scholarly journals EFFICIENCY OF THE PREPARATION OF THE PROLONGED ACTION ON THE BASIS OF MOXIDECTIN "NEOTERICA PROTECTO SYRUP" IN ECTOAND ENDOPARASITOSIS OF CARNIVORE ANIMALS

2021 ◽  
pp. 74-79
Author(s):  
Arisova
Keyword(s):  
Clinical Examination ◽  
Active Ingredient ◽  
Therapeutic Efficacy ◽  
Therapeutic Dose ◽  
Prolonged Action ◽  
Antiparasitic Activity ◽  
Prophylactic Efficacy ◽  
Wide Range ◽  
Nematode Eggs ◽  
Domestic Carnivores

This article presents the results of studies of the therapeutic and prophylactic efficacy of the drug "Neoterica Protecto Syrup" for arachnoentomoses and nematodes of domestic carnivores. The drug contains the active ingredient moxidectin, which provides a wide range of antiparasitic action of the drug against ecto- and endoparasites. The studies were conducted from April to August 2020 in veterinary clinics in Moscow and the Moscow region on dogs and cats free from parasites and naturally infested with fleas, lice, ixodid and scabies mites, intestinal nematodes and dirofilaria larvae. The animals were administered the drug once orally individually at a therapeutic dose at the rate of 1.5 mg moxidectin per 1 kg of animal weight. The diagnosis and efficacy of the diseases were confirmed by clinical (examination of the skin and hair for the presence of ectoparasites) and laboratory (Priselkova's method for detecting acariform mites in scrapings, the "thick crushed drop method" for detecting dirofilariae, Fülleborn's method for detecting nematode eggs) studies have confirmed the therapeutic efficacy the drug, the antiparasitic activity persisted for 90 days after application, which confirms the preventive effectiveness of the drug.

scholarly journals The biopsychosocial-digital continuum of foot orthosis practice and research: the VALUATOR model

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Kevin Deschamps ◽  
Chris Nester ◽  
Veronica Newton ◽  
Gabriel Gijon-Nogueron ◽  
Engin Simsek ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Social Stress ◽  
Clinical Value ◽  
Holistic Model ◽  
Scientific Discussion ◽  
Wide Range ◽  
Clinical Strategies ◽  
Person Centered Approach ◽  
First Time ◽  
Foot Orthosis

AbstractFoot orthoses have been used for decades despite uncertainty surrunding their therapeutic efficacy. Orthoses have been used exclusively to affect neuro-biomechanical input and outcome variables, however, there is emerging evidence that therapeutic efficacy may be affected by a psychological stimulus. Critical appraisal of the literature highlights that there is no holistic model upon which foot orthosis practice is taught, practised nor investigated. This paper introduces a conceptual model of foot orthosis practice (Value Based Foot Orthosis Practice (VALUATOR) model) that embraces a broader range of factors that are pertinent to orthosis practice, incorporating contemporary health service behaviours and values into orthosis practice for the first time.Within the VALUATOR model, foot orthosis design and clinical value is considered along a bio-psycho-social-digital continuum that reflects the reality of foot orthosis practice. The model contextualises the variable outcomes that are observed in research and practice within 6 key areas: 1) value, 2) person-centered approach, 3) zone of optimal bio-psycho-social stress, 4) bio-psycho-social assessment, 5) monitoring, 6) primary and secondary clinical strategies.The VALUATOR model is targeted at students, lecturers, scientists and practitioners and includes carefully chosen terminology to support a robust basis for educational and scientific discussion. It is believed that it provides a contemporary viewpoint and a structured conceptual metaphor that builds on existing evidence from a wide range of sources, invites constructive intellectual debate, and is anchored in the experiences of practitioners too. Stress testing the VALUATOR model will help determine its model and support further developments and evolution of orthotic practice in a evidence based way.

Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy

Blood ◽  
2021 ◽  
Author(s):  
Toshiaki Yoshikawa ◽  
Zhiwen Wu ◽  
Satoshi Inoue ◽  
Hitomi Kasuya ◽  
Hirokazu Matsushita ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Therapeutic Efficacy ◽  
T Cell Differentiation ◽  
Memory Phenotype ◽  
A Genome ◽  
Wide Range ◽  
Engineered T Cells ◽  
Early Memory

