An observational study to evaluate the efficacy Pachana
Poorvaka Shodhana i.e. Agnilepa Chikitsa followed by
Virechana Karma in the management of Amavata w.s.r.
to Rheumatoid Arthritis

The change in life style, food habits have contributed to a number of new diseases which have become a challenge for the human race, one among such diseases is Rheumatoid arthritis which is the commonest joint disorder. It is a systemic inflammatory disease of undetermined aetiology involving primarily the synovial membrane and articular structures of multiple joint. The disease is often progressive and result in pain, stiffness and swelling of joint. In India the prevalence rate is 0.1-0.4%. The symptoms of Rheumatoid arthritis are parallel with Amavata, as the name suggests Amavata is comprise of two terms, Ama and Vata. The Nidanas such as Viruddhaahara, Viruddhacheshta, Mandagni, Nischalatva etc. due to consumption of Viruddahara and indulging in Viruddhacheshta the Ama will be manifested. The manifested ama is carried by vata and circulates throughout the body and takes ashraya in Sandhis. Commonly affecting the joints of Hasta, Pada, Shira, Gulpha, Trika, Janu and Uru and characterized by pain similar to vrischika damshtra. In this present clinical trial, 10 diagnosed patients of Amavata / Rheumatoid arthritis were selected randomly to evaluate the efficacy of Pachana Poorvaka Shodhana that is Agnilepa Chikitsa followed by Virechana Karma in Amavata w.s.r. to Rheumatoid Arthritis. Statistical analysis showed highly significant results p value (less than 0.0001) in almost all subjective and objective parameters of Amavata.

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Terapi bekam basah area punggung mengurangi nyeri sendi pada pasien rheumathoid arhtritis

Wellness And Healthy Magazine ◽

10.30604/well.68212020 ◽

2020 ◽

Vol 2 (1) ◽

pp. 55-60

Author(s):

Fitra Pringgayuda ◽

I Idayati ◽

Purwati Indiaresti

Keyword(s):

Rheumatoid Arthritis ◽

Statistical Test ◽

Cupping Therapy ◽

Wilcoxon Test ◽

P Value ◽

Sampling Techniques ◽

Systemic Inflammatory Disease ◽

Quasi Experimental ◽

Pain Prevalence ◽

Test Result

Rheumatoid Arthritis (RA) is a chronic systemic inflammatory disease of unknown cause with peripheral joint manifestations. The numbers of Genesis Rheumatoid Arthritis in Indonesia is quite high. RA Pain prevalence in Indonesia reached 25.6% to 35.8%. This figure suggests that pain due to RA already bothersome activity of Indonesia society. The aim of this research is conducted to know the effect find of wet cupping therapy in the area of paint in the back joint to changes in outpatient RA patients in clinics of the year 2018. A quasi-experimental design with One Group Pretestpostest Design without control. The population in this research is the sufferer Rheumatoid Arthritis 30-50 years old visiting Clinics Sukoharjo, with a sample of 16 respondents, purposive Sampling techniques. Wilcoxon test result indicates that there is a difference between pain before with after bekam, based on the result of the statistical test p-value obtained value is a ρ=0,001 (less than 0,05), this means there is a significant influence of wet cupping therapy to changes pain in people with Rheumtaoid Arthitis. Thus, wet cupping therapy can be a solution to reduce joint pain for patients with Rheumatoid Arthritis.

