Luo ◽  
Jenn-Haung Lai
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Bone Destruction ◽  
Response To Therapy ◽  
Current Evidence ◽  
Prognosis Prediction ◽  
Diagnosis And Prognosis ◽  
Systemic Inflammatory Disease ◽  
Citrullinated Protein

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease mainly involving synovial inflammation and articular bone destruction. RA is a heterogeneous disease with diverse clinical presentations, prognoses and therapeutic responses. Following the first discovery of rheumatoid factors (RFs) 80 years ago, the identification of both anti-citrullinated protein antibodies (ACPAs) and anti-carbamylated protein antibodies (anti-CarP Abs) has greatly facilitated approaches toward RA, especially in the fields of early diagnosis and prognosis prediction of the disease. Although these antibodies share many common features and can function synergistically to promote disease progression, they differ mechanistically and have unique clinical relevance. Specifically, these three RA associating auto-antibodies (autoAbs) all precede the development of RA by years. However, while the current evidence suggests a synergic effect of RF and ACPA in predicting the development of RA and an erosive phenotype, controversies exist regarding the additive value of anti-CarP Abs. In the present review, we critically summarize the characteristics of these autoantibodies and focus on their distinct clinical applications in the early identification, clinical manifestations and prognosis prediction of RA. With the advancement of treatment options in the era of biologics, we also discuss the relevance of these autoantibodies in association with RA patient response to therapy.

scholarly journals Chinese Herbal Medicine Alleviates Thyroidectomy-Induced Cardiopulmonary Exercise Dysfunction in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Tai-Yuan Chuang ◽  
Chia-Ying Lien ◽  
Chih-Hsiang Hsu ◽  
Chen-Wen Lu ◽  
Chung-Hsin Wu
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Negative Control ◽  
The Body ◽  
Male Rats ◽  
Free Triiodothyronine ◽  
Cardiopulmonary Exercise ◽  
Chinese Herbal ◽  
Subcutaneous Blood Flow ◽  
Tsh Levels

Hypothyroidism frequently causes cardiopulmonary dysfunction, such as heart failure and respiratory and metabolic deficiencies. This study investigated the effects of Chinese herbal formula B307 on thyroidectomy-induced cardiopulmonary exercise dysfunction in rats. Twenty male rats were equally divided into four groups: negative control with sham treatment, positive control with oral B307 treatment only, thyroidectomy treatment only, and thyroidectomy with B307 posttreatment groups. The feeding dose of B307 was 50 mg/kg per day for 14 days. We examined and then compared the thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), and reactive oxygen species (ROS) from the blood of these four groups. Also, we compared the body weight, neck subcutaneous blood flow, cardiac ejection function, cardiopulmonary exercise function of oxygen consumption (VO2), carbon dioxide production (VCO2), and respiratory quotient (RQ = VCO2/VO2) among the four groups. Our results indicated that thyroidectomized rats had significantly decreased body weight, neck subcutaneous blood flow, cardiac ejection function, serum T3 and T4, and VO2 and VCO2, but had significantly increased ROS and TSH levels and RQ values compared with sham rats (P<0.01–0.05). In addition, thyroidectomized rats receiving oral B307 treatment had significantly increased body weight, neck subcutaneous blood flow, cardiac ejection function, and VO2, but significantly decreased ROS and TSH levels and VCO2 and RQ values compared with thyroidectomized rats (P<0.01–0.05). We suggest that the B307 could be a protective and beneficial alternative treatment for thyroidectomy-induced cardiopulmonary exercise dysfunction.

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