scholarly journals Eclipta prostrata (L.) L. (uses and bioactivities)

2022 ◽  
Vol 18 (1) ◽  
pp. 001-007
Author(s):  
Marina Silalahi
Keyword(s):  
Diabetes Mellitus ◽  
Literature Review ◽  
Traditional Medicine ◽  
Liver Disorders ◽  
Echinocystic Acid ◽  
Eclipta Prostrata ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
The Relationship ◽  
Cancer Activity

Eclipta prostrata has been long used by humans as traditional medicine and hair fertilizer. This study aims to explain the relationship between utilization and bioactivity of E. prostrata. The method used is a literature review of articles published online on Google Scholar using the keywords E. prostrata, uses E. prostrata, and bioactivity of E. prostrata. Ethnobotanically, E. prostrata is used to treat liver disorders, liver tonic, respiratory disorders (asthma, cough), hepatitis, snake venom poisoning, and gastritis. In the field of beauty E. prostrata is used to nourish hair and treat baldness. The E. prostrata has bioactivity to treat neurodegeneration, asthma, anti-cancer, overcoming baldness, anti-diabetes mellitus, anti-oxidant, anti-inflammatory, anti-microbial, hepatoprotective, anti-osteoporosis, and anti-hypercholesterolemia. The bioactivity of E. prostrata is related to the content of its secondary metabolite compounds. Echinocystic acid and ecclalbasaponin II from E. prostrata are associated with anti-cancer activity.

scholarly journals Utilization of Elephantopus scaber as traditional medicine and its bioactivity

2021 ◽  
Vol 15 (1) ◽  
pp. 112-118
Author(s):  
Marina Silalahi
Keyword(s):  
Diabetes Mellitus ◽  
Chest Pain ◽  
Traditional Medicine ◽  
Hair Growth ◽  
Local Communities ◽  
Anti Cancer ◽  
Elephantopus Scaber ◽  
Anti Fungal ◽  
The Relationship ◽  
Comprehensive Study

Elephantopus scaber has been used various ethnic groups in Indonesia and other countries as traditional medicine. Comprehensive study of the bioactivity of E. scaber is still limited, therefore this paper aims to explain the relationship between the use and its bioactivity. The writing of this article is based on a study of literature published online and offline used keywords E. scaber, bioactivities of E. scaber and uses of E. scaber. Ethnobotanically, E. scaber used to tread wound, nephritis, edema, chest pain, fever, scabies, sores, coughs, tonics, fever, and bronchitis, and asthma. The local communities in China, E. scaber leaves have been developed into "tea" to cure various diseases. The bioactivity of E. scaber is anti-bacterial, anti-fungal, anticancer, hepatoprotective, stimulates hair growth, anti-diabetes mellitus, anti-wound, antioxidant, and overcoming kidney disorders. Deoxyelephantopin is one of the main sesquiterpenes lactones derived from E. scaber has anti-cancer anticancer development. The development of E. scaber tea as an anti-cancer needs to be further investigated because this plant is very easy to find in Indonesia.

scholarly journals New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3888
Author(s):  
Boon-Peng Puah ◽  
Juriyati Jalil ◽  
Ali Attiq ◽  
Yusof Kamisah
Keyword(s):  
Immune Cells ◽  
Scientific Evidence ◽  
Special Role ◽  
Real Potential ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
The Relationship ◽  
Cancer Activity ◽  
Reduced Risk

Lycopene is a well-known compound found commonly in tomatoes which brings wide range of health benefits against cardiovascular diseases and cancers. From an anti-cancer perspective, lycopene is often associated with reduced risk of prostate cancer and people often look for it as a dietary supplement which may help to prevent cancer. Previous scientific evidence exhibited that the anti-cancer activity of lycopene relies on its ability to suppress oncogene expressions and induce proapoptotic pathways. To further explore the real potential of lycopene in cancer prevention, this review discusses the new insights and perspectives on the anti-cancer activities of lycopene which could help to drive new direction for research. The relationship between inflammation and cancer is being highlighted, whereby lycopene suppresses cancer via resolution of inflammation are also discussed herein. The immune system was found to be a part of the anti-cancer system of lycopene as it modulates immune cells to suppress tumor growth and progression. Lycopene, which is under the family of carotenoids, was found to play special role in suppressing lung cancer.

