scholarly journals Pengaruh C-Phycocyanin Terhadap Kadar Soluble Glikoprotein (Sgp130) Pada Trofoblas Tikus Wistar Yang Dipapar Interleukin-6 (IL-6)

2018 ◽  
Vol 6 (1) ◽  
pp. 23
Author(s):  
Elizabeth Haryanti ◽  
Harry K Gondo
Keyword(s):  
Treatment Group ◽  
Interleukin 6 ◽  
Wistar Rats ◽  
Control Group ◽  
Placental Development ◽  
Successful Pregnancy ◽  
Treatment Groups ◽  
Significant Difference ◽  
Post Test ◽  
One Way Anova

The placenta is a joint organ of the uterus surface mother and fetus. One of cytokines of the placenta is IL-6 which is essential for normal placental development and successful pregnancy. Sgp130 binds Interleukin-6-sIL-6R complex, so Interleukin-6 signal cannot be passed on. Both factors play an important role in pre-eclampsia which has high levels of IL-6 and sgp130. They are expected to be suppressed by administration of C-phycocyanin. The aim of this study to prove effect of C-phycocyanin on sgp130 levels among wistar rats’ trophoblasts exposed to IL-6. The design of the study was Experiment, Post Test Only Control, analyse with One way Anova. The samples were 25 rats divided four treatment groups. Dose of C-Phycocyanin (10mg, 20mg, 40mg). The results significant difference between control and treatment group IL-6, IL-6 + CPC10, IL-6 + CPC20. But there was no significant difference between control group and IL-6 + CPC40, sig value. 0.214 (sig. <0.05). Conclusion. There is an effect of C-Phycocyanin on Sgp130 levels in wistar rats’ trophoblasts exposed to IL-6 at a dose of C-Phycocyanin 40mg.  

scholarly journals The Effectiveness Fig Leaves (FICUS CARICA L) Steeping Water Towards SGOT SGPT Serum on Male Wistar Rats in Critical Hepatitis Model

2019 ◽  
Vol 7 (1) ◽  
pp. 826-835
Author(s):  
Yosi Julianti ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Wistar Rats ◽  
Ficus Carica ◽  
Negative Group ◽  
Positive Group ◽  
Treatment Groups ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Food And Drink ◽  
One Way Anova

Critical Hepatitisis is the inflammation of the liver that is caused by viruses, alchol and drugs which are characterized by the increasing values of SGOT SGPT. The purpose of this study is to determine the effectiveness of fig leaves (Ficuss carica L) steeping water towards the decrease of SGOT SGPT serum on male wistar rats in critical hepatitis model. The object of this study is 30 male wistar rats with the age of 2-3 months and weight 180-200 grams and randomly divide into 3 groups, which are the negative group that is only by giving an usual food and drink, the positive group and the treatment groups are given paracetamol 120mg/ oral for 7 days. The treatment group is given 0.65 gram/ day of fig leaves steeping water for 7 days. One way ANOVA of SPSS version 24 is used to analyze this research. The result of the study shows that there is a significant difference in SGOT serum level between the treatment group, positive group and negative group (p<0,05). And there is a significant difference  in SGPT level between the treatment group and the positive group (p<0,05). The conclusion of this study is tin leaves (Ficus carica L) steeping water has an effect towards the decrease of SGOT SGPT in male Wistar rats in critical hepatitis model.

scholarly journals Pengaruh Pelatihan Quick Leap dan Double Leg Speed Hop terhadap Power Otot Tungkai

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
I Ketut Addy Putra Indrawan ◽  
I Ketut Yoda ◽  
I Nyoman Sudarmada
Keyword(s):  
Treatment Group ◽  
Muscle Power ◽  
Control Group ◽  
Significance Level ◽  
Significant Difference ◽  
Post Test ◽  
Randomized Control ◽  
Leg Muscle ◽  
One Way Anova ◽  
Leg Muscle Power

Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan quick leap dan double leg speed hop terhadap peningkatan power otot tungkai. Rancangan penelitian ini adalah the non-randomized control group pretest posttest design. Subjek penelitian adalah siswa putri peserta ektrakurikuler bolavoli SMP Negeri 3 Mendoyo berjumlah 45 orang. Data dianalisis dengan uji F (one way anova) pada taraf signifikansi (α) = 0,05 dengan bantuan program SPSS 16.0. Hasil analisis data pada kelompok perlakuan quick leap terjadi peningkatan power otot tungkai sebesar 27,4 pada kelompok perlakuan double leg speed hop sebesar 11,6 dan pada kelompok kontrol sebesar 0,33. Hasil uji one way anova variabel power otot tungkai antara kelompok perlakuan dan kelompok kontrol didapat Fhitung sebesar 22,325 dan signifikasi 0,000 yang berarti terdapat perbedaan pengaruh antara pelatihan quick leap dan double leg speed hop terhadap power otot tungkai. Disimpulkan bahwa; (1) pelatihan quick leap dan double leg speed hop berpengaruh signifikan terhadap peningkatan power otot tungkai. (2) terdapat perbedaan pengaruh signifikan antara pelatihan quick leapp dan double leg speed hop terhadap peningkatan power otot tungkai. (3) pelatihan quick leap lebih baik dari pada double leg speed hop terhadap peningkatan power otot tungkai. Saran; (1) bagi pelatih disarankan dapat menggunakan pelatihan ini dalam meningkatkan power otot tungkai. (2) bagi atlet perlu memperhatikan set dan repetisi yang tepat karena setiap individu memiliki kemampuan berbeda. (3) bagi peneliti yang ingin melakukan penelitian sejenis disarankan menggunakan variabel dan sampel penelitian berbeda. Kata Kunci : Kata-kata kunci: quick leap, double leg speed hop, daya ledak otot tungkai. Abstract This study aims to determine the effect of leap quick and double leg speed hop research to increase leg muscle power. The design of this study is the non-randomized control group pretest post-test design. The subjects were female students who join volleyball extracurricular SMP Negeri 3 Mendoyo amounted to 45 students. Data were analyzed by F (one way anova) test at significance level (a) = 0.05 with the help of SPSS 16.0. The results of data analysis in the quick leap treatment group, an increase on lamb muscle power of 27.4, in the treatment group double leg speed hop of 11.6 and in the control group of 0.33. One way anova variable of limb muscle power variable between treatment group and control group was obtained Fcount 22.225 and significance 0.000, which means difference of influence between quick leap and double leg speed hop training toward leg muscle power. It was concluded that; (1) the influence between quick leap and double leg speed hop training significantly influenced the increase of leg muscle power, (2) there is significant difference of influence between quick leap and double leg speed hop training toward increasing leg muscle power, (3) quick leap training more Both on double leg speed hop against increased leg muscle power. Suggestion: (1) for trainers it is advisable to use this training in improving leg muscle power, (2) for athletes need to care for cells and proper repetition because each individual has different capabilities, (3) for researchers who want to do similar research is suggested using variables and Different research samples. keyword : Key Words: quick leap, double leg speed hop, explosive muscle limb power.

scholarly journals Oral Candidiasis in Immunosuppressed Wistar Rats (Rattus norvegicus) Post Dexamethasone Injection at 7.2 mg/kg and 16 mg/kg Doses

2020 ◽  
Vol 23 (4) ◽  
pp. 7p
Author(s):  
Ucy Nur Hamida Al Abrori ◽  
Nurina Febriyanti Ayuningtyas ◽  
Diah Savitri Ernawati ◽  
Hening Tuti Hendarti ◽  
Meircurius Dwi Condro Surboyo ◽  
...  
Keyword(s):  
Treatment Group ◽  
Group Treatment ◽  
Wistar Rats ◽  
Oral Candidiasis ◽  
Control Group ◽  
Clinical Appearance ◽  
Significant Difference ◽  
Group 2 ◽  
Hyphal Formation ◽  
One Way Anova

Objective: Oral candidiasis is an infection that occurs in the oral cavity and is caused by candida species, often Candida albicans. This infection commonly occurs in a condition of immunosuppression caused by dexamethasone. Due to the side effects of antifungal therapy, developing a standardized immunosuppressed animal model to induce oral candidiasis for new therapies is required. The aim of this study is to observe oral candidiasis in immunosuppressed Wistar rats post dexamethasone injection at 7.2 mg/kg and 16 mg/kg doses. Material and Methods: Twenty-one Wistar rats were divided into three groups: control group, treatment group 1 (injected with dexamethasone at a concentration of 7.2 mg/kg), and treatment group 2 (at a concentration of 16 mg/kg) for five days. Immunosuppression status was observed by leukocyte count and all the subjects’ palates were inoculated with C.albicans 0.1 ml of 15x108 UFC/ml 24 hours later. The subjects’ tongues were observed and confirmed by laboratory examination on day 10. A statistical analysis was performed using one way ANOVA, Kruskal–Wallis, Tukey HSD, and Mann-Whitney U tests. Results: A significant clinical appearance of the subjects’ tongues was observed only between C and T1 (p=0.023;p<0.05). Significant hyphal formation was observed between C and T1 (p= 0.037;p<0.05) and between C and T2 (p=0.007;p<0.05), and no significant difference was observed between T1 and T2. A significant increase in the colony count was also observed in similar results. Conclusion: Dexamethasone injection at doses of 7.2 mg/kg and 16 mg/kg is effective in triggering immunosuppression to induce oral candidiasis in immunosuppressed Wistar rats. Keywords Dexamethasone; Immunosuppression; Oral candidiasis.

