scholarly journals Rotula aquatica. Lour-A Review on Medicinal uses Phytochemistry and Pharmacological actions

2017 ◽  
Vol 5 (04) ◽  
pp. 04-09
Author(s):  
Baby T. Bency ◽  
K. Remya ◽  
Smitha Rani ◽  
Shebina P. Rasheed ◽  
A. K. Azeem
Keyword(s):  
Clinical Trials ◽  
Medicinal Herb ◽  
Therapeutic Effects ◽  
Preclinical Studies ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
The Family ◽  
Stream Beds ◽  
Anti Inflammatory

Rotula aquatic Lour is an important medicinal herb in Ayurvedic system of medicine. The plant occurs as a small branched shrub that grows characteristically among rocks and trailing over pebbles in stream beds, belonging to the family Boraginaceae and widely distributed throughout India. It is commonly called as Pasanabheda in Ayurveda. As only few studies are done on this plant, the comprehensive review presenting here will summarize regarding its Phytochemical and Pharmacological activities with the help of available and update information. Various studies indicated the antiurolithiatic, hypoglycemic, anti-inflammatory, antibacterial and anthelmintic properties of Rotula aquatica. Although the information are very encouraging and revealed some of the constituents of the plant like polyphenols and tannins as important therapeutically agents. The herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Various traditional claims of the plant are still remain to be validated scientifically. Clinical trials for the reported preclinical studies should be performed urgently to further validate the claims on humans

A Review of Phytochemical and Pharmacological Studies of Inula Species

2020 ◽  
Vol 16 (5) ◽  
pp. 557-567
Author(s):  
Aparoop Das ◽  
Anshul Shakya ◽  
Surajit Kumar Ghosh ◽  
Udaya P. Singh ◽  
Hans R. Bhat
Keyword(s):  
Bacterial Infections ◽  
Chemical Constituents ◽  
Valuable Insight ◽  
Important Ingredient ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
The Family ◽  
Pharmacological Studies ◽  
Perennial Herbs ◽  
Insight Into

Background: Plants of the genus Inula are perennial herbs of the family Asteraceae. This genus includes more than 100 species, widely distributed throughout Europe, Africa and Asia including India. Many of them are indicated in traditional medicine, e.g., in Ayurveda. This review explores chemical constituents, medicinal uses and pharmacological actions of Inula species. Methods: Major databases and research and review articles retrieved through Scopus, Web of Science, and Medline were consulted to obtain information on the pharmacological activities of the genus Inula published from 1994 to 2017. Results: Inula species are used either alone or as an important ingredient of various formulations to cure dysfunctions of the cardiovascular system, respiratory system, urinary system, central nervous system and digestive system, and for the treatment of asthma, diabetes, cancers, skin disorders, hepatic disease, fungal and bacterial infections. A range of phytochemicals including alkaloids, essential and volatile oils, flavonoids, terpenes, and lactones has been isolated from herbs of the genus Inula, which might possibly explain traditional uses of these plants. Conclusion: The present review is focused on chemical constituents, medicinal uses and pharmacological actions of Inula species and provides valuable insight into its medicinal potential.

scholarly journals Bauhinia purpurea: An Updated Pharmacological Profile

2020 ◽  
Vol 6 (2) ◽  
pp. 81-85
Author(s):  
SumitKArora ◽  
◽  
MaviyaHussain ◽  
SubhashRYende ◽  
KeshavMoharir ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cardiac Activity ◽  
Pharmacological Profile ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Cytoprotective Activity ◽  
Bauhinia Purpurea ◽  
Anti Inflammatory ◽  
Pharmacological Potential

Bauhinia purpurea (B. purpurea) (family: Fabaceae) commonly called as butter fly tree has vast medicinal uses and remarkable pharmacological potential. Various phytoconstituents, extracts and parts of this plant were possess significant pharmacological activities such as cardiac activity, antifungal, wound healing, antidiabetic, antiulcer, antioxidant, antinociceptive, hepatoprotective, nephroprotective, antidiarrhoeal, anti-inflammatory, antipyretic, analgesic, antimalarial, gastro protective and cytoprotective activity. The present study emphasizes the overview of recent studies and/or updates on pharmacological potential of B. purpurea.

