scholarly journals Oral care precautions for patients with cystic fibrosis

2021 ◽  
Vol 3 (2) ◽  
pp. 073-079
Author(s):  
H. Goumghar ◽  
M. Sidqui
Keyword(s):  
Cystic Fibrosis ◽  
Oral Hygiene ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Oral Care ◽  
Poor Oral Hygiene ◽  
Optimal Care ◽  
Hygiene Practices ◽  
Medical Issues ◽  
Increased Risk

Cystic fibrosis (CF) is the most common severe autosomal recessive disease in the Caucasian population. Although it remains incurable, it is currently possible to extend the life expectancy of patients with modern therapeutic possibilities. Given the medical issues that a child with CF faces, oral health may be perceived as being of lesser importance. Thus, the establishment of good dietary and oral hygiene practices may not take place, leading to an increased risk of caries and gingivitis due to poor oral hygiene. A change in patient management may be necessary to ensure optimal care.

scholarly journals Capnocytophaga gingivalis Bacteremia After Upper Gastrointestinal Bleeding in Immunocompromised Patient

2021 ◽  
Vol 9 ◽  
pp. 232470962110206
Author(s):  
Folake J. Lawal ◽  
Stephanie L. Baer
Keyword(s):  
Gastrointestinal Bleeding ◽  
Oral Hygiene ◽  
Upper Gastrointestinal Bleeding ◽  
Immunocompromised Patient ◽  
Periodontal Diseases ◽  
Oral Care ◽  
Chronic Obstructive ◽  
Poor Oral Hygiene ◽  
Oral Flora ◽  
Upper Gastrointestinal

Odontogenic bacteremia, most commonly involving gram-positive oral flora, can result from daily self-care practices or professional dental procedures. Though usually transient and quickly cleared by the immune system, the presence of periodontal disease increases the frequency of exposure and risk of persistence of oral-systemic infections. Comorbidities such as asplenia, alcoholism, and immunocompromise increase the risk of complications of hematogenous spread and severe systemic illness. Capnocytophaga is a genus of anaerobic fastidious gram-negative bacilli, which is a common member of human oral flora, and its density is proportional to mass of dental plaques and periodontal diseases. Capnocytophaga spp that colonize humans are less virulent and are uncommon causes of bacteremia when compared with the Capnocytophaga typical of canines. C gingivalis has been rarely reported as a cause of disease in immunocompromised or immunocompetent hosts. In this article, we present a case of an immunocompromised 70-year-old man with poor oral hygiene, on methotrexate and prednisone for rheumatoid arthritis and sarcoidosis, who was admitted for chronic obstructive pulmonary disease exacerbation and developed C gingivalis bacteremia and septic shock after an episode of upper gastrointestinal bleeding. Poor oral hygiene in our patient is believed to have increased his risk as an immunocompromised patient to developing C gingivalis bacteremia. This case highlights the importance of oral care in immunocompromised patients especially while hospitalized, and those about to receive transplant, chemotherapy, or on immune modulators.

scholarly journals Therapeutic guidelines for the treatment of cystic fibrosis

Pharmacia ◽  
2021 ◽  
Vol 68 (1) ◽  
pp. 151-154
Author(s):  
Maria Becheva ◽  
Petar Atanasov
Keyword(s):  
Cystic Fibrosis ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Clinical Evaluations ◽  
Number Of Patients ◽  
Therapeutic Guidelines ◽  
Therapeutic Measures ◽  
One Year ◽  
Respiratory Rehabilitation

Cystic fibrosis (CF) is a complex, systemic autosomal recessive disease that affects the functions of the respiratory system, the digestive tract and all exocrine glands. The frequency for Europe averages 1: 2500 to 1: 3500 live births. The total number of patients with cystic fibrosis in Bulgaria is about 180. About 10% of the patients are diagnosed at birth. About 60–70% of patients are diagnosed before they reach one year of age. Respiratory symptoms predominate in the clinical picture in patients with cystic fibrosis and determine the prognosis in more than 90% of the patients. The treatment of patients with cystic fibrosis is strictly individualized, pharmacological and non-pharmacological and requires a comprehensive therapeutic approach. The complex therapy also includes bronchodilators, NSAIDs, corticosteroids, respiratory rehabilitation in combination with general body massage. Continued courses of broad-spectrum antibiotics are required to suppress chronic infection. With the progression of the disease, complications such as atelectasis, pneumothorax and pulmonary hemorrhages are observed. The establishment of specialized centers with trained and experienced professionals is essential in order to provide optimal patient care. These include frequent clinical evaluations, follow-up of complications, and early interventions for the treatment of patients with cystic fibrosis. The aim of the article is to familiarize the audience with the therapeutic measures applied in the treatment of patients with cystic fibrosis.

scholarly journals Neurodegenerative Disease Risk in Carriers of Autosomal Recessive Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Sophia R. L. Vieira ◽  
Huw R. Morris
Keyword(s):  
Genetic Risk ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Disease Risk ◽  
Late Onset ◽  
Gene Mutations ◽  
Carrier Status ◽  
Lysosomal Storage ◽  
Increased Risk ◽  
Distinct Allele