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The clinical aspect of overweight on rheumatoid arthritis and disease activity

Journal of Biotechnology Research Center ◽

10.24126/jobrc.2019.13.2.576 ◽

2019 ◽

Vol 13 (2) ◽

pp. 10-16

Author(s):

Haitham Ahmed ◽

Tagreed A. Al-Sadoon ◽

Khudhair A. Khudhair

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Body Mass ◽

Acute Phase ◽

Acute Phase Response ◽

The Body ◽

Phase Response ◽

Fat Free Mass ◽

P Value ◽

Serological Tests

Objective: To investigate the influence of obesity on disease activity in rheumatoid arthritis patients and to determine a probable connection with the acute phase response. Materials and methods: The recruited patients satisfied the criteria from the American College of Rheumatology (ACR). To evaluate the body mass index (BMI), anthropometric tests were carried out at the Rheumatology Department at Baquba Teaching Hospital, which has a consultation unit. The serum levels of anti-cyclic citrullinated peptide antibodies (anti-CCP) were measured from blood samples taken through the particle-enhanced (latex) immunonephelometry assays on the genius analyser (CO, Ltd. China) and test kits from IMTEC-CCP-Antibodies. RF screen and serological tests (latex) were carried out to determine the C-reactive protein (CRP), measure Hb and the total WBCs count, the erythrocyte sedimentation rate (ESR) was also carried out. Results: The current study findings from the sample of RA patients showed that the proportion of patients falling into the overweight classification (BMI 25-29) was 80.6% while the obese classification (BMI 30-35) was 33.33%. Among the RF and ACCP-positive cases, a marginally stronger relationship between the development of RA and the history of obesity was found. Additionally, a significant correlation between acute phase response and free mass was found in RA patients (anti-CCP p-value≤ 0.00021 ESR p≤ 0.00072 Hb p≤ 0.00054, and W.B.C p =≤ 0.000.94, CRP p≤1). Conclusion: The present study’s findings show an elevated prevalence of high body mass among the RA patients. Furthermore, a linear association existed between the fat free mass and the acute phase response.

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SMOKING GENOTOXICITY IN PERIPHERAL BLOOD LYMPHOCYTES USING THE COMET ASSAY

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703675 ◽

2013 ◽

Vol 03 (03) ◽

pp. 038-041

Author(s):

Shobha S. Shetty ◽

Hrishikesh Nachane

Keyword(s):

Dna Damage ◽

Comet Assay ◽

Peripheral Blood ◽

Peripheral Blood Lymphocytes ◽

The Body ◽

P Value ◽

Tail Moment ◽

Blood Lymphocytes ◽

Significant Difference ◽

Almost All

Abstract Background: Smoking has been shown to have a positive effect on DNA damage in almost all the cells of the body. Quantitative analysis of this damage will help in assessing the etiopathogenesis of various nicotine induced damage to the body. Comet assay has been an emerging tool in this regard and hence was applied by us to estimate the severity of DNA damage in smokers. Aims & Objectives: To evaluate the DNA genotoxicity in peripheral blood lymphocytes in smokers and their comparison with non smokers & assess the quantitative damage. Materials and methods: 30 smokers & 20 non smokers were recruited & their peripheral blood was taken for the comet assay to look for Olive moment & Tail moment to quantitatively assess the DNA damage due to cigarette smoking. Results: In our study there was no significant difference in the analysis of DNA damage (with regard to tail moment & olive moment) in smokers versus non smokers (P value: more than 0.05). Conclusions: Though smoking is known to cause DNA damage, we did not find significant differences between the two groups probably due to other multifactorial etiologies for genotoxicity.

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Effect of dietary combinations on plaque pH recovery after the intake of pediatric liquid analgesics

European Journal of Dentistry ◽

10.4103/1305-7456.163220 ◽

2015 ◽

Vol 09 (03) ◽

pp. 340-345 ◽

Cited By ~ 1

Author(s):

Shaam Saeed ◽

Nada Bshara ◽

Juliana Trak ◽

Ghiath Mahmoud

Keyword(s):

