scholarly journals Utilization and bioactivity of Blumea balsaminifera (L.) DC.

2021 ◽  
Vol 16 (2) ◽  
pp. 224-228
Author(s):  
Marina Silalahi
Keyword(s):  
Wound Healing ◽  
Secondary Metabolites ◽  
Literature Review ◽  
Traditional Medicine ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Volatile Oil ◽  
Flavonoid Glycosides ◽  
Comprehensive Information ◽  
Anti Cancer

Sembung or Blumea balsaminifera a species belonging of Asteraceae has been long used as a traditional medicine. The using of plants as traditional medicine, directly or indirectly related to their bioactive compounds. The writing of this article is based on literature review of the published online and offline such as journals, books, and other research to obtained comprehensive information of the benefits, secondary metabolites, bioactivity, and prospects for the use of B. balsaminifera. The ethnobotany of B. balsaminifera uses as an ingredient of loloh (Bali Aga ethnic health drink), treat of wounds, diarrhea, malnutrition, kidney stone, and traditional sauna ingredients, headaches, gastric disorders, and rheumatism. Blumea balsaminifera has bioactivity such as: anti-wound, anti-microbial, anti-cancer, gastroprotective, antioxidant, and anti-kidney stones. Blumea balsaminifera leaves contains volatile oil and falvonoid compounds. The volatile oil in B. balsaminifera is borneol, 1,8-cineole, limonene, kampor, β-eudesmol, β-champene, myrcene, dimethoxydurene, β-caryophyllene, and α-caryophyllene. The Dimethoxydurene, β-caryophyllene, and α-caryophyllene of B. balsaminifera have activities as antioxidant. The flavonoid glycosides of B. balsaminifera has a therapeutic effect on wound healing while anti-microbial activity has associated with borneol.

scholarly journals Study of drugs potential of fern collections at Purwodadi Botanic Gardens

2021 ◽  
Vol 10 (2) ◽  
pp. 199
Author(s):  
Elga Renjana ◽  
Muhamad Nikmatullah
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Literature Review ◽  
Traditional Medicine ◽  
Conservation Status ◽  
Iucn Red List ◽  
Red List ◽  
Botanic Gardens ◽  
Anti Cancer ◽  
Pharmacological Studies

Ferns (Pteridophyta) is the oldest group of plants on earth that has more than 11.000 species. Ethnobotany and pharmacological studies have revealed that ferns contain potentially secondary metabolites as medicine. Purwodadi Botanic Gardens (Purwodadi BG) has fern collections that have not revealed information about drug potential. This research was conducted to inventory Purwodadi BG’s fern collections which have potential as medicine and to determine their conservation status. Inventory of fern collections is carried out by collecting data from the Registration Unit and observing directly in the field, while information about drug potential is obtained by literature review. A total of 31 species of 171 specimens of Purwodadi BG’s fern collections are known to be efficacious for treating various diseases, both traditional medicine, and research results. As many as 6 species of fern collections that have medicinal potential are included in IUCN Red List and categorized as least concern/LC and critically endangered/CR. The potential for medicinal plants of fern collections include anti-oxidants, anti-inflammatory, anti-microbial, anti-viral, and anti-cancer properties. This potential information is expected to increase the value of the fern’s function and their conservation efforts.

scholarly journals AGERATUM CONYZOIDES L. (PEMANFAATAN SEBAGAI OBAT DAN BIOAKTIVITASNYA)

2019 ◽  
Vol 11 (3) ◽  
pp. 197
Author(s):  
Marina Silalahi
Keyword(s):  
Fatty Acids ◽  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Wild Plants ◽  
Ageratum Conyzoides ◽  
Comprehensive Information