Genetics has driven significant discoveries in the field of neurodegenerative diseases (NDDs). An emerging theme in neurodegeneration warrants an urgent and comprehensive update: that carrier status of early-onset autosomal recessive (AR) disease, typically considered benign, is associated with an increased risk of a spectrum of late-onset NDDs. Glucosylceramidase beta (GBA1) gene mutations, responsible for the AR lysosomal storage disorder Gaucher disease, are a prominent example of this principle, having been identified as an important genetic risk factor for Parkinson disease. Genetic analyses have revealed further examples, notably GRN, TREM2, EIF2AK3, and several other LSD and mitochondria function genes. In this Review, we discuss the evidence supporting the strikingly distinct allele-dependent clinical phenotypes observed in carriers of such gene mutations and its impact on the wider field of neurodegeneration.

scholarly journals Association Between Infection With Campylobacter Species and the Risk of Esophageal Cancer: A Hospital-Based Case–Control Study in Thailand

2021 ◽  
Author(s):  
Arisara Poosari ◽  
Thitima Nutravong ◽  
Prakasit Sa-ngiamwibool ◽  
Wises Namwat ◽  
Supaporn Chatrchaiwiwatana ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
Poor Oral Hygiene ◽  
Increased Risk ◽  
History Of ◽  
Campylobacter Species ◽  
Control Study ◽  
Campylobacter Spp

Abstract Background Previous studies have shown the association between Campylobacter species infection and environmental factors, poor oral hygiene in particular, is linked to an increased risk of esophageal cancer (EC). However, no study has reported on these factors in Thai. Thus, this study objective was to evaluate the impact of the relationship between Campylobacter infection and environmental factors on EC incidence in the population Thailand. Methods Data from a case–control study were collected from 105 newly diagnosed EC cases and 105 controls recruited from 2007 to 2017. Infection with Campylobacter spp. was detected in the Formalin-fixed paraffin-embedded (FFPE) tissue of EC taken from gastroesophageal biopsy specimens obtained from the participants and evaluated using a TaqMan® real-time PCR. Multivariable logistic regression was performed to calculate the odds ratios (ORs) and perform data analysis. Results Smoking, alcohol use, a family history of cancer, history of gastroesophageal reflux disease, poor oral hygiene and Campylobacter spp. infection were shown to be significant risk factors for EC (p < 0.05). The combination of poor oral hygiene and infection with Campylobacter spp. constituted significant risk for EC (p < 0.001). In addition, the risk of EC in subjects co-infected with C. rectus and C. concisus practiced poor oral hygiene was even higher and was significant (ORadj = 4.7, 95%CI: 2.41–9.98, p = 0.003). Conclusions In Thailand, poor oral hygiene and infection with Campylobacter spp. was associated with an increased risk of EC.

scholarly journals ASTHMA IN CYSTIC FIBROSIS

2015 ◽  
Vol 64 (2) ◽  
pp. 118-121
Author(s):  
Marcela Daniela Ionescu ◽  
◽  
Ioana-Alina Anca ◽  
Mihaela Balgradean ◽  
◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Airway Obstruction ◽  
Autosomal Recessive ◽  
Pulmonary Infection ◽  
Autosomal Recessive Disease ◽  
Personal History ◽  
Common Symptom ◽  
Infection And Inflammation ◽  
History Of

Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians. Lung disease is characterized by impaired mucocilliary clearance with airway obstruction and chronic pulmonary infection and inflammation. Wheeze is a common symptom in CF, but in some cases the wheeze is due to the presence of concomitant asthma. There is no consensus on how to define CF asthma, but the diagnosis is predominantly based on the patient’s strong family and personal history of atopy.

EVALUATION OF CFTR CHANNEL FUNCTION AND RESPONSES TO MODULATORS FOR CYSTIC FIBROSIS PATIENTS WITH GENETIC VARIANT F508DEL

2020 ◽  
pp. 232-234
Author(s):  
A. Efremova ◽  
T. Bukharova ◽  
N. Petrova ◽  
N.Kashirskaya Kashirskaya ◽  
Y. Melyanovskaya ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Autosomal Recessive ◽  
Genetic Variant ◽  
Autosomal Recessive Disease ◽  
Target Therapy ◽  
Allelic Frequency ◽  
Common Life ◽  
Life Threatening ◽  
Cftr Protein ◽  
The Russian Federation

Cystic fibrosis (CF) is the most common life-threatening autosomal recessive disease. CF is caused by mutations in the CFTR gene that encodes an anionic channel, which is expressed in epithelial cells. The most common genetic variant is F508del, its allelic frequency in the Russian Federation 52.81% (2017). This variant belongs to class II, leads to incorrect folding of the CFTR protein and its premature degradation. Currently, the effectiveness of target therapy can be individually evaluated by forskolin-induced swelling (FIS) assay on intestinal organoids obtained from CF patients with different genotypes.

scholarly journals Mucus Distribution Model in a Lung with Cystic Fibrosis

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sara Zarei ◽  
Ali Mirtar ◽  
Forest Rohwer ◽  
Douglas J. Conrad ◽  
Rebecca J. Theilmann ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Volume Growth ◽  
Early Mortality ◽  
Distribution Model ◽  
Construction Process ◽  
Airway Wall ◽  
Single Patient ◽  
Live Births

Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians with a reported incidence of 1 in every 3200 live births. Most strikingly, CF is associated with early mortality. Host in flammatory responses result in airway mucus plugging, airway wall edema, and eventual destruction of airway wall support structure. Despite aggressive treatment, the median age of survival is approximately 38 years. This work is the first attempt to parameterize the distributions of mucus in a CF lung as a function of time. By default, the model makes arbitrary choices at each stage of the construction process, whereby the simplest choice is made. The model is sophisticated enough to fit the average CF patients' spirometric data over time and to identify several interesting parameters: probability of colonization, mucus volume growth rate, and scarring rate. Extensions of the model appropriate for describing the dynamics of single patient MRI data are also discussed.

scholarly journals Oral hygiene practices and their influence on the oral health of adolescents

2020 ◽  
Vol 7 (7) ◽  
pp. 2556
Author(s):  
Rekha P. Shenoy ◽  
Abdul Salam T. A. ◽  
Reema Agrawal ◽  
Prashanth Shenoy K.
Keyword(s):  
Dental Caries ◽  
Private Schools ◽  
Oral Hygiene ◽  
Rural Areas ◽  
Tooth Brushing ◽  
Poor Oral Hygiene ◽  
Public And Private ◽  
Hygiene Practices ◽  
High Prevalence ◽  
Urban And Rural Areas

Background: Oral diseases are major public health problems due to their high prevalence and significant social impact. Oral hygiene practices play a critical role in their prevention and control. This study was carried out to evaluate oral hygiene practices and oral status among adolescents in Mangalore taluk, taking into account differences based on location and type of school.Methods: A descriptive cross-sectional study was carried out among 1340 students enrolled in public and private high schools in urban and rural areas of Mangalore taluk. The study sample was equally distributed among urban and rural areas, and among public and private schools. Proforma was prepared to record demographic data, oral hygiene practices, dental caries and periodontal disease. Data were analyzed using Chi-squared test and t-test, with p<0.05 considered statistically significant.Results: Majority of the students used toothbrush and toothpaste to clean their teeth. Horizontal tooth brushing motion and once/twice daily tooth brushing frequency was reported by the highest number of students. Good oral hygiene was found among 55.2% participants. Female participants, urban children and those attending private schools presented with better oral hygiene. Prevalence of dental caries was 59.2%. Prevalence of gingivitis was 83.2%, with higher prevalence among females and rural participants. Poor oral hygiene was found to be associated with gingivitis (r=0.59).Conclusions: Although majority of the participants reported use of requisite oral hygiene aids and regular tooth brushing habits, the high prevalence of oral disease among them can be attributed to poor oral hygiene.

scholarly journals Cystic Fibrosis - Related Diabetes

2021 ◽  
Vol 11 (6) ◽  
pp. 42-46
Author(s):  
Marcin Makuch ◽  
Marcelina Makuch
Keyword(s):  
Cystic Fibrosis ◽  
Autosomal Recessive ◽  
Glucose Tolerance Test ◽  
Autosomal Recessive Disease ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Regulator Protein ◽  
Cystic Fibrosis Transmembrane

Cystic fibrosis (CF) is life-shortening autosomal recessive disease, caused by mutations in the cystic fibrosis transmembrane conductance regulator protein. The most common of CF complications is cystic fibrosis-related diabetes (CFRD). The pathophysiology of CFRD is complex. The best test for screening and diagnosis of CFRD is the oral glucose tolerance test (OGTT). Insulin therapy is a treatment of choice in CFDR pharmacotherapy. An inseparable element of CFRD therapy is also physical activity and diet.

scholarly journals THE ROLE OF CONNECTIVE TISSUE DYSPLASIA IN CHILDREN’S CYSTIC FIBROSIS. CLINICAL AND GENETIC ASPECTS

2018 ◽  
Vol 63 (5) ◽  
pp. 20-28
Author(s):  
A. V. Goryainova ◽  
P. V. Shumilov ◽  
N. Yu. Kashirskaya ◽  
S. Yu. Semykin
Keyword(s):  
Cystic Fibrosis ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Clinical Manifestations ◽  
History Of ◽  
Connective Tissue Dysplasia ◽  
Severe Fibrosis

The article considers the issue of cystic fibrosis – a monogenic autosomal recessive disease. It describes the history of the CFTR gene discovery, the further search for modifier genes to explain the variability of the clinical manifestations of cystic fibrosis. The review discusses problems of connective tissue dysplasia and somatic pathology, which is formed due to the connective tissue dysmorphogenesis in patients with cystic fibrosis; and also the article contains justification for the connection between the formation of severe fibrosis of the lungs and liver and the presence of clinical and genetic markers of connective tissue dysplasia. The author assumes that the clinical and genetic polymorphisms of connective tissue influence the course of cystic fibrosis, formation of bronchiectasis, interstitial pneumofibrosis, cystic fibrosis dysplasia, liver fibrosis and cirrhosis.

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