Clinical Trial ◽

Statistical Analysis ◽

Randomized Clinical Trial ◽

Sampling Method ◽

Chewing Gum ◽

P Value ◽

Plaque Ph ◽

Significant Difference ◽

Before And After ◽

Difference Test

ABSTRACT Objectives: To study the effect of water, halloumi cheese and sugar-free (SF) chewing gum on plaque pH recovery after the intake of sweetened PLAs. Settings and Design: A randomized clinical trial was conducted on 17 children (10 females, 7 males) aged 11–12 years with DFT/dft of more than 3. Materials and Methods: Each volunteer tested paracetamol and ibuprofen suspension alone or followed with water, halloumi cheese or SF gum, as well as 10% sucrose and 10% sorbitol as controls. Plaque pH was measured using the sampling method before and after 5, 10, 15, 20, 30 min of ingestion. Statistical Analysis: Statistical analysis was performed using analysis of variance followed by least significant difference test to assess minimum pH (min pH), maximum pH drop (ΔpH), and the area under baseline pH, and P value was set as 0.05. Results: Both ibuprofen and paracetamol were not significantly different from 10% sucrose in terms of min pH, ΔpH, and area under baseline pH except for min pH of ibuprofen (P = 0.034). Water and halloumi cheese did not have a significant effect on plaque pH recovery after the intake of both analgesics as min pH, ΔpH, and area under baseline pH were similar to 10% sucrose except for min pH of ibuprofen + water (P = 0.048). However, plaque pH variables after chewing SF gum for 20 min were similar to 10% sorbitol. Conclusion: Chewing SF gum immediately after the intake of sweetened PLAs for 20 min restores plaque pH and could be recommended as a complementary aid in caries prevention.

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Rheumatoid Arthritis with Avascular Necrosis of Femur Head (AVN): A Case Report

National Journal of Research in Ayurved Science ◽

10.52482/ayurlog.v6i04.131 ◽

2018 ◽

Vol 6 (04) ◽

Author(s):

Rani Khushboo ◽

Umesh Kumar Sapra ◽

Vidula Gujjarwar

Keyword(s):

Rheumatoid Arthritis ◽

Case Report ◽

Inflammatory Disease ◽

Clinical Symptoms ◽

Visual Analogue Score ◽

The Body ◽

Femur Head ◽

Remarkable Improvement ◽

Systemic Inflammatory Disease ◽

The Status

Rheumatoid arthritis is a chronic systemic inflammatory disease whichinvolve multiple joints of the body.The clinical symptoms of the Rheumatoid Arthritisresemble with Amavata described in Ayurvedic literature. In thisdisease, the vitiated Vatadosha and Ama spread all along the body and localisein kaphasthana likejoints and producing symptoms like pain, stiffness, swelling, tendernessetc.Treatment principle recommended are to correct the status of the digestive fireof the bodyand balance of Vata in the body. In this case, a male patient of 28 years old presented with the symptoms of inabilityto walk and stand without support associated with pain, swelling and stiffnessover multiple jointsalong with deformity of hands. Pain was assessed by Visual analogue score(VAS).The patient was admitted in IPD of the hospital andtreatedwith Ayurvedic medicines and Panchakarma therapy for 28 days. Remarkable improvement was seen in pain, swelling and stiffness after the treatment.

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Predominant Bacterial Diversity in Rheumatoid Arthritis Rat After Treated with Caprine CSN1S2 Protein

Journal of Tropical Life Science ◽

10.11594/jtls.11.02.01 ◽

2021 ◽

Vol 11 (2) ◽

pp. 121-131

Author(s):

Eko Suyanto ◽

◽

Fatchiyah Fatchiyah ◽

◽

Keyword(s):