Design and synthesis of novel benzimidazoles containing 1,2,3-triazolesas in vitro, anticancer and anti-oxidant agents

2021 ◽  
Vol 25 (11) ◽  
pp. 104-109
Author(s):  
Gullapelli Kumaraswamy ◽  
Ravichandar Maroju ◽  
Srinivas Bandari ◽  
Gouthami Dasari ◽  
Gullapelli Sadanandam
Keyword(s):  
Spectroscopic Methods ◽  
Moderate Activity ◽  
Design And Synthesis ◽  
Anti Cancer ◽  
Excellent Activity ◽  
Test Organisms ◽  
Anti Oxidant ◽  
High Yields ◽  
Cancer Activity

A novel series of 2-(1-((1-substitutedphenyl-1H-1,2,3- triazol-4-yl)methoxy)ethyl)-1-((1-substituted phenyl- 1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazole (3a-j)derivatives was synthesized in moderate to high yields. The structures of all the synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopic methods. The title compounds were screened for their anti-oxidant activity and anti-cancer activity. The cancer activity results reveal that the compounds 3j, 3b and 3f are showing promising activity and remaining compounds exhibited moderate activity against all the tested cancer cell lines. The anti-oxidant activity also shows that the compounds 3c and 3d have shown excellent activity and remaining compounds were also found to exhibit moderate activity against the test organisms employed.

scholarly journals The relationship between periodontite and diabetes mellitus type ii facing the new classification of periodontal diseases: literature review

2020 ◽  
Vol 68 ◽  
Author(s):  
Lívia Maria Lopes de OLIVEIRA ◽  
Lívia Mirelle BARBOSA
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Literature Review ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
New Classification ◽  
The Relationship

ABSTRACT Periodontal disease and type 2 diabetes mellitus are considered chronic diseases that at their core have a deep relationship with inflammation. It is assumed that there is a bidirectional relationship between periodontal disease and type 2 diabetes mellitus. It is estimated that approximately 10% of the world’s population is affected by periodontal disease, in its most severe form, almost the same percentage estimated for people with diabetes, which is considered a 21st century emergency. The World Workshop for the Classification of Periodontal and Peri-implant Diseases and Conditions took place from September 9-11, 2017. The aim of this study is to analyze the results of this workshop with regard to the relationship between periodontal diseases/conditions and diabetes mellitus, in addition to conducting an integrative review on the topic. A literature review was conducted, using the Medline electronic databases via Pubmed, Scientific Electronic Library Online, Scientific and Technical Literature of Latin America and the Caribbean and Virtual Health Library. A new classification of periodontal disease included tools for individual assessment of the patient and recognizing risk factors that might negatively interfere in response to treatment. The occurrence of metabolic lack of control in periodontal patients with type 2 diabetes mellitus is now considered a factor of great importance for the assessment of individual susceptibility to the progression of periodontitis. Diabetes is believed to promote a hyper inflammatory response to bacterial challenge by modifying the tissue response of periodontal tissues.

scholarly journals Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248103
Author(s):  
Carsten Lange ◽  
Amanda Machado Weber ◽  
Ronny Schmidt ◽  
Christoph Schroeder ◽  
Thomas Strowitzki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Endometrial Cancer ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Metformin Treatment ◽  
Type Ii ◽  
Anti Cancer ◽  
Cancer Activity

The incidence of endometrial cancer (EC) has increased over the past years and mainly affects women above the age of 45 years. Metabolic diseases such as obesity and type II diabetes mellitus as well as associated conditions like polycystic ovary syndrome (PCOS), insulin resistance and hyperinsulinemia lead to elevated levels of circulating estrogens. Increased estrogen concentrations, in turn, further trigger the proliferation of endometrial cells and thus promote EC development and progression, especially in the absence of progesterone as seen in postmenopausal women. Elevated blood glucose levels in diabetic patients further contribute to the risk of EC development. Metformin is an insulin-sensitizing biguanide drug, commonly used in the treatment of type II diabetes mellitus, especially in obese patients. Besides its effects on glucose metabolism, metformin displayed anti-cancer effects in various cancer types, including EC. Direct anti-cancer effects of metformin target signaling pathways that are involved in cellular growth and proliferation, e.g. the AKT/PKB/mTOR pathway. Further proteins and pathways have been suggested as potential targets, but the underlying mechanism of action of metformin’s anti-cancer activity is still not completely understood. In the present study, the effects of metformin on protein expression were investigated in the human EC cell line HEC-1A using an affinity proteomic approach. Cells were treated with 0.5 mmol/L metformin over a period of 7 days and changes in the expression pattern of 1,300 different proteins were compared to the expression in untreated control cells as well as insulin-treated cells. Insulin treatment (100 ng/mL) was incorporated into the study in order to implement a model for insulin resistance and associated hyperinsulinemia, conditions that are often observed in obese and diabetic patients. Furthermore, the culture medium was supplemented with 10 nmol/L ß-estradiol (E2) during treatments to mimic increased estrogen levels, a common risk factor for EC development. Based on the most prominent and significant changes in expression, a set of 80 proteins was selected and subjected to a more detailed analysis. The data revealed that metformin and insulin targeted similar pathways in the present study and mostly acted on proteins related to proliferation, migration and tumor immune response. These pathways may be affected in a tumor-promoting as well as a tumor-suppressing way by either metformin treatment or insulin supplementation. The consequences for the cells resulting from the detected expression changes were discussed in detail for several proteins. The presented data helps identify potential targets affected by metformin treatment in EC and allows for a better understanding of the mechanism of action of the biguanide drug’s anti-cancer activity. However, further investigations are necessary to confirm the observations and conclusions drawn from the presented data after metformin administration, especially for proteins that were regulated in a favorable way, i.e. AKT3, CCND2, CD63, CD81, GFAP, IL5, IL17A, IRF4, PI3, and VTCN1. Further proteins might be of interest, where metformin counteracted unfavorable effects that have been induced by hyperinsulinemia.