scholarly journals The Effect of Music Therapy on Pain The Level of Postoperative Patients' with Caesarean Section at Islamic Hospital A.Yani, Surabaya

2015 ◽  
Vol 5 (2) ◽  
Author(s):  
Nanik Handayani
Keyword(s):  
Treatment Group ◽  
Caesarean Section ◽  
Music Therapy ◽  
Control Group ◽  
Pain Level ◽  
Pharmacological Management ◽  
Treatment Groups ◽  
Significant Difference ◽  
Post Test ◽  
Test Control

Pain is the most common effects in patients after undergoing surgery of Caesarean section. Pain management using pharmacological and non pharmacological management, one of non-pharmacological management is using music therapy The purpose of this study was to analyze the effect of music therapy on pain level of postoperative patients' with Caesarean section. The type of study is analytic with True Experimental type with Pre Post Test Control Group Design done by Random Allocation. The study population is post-operative Caesarean section mothers who are hospitalized in Surabaya Islamic Hospital Surabaya Jl. A Yani since May 2011. The Sample are some populations above mentioned with amount of 24 respondents, 12 respondents as a control and 12 respondents were given music therapy. The Sampling technique uses Consecutive Sampling. Independent variable is music therapy and dependent variable is pain level. The instrument used to measure the independent variables is a check sheet lists while the dependent variable is Descriptive Pain Intensity Scale. To analyze the changes of pain level in the control group and the treatment used Paired T Test, the result showed that values of ρ is 0.166 or (ρ > 0.05), so there is no significant change of pain level on a pre test and post test control group, whereas in treatment group obtained value of ρ is 0.000 or (ρ < 0.05), so there is a significant change of pain level on a pre test and post test. To analyze differences of pain levels in control group and treatment group is used Independent T Test. The results of study got value of ρ is 0.807 (ρ > 0.05). So there is no significant difference of pain level pre test in control and treatment groups, while the post test value of ρ is 0.024 (ρ < 0.05). So there is a significant difference of pain level post test in control and treatment groups. So it can be conclude that there is influence of music therapy toward pain levels of postoperative patients of Caesarean section. Music therapy is expected to be used as a Complementary Therapy to reduce pain at the incision Caesarean section.

scholarly journals Evaluation of osteogenic properties after application of hydroxyapatite-based shells of Portunus pelagicus

2021 ◽  
Vol 54 (3) ◽  
pp. 119
Author(s):  
Michael Josef Kridanto Kamadjaja ◽  
Alya Nisrina Sajidah Gatia ◽  
Agtadilla Novitananda ◽  
Lintang Maudina ◽  
Harry Laksono ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Control Group ◽  
Portunus Pelagicus ◽  
Treatment Groups ◽  
Significant Difference ◽  
Hydroxyapatite Gel ◽  
One Way Anova ◽  
Bone Dimensions

Background: After tooth extraction, the socket leaves a defect on the alveolar bone. The administration of shell crab-derived hydroxyapatite maintains bone dimensions that are important for achieving successful prosthodontic treatment. Purpose: The aim of the study was to determine the osteogenic properties, such as the number of osteoclasts, osteoblasts and osteocytes, after the application of hydroxyapatite-based shell crab in the post-extraction sockets of Wistar rats. Methods: There were two groups: the control group (K) and the treatment group (T). Wistar rats were randomly divided into control and treatment groups. After tooth extraction, hydroxyapatite gel derived from Portunus pelagicus shells was applied to the tooth sockets of Wistar rats. Observations and calculations of osteoclasts, osteoblasts and osteocytes were carried out on the 14th and 28th days under a light microscope with 400 times magnification. Statistical analysis was performed using one-way ANOVA. Results: There was a significant difference (p<0.05) between the K14 and P14 groups, K28 and P28 groups, K14 and K28 groups, and P14 and P28 groups. The results indicated that there were significant differences between groups of variables. Conclusion: The application of shell crab-derived hydroxyapatite (Portunus pelagicus) was able to decrease the number of osteoclasts and increase the number of osteoblasts and osteocytes.

