scholarly journals Clinicohistopathological correlation of leprosy

2017 ◽  
Vol 7 (1) ◽  
pp. 1095-1102
Author(s):  
A Shrestha ◽  
S Chauhan ◽  
M Mathur
Keyword(s):  
Clinical Diagnosis ◽  
Clinical Information ◽  
Lepromatous Leprosy ◽  
P Value ◽  
Histopathological Diagnosis ◽  
Histopathological Correlation ◽  
The Social ◽  
Tuberculoid Leprosy

BACKGROUND: Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae. It is a spectral disease which is classified into five groups according to Ridley and Jopling based on clinical, histological, microbiological and immunological criteria. Adequate clinical information combined with bacilloscopy and histopathology is helpful not only in classification of different types of leprosy but also useful for management of the cases.METHOD: 50 cases of leprosy were examined and clinical data was recorded. Slit skin smears were stained with Ziehl Neelsen stain. Skin biopsy was stained with Hematoxylin-Eosin stain and Fite Farraco stain was performed to demonstrate acid fast bacilli. All patients were classified according to Ridley & Jopling classification. Clinico-histopathological correlation was done. Statistical analysis was done using SPSS (Statistical Package for the Social Sciences) 16.0.RESULTS: Most common histological type of leprosy was tuberculoid leprosy seen in 19(38%) cases followed by indeterminate leprosy. Overall clinico-histopathological correlation was seen in 39.58%. The correlation was highest in indeterminate and histoid leprosy (100%) followed by lepromatous leprosy (66.66 %%) and tuberculoid leprosy (50%). Slit skin smear showed bacilli in 12 out of 48 cases (25%) while biopsy showed bacilli in 16 out of 48 cases (33.3%).CONCLUSION: In the present study, clinical diagnosis did not correlate with histopathological diagnosis significantly (p value=0.04159). The study emphasizes the role of histopathological and bacilloscopic examination to aid the clinical diagnosis for accurate typing of leprosy cases then better management of the patient.

scholarly journals Clinico-histopathological correlation of skin biopsies in leprosy

2013 ◽  
Vol 3 (6) ◽  
pp. 452-458 ◽  
Author(s):  
U Manandhar ◽  
RC Adhikari ◽  
G Sayami
Keyword(s):  
Clinical Information ◽  
Lepromatous Leprosy ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Granulomatous Lesions ◽  
Tuberculoid Leprosy ◽  
Special Stain ◽  
Different Types ◽  
Skin Biopsies

Background: In leprosy, there is a range of varied clinicopathologic manifestations and the diagnosis is made from adequate clinical information combined with bacilloscopy and histopathology which helps in diagnosing different types of leprosy and separating it from other granulomatous lesions. Aim of the study was to classify leprosy according to Ridley Jopling classification and perform the clinicopathological correlation. Materials and Methods: A cross sectional comparative study of skin biopsies of newly diagnosed leprosy recieved over a period of 18 months from January 2009 to June 2010 and clinicopathologic correlation was done along with special stain. Results: This study included 75 patients diagnosed clinically as leprosy. Skin biopsy revealed evidence of leprosy in 72 cases. Maximum number of patient clinically belonged to tuberculoid leprosy which constituted 25 (33%) cases followed by borderline tuberculoid 19 (25.33%). On the contrary, histologically borderline tuberculoid was the most common type (40%, n=30) cases and tuberculoid leprosy constituted (13.33%, n=10) cases. Three cases of clinically diagnosed tuberculoid leprosy showed no features of leprosy histologically. Clinical and histopathological correlation was seen in 34 cases (45.33%). The correlation was highest in borderline tuberculoid (63.15%) followed by borderline lepromatous and lepromatous leprosy. Slit skin smear was positive in 31 cases (43.05%). Fite Farraco stain was positive in 18 cases (25%). Conclusion: The classification of leprosy requires attention to the histopathological criteria and correlation with clinicalinformationand bacteriological examination so as to facilitate accurate therapy to prevent undesirable complication. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8992   Journal of Pathology of Nepal (2013) Vol. 3, 452-458

scholarly journals Evaluation of agreement between clinical and histopathological diagnosis of