scholarly journals Spectrum of Leprosy Patients with Clinico-Histopathological Correlation: A Hospital Based Study

2013 ◽  
Vol 4 (4) ◽  
pp. 11-16
Author(s):  
Arjun Singh ◽  
R Gaur ◽  
R Ambey
Keyword(s):  
Histopathological Examination ◽  
Medical Science ◽  
Polar Group ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Leprosy Patients ◽  
Diagnosis And Classification ◽  
Skin Biopsies ◽  
Hematoxylin And Eosin ◽  
Minor Disagreement

Introduction: Leprosy is a chronic granulomatous, infectious disease involving skin and peripheral nerves. It is present in various clinicopathological forms depending upon immune status of the patients. Histopathological examination of skin provides confirmatory diagnosis in suspected cases and gives indication of progression and regression of disease under treatment. Ridley and Jopling classification is used to classify leprosy. The objective of study was to identify the clinical pattern of leprosy and performed detail clinico- histopathological correlation in our institute. Method: The study was carried out on the skin biopsies received in between 2007-2010. Biopsies were fixed in 10% formalin, processed and stained with Hematoxylin and Eosin, modified Fite Ferraco and Ziehl-Neelsen stains. The predesigned Performa was used to record observation. The clinical diagnosis were correlated with histopathology in all 120 cases. Result: The age of the patients was ranged from 8 to 79 years with mean age of 36.38 years. The male to female ratio of patients was 1.5 to 1. The majority of cases 79 (65.8%) were in the age group of 21-50 years. Highest parity was observed in stable polar group TT 100%. Clinco-histopathological agreement was seen in 98 (81.67%) cases, 14 (11.67%) cases shows minor disagreement and 8 (6%) cases major disagreement. Conclusion: The clinical and histopathological features along with bacteriological index are useful than any single parameter in arriving definitive diagnosis and classification of the leprosy. Asian Journal of Medical Science, Volume-4 (2013), Pages 11-16 DOI: http://dx.doi.org/10.3126/ajms.v4i4.7997 

scholarly journals A study of clinico pathological spectral correlation in multibacillary leprosy

2020 ◽  
Vol 6 (2) ◽  
pp. 218
Author(s):  
Anita Sanker ◽  
P. S. Mathew ◽  
G. Nandakumar ◽  
Sandhya George ◽  
V. G. Binesh
Keyword(s):  
Histopathological Examination ◽  
Lepromatous Leprosy ◽  
Newly Diagnosed ◽  
Spectral Correlation ◽  
Medical College ◽  
Additional Information ◽  
Histopathological Correlation ◽  
Leprosy Patients ◽  
Diagnosis And Classification ◽  
Multibacillary Leprosy

<p class="abstract"><strong>Background:</strong> Leprosy expresses itself in different clinico-pathological forms, depending on the immune status of the host.The diagnosis and classification of leprosy have traditionally been based on the clinical examination with additional information from skin smears and histopathological examination. Very often, disparities between clinical and histopathological findings are observed. This study was aimed to correlate between clinical and histopathological spectral correlation of newly diagnosed multibacillary leprosy cases for a period of 1 year.</p><p class="abstract"><strong>Methods:</strong> The study was conducted in the Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, for a period of 1 year. All newly diagnosed multibacillary leprosy cases were included.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 40 patients with clinically diagnosed multi bacillary leprosy were studied. Maximum numbers of leprosy patients studied were in the age group of 40-49 years. Maximum clinical and histopathological correlation was found in 75% (9/12) in lepromatous leprosy and least correlation of 44.44% was noted in borderline lepromatous (4/9).</p><p class="abstract"><strong>Conclusions:</strong> In this study maximal clinico-histopathological spectral correlation was found in lepromatous  spectrum. The percentage of correlation was considerably less in all the other groups.</p>

TO STUDY THE CYTOMORPHOLOGICAL PATTERNS OF TUBERCULAR LYMPHADENOPATHY AND ITS HISTOPATHOLOGICAL CORRELATION

2021 ◽  
pp. 26-27
Author(s):  
Rashmi Sharma ◽  
Poonum Gogania ◽  
Geeta Pachori ◽  
Akhilesh Bharadwaj
Keyword(s):  
Epithelioid Cell ◽  
Cervical Region ◽  
Tuberculous Lymphadenitis ◽  
Female Ratio ◽  
Caseous Necrosis ◽  
Histopathological Correlation ◽  
Histopathological Evaluation ◽  
Special Stain ◽  
Hematoxylin And Eosin ◽  
Tubercular Lymphadenitis