Particular Matter of Motor Vehicle Exposure and High-Fat Diet Effects on Kidney Histopathology, Creatinine, and Malondialdehyde (MDA) Levels in Wistar Rats

2021 ◽  
Vol 5 (3) ◽  
pp. 124-128
Author(s):  
Rizka Veni ◽  
Awal Prasetyo ◽  
Muflihatul Muniroh
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Motor Vehicle ◽  
Histopathological Change ◽  
Normal Diet ◽  
Control Group ◽  
High Fat ◽  
Control Group Design ◽  
Treatment Groups ◽  
Significant Difference

This study aims to analyze the effect of combination of motor vehicle particular matter exposure and high-fat diet in kidney histopathology, creatinine levels, and MDA levels in Wistar rats. This study used a posttest-only control group design. Eighteen healthy male Wistar rats were divided into three groups. The intervention groups received motor vehicle fume exposure for 100 s with normal diet (X1) or high-fat diet (X2), and the control group received no exposure (C). Data analysis was processed with a SPSS 25.0 computer program by using the one-way ANOVA test followed by post hoc LSD. The degree of kidney histopathological damage showed significant differences between the X1 and X2 groups when compared with the control group (p < 0.05). The results of the creatinine level examination found a significant difference between the X2 and C groups (p < 0.05) and the treatment groups X1 and X2 (p < 0.05). The results of kidney MDA level examination showed a significant difference between the treatment groups (X1 and X2) and the control group (p < 0.05). The combination of particular matter of motor vehicle fumes exposure and high-fat diet could induce kidney damage through histopathological change and increased creatinine levels and kidney MDA levels in Wistar rats.

scholarly journals The Effect of Aloe Vera Extract to Extensive Lesion and Expression of Transforming Growth Factor (TGF-β) on Alkaline Chemical Trauma Cornea Model

2018 ◽  
Vol 1 (2) ◽  
pp. 1-17
Author(s):  
Fahcreza ◽  
Elsa Iskandar ◽  
Rachmat Hidayat ◽  
Petty Purwanita ◽  
Anang Tribowo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Wistar Rats ◽  
Aloe Vera ◽  
Control Group ◽  
Treatment Groups ◽  
White Rats ◽  
Significant Difference ◽  
The Difference ◽  
In Cells

Abstract Background: Chemical trauma to the cornea is an emergency condition of the eye that requires early diagnosis and good treatment. Alkaline have ability to saponify fatty acids in cells and cell membranes which can make penetration into the stroma and destroy proteoglycans and collagen in cells. Aloe vera (AV) contains several active substances that are reported to have anti-inflammatory, immunomodulatory, and wound healing effects. AV has been reported to accelerate the healing process of corneal epithelial defects by increasing fibroblast proliferation, collagen production and growth factor production. This study aims to determine the difference between the effect of aloe vera extract with a concentration of 10%, 20%, 40% and BSS on the healing of extensive corneal lesions in white wistar rats alkaline trauma models. Method: This study was an experimental study with a pre and posttest only with control group design in vivo approach to 30 Wistar white rats which were divided into 5 treatment groups for 3 days. Comparative analysis of effectiveness using the ANNOVA test or the Kruskal Wallis test and continued by the post hoc test. Results: Based on the one way ANOVA test there was a statistically significant difference in effectiveness between the five treatment groups on the percentage of corneal wound healing area and TGF-β expression with an assessment of p = 0,000 each. The administration of alloevera (AV) concentration of 20% had a significant difference in percentage of healing of corneal lesions and TGF-β expression compared with other treatment groups with p = 0,000 each. Large differences in the area of corneal lesions in the 40% AV group were -0.45 in the BBS group, 0.146 in the 10% AV group, 0.493 in the 20% AV group. The difference in the AV group 10% was 0.30 in the BBS group, -064 in the AV group 20%, and -0.14 in the AV group 40%. However, TGFβ expression in the normal control group that did not receive treatment was 54.94 (53.21-56-12). TGFβ levels in the BSS group were 10.44, the 10% aloe vera group was 25.43, 47.99 for the 20% aloe vera group and 37.95 for the 40% aloe vera group. Conclusion: There is a difference between the effect of aloe vera extract with concentrations of 10%, 20%, 40% and BSS on the extensive healing of corneal lesions in white wistar rats with alkaline chemical trauma models.