Rheumatoid Arthritis ◽

Bacterial Diversity ◽

Dna Sequences ◽

Pathogenic Bacteria ◽

Bacillus Coagulans ◽

The Body ◽

Bacterial Composition ◽

Cultivable Bacteria ◽

Rheumatoid Arthritis Disease ◽

Systemic Inflammatory Disease

Rheumatoid arthritis (RA) is an autoimmune and systemic inflammatory disease that is affected to microbial abnormalities in the gut and altered the metabolism and immune system. Bioactive peptides have many functions in the body that related to health. This study aimed to investigate the effect of caprine CSN1S2 protein and to identify the predominant bacterial diversity in rheumatoid arthritis rats through fecal analysis based on PCR-DGGE and phylogenetic analysis. The animals were divided into 6 groups with 2 types of the rat model, namely control rats (untreated (C), treated with caprine CSN1S2 protein from milk (CM), and treated with caprine CSN1S2 protein from yogurt (CY)) and rheumatoid arthritis rats (rheumatoid arthritis (RA), treated with caprine CSN1S2 protein from milk (RAM), and treated with caprine CSN1S2 protein from yogurt (RAY). Predominant cultivable bacteria were obtained by direct culture and analyzed using PCR-DGGE with several specific primers. The DNA sequences were analyzed and aligned using bioinformatics software to construct the phylogenetic tree. The results showed that bacterial composition in all control groups was dominated by Lactobacillus group but in the rheumatoid arthritis rat (RA) group was dominated by Enterococcus group, particularly Enterococcus faecium and Enterococcus faecalis. Meanwhile, Bacillus coagulans dominated in rheumatoid arthritis rats after treated with caprine CSN1S2 protein. The caprine CSN1S2 protein has effects in rheumatoid arthritis rats with the emergence of predominant bacteria that can promote the growth of B. coagulans and it might be suppressed pathogenic bacteria in the development of rheumatoid arthritis disease.

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The prevalence of Rheumatoid arthritis on female patients of child-bearing age at University of Port Harcourt Teaching Hospital, Rivers State, Nigeria

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2021.8.2.0163 ◽

2021 ◽

Vol 8 (2) ◽

pp. 001-007

Author(s):

Henrrietta Ogadimma Asuzu-Samuel

Keyword(s):

Rheumatoid Arthritis ◽

Qualitative Analysis ◽

Teaching Hospital ◽

Negative Control ◽

The Body ◽

Female Patients ◽

Port Harcourt ◽

Child Bearing ◽

Systemic Inflammatory Disease ◽

Test Control

Rheumatoid arthritis (RA) is the most commonly diagnosed systemic inflammatory disease that can affect multiple joints of the body. RA affects women 2-3 times more than men. Pregnancy has been reported to have an ameliorating effect on the course of existing RA and the flare-up of disease activity in the postpartum period. This study was carried out on two hundred and forty (240) female patients of child bearing age after obtaining an ethical approval from the Ethical Committee of University of Port Harcourt Teaching Hospital. 5ml of blood samples were drawn from the ante-cubital fossa of each woman with 5ml syringe and needle, between 8am to 11am each day. The samples were sent to the laboratory for analysis. The Latex Slide Test kit used for the serological analysis contains both the positive and negative control. The result obtained was compared with both the positive and negative control. Twelve (12) of the samples tested positive for the Rheumatoid Factor during the qualitative analysis, while the remaining two hundred and twenty-eight (228) tested negative. All positive results from the qualitative analysis tested positive when the test control was carried out, likewise the negative results which were all negative for the test control. The prevalence of rheumatoid arthritis in female patients of child bearing age for this study was calculated to be 5% which was 4% higher than the world prevalence, estimated to be 1%. The relevance of this study was to ascertain the occurrence of rheumatoid arthritis in female patients of child bearing age, which would serve as a useful tool in other rheumatoid arthritis prevalence studies that could be directed towards a better understanding of the flare of the disease and for the development of a more effective preventive and curative therapy.