Adoptive cancer immunotherapy can induce objective clinical efficacy in patients with advanced cancer; however, a sustained response is achieved in a minority of cases. The persistence of infused T cells is an essential determinant of a durable therapeutic response. Antitumor T cells undergo a genome-wide remodeling of the epigenetic architecture upon repeated antigen encounters, which inevitably induces progressive T-cell differentiation and the loss of longevity. In this study, we identified PR domain zinc finger protein 1 (PRDM1) i.e., Blimp-1, as a key epigenetic gene associated with terminal T-cell differentiation. The genetic knockout of PRDM1 by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) supported the maintenance of an early memory phenotype and polyfunctional cytokine secretion in repeatedly stimulated chimeric antigen receptor (CAR)-engineered T cells. PRDM1 disruption promoted the expansion of less differentiated memory CAR-T cells in vivo, which enhanced T-cell persistence and improved therapeutic efficacy in multiple tumor models. Mechanistically, PRDM1-ablated T cells displayed enhanced chromatin accessibility of the genes that regulate memory formation, thereby leading to the acquisition of gene expression profiles representative of early memory T cells. PRDM1 knockout also facilitated maintaining an early memory phenotype and cytokine polyfunctionality in T-cell receptor-engineered T cells as well as tumor-infiltrating lymphocytes. In other words, targeting PRDM1 enabled the generation of superior antitumor T cells, which is potentially applicable to a wide range of adoptive cancer immunotherapies.

scholarly journals Molecular Detection of Arthropod-Borne Pathogens in Eurasian Badgers (Meles meles) from the United Kingdom

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 446
Author(s):  
Lisa Guardone ◽  
Valentina Virginia Ebani ◽  
Ranieri Verin ◽  
Simona Nardoni ◽  
Antonio Consolazione ◽  
...  
Keyword(s):  
Public Health ◽  
Great Britain ◽  
Coxiella Burnetii ◽  
Anaplasma Phagocytophilum ◽  
Molecular Detection ◽  
Meles Meles ◽  
Widespread Distribution ◽  
The United Kingdom ◽  
Wide Range ◽  
Domestic Carnivores

Arthropod-borne diseases (ABD) are of increasing interest in veterinary and public health. Eurasian badgers (Meles meles) are known to harbor a wide range of pathogens, but information on their role as ABD reservoirs and their potential epidemiological relevance is limited. This study aimed to investigate the occurrence of arthropod-borne pathogens, specifically piroplasmids and the bacteria Anaplasma phagocytophilum, Ehrlichia canis, Coxiella burnetii, Francisella tularensis and Bartonella spp., in badgers from Great Britain (GB). Blood and heart samples from 18 badgers were examined using PCR and sequencing. A neighbour-joining (NJ) phylogram was also produced. Nine animals tested positive for Babesia sp., while none of the samples was positive for the investigated bacteria. The sequences obtained clustered with other sequences of Babesia sp. from badgers from GB and elsewhere, including China, Hungary, Spain and Italy, showing a widespread distribution of this parasite in badgers. Badger-associated Babesia DNA was also found recently in a wild cat in Bosnia Herzegovina, in a wolf in Italy and in dogs in Hungary. Further investigations are needed to understand the epidemiology of this putative pathogen and its impact on the health of wild and domestic carnivores.

scholarly journals Successful Control of External Biliary Fistula by Using SMS 201-995 in a Child

HPB Surgery ◽  
1996 ◽  
Vol 9 (3) ◽  
pp. 183-184 ◽  
Author(s):  
Mohamad Abid Bakhotmah
Keyword(s):  
Bile Secretion ◽  
Biliary Fistula ◽  
Gastrointestinal System ◽  
Synthetic Analogue ◽  
Prolonged Action ◽  
Daily Output ◽  
Wide Range ◽  
Successful Control

Somatostatin is a potent inhibitory hormone, it's synthetic analogue is more potent and has a prolonged action. It has a wide range of actions in the gastrointestinal system; among which is an anticholeritic action on bile secretion.The use of Sandostatin in the management of a case of complicated biliary fistula is reported; it controlled the fistula reducing its daily output from 200 ml to less than 5 ml per day.

Herbicide Dispersal Patterns: II. Mapping Residues Using X-ray Fluorescence

Weed Science ◽  
1975 ◽  
Vol 23 (4) ◽  
pp. 308-314 ◽  
Author(s):  
F. D. Hess ◽  
R. H. Falk ◽  
D. E. Bayer
Keyword(s):  
Atomic Number ◽  
Active Ingredient ◽  
Distribution Patterns ◽  
Plant Surface ◽  
Dispersal Patterns ◽  
X Ray ◽  
Minimum Detectable Limit ◽  
Wide Range ◽  
Reduced Pressures ◽  
Element Mapping

Distribution patterns of foliar applied herbicides can be studied by x-ray element mapping provided the herbicide contains an atom with an atomic number of 11 (sodium) or greater. The suitability of an herbicide for element mapping increases as the number of similar detectable atoms per molecule increases. Herbicides containing one detectable atom per molecule provide usable element maps at concentrations of 1.12 kg/ha and higher. Inaccurate element maps can result from: (1) Formulation components containing detectable atoms the same as those of the active ingredient. (2) Herbicide volatility during analysis due to reduced pressures and heating. (3) Specimen topography preventing x-ray detection at some locations on the plant surface. (4) Herbicide concentrations that are below the minimum detectable limit. If adequate precautions are followed in the use of x-ray element mapping, a wide range of uses exist in weed science.