ABSTRACTAgeratum conyzoides or badotan is a wild plants which uses as traditional medicine. This plant has a distinctive aroma similar to "the smell of goats" so it is called "goatweed". This article aims to explain the use of A. conyzoides as a drug and its bioactivity. The writing of this article is based on the study of literature obtained online and offline including various scientific articles then reviewed and synthesized so as to provide comprehensive information regarding the use of A. conyzoides as traditional medicine. In traditional medicine, Ageratum conyzoides is used as medicine for wounds, ulcers, and fever. Ageratum conyzoides have secondary metabolites such as terpenoids, flavonoids, steroids, terpenes, saponins, fatty acids, and alkaloids, with the main compounds stigmasterol and β-sitosterol. Bioactivity of A. conyzoides are antihistamine, antimicrobial, antiplasmodial, cytoprotective, analgesic, antioxidant and anti diabetes mellitus.Keywords: Ageratum conyzoides, antimicrobial, β-sitosterol, cytoprotective, analgesic. ABSTRAKAgeratum conyzoides atau badotan merupakan salah satu tumbuhan liar yang banyak dimanfaatkan sebagai obat tradisional. Tumbuhan ini memiliki aroma khas mirip dengan “bau kambing” sehingga disebut juga sebagai “goatweed”. Artikel ini bertujuan untuk menjelaskan pemanfaatan A. conyzoides sebagai obat dan bioaktivitasnya. Penulisan artikel ini didasarkan pada kajian literatur yang diperoleh secara online maupun offline meliputi berbagai artikel ilmiah kemudian dikaji dan disintesakan sehingga memberikan informasi yang kompehensif mengenai pemanfaatan A. conyzoides sebagai obat tradisional. Dalam pengobatan tradisional Ageratum conyzoides dimanfaatkan sebagai obat luka, bisul, dan demam. Ageratum conyzoides mengandung metabolit sekunder dari golongan terpenoid, flavonoid, steroid, terpen, senyawa, saponin, asam lemak, dan alkaloid, dengan senyawa utama stigmasterol dan β‐sitosterol. Bioaktivitas yang dimiliki oleh A. conyzoides antara lain sebagai anti histamin, antimikroba, antiplasmodial, sitoprotektif, analgesik, antioksidan dan anti diabetes mellitus.Kata Kunci : Ageratum conyzoides, antimikroba, β‐sitosterol, sitoprotektif, analgesik.

scholarly journals Kajian Etnosains Pada Potensi Penggunaan Saliva untuk Penyembuhan Luka Ringan di Lampung

2021 ◽  
Vol 4 (1) ◽  
pp. 43-54
Author(s):  
Silvia Nur Azizah ◽  
Mustajib Mustajib ◽  
Ahsanul Buduri Agustiar ◽  
Hafidha Asni Akmalia
Keyword(s):  
Wound Healing ◽  
Literature Review ◽  
Traditional Medicine ◽  
Field Observations ◽  
Keratinocyte Migration ◽  
The People ◽  
Minor Injuries ◽  
Potential Use

Traditional medicine is the local wisdom of the Indonesian people. The people of the Jaya Sakti area of Central Lampung use saliva as a medicine to heal minor wounds. This study aims to determine the potential use of saliva in healing minor wounds. This study uses the method of observing the community. The results showed that based on the percentage of data from field observations related to the use of saliva for minor injuries in communities around Jayasakti village, Anak Tuha District, Central Lampung Regency, it is known that most people have used saliva to treat minor wounds, while other communities have never used it. or seeing other people use saliva as a remedy for minor wounds. Based on the literature review, the content contained in saliva, especially histatin, plays a major role in improving wound healing by increasing the revitalization phase, especially through increasing keratinocyte migration and proliferation. Besides, people use saliva as a medicine to heal minor wounds because they follow the habits of people who have been passed down from generation to generation and already know the content of saliva that can heal minor wounds, namely histatin and alkaline acids. In conclusion, saliva is effective to use as a wound-healing drug because of the compounds contained in saliva and people's experiences when using it.

Cytotoxicity and Anti-cancer Activity of the Genus Achillea L.

2020 ◽  
Vol 27 (41) ◽  
pp. 6910-6925 ◽  
Author(s):  
Konstantina Papakosta ◽  
Maria-Eleni Grafakou ◽  
Christina Barda ◽  
Ioannis V. Kostopoulos ◽  
Ourania Tsitsilonis ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Human Cancer ◽  
Biological Activities ◽  
Northern Greece ◽  
Human Cancer Cell Lines ◽  
Anti Cancer ◽  
Analgesic Agents ◽  
Selection Of

Background: The genus Achillea L. is rich in bioactive sesquiterpenes and flavonoids; most of the studied species exhibit several biological activities and are used as emmenagogue, wound healing and analgesic agents. Some species are also used in local folklore medicine. Objective: Following a literature survey, we discuss the anti-cancer properties of Achillea species, taking into consideration ethnopharmacological data on their use in traditional medicine for the treatment of cancer. In addition, we screened extracts and isolated secondary metabolites from A. coarctata for cytotoxicity, upon information based on local traditional medicine. The plant was collected in Kozani (Northern Greece), where it is locally used for treating gastrointestinal disorders, including stomach cancer. Methods: A selection of the relevant data was performed through a search in PubMed, Scopus, Google Scholar and Science Direct databases. In addition, extracts and isolated compounds from A. coarctata were tested for their in vitro activity against the human cancer cell lines MCF-7 and HeLa. Conclusion: The genus Achillea L. is a valuable source of bioactive secondary metabolites. The most significant outcome of the investigation of medicinal plants is the documentation and the assessment of the traditional information and its use and perspectives in the light of modern pharmacology.