Health benefits of avicularin in the medicine against cancerous disorders and other complications: Biological importance, therapeutic benefit and analytical aspects of the medicine

2021 ◽  
Vol 17 ◽  
Author(s):  
Kanika Patel ◽  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Scientific Data ◽  
Lespedeza Cuneata ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Biological Importance ◽  
Anti Cancer ◽  
Scientific Data Analysis ◽  
Different Types ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals have been used in medicine for the preparation of different types of pharmaceutical products. Pure phytochemicals including flavonoids, alkaloids and terpenoids have been used in medicine for the treatment of different types of human disorders including cancerous disorders. Flavonoids have been well known in medicine for their anti-viral, anti-bacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-aging and cardioprotective potential. Avicularin, also called quercetin-3-α-l-arabino furanoside, is a pure flavonoid, a class of phytochemicals, found to be present in Lindera erythrocarpa and Lespedeza cuneata. Avicularin has been well known in medicine for its anti-cancer properties. Methods: In the present work, scientific data of avicularin have been collected from different databases such as Google, PubMed, Science Direct, Google Scholar and Scopus and summarized with reference to medicinal importance, pharmacological activities and analytical aspects of avicularin. The present review summarized the health beneficial properties of avicularin in medicine through data analysis of various scientific research works. Further analytical progress in medicine for the qualitative and quantitative analysis of avicularin in medicine has been also discussed in the present work. Results: Scientific data analysis of different literature work revealed the biological importance of flavonoid class of phytochemical ‘avicularin’ in medicine. Scientific data analysis revealed that avicularin was found to be present in the Lindera erythrocarpa, Lespedeza cuneata, Rhododendron schlipenbachii and Psidium guajava. Avicularin has been well known in medicine for its anti-inflammatory, anti-allergic, anti-oxidant, anti-tumor and hepatoprotective activities. Avicularin protects cardiomyocytes and hepatocytes against oxidative stress-induced apoptosis and induces cytotoxicity in cancer lines and tumor tissues. Avicularin has positive influence on human hepatocellular carcinoma and inhibits intracellular lipid accumulation. The role of avicularin in rheumatoid arthritis has been also established with its underlying molecular mechanisms in the scientific work. Recent interest in avicularin has focused on pharmacological investigations for its anti-cancer activity in the medicine. Conclusion: The present work signified the biological importance of avicularin in medicine through its medicinal uses, pharmacological activities and analytical aspects in the biological system.

scholarly journals What Is the Role of Interleukins in Breast Cancer Bone Metastases? A Systematic Review of Preclinical and Clinical Evidence

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2018 ◽  
Author(s):  
Francesca Salamanna ◽  
Veronica Borsari ◽  
Deyanira Contartese ◽  
Viviana Costa ◽  
Gianluca Giavaresi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Bone Metastases ◽  
Metastatic Breast ◽  
World Health ◽  
Therapeutic Effects ◽  
Preclinical Studies ◽  
Functional Roles ◽  
Novel Strategy ◽  
Health Organization

Breast cancer cells produce stimulators of bone resorption known as interleukins (ILs). However, data on the functional roles of ILs in the homing of metastatic breast cancer to bone are still fragmented. A systematic search was carried out in three databases (PubMed, Scopus, Web of Science Core Collection) to identify preclinical reports, and in three clinical registers (ClinicalTrials.gov, World Health Organization (WHO) International Clinical Trials Registry Platform, European Union (EU) Clinical Trials Register) to identify clinical trials, from 2008 to 2019. Sixty-seven preclinical studies and 11 clinical trials were recognized as eligible. Although preclinical studies identified specific key ILs which promote breast cancer bone metastases, which have pro-metastatic effects (e.g., IL-6, IL-8, IL-1β, IL-11), and whose inhibition also shows potential preclinical therapeutic effects, the clinical trials focused principally on ILs (IL-2 and IL-12), which have an anti-metastatic effect and a potential to generate a localized and systemic antitumor response. However, these clinical trials are yet to post any results or conclusions. This inconsistency indicates that further studies are necessary to further develop the understanding of cellular and molecular relations, as well as signaling pathways, both up- and downstream of ILs, which could represent a novel strategy to treat tumors that are resistant to standard care therapies for patients affected by breast cancer bone disease.

Minocycline: a bacteriostatic antibiotic with pleiotropic cardioprotective effects

2015 ◽  
Vol 93 (10) ◽  
pp. 863-866 ◽  
Author(s):  
Jorge A. Brenes-Salazar
Keyword(s):  
Clinical Trials ◽  
Therapeutic Agent ◽  
Mechanisms Of Action ◽  
Clinical Neurology ◽  
The Family ◽  
Cardioprotective Effects ◽  
Cardiac Models ◽  
Anti Inflammatory ◽  
Cardioprotective Drug

Minocycline belongs to the family of tetracyclines, which are drugs traditionally approved as antibiotics. Based on preclinical animal cardiac models and clinical neurology trials, this drug has gained special attention as a promising cardiovascular therapeutic agent given its anti-inflammatory, antiapoptotic, antioxidant, and antienzymatic properties. This review focuses on the available evidence for minocycline as a cardioprotective drug, with special attention to mechanisms of action. Ongoing cardiovascular clinical trials are briefly discussed.