scholarly journals Medicinal properties of Abutilon indicum

2018 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
S Rajeshwari ◽  
SP Sevarkodiyone
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Phytochemical Analysis ◽  
Vaginal Infections ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Larvicidal Activities ◽  
Abutilon Indicum

Abutilon indicum is a common Indian shrub, belonging to the family Malvaceae; Also known as Mallow in english, Abutilon indicum is used as a medicinal plant. It has been extensively used as a traditional medicine as a laxative, emollient, analgesic, anti-diabetic, anti-inflammatory and blood tonic agent and also in the treatment of leprosy, urinary disease, jaundice, piles, relieving thirst, cleaning wounds and ulcers, vaginal infections, diarrhea, rheumatism, mumps, pulmonary tuberculosis, bronchitis, allergy, blood dysentery, some nervous and some ear problems. Various studies on the plant extract have been performed to confirm the anti-oxidant, anti-bacterial, analgesic, anti-inflammatory, anti-cancer, hepato-protective, immuno-modulatory and larvicidal activities of the plant. This plant is often used as a medicinal plant and is considered invasive on certain tropical islands. In traditional medicine, A. indicum is used as a aphrodisiac, demulcent, diuretic, laxative, pulmonary and sedative (leaves). The bark is astringent and diuretic; laxative, expectorant and demulcent (seeds); laxative and tonic, anti-inflammatory and anthelmintic (plant); analgesic (fixed oil); diuretic and for leprosy (roots). The plant is very much used in Siddha medicines. In fact, the bark, root, leaves, flowers and seeds are all used for medicinal purposes by Tamils. The leaves are also used to treat for pile complaints. The flowers are traditionally used to increase semen in men. The phytochemical analysis showed the Presence of Alkaloid, Saponins, Amino acid, Flavonoids, Glycosides and steroids. This plant exhibits several potential pharmacological activities. A review on the various studies on the plant has been provided for the purpose of understanding its medicinal properties.

IN VIVO AND IN VITRO EVALUATION OF ANTI-CANCER ACTIVITY OF NEWLY SYNTHESIZED COBALT COMPLEX OF COUMARIN SCHIFF BASES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (04) ◽  
pp. 61-69
Author(s):  
A. Rayaji ◽  
A. H. M. Viswanatha Swamy ◽  
Keyword(s):  
Nitric Oxide ◽  
Hepg2 Cell ◽  
Cobalt Complex ◽  
Reducing Ability ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Hepg2 Cell Lines ◽  
Cancer Activity

Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocytes. Modern treatment of cancer includes chemotherapy, hormone therapy, radiotherapy and surgery but they are associated with several adverse effects such as alopecia, fatigue and general weakening of the body’s immune system due to bone marrow suppression. However, there is a continual need to look out for newer drugs to overcome the menace of cancer. In view of this we synthesized the new Coumarin-Cobalt complex derivatives. Structures of all the newly synthesized metal complexes are supported by Spectral data such as IR, NMR, and mass spectrometry. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity by in vivo anticancer activity (BrdU estimation). Immunohistochemical analysis has been done by BrdU and the synthesized compounds were screened for anti-oxidant activity and in vitro HepG2 cell lines. The IC50 values of the HepG2 cell lines as compared with that of standard Cisplatin and compounds IIIb, IIId, IIIe, IIIh and IIIj showed appreciable activity at a concentration less than 10 μG. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity. Anti-oxidant activity performed by Nitric oxide reducing ability, Superoxide dismutase and reducing activity:Compounds IIIc, IIIe and IIIg showed appreciable activity at 400μg/mL and 800 μg/mL screened by nitric oxide reducing ability, superoxide anion was effectively scavenged by compound IIIg at 400μg/mL and 800 μg/mL and reducing power of compounds IIIc and IIIj is comparable with standard ascorbic acid at concentrations 400μg/mL and 800 μg/mL.