scholarly journals Jamblang (Syzygium Cumini (L.) Dan Bioaktivitasnya

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Marina Silalahi
Keyword(s):  
Diabetes Mellitus ◽  
Traditional Medicine ◽  
Negative Impact ◽  
Home Garden ◽  
Syzygium Cumini ◽  
Comprehensive Information ◽  
Anti Cancer ◽  
On Line ◽  
Anti Inflammation ◽  
Better Than

Backgoun: Syzygium cumini is a species in the Myrtaceae, which is used as traditional medicine. In Indonesia S. cumini found in the yard and home garden, which use as producer of fruit and shading. The using of natural product as traditional medicine is better than sintetic, but improper has a negative impact. This article aims to explain the uses of S. cumini as traditional medicine and its bioactivity. Method: This article is based on the study of literature obtained on line and off line such as used Web, Scopus, Pubmed, and scientific journals, then synthesized according to the research objectives so that comprehensive information. Result: The traditional medicine of S. cumini have been used to cure diabetes mellitus, anti-inflammation, anti-ulcers, vaginal discharge, stomach disorders, fever, stomach aches, wounds, digestive disorders, and skin infection. The bioassay of S. cumini has activities as anti-diabetes mellitus, antioxidant, antimicrobial, anti-allergy, anti-hyperlipidemic, anti-cancer, gastroprotective, hepatoprotective, cardioprotective, anti-inflammatory, and anti-pyretic. Conclusion. Our study of S. cumini is very potential to be developed as an anti-diabetes mellitus drug because it is considered safer therefore it is necessary to do further research.

scholarly journals Eclipta prostrata (L.) L. (uses and bioactivities)

2022 ◽  
Vol 18 (1) ◽  
pp. 001-007
Author(s):  
Marina Silalahi
Keyword(s):  
Diabetes Mellitus ◽  
Literature Review ◽  
Traditional Medicine ◽  
Liver Disorders ◽  
Echinocystic Acid ◽  
Eclipta Prostrata ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
The Relationship ◽  
Cancer Activity

Eclipta prostrata has been long used by humans as traditional medicine and hair fertilizer. This study aims to explain the relationship between utilization and bioactivity of E. prostrata. The method used is a literature review of articles published online on Google Scholar using the keywords E. prostrata, uses E. prostrata, and bioactivity of E. prostrata. Ethnobotanically, E. prostrata is used to treat liver disorders, liver tonic, respiratory disorders (asthma, cough), hepatitis, snake venom poisoning, and gastritis. In the field of beauty E. prostrata is used to nourish hair and treat baldness. The E. prostrata has bioactivity to treat neurodegeneration, asthma, anti-cancer, overcoming baldness, anti-diabetes mellitus, anti-oxidant, anti-inflammatory, anti-microbial, hepatoprotective, anti-osteoporosis, and anti-hypercholesterolemia. The bioactivity of E. prostrata is related to the content of its secondary metabolite compounds. Echinocystic acid and ecclalbasaponin II from E. prostrata are associated with anti-cancer activity.

Flavonoids and other Non-Alkaloidal Constituents of Genus Erythrina: A Detailed Account of Phytochemical Review

2019 ◽  
Vol 23 ◽  
Author(s):  
Ninh The Son ◽  
Abdelsamed I. Elshamymistry
Keyword(s):  
Secondary Metabolites ◽  
Web Of Science ◽  
Herbal Medicines ◽  
Original Research ◽  
Chemical Structures ◽  
Fatty Acid Derivatives ◽  
Material Sources ◽  
Anti Cancer ◽  
Alkaloidal Constituents ◽  
The Web

: Genus Erythrina belongs to family Fabaceae, which widely distributed in tropical and subtropical areas, and has been applied in both traditional herbal medicines, and pharmacological uses. Original research articles and publications on overview of alkaloids related to this genus are available, but a supportive systematic review account highlighted phytochemical aspects of other types of secondary metabolites is now insufficient. Utilizing data information from SCI-Finder, Google Scholar, the Web of Science, Scopus, Science Direct, PubMed, Chemical Abstracts, ACS journals, Springer, Taylor Francis, Bentham Science and IOP Science, the reliable material sources of this systematic manuscript paper were obtained from the literature published from 1980s to now. A vast amount of data showed that the non-alkaloidal secondary metabolites obtained from genus Erythrina with various classes of chemical structures. Herein, approximately five hundred constituents were isolated comprising of flavonoids, terpenoids, saponins, phytosterols, phenols, arylbenzofurans, coumarins, alcohols, ceramides, mono-sugars and fatty acid derivatives. It resembles the previously phytochemical reports on the plants of differential genus of family Fabaceae, flavonoids reached to the high amount in plants of genus Erythrina. Numerous biological researches such as anti-microbacteria, anti-cancer, anti-virus using isolated compounds from Erythrina species suggested that secondary metabolites of Erythrina plants are now becoming promising agents for drug developments.