scholarly journals An Eye-Catching and Comprehensive Review on Leucas zeylanica (Ceylon slitwort’ )

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2932-2938
Author(s):  
Subba Rao Chamakuri ◽  
Prasenjit Mondal ◽  
Ashish Suttee
Keyword(s):  
Skin Diseases ◽  
Primary Sources ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Traditional System ◽  
The Family ◽  
Anti Inflammatory ◽  
Anti Fungal

The traditional system of medicine has many plants with medicinal and pharmacological importance. The primary sources of food and medicine are plants and their highly beneficial products for various animals and humans. This article mainly focuses on the complete Leucas zeylanica profile, which is also called Ceylon slitwort, a small, erect, annual, herbaceous, terrestrial or occasionally aromatic, hispid and tufted plant of the family Lamiaceae subfamily Lamioideae. It is widely available in several places in India and Nueva Viscaya’s low altitudes open grasslands and Luzon’s Bataan Provinces and Mindanao and Panay (Davao and Lanao). This article provides a comprehensive review of the complete profile of a vital plant, Leucas zeylanica. Traditional use of Leucas zeylanica in various diseases includes Antibacterial, Anti-fungal, Anti-inflammatory, nociceptive, analgesia, gout, antidiabetic a photoprotective agent in various skin diseases. The isolated components are Alkaloids, Terpenoids, Vitamins, Carbohydrates, Flavonoids, glycosides, saponins, fixed oils, and other miscellaneous compounds. Hence, this review can be a useful reference for researchers who are willing to undertake further investigation about Leucas zeylanica.

scholarly journals Allium sativum L. (Garlic) Role in Osteoarthritis: A Systematic Review of Clinical Trials

2021 ◽  
Vol 11 (4) ◽  
pp. 12104-12119
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Side Effects ◽  
Allium Sativum ◽  
Inflammatory Diseases ◽  
Control Group ◽  
Therapeutic Effects ◽  
Inflammatory Factor ◽  
Anti Inflammatory ◽  
Over Time

Osteoarthritis is a chronic degenerative disease involving the joints and bones, causing their degradation over time. Inflammation, pain, and stiffness in joints are indicators of the disease. Pharmacotherapy cannot always be efficient and may cause side effects. So, adjuncts such as complementary herbs have become of note. Garlic is a herb well-known for its various therapeutic effects such as anti-bacterial, anti-hypertension, antioxidant and anti-inflammatory effects. Due to garlic's widespread use, studying its effects and mechanisms on inflammatory diseases such as osteoarthritis has been noteworthy. We searched Science Direct, Pubmed, Cochrane, and Google Scholar databases for all articles published until October 2020, based on PRISMA. Searched keywords were the following: [(garlic and arthritis), (garlic and osteoarthritis), (Garlic and OA), (Allium sativum and arthritis), (Allium sativum and osteoarthritis), (Allium sativum and OA)]. The results showed garlic, and its constituents have remarkable effects on improving OA symptoms through antioxidant and anti-inflammatory pathways. Our review shows that groups receiving garlic as a treatment showed a significant reduction in pain and inflammatory factor levels and an improved physical function instead of the control group.

scholarly journals Neuroprotective and Anti-Inflammatory Effects of Low–Moderate Dose Ionizing Radiation in Models of Alzheimer’s Disease

2020 ◽  
Vol 21 (10) ◽  
pp. 3678 ◽  
Author(s):  
Sujin Kim ◽  
Yunkwon Nam ◽  
Chanyang Kim ◽  
Hyewon Lee ◽  
Seojin Hong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Ionizing Radiation ◽  
Pharmacological Intervention ◽  
Therapeutic Effects ◽  
Moderate Dose ◽  
Short Term ◽  
Anti Inflammatory ◽  
5Xfad Mice

Alzheimer’s disease (AD) is the most common cause of dementia. The neuropathological features of AD include amyloid-β (Aβ) deposition and hyperphosphorylated tau accumulation. Although several clinical trials have been conducted to identify a cure for AD, no effective drug or treatment has been identified thus far. Recently, the potential use of non-pharmacological interventions to prevent or treat AD has gained attention. Low-dose ionizing radiation (LDIR) is a non-pharmacological intervention which is currently being evaluated in clinical trials for AD patients. However, the mechanisms underlying the therapeutic effects of LDIR therapy have not yet been established. In this study, we examined the effect of LDIR on Aβ accumulation and Aβ-mediated pathology. To investigate the short-term effects of low–moderate dose ionizing radiation (LMDIR), a total of 9 Gy (1.8 Gy per fraction for five times) were radiated to 4-month-old 5XFAD mice, an Aβ-overexpressing transgenic mouse model of AD, and then sacrificed at 4 days after last exposure to LMDIR. Comparing sham-exposed and LMDIR-exposed 5XFAD mice indicated that short-term exposure to LMDIR did not affect Aβ accumulation in the brain, but significantly ameliorated synaptic degeneration, neuronal loss, and neuroinflammation in the hippocampal formation and cerebral cortex. In addition, a direct neuroprotective effect was confirmed in SH-SY5Y neuronal cells treated with Aβ1–42 (2 μM) after single irradiation (1 Gy). In BV-2 microglial cells exposed to Aβ and/or LMDIR, LMDIR therapy significantly inhibited the production of pro-inflammatory molecules and activation of the nuclear factor-kappa B (NF-κB) pathway. These results indicate that LMDIR directly ameliorated neurodegeneration and neuroinflammation in vivo and in vitro. Collectively, our findings suggest that the therapeutic benefits of LMDIR in AD may be mediated by its neuroprotective and anti-inflammatory effects.