INTRODUCTION: Tubercular lymphadenopathy is one of the common clinical problems. Practically diagnosis of tuberculosis sometimes creates a challenge to the pathologist and clinician. A combined approach of cytology with aid of special stain and histopathological evaluation helps to conrm the diagnosis. AIM -The present study was carried out to evaluate the different cytological patterns of tuberculous lymphadenitis along with utility of special stain like Acid fast stain and further histopathological evaluation. MATERIAL AND METHOD: Smears from 833 cytologically diagnosed cases of tubercular lymphadenitis were prepared and stained with Hematoxylin and Eosin (H&E), Giemsa and Acid-fast stain. All the smears were categorized into four cytomorphological patterns and correlated with 250 histopathologically available cases. RESULT: Tuberculosis is the major cause of lymphadenopathy. Majority of cases (63 %) were in their second to third decades of life, with male to female ratio of 1:1.4. Cervical region was the most common site of involvement (83.5 %). Smear revealed epithelioid granulomas with caseous necrosis in maximum cases (46.9 %). AFB positivity was seen highest in smear revealing necrosis only with or without epithelioid cell (93,8 %). histopathological correlation was seen in 248 cases out of 250 available cases. CONCLUSION: FNAC has been proved very safe, highly sensitive, and rst line investigation in diagnosing tubercular lymphadenitis. The approach to tubercular lymphadenitis attains completeness with cytopathological, Acid Fast stain and histopathological evaluation.

scholarly journals Study of glottic lesions in patients undergoing microlaryngeal surgery

2020 ◽  
Vol 6 (2) ◽  
pp. 277
Author(s):  
Vikrant Mittal ◽  
Manish Munjal ◽  
Rohit Verma ◽  
Parth Chopra ◽  
Hemant Chopra
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Detailed Examination ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Male Female Ratio ◽  
Male Preponderance ◽  
Vocal Nodules ◽  
Microlaryngeal Surgery

<p class="abstract"><strong>Background:</strong> Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.</p><p class="abstract"><strong>Methods:</strong> 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed.  </p><p class="abstract"><strong>Results:</strong> There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.</p><p class="abstract"><strong>Conclusions:</strong> In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.</p>

scholarly journals Clinico-pathological and radiological correlation of sino-nasal masses in a tertiary care center

2020 ◽  
Vol 6 (7) ◽  
pp. 1342
Author(s):  
Dimple Sahni ◽  
Gagandeep Kaur ◽  
Peeyush Verma ◽  
Rajwant Kaur ◽  
Harpal Singh
Keyword(s):  
Histopathological Examination ◽  
Care Center ◽  
Tertiary Care ◽  
Inflammatory Lesion ◽  
P Value ◽  
Radiological Investigation ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

<p class="abstract"><strong>Background:</strong> The nasal masses are most commonly encountered condition in outpatient department of otorhinolaryngology. The purpose of this study was to show the clinical, radiological and histopathological correlation of sino nasal masses.</p><p class="abstract"><strong>Methods:</strong> This study was conducted on 100 cases with sino nasal masses over a period of 2 years. A provisional diagnosis was made after clinical and radiological investigation which was confirmed with histopathological examination and the findings were correlated.  </p><p class="abstract"><strong>Results:</strong> The number of non-neoplastic lesions were more than neoplastic lesions (75% vs 25%). Incidence was highest in the age group of 31-40 year (21%) with male to female ratio of 1.5:1. In our study among non-neoplastic lesion, inflammatory lesion had highest frequency (75%). We found clinical and histopathological correlation in 94.6% cases (p value 0.04). 93.33% cases correlated radiologically and histopathologically (p value 0.04).    </p><p class="abstract"><strong>Conclusions:</strong> We concluded that for proper evaluation of sino nasal masses, clinical, radiological, histopathological evaluation should be carried out conjointly. Histopathologic evaluation remains the gold standard.</p>

scholarly journals Clinico-etiological study of erythroderma cases from tertiary care hospital, Chitradurga, Karnataka, India