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The Correlation between Body Mass Index with the Occurrence of Skin Tag

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2017.061 ◽

2017 ◽

Vol 5 (3) ◽

pp. 271-274 ◽

Cited By ~ 3

Author(s):

Nelva K. Jusuf ◽

Imam B. Putra ◽

Johan Kartayana

Keyword(s):

Body Mass Index ◽

Statistical Analysis ◽

Physical Examination ◽

Body Mass ◽

The Body ◽

Control Group ◽

P Value ◽

Cross Sectional ◽

Skin Tag ◽

The Mean

BACKGROUND: Skin tag is a benign tumour of the skin with a soft consistency which commonly occurs in the flexure area. Skin tag often found in individuals with middle and old age. Until now, there are many of theories have been proposed to explain the mechanism of the skin tag, one of the theory is obesity.AIM: To determine the body mass index (BMI) in patients with skin tag.METHODS: This study is an analytic study with cross-sectional designs involving 32 subjects with skin tag and 32 controls. Diagnosis of skin tag was made based on anamnesis and clinical examination. All subjects underwent a physical examination (height and weight) to determine BMI (weight in kilogrammes divided by the square of height in meters). To analyse association between higher BMI with the occurrence of skin tag we use student t-test.RESULTS: The mean BMI in the skin tag group (28.1+ 3.9 kg/m^2) was higher compared with the control group (24.1 + 2.3 kg/m^2). Statistical analysis by Student t-test found the p-value < 0.05.CONCLUSION: We found a correlation between increased BMI with the occurrence of the skin tag.

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Kejadian Rheumatoid Arthritis pada lansia di Poliklinik Bandar Lampung

HOLISTIK JURNAL KESEHATAN ◽

10.33024/hjk.v14i3.2106 ◽

2020 ◽

Vol 14 (3) ◽

pp. 375-382

Author(s):

Athaya Hafizhah ◽

Umi Romayati Keswara ◽

Dhiny Easter Yanti

Keyword(s):

Rheumatoid Arthritis ◽

Quantitative Research ◽

Economic Status ◽

The Elderly ◽

Organ Damage ◽

Case Control ◽

The Body ◽

Dominant Factor ◽

P Value ◽

Study Population

Rheumatic disease in the elderly: Rheumatoid arthritis cases and non–rheumatoid arthritis controlsBackground: Rheumatoid arthritis (RA) is an autoimmune disease that affects most people and the exact cause is unknown. Based on data from Bandar Lampung, RA ranks fourth in the profile of the top 10 diseases that have emerged since 2012. Although the cause is unknown, RA complications are very dangerous, ranging from joint deformities & disabilities, internal organ damage, to death.Purpose: To determine the factors associated with the incidence of rheumatoid arthritis in the elderlyMethod: Quantitative research with a case control design. The study population was all elderly patients at Pertamina Bintang Amin Hospital. The samples used were 47 cases and 47 controls. Multivariate analysis using multiple logistic regression tests.Results: It shows that there is no relationship between economic status (p-value 0.062) and the incidence of RA at Pertamina Bintang Amin Hospital. There was a significant relationship between smoking (p-value 0.042; OR 2.86), diet (p-value 0.013; OR 3.61), occupational (p-value 0.000; OR 6.80), and obesity (p-value. 0.017; OR 3.25) with RA.Conclusion: The most dominant factor associated with the incidence of RA in the elderly is work (OR 7,8). Workers at high risk are advised to use personal protective equipment while working and provide time for fun outdoor physical activity so as to reduce stress and help the absorption of vitamin D in the body more optimally.Keywords: Elderly; Rheumatoid arthritis; Obesity; Smoking; Economic status; OccupationalPendahuluan: Rheumatoid arthritis (RA) merupakan penyakit autoimun yang paling sering terjadi di masyarakat dan belum diketahui secara pasti penyebabnya. Berdasarkan Data Kota Bandar Lampung, RA berada diurutan keempat dalam profil 10 penyakit terbesar yang muncul sejak tahun 2012. Meski penyebabnya belum diketahui, komplikasi RA sangat berbahaya, mulai dari deformitas sendi & disabilitas, kerusakan organ-organ dalam, hingga kematian.Tujuan: Mengetahui faktor-faktor yang berhubungan dengan kejadian rheumatoid arthritis pada lansia di poliklinik rawat jalan Rumah Sakit Pertamina Bintang Amin (RSPBA) Tahun 2019.Metode : Penelitian kuantitatif dengan rancangan kasus control (case control). Populasi penelitian adalah seluruh pasien lansia di Rumah Sakit Pertamina Bintang Amin. Sampel yang digunakan sebanyak 47 kasus dan 47 kontrol. Analisis multivariat menggunakan uji regresi logistik ganda.Hasil : Tidak ada hubungan antara status ekonomi (nilai p 0,062) dengan kejadian RA di RSPBA. Ada hubungan yang signifikan antara merokok (nilai p 0,042; OR 2,86), diet (nilai p 0,013; OR 3,61), pekerjaan (nilai p 0,000; OR 6,80), dan obesitas (nilai p 0,017; OR 3,25) dengan kejadian RA.Simpulan: Faktor yang paling dominan berhubungan dengan kejadian RA pada lansia di poliklinik rawat jalan RSPBA Tahun 2019 adalah pekerjaan (OR 7,8). Disarankan pekerja berisiko untuk menggunakan alat pelindung diri saat bekerja, dan menyediakan waktu melakukan aktifitas fisik di luar ruangan yang menyenangkan sehingga dapat mengurangi stress dan membantu penyerapan vit. D lebih maksimal.