scholarly journals Interactions between crop sequences, weed populations and herbicide use in Western Australian broadacre farms: findings of a six-year survey

2020 ◽  
Vol 71 (5) ◽  
pp. 491 ◽  
Author(s):  
Martin Harries ◽  
Ken C. Flower ◽  
Craig A. Scanlan ◽  
Michael T. Rose ◽  
Michael Renton
Keyword(s):  
Land Use ◽  
Herbicide Resistance ◽  
Western Australia ◽  
Active Ingredient ◽  
Weed Management ◽  
Weed Seed ◽  
Pasture Production ◽  
Weed Density ◽  
Wide Range ◽  
Herbicide Use

Six years of survey data taken from 184 paddocks spanning 14 million ha of land used for crop and pasture production in south-west Western Australia were used to assess weed populations, herbicide resistance, integrated weed management (IWM) actions and herbicide use patterns in a dryland agricultural system. Key findings were that weed density within crops was low, with 72% of cropping paddocks containing fewer than 10 grass weeds/m2 at anthesis. Weed density and herbicide resistance were not correlated, despite the most abundant grass weed species (annual ryegrass, Lolium rigidum Gaudin) testing positive for resistance to at least one herbicide chemistry in 92% of monitored paddocks. A wide range of herbicides were used (369 unique combinations) suggesting that the diversity of herbicide modes of action may be beneficial for reducing further development of herbicide resistance. However, there was a heavy reliance on glyphosate, the most commonly applied active ingredient. Of concern, in respect to the evolution of glyphosate resistant weeds, was that 45% of glyphosate applications to canola were applied as a single active ingredient and area sown to canola in Western Australia expanded from 0.4 to 1.4 million hectares from 2005 to 2015. In order to minimise the weed seed bank within crops, pastures were used infrequently in some regions and in 50% of cases pastures were actively managed to reduce weed seed set, by applying a non-selective herbicide in spring. The use of non-selective herbicides in this manner also kills pasture plants, consequently self-regenerating pastures were sparse and contained few legumes where cropping intensity was high. Overall, the study indicated that land use selection and utilisation of associated weed management actions were being used successfully to control weeds within the survey area. However, to successfully manage herbicide resistant weeds land use has become less diverse, with pastures utilised less and crops with efficacious weed control options utilised more. Further consideration needs to be given to the impacts of these changes in land use on other production factors, such as soil nutrient status and plant pathogens to assess sustainability of these weed management practices in a wider context.

scholarly journals Nanocarriers in the Enhancement of Therapeutic Efficacy of Natural Drugs

2021 ◽  
Author(s):  
Xiuling Li ◽  
Shunung Liang ◽  
Chee Hwee Tan ◽  
Shuwen Cao ◽  
Xiaoding Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Local Population ◽  
Modern Medicine ◽  
Delivery Systems ◽  
Plant Materials ◽  
Wide Range ◽  
Natural Drugs

Since time immemorial, plant derived natural products have been used for the treatment of various human diseases before the intervention of modern medicine. The basis of modern medicine is still being inspired from traditional medicine and therapies. However, despite their tremendous therapeutic potential, these natural drugs often have poor bioavailability, metabolic instability, and aqueous insolubility. These factors greatly impede a natural drug’s commercialization potential as a mainstream medicine. Therefore, the development of nanocarrier drug delivery systems is indispensable in overcoming the various constraints of the bottlenecks which occur with natural drugs. Of particular interest in this review are four plant materials endogenous to China with the common names of barrenwort or horny goat weed (Epimedium), Shu Di Huang (Rehmannia glutinosa, RG), ginseng (Panax ginseng), and Dong Quai or female ginseng (Angelica sinensis, AS), each having been scientifically investigated for a wide range of therapeutic uses as has been originally discovered from the long history of traditional usage and anecdotal information by local population groups in Asia. The integration of natural drugs from the East and nanocarrier drug delivery systems developed from the West is paving the way towards further accurate and efficient medicine therapy. We further discuss the potential benefits of these plants and the enhancement of their therapeutic efficacy by nanotechnology intervention.

scholarly journals Biodata Mining-based Elucidation of Mechanisms of Hesperetin as a Candidate for Atherosclerosis