A Review on the Pharmacokinetic Properties of Naringin and Its Therapeutic Efficacies in Respiratory Diseases

2020 ◽  
Vol 20 (4) ◽  
pp. 286-293 ◽  
Author(s):  
Xuan Zeng ◽  
Weiwei Su ◽  
Buming Liu ◽  
Ling Chai ◽  
Rui Shi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Respiratory Diseases ◽  
Pulmonary Inflammation ◽  
Therapeutic Effects ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Pharmacological Activities ◽  
Bioactive Properties ◽  
Pharmacokinetic Properties ◽  
Experimental Works ◽  
Flavanone Glycoside

Flavonoids are an important class of phytopharmaceuticals in plants. Naringin (naringenin- 7-O-rhamnoglucoside) is a flavanone glycoside isolated from folk herbal medicine Exocarpium Citri grandis (called Huajuhong in Chinese). Massive experimental works have been performed on naringin describing its phytochemical, pharmacokinetic, and bioactive properties. Naringin was found to possess multiple pharmacological activities in relieving inflammation, diabetes, neurodegeneration, cardiovascular disorders, and metabolic syndrome. Recently, it has been approved as a potential antitussive and expectorant for clinical trials. However, the pharmacokinetic aspects of naringin and its therapeutic potentials in respiratory diseases have not been comprehensively reviewed. The present review provides highlights of naringin with respect to its absorption, distribution, metabolism, excretion and its therapeutic effects on cough, phlegm, and pulmonary inflammation. This review would be helpful for the interpretation of pharmacokinetics and pharmacodynamics of naringin in clinical trials.

Health Benefits of Furanocoumarins ‘Psoralidin’ An Active Phytochemical of Psoralea corylifolia: The Present, Past and Future Scenario

2019 ◽  
Vol 15 (4) ◽  
pp. 369-376
Author(s):  
Kanika Patel ◽  
Vikas Kumar ◽  
Amita Verma ◽  
Mahfoozur Rahman ◽  
Dinesh Kumar Patel
Keyword(s):  
Biological Activities ◽  
Modern Medicine ◽  
Present Review ◽  
Psoralea Corylifolia ◽  
Antitumor Activities ◽  
Pharmacological Activities ◽  
Discussion Section ◽  
Medicinal Uses ◽  
Anti Inflammatory ◽  
Analytical Tools

Background: Phytoconstituents of fruits, vegetables, spice and herbs are important for human health. Phytoconstituents play an important role in the growth, development, defensive mechanism, colors, odour and flavors of plants. Psoralea corylifolia Linn (P. corylifolia) commonly known as ‘Bakuchi’ belongs to Leguminosae family widely distributed in China and Southeastern Asian countries. Methods: Various electronic databases such as PubMed, Science Direct, Scopus and Google were searched to collect the data of the present review. Further, all the collected information was categorized into different section as per the aim of the paper. Moreover, analyzed data were also presented in the graphical abstract. Results: Seventy-two research and review papers have been collected and were included in the present review. Nineteen papers contained general information’s of P. corylifolia, Psoralens and psoralidin whereas thirty paper data were presented in the pharmacological activities sections and remaining in the Analytical tools and discussion section. From these databases, we can say that P. corylifolia possesses antibacterial, anti-inflammatory, antifungal, antioxidant, antiflarial, estrogenic, antitumour, and immunomodulatory activities. Psoralens are mainly used in the treatment of psoriasis, vitiligo and dermatitis. Topical or oral psoralens followed by UVA radiation exposure are one of the best treatments of leucoderma. Psoralidin exhibits antioxidant, anti-apoptotic, anti-inflammatory and antitumor activities. Conclusion: This review summarizes an overview of P. corylifolia, psoralen and its derivative psoralidin with respects to their pharmacological activities, medicinal uses, biological activities and bioanalytical aspects. These data will be helpful in the translation of information from traditional to the modern medicine of psoralidin.

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