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ASSOCIATION BETWEEN THE NUTRITIONAL STATUS AND RISK OF CARDIOVASCULAR DISEASES IN PATIENTS WITH RHEUMATOID ARTHRITIS ACCOMPANIED IN A REFERENCE CENTER IN A BRAZIL NORTHEAST REFERENCE CENTER

American Journal of Cardiology Research and Reviews ◽

10.28933/ajcrar-2021-05-2005 ◽

2021 ◽

pp. 12

Author(s):

◽

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Cardiovascular Diseases ◽

Nutritional Status ◽

Body Mass ◽

The Body ◽

P Value ◽

Reference Center ◽

Informed Consent Form ◽

Increased Risk

Introduction: Rheumatoid arthritis is an autoimmune and inflammatory disease, chronic and progressive, highly limiting, which can be aggravated when the nutritional status of this patient has dystrophy, so the body composition can influence the activity of this disease. Objective: To evaluate the association between nutritional status and the risk of cardiovascular disease in patients with rheumatoid arthritis in a reference center in the northeast. Material and Methods: Cross-sectional study carried out in a rheumatology clinic of a reference center in Northeast Brazil (Recife / PE) with patients with rheumatoid arthritis. Anthropometric measurements of weight and height were taken to assess the parameter of Body Mass Index (BMI). Measures of waist circumference (WC) and hip circumference (HC) were also taken to assess the parameters of waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR), in order to investigate cardiovascular risk. The data were treated using the SPSS version 17.0 for Windows and Excel 2010. For the correlation analysis, the Chi-square test was used. The level of significance was set at 5%. The Bioethics Research Committee of the Instituto de Medicina Integral Professor Fernando Figueira (IMIP) approved the present study under nº 19163619.1.0000.5201 the participants signed the Informed Consent Form (ICF). Results: The study included 54 patients aged between 18 and 58 years old and a mean age of 47.26 years +/- 11.72 SD, 96.3% of whom were female. 42.9% of the studied population had obesity according to the Body Mass Index, followed by 35.7% with overweight. According to WC 52.6% had an increased risk for cardiovascular diseases. WHR and WHtR found risk for cardiovascular diseases in 64.9% and 84.5%, respectively. The association between BMI and WC was 0.000 p-value, whereas for BMI and WHR, WHtR was 0.176 p-value and 0.095 p-value respectively. Conclusions: There was a prevalence of obesity and overweight in patients with rheumatoid arthritis, which may suggest a greater risk for disease activity, and difficulty in controlling symptoms.

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