2020 ◽  
Vol 6 (4) ◽  
pp. 502
Author(s):  
Harish Gangaraju ◽  
Raghu M. T. ◽  
Yogendra M. ◽  
Virupakshappa H. E. ◽  
Ashwini S. ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Drug Induced ◽  
College Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Histopathological Correlation

<p class="abstract"><strong>Background:</strong> Erythroderma is a cutaneous morphological reaction pattern of skin having many underlying causes and finding the etiology helps in the proper management of erythroderma cases.</p><p class="abstract"><strong>Methods:</strong> A cross sectional study was performed at the department of dermatology, Basaveshwara Medical College, Hospital and Research center, Chitradurga. Authors studied 30 consecutive cases of erythroderma from July 2017 to June 2019 with respect to the epidemiological, clinical and histological data. Clinico-histological correlation was analyzed for etiology of erythroderma.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age of onset was 35.03 years with a male to female ratio of 3:2. In addition to erythrema and scaling that were present in all patinets, other co-existent features included were pruritus (43.3%), fever (23.3%), and edema (16.7%). Of the pre-existing dermatoses, psoriasis was the most common (36.6%) disease followed by eczema (26.7%), drug-induced erythroderma (16.7%), colloidan baby (3.3%), pityriasisrubrapilaris (3.3%) and in 13.3% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases.</p><p class="abstract"><strong>Conclusions:</strong> In all erythroderma cases cutaneous features were identical irrespective of etiology. Detailed history, clinico-histopathological examination and other necessary haematological investigations helps to establish the etiology of erythroderma which helps in further management.</p>

scholarly journals CORRELATION BETWEEN ENDOSCOPIC AND HISTOPATHOLOGICAL FINDINGS IN GASTRIC LESIONS.

2019 ◽  
pp. 1-3
Author(s):  
Amarnath Kumar Nayak
Keyword(s):  
Intestinal Metaplasia ◽  
Histopathological Examination ◽  
Medical Science ◽  
Pathological Process ◽  
Endoscopic Examination ◽  
Poor Correlation ◽  
Gastric Lesions ◽  
Female Ratio ◽  
Endoscopic Biopsies ◽  
Male Female Ratio

Background: Stomach is a common site for wide variety of lesions. The visualisation of the site with endoscopy and its biopsy leads to the early detection of the pathological process and appropriate therapy. Objectives: The objective of this study is to correlate the histopathological pattern of endoscopic biopsies with distribution of gastric lesions according to age and sex. Method: The study was carried out among 100 cases with endoscopic biopsies and histological assessment, received at Department of pathology, Rajendra Institute of Medical Science, Ranchi. Result: Out of 100 cases majority of cases were male gender with male : female ratio was 2.1:1. Our study showed a poor correlation between endoscopic and histopathologic evidence of inammation of the stomach. Five cases were diagnosed as intestinal metaplasia which were diagnosed as intestinal metaplasia which were diagnosed endoscopically as ulcer and erosion. Out of 34 of cases diagnosed endoscopically as ulcer , only 4 cases were conrmed histologically. Our study showed good correlation in the cases of carcinoma. Out of 32 cases diagnosed endoscopically as gastric carcinoma correlated histologically as gastric adenocarcinoma. Majority of carcinoma cases showed ulcerating fungating growth followed by ulcero-proliferative growth. Conclusion: Endoscopy is incomplete without biopsy and histopathology. Histopathology is the gold standard for the diagnosis of endoscopically detected lesions. Endoscopic examination and histopathological examination of suspected gastric lesions should go parallel and neither should be a substitute of each other.

scholarly journals Correlation of Clinico-Histopathological Findings in Leprosy Patients at Tertiary Care Hospital, Bhilai, CG

2021 ◽  
Vol 8 (3) ◽  
pp. 28-31
Author(s):  
Bhuvaneshwari Dewangan
Keyword(s):  
Clinical Examination ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Clinical Signs ◽  
Public Health Problem ◽  
Research Centre ◽  
Care Hospital ◽  
Female Ratio ◽  
Histopathological Findings ◽  
Leprosy Patients