An Overview on Phytochemical and Pharmacological Profile of Morus alba Linn.

2020 ◽  
Vol 16 ◽  
Author(s):  
Arpita Paul ◽  
Monami Rajiung ◽  
Kamaruz Zaman ◽  
Sushil Kumar Chaudhary ◽  
Hans Raj Bhat ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Morus Alba ◽  
Biologically Active ◽  
Pharmacological Profile ◽  
Pharmacological Activities ◽  
Significant Information ◽  
The Past ◽  
Comprehensive Information ◽  
The Family ◽  
White Mulberry

Background: Morus alba Linn. commonly known as white mulberry, belongs to the family Moraceae, is a promising traditional medicine. In Asia, besides its use in the preparation of delicacies, every part of this plant is utilized in traditional medicine. Over the past decade, studies related to identification and isolation of biologically active compounds, with flavonoids as the major class of phytoconstituents, from this plant has been reported. These phytoconstituents are not only found to be beneficial for the maintenance of general health but also are associated with a range of potential pharmacological activities such as antioxidant, anti-inflammatory, anti-diabetic, anticancer, hepatoprotective, cardioprotective, neuroprotective to name a few. Objective: This review aims to provide upgraded and comprehensive information regarding the phytochemical, ethnomedicinal use and pharmacological profile of the plant Morus alba Linn. Method: The significant information has been collected through various database viz. PubMed, Scopus, Web of Science, Science Direct based on the recent findings, using different terms of Morus alba. Results: The outcome of the study suggests that Morus alba is a multifunctional plant numerous phytochemicals, and possess a range of pharmacological activities. Conclusion: The data assembled on Morus alba will be beneficial to trigger research in various fields of pharmaceutical and allied science to explore the medicinal importance of this unique plant.

A Prospective Review on Phyto-pharmacological Aspects of Vitex negundo Linn.

2019 ◽  
Vol 05 ◽  
Author(s):  
Mohd Faisal Khan ◽  
Poonam Arora ◽  
Mahaveer Dhobi
Keyword(s):  
Chlorogenic Acid ◽  
Biological Activities ◽  
Volatile Oil ◽  
Vitex Negundo ◽  
Bioactive Constituents ◽  
Traditional System ◽  
Comprehensive Information ◽  
Medicinal Properties ◽  
Main Components ◽  
Important Drug

Background: Vitex negundo Linn. commonly known as five leave chase tree is an ethnobotanically important drug in traditional system of medicine. The plant is widely distributed in India, China and other Asian and American countries. Objective: The review aims at presenting comprehensive information with respect to ethnopharmacological rele-vance and recent findings on phytochemical and biological activities of Vitex negundo. Method: Literature was collected from various sources such as pubmed, scopus, science direct, and others. Results: Extracts and secondary metabolites of this plant, particularly those from roots and leaves, possess useful pharmacological activities such as anti-inflammatory, antitumor, antioxidant, antimicrobial, galactagogue, antigas-tric, antiflatulant, antiparasitic, analgesic, hepatoprotective and antihypertensive, some of which have been vali-dated scientifically. All parts of plant especially leave and roots contain a large number of bioactive phytoconstitu-ents including flavonoids, iridoids, lignans, volatile oil, terpenes, coumarins, phenolic and steroidal compounds which impart it multiple medicinal properties. Vitexin, isovitexin, viridifol, caffeic acid, chlorogenic acid and iso-chlorogenic acid are the main components. Conclusion: The review emphasises the medicinal importance of Vitex negundo and its bioactive constituents in traditional system of medicine.

scholarly journals Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review

2021 ◽  
Vol 43 (1) ◽  
pp. 127-141
Author(s):  
Matúš Čoma ◽  
Veronika Lachová ◽  
Petra Mitrengová ◽  
Peter Gál
Keyword(s):  
Wound Healing ◽  
Side Effects ◽  
Biologically Active ◽  
Estrogen Receptor Modulators ◽  
Age Related ◽  
Skin Repair ◽  
Genistein Treatment ◽  
Anti Cancer ◽  
Major Factors ◽  
Promising Source

Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.

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