scholarly journals THE TRAINING OF GRATEFULNESS IN IMPROVING LIFE MEANING OF CONVICTS AT CLASS 2 LPKA PEKANBARU

2020 ◽  
Vol 6 (1) ◽  
pp. 42-47
Author(s):  
Vivik Shofiah ◽  
Khairunnas Rajab
Keyword(s):  
Treatment Group ◽  
Meaning Of Life ◽  
T Test ◽  
Average Score ◽  
Control Group ◽  
Life Meaning ◽  
Treatment Groups ◽  
Know How ◽  
Post Test ◽  
Test Control

Religious values need are very imporant for convicts at LPKA Class two Pekanbaru. Religion is an obvious influenced source in issuing the meaning of life to convicts. The research objective is to know how far the influence of gratefulness training in improving life meaning of convicts at LPKA class two Pekanbaru is.The researcher used experiment approaching pre and post-test control group designwith 23 control groupsand 23 treatment groups,anddata analysis independent sample t-test was obtained score  t= 6,894 (p<0,01). Average score from treatment group are higher  (23,057) than control group average (15,6). It shows that life meaning of convicts who get gratefulness training are higher than convicts who don’t join the training. With thus, it can be concluded that gratefulness training very influence significantly to the life meaning of convicts at LPKA class 2 Pekanbaru.

scholarly journals Anti-Inflammatory Effect of Musa acuminata Stem

2020 ◽  
Vol 14 (02) ◽  
pp. 294-298
Author(s):  
Maharani Laillyza Apriasari ◽  
Selviana Rizky Pramitha ◽  
Dewi Puspitasari ◽  
Diah Savitri Ernawati
Keyword(s):  
Treatment Group ◽  
Musa Acuminata ◽  
Control Group ◽  
Control Group Design ◽  
Treatment Groups ◽  
Tnf Α ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
Mucosal Wound ◽  
Inflammatory Effect

Abstract Objective This study was designed to assess the anti-inflammatory effect of Musa acuminata through the expression of tumor necrosis factor-α (TNF-α) and nuclear factor kappa β (NF-κB) after 3 days of application of Musa acuminata stem extract (MASE) gel on oral mucosal wound. Materials and Methods An experimental study with post-test only control group design was conducted. Twenty male Rattus norvegicus (Wistar) were injured on their left buccal mucosa and treated three times a day with MASE gel of varying concentrations: 0% (as control), MASE 25%, MASE 37.5%, and MASE 50%. On day 3, a biopsy was performed on each mucosal wound for later immunohistochemical analysis for the expressions of TNF-α and NF-κB. Results The highest expression of TNF-α was observed in the control group (13.20 ± 1.79), while the lowest was in the treatment group using 50% MASE (6.40 ± 1.14). Meanwhile the comparison between treatment groups did not highlight any significant difference (p > 0.05). The highest expression of NF-κB was observed in the control group (13.20 ± 1.30), whereas the lowest was in the treatment group using MASE 50% (6.40 ± 1.14). NF-κB was significantly lower in the treatment group using MASE 50% when compared with other treatment groups (p < 0.05). Conclusion Application of MASE on mucosal wound reduces the expression of TNF-α and NF-κB at all concentrations. The anti-inflammatory effect of MASE 50% was the strongest one.

scholarly journals Esktrak ikan haruan (Channa striata) menurunkan jumlah makrofag pada fase inflamasi proses penyembuhan luka (Extract of haruan (Channa striata) decreases macrophages count in inflammation phase of wound healing process )

2015 ◽  
Vol 14 (1) ◽  
pp. 6
Author(s):  
Putri Sri Hartini ◽  
Nurdiana Dewi ◽  
Lisda Hayatie
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Wistar Rats ◽  
Healing Process ◽  
Positive Control ◽  
Wound Healing Process ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Post Test ◽  
Channa Striata

Haruan is a kind of freshwater fishes commonly found in South Kalimantan. Haruan extract contains nutritional substancessuch as albumin, Zn, Fe, Cu, and unsaturated fatty acid which can help accelerate wound healing. The aim of this studywas to histopathologically assess the effect of 100%, 50%, and 25%haruan extract compared to aquadest and ibuprofenon macrophages count in inflammation phase of wistar rats’ buccal mucosa wound healing. This research was a trueexperimental with post test-only with control design. Samples used were 30 wistar rats divided into 5 groups, 100%, 50%,25% haruan extract treatment groups, ibuprofen treatment group as positive control, and aquadest treatment group asnegative control. Mean macrophages counted on day 3 of 100%, 50%, 25% haruan extract treatment groups aquadest,and ibuprofenl were 2.05, 4.4, 3.9, 3.3, 2.4 respectively. In conclusion, haruan extract had a significant effect in decreasingmacrophages count in inflammation phase of wound healing.

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