2020 ◽  
Author(s):  
Lianzhou Huang ◽  
Zexiu Huang ◽  
Yuanqiu Chen ◽  
Xin Jin ◽  
Ji Xiao ◽  
...  
Keyword(s):  
Active Ingredient ◽  
Molecular Mechanisms ◽  
Fluid Shear Stress ◽  
Biological Activities ◽  
Interaction Network ◽  
Enrichment Analysis ◽  
Network Pharmacology ◽  
Citrus Aurantium ◽  
Wide Range ◽  
Anti Inflammatory

Abstract BackgroundHesperetin, an active ingredient derived from Citrus × aurantium L., possesses a wide range of biological activities, including anti-inflammatory, anti-oxidation, and anti-cancer activity. Notably, hesperetin has been proposed as a candidate for atherosclerosis owing to the lipid-regulating and anti-inflammatory effect, while the underlying mechanisms remains obscure.ResultsIn our present study, the pharmacological and molecular properties of hesperetin were first evaluated to determine the druggability of hesperetin. Subsequently, 53 hesperetin-atherosclerosis crossover targets were collected to establish the protein-protein interaction network. The result of Gene Ontology enrichment analysis indicated that the crossover targets were involved in the regulation of lipid metabolism and inflammatory response. Moreover, the Kyoto Encyclopedia of Genes and Genomes pathway analyses demonstrated that the crossover targets were highly correlated with the pathogenesis of atherosclerosis, such as fluid shear stress and atherosclerosis pathway and the TNF signaling pathway. Finally, an entire hesperetin-target-pathway network was constructed to provide a systematic overview of the pharmacological mechanisms of action of hesperetin against atherosclerosis.ConclusionsThe pharmacological mechanisms of actions of hesperetin against atherosclerosis was unveiled based on biodata mining from the public database and the bioinformatics data analysis-based strategy in this study, contributing to a deeper understanding of the molecular mechanisms of hesperetin in the treatment of atherosclerosis. Based on the results of network pharmacology analysis, we can conclude that hesperetin is surely an excellent candidate for atherosclerosis. We believe our work would be beneficial for further research and development of hesperetin as a natural active ingredient derived from Citrus × aurantium L. for the treatment of atherosclerosis.

scholarly journals Fluconazole in the therapy of Pityriasis versicolor

2005 ◽  
pp. 283-289
Author(s):  
Mirjana Poljacki ◽  
Slobodan Stojanovic ◽  
Sinisa Tasic ◽  
Marina Jovanovic ◽  
Zoran Golusin ◽  
...  
Keyword(s):  
Single Dose ◽  
Clinical Efficacy ◽  
Clinical Examination ◽  
Therapeutic Efficacy ◽  
Pityriasis Versicolor ◽  
Mycological Examination ◽  
Clinical Healing ◽  
Systemic Application ◽  
Diagnosis Of Diseases

The authors present the results of the systemic application of flukonazole in therapy of Pityriasis versicolor. It was arranged for the total number of 38 patients, 18 females and 20 males. The diagnosis of diseases was established on the base of the clinical examination, the native mycological examination and by the using of Wood lamps. The therapy was passed by the using of 300 mg flukonazole in a single dose, once weekly, during two weeks. The following period amounted to one week after the passed therapy. The therapeutic efficacy was assessed with regard to the clinical and mycological healing. The clinical efficacy was assessed semiquantitative on the base of increasing of the percentage rates of the total score of disease that was computed by collecting of the numeric values for every clinical argument typical for the disease, and the mycological efficacy on the base of the mycological findings and the fluorescence finding after lightening with the Wood's lamp. The controlling examinations were performed on day 0, 14 and 22. The results of investigations have shown that the complete clinical healing was achieved after two weeks of therapy in 94,74%, and the mycological healing in 92,11% patients. The rate of the mycological healing was evaluated after 1 week of following period equal to the rate of the clinical healing and it was also 94,74%. The undesirable effects of the drug applications weren't by any patient.

Enzymic Activities of Commercial Preparations of Pancreatic Enzymes

1977 ◽  
Vol 22 (3) ◽  
pp. 221-224 ◽  
Author(s):  
Sheena Drummond ◽  
J. H. B. Saunders ◽  
R. Leach ◽  
K. G. Wormsley
Keyword(s):  
Therapeutic Efficacy ◽  
Pancreatic Enzymes ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
British Pharmacopoeia ◽  
Standard Preparation ◽  
Wide Range ◽  
Pancreatic Exocrine

The enzymic activities of 20 commercial pancreatic extracts have been measured by standard (F.I.P.) methods of assay and the activities have been compared with a standard preparation of pancreatin supplied by the British Pharmacopoeia Commission. A wide range of enzymic activities was found. The tabulated cost per unit of enzymic activities provides a guide to one aspect of the potential therapeutic efficacy of pancreatic extracts in the treatment of pancreatic exocrine insufficiency.

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