Host–Guest Inclusion System of Luteolin with Polyamine-β-cyclodextrin: Preparation, Characterisation, Anti-oxidant and Anti-cancer Activity

2016 ◽  
Vol 69 (2) ◽  
pp. 174 ◽  
Author(s):  
Manshuo Liu ◽  
Rongqiang Liao ◽  
Yulin Zhao ◽  
Bo Yang
Keyword(s):  
Water Solubility ◽  
Inclusion Complexation ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
2D Nmr Spectroscopy ◽  
Binding Ability ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Cancer Activity

The characterisation, inclusion complexation behaviours, and binding ability of inclusion complexes of luteolin (LU) with four polyamine-modified β-cyclodextrins (NH2-βCD, EN-βCD, DETA-βCD, TETA-βCD; where EN = ethylenediamine; DETA = diethylenediamine; TETA = triethylenetetramine) were investigated in both the solid and solution forms by photoluminescence spectroscopy, 1H and 2D NMR spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. The results showed that the water solubility, and the anti-oxidant activity and anti-cancer activity of LU were significantly increased in the inclusion complex with polyamine-β-cyclodextrin. The LU/CDs complex will be useful for its application as herbal medicine or healthcare product.

scholarly journals Utilization and bioactivity of Blumea balsaminifera (L.) DC.

2021 ◽  
Vol 16 (2) ◽  
pp. 224-228
Author(s):  
Marina Silalahi
Keyword(s):  
Wound Healing ◽  
Secondary Metabolites ◽  
Literature Review ◽  
Traditional Medicine ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Volatile Oil ◽  
Flavonoid Glycosides ◽  
Comprehensive Information ◽  
Anti Cancer

Sembung or Blumea balsaminifera a species belonging of Asteraceae has been long used as a traditional medicine. The using of plants as traditional medicine, directly or indirectly related to their bioactive compounds. The writing of this article is based on literature review of the published online and offline such as journals, books, and other research to obtained comprehensive information of the benefits, secondary metabolites, bioactivity, and prospects for the use of B. balsaminifera. The ethnobotany of B. balsaminifera uses as an ingredient of loloh (Bali Aga ethnic health drink), treat of wounds, diarrhea, malnutrition, kidney stone, and traditional sauna ingredients, headaches, gastric disorders, and rheumatism. Blumea balsaminifera has bioactivity such as: anti-wound, anti-microbial, anti-cancer, gastroprotective, antioxidant, and anti-kidney stones. Blumea balsaminifera leaves contains volatile oil and falvonoid compounds. The volatile oil in B. balsaminifera is borneol, 1,8-cineole, limonene, kampor, β-eudesmol, β-champene, myrcene, dimethoxydurene, β-caryophyllene, and α-caryophyllene. The Dimethoxydurene, β-caryophyllene, and α-caryophyllene of B. balsaminifera have activities as antioxidant. The flavonoid glycosides of B. balsaminifera has a therapeutic effect on wound healing while anti-microbial activity has associated with borneol.

scholarly journals Study of drugs potential of fern collections at Purwodadi Botanic Gardens

2021 ◽  
Vol 10 (2) ◽  
pp. 199
Author(s):  
Elga Renjana ◽  
Muhamad Nikmatullah
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Literature Review ◽  
Traditional Medicine ◽  
Conservation Status ◽  
Iucn Red List ◽  
Red List ◽  
Botanic Gardens ◽  
Anti Cancer ◽  
Pharmacological Studies

Ferns (Pteridophyta) is the oldest group of plants on earth that has more than 11.000 species. Ethnobotany and pharmacological studies have revealed that ferns contain potentially secondary metabolites as medicine. Purwodadi Botanic Gardens (Purwodadi BG) has fern collections that have not revealed information about drug potential. This research was conducted to inventory Purwodadi BG’s fern collections which have potential as medicine and to determine their conservation status. Inventory of fern collections is carried out by collecting data from the Registration Unit and observing directly in the field, while information about drug potential is obtained by literature review. A total of 31 species of 171 specimens of Purwodadi BG’s fern collections are known to be efficacious for treating various diseases, both traditional medicine, and research results. As many as 6 species of fern collections that have medicinal potential are included in IUCN Red List and categorized as least concern/LC and critically endangered/CR. The potential for medicinal plants of fern collections include anti-oxidants, anti-inflammatory, anti-microbial, anti-viral, and anti-cancer properties. This potential information is expected to increase the value of the fern’s function and their conservation efforts.

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