Background: Leprosy continues to be public health problem in India. In India, Chhattisgarh state is having the highest prevalence rate of 2.33 per 10000 populations presently. Leprosy expresses itself in different clinics - histopathological forms depending on the immune system the host. Objective: To find the strength of the relationship between clinically diagnosed leprosy patients with histopathological findings. Materials & Methods: This was a prospective study was carried out on 42 new cases of leprosy attending the outpatient department of dermatology and venereology of J. L. N. Hospital and Research Centre Bhilai Steel Plant Bhilai from March 2009 to December 2010 & all the patients were included after taking informed consent. All the cases were subjected detailed history and through clinical examination & histopathological examination of skin tissue as per the structured pro forma. Results: The Male female ratio was 1:1. Majority of the patients were belonged to the age group between 41 to 60 years. Overall positive correlation found between Clinico - histopathological was 0.69. Majority of the patients were found in the borderline tuberculoid leprosy in Clinically & Histopathological findings. The overall agreement was good between clinical spectrum and histopathological findings. Conclusion: In some early cases, clinical signs and symptoms may precede the presently known characteristic tissue changes or vice versa. If a biopsy is taken at an early stage, there is likely to be discordance between the clinical and histopathological observations. Keywords: Leprosy, Clinical Examination, Histopathological Examination, Strength of relationship.

scholarly journals Clinicohistopathological Correlation in Leprosy

2012 ◽  
Vol 9 (4) ◽  
pp. 248-251 ◽  
Author(s):  
M C Mathur ◽  
R B K Ghimire ◽  
P Shrestha ◽  
S K Kedia
Keyword(s):  
Infectious Disease ◽  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Mycobacterium Leprae ◽  
P Value ◽  
Histopathological Diagnosis ◽  
Common Infectious Disease ◽  
Clinical Diagnoses ◽  
Leprosy Patients ◽  
Skin Biopsies

Background Leprosy is a chronic, infectious disease caused by Mycobacterium leprae. It is classified into five groups based on clinical, histological, microbiological and immunological criteria (Ridley & Jopling Classification). However, a great variation has been observed in the interpretation of histopathological examination ok skin biopsies and clinical presentation of the disease. Objective To correlate clinical diagnosis with histopathological diagnosis of leprosy patients in Nepal. Methods A retrospective hospital-based study was conducted among patients with all clinical types of leprosy, classified as per the Ridley-Jopling classification. Skin biopsies were taken from active lesions in all patients and were stained with Hematoxylin & Eosin stain and modified Fite-Ferraco stain for identification of Mycobacterium leprae. The histopathological findings were compared with clinical diagnoses. Results A total 156 patients were studied, out of which 84 (53.8%) males and 72 (46.1%) females between 8 and 86 years of age. The majority of patients 33 (23.57%) were in the age group of 21-30 years and least affected was children below 10 years 1(0.007%).Overall coincidence of clinical and histopathological diagnoses of classification was seen in 115 cases (80.4%). The maximum correlation (95.2%) was noted in LL patients (p value 0.000049) followed by BT(89.74%), TT (73.2%), BL(72.4%), BB(64.7%). Conclusion Leprosy still continues to be one of the common infectious disease in Nepal and skin biopsy is a useful tool in confirming the clinical diagnosis of leprosy as well as for the therapeutic guide. DOI: http://dx.doi.org/10.3126/kumj.v9i4.6338 Kathmandu Univ Med J 2011;9(4):248-51

scholarly journals Clinico-Histopathological histopathological correlation and detection of anti PGL-1 antibodies in leprosy patients

2014 ◽  
Vol 13 (3) ◽  
pp. 316-322
Author(s):  
Soma Datta ◽  
SP Pandya ◽  
YR Marfatia ◽  
Arindam Rakshit
Keyword(s):  
Blood Donors ◽  
Medical Science ◽  
Pathological Examination ◽  
Adequate Treatment ◽  
Smear Examination ◽  
Histopathological Correlation ◽  
Histopathological Evaluation ◽  
Leprosy Patients ◽  
Preclinical Diagnosis ◽  
Monitoring Treatment

Background: Leprosy (Hansen’s disease) is one of the major health problems of the world especially in developing countries. In India, it was first described in “Sushruta Samhita” & treated by Chaulmoogra oil and caused by Mycobacterium Leprae. Early diagnosis of leprosy, an absolute necessity for control as well as effective therapy. For this, clinical diagnosis, skin smear examination is adequate coupled with histo-pathological examination of skin and nerve lesions with modified Fite Faraco stain for demonstration of acid-fast bacilli. Moreover, bacillary index is required for adequate combined chemotherapy regimen. Detection of anti PGL-1 antibodies in serum gives an added advantage for detection and monitoring treatment. Materials & Methods : A total of 85 cases of leprosy who attended outpatient department of Skin & VD, Shri Sayaji General Hospital Baroda chosen for study during ‘07-08’ period with 75 cases from leprosy hospital, Baroda which included 50 detected patients and 25 child contacts with 25 healthy voluntary blood donors from blood bank, SSGH selected. Clinical, past and family history taken with slit skin smears stained with Z-N stain, graded and histopathological evaluation done. Serological study done from serum of leprosy patients and healthy blood donors; tested by Serodia Kitsand interpretation made. Results: Most cases were in 2nd to 4th decade and males dominated. Clinically most cases were of indeterminate and tuberculoid type and histologically indeterminate and border-line tuberculoid. Clinico-histopathological correlation was found most in indeterminate followed by histoid type. Voluntary blood donors were seronegative. 21 out of 48 multibacillary cases and 6 out of 28 pauci-bacillary showed seropositivity for anti PGL-1 anti-bodies (p<0.001) Conclusion: All suspected leprosy cases clinically should be subjected to slit skin smear examination with histopathological evaluation; bacillary study which helps in diagnosis and adequate treatment of patients. Detection of antibodies to PGL-1 in patients indicate presence of leprosy bacilli and useful in preclinical diagnosis and determining progress of therapy. DOI: http://dx.doi.org/10.3329/bjms.v13i3.9153 Bangladesh Journal of Medical Science Vol.13(3) 2014 p.316-322

scholarly journals Pulmonary hamartoma, a rare benign tumour of the lung - Case series

2014 ◽  
Vol 5 (3) ◽  
pp. 112-115 ◽  
Author(s):  
Ruchita Tyagi ◽  
Amamjit Bal ◽  
Divyesh Mahajan ◽  
Raje Nijhawan ◽  
Ashim Das
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Medical Science ◽  
Lung Nodule ◽  
Case Series ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Ct Guided ◽  
Female Ratio ◽  
Pulmonary Hamartoma

Introduction - Pulmonary hamartoma, with incidence of 0.25-0.32%, accounts for 6% of solitary pulmonary nodules. The role of radiology is limited as only 10-30% of cases show characteristic ‘popcorn’ calcification and Computed Tomography can detect approximately  50% of hamartomas. Hence cytological and/or histopathological examination is required to make a definitive diagnosis and exclude malignancy. Objective – As pulmonary hamartoma is a rare entity detected serendipitously on radiography and requires cytological and histopathological examination for confirmation of diagnosis, we present nine cases of solitary pulmonary nodules which were diagnosed as pulmonary hamartoma.  Methods - We retrospectively screened departmental records and slides and found nine cases of pulmonary hamartoma in our tertiary care institute. Three cases were diagnosed on CT guided Fine Needle Aspiration Cytology and four cases were diagnosed on histopathological examination of surgical specimens, over a period of 16 years (1997-2012). Two cases were incidentally discovered to have pulmonary hamartoma at autopsy.  Observations – The age of the patients ranged from 17-63 years (mean-46.3), with male to female ratio being 3.5:1. The size of the hamartoma varied from 0.4 – 1.3 cm, with mean diameter of 1 cm. Cytology showed mixture of bronchial epithelial cells, adipocytes and stromal fragments in fibromyxoid and chondroid background. Histopathology demonstrated lobules of cartilage and adipose tissue with intervening clefts lined by respiratory epithelium and mesenchymal stroma. Conclusion – Every solitary pulmonary nodule is not malignant. It is important to correctly diagnose pulmonary hamartoma, a rare, yet benign neoplasm presenting as a solitary lung nodule and distinguish it from malignancy.Asian Journal of Medical Science, Volume-5(3) 2014: 112-115 http://dx.doi.org/10.3126/ajms.v5i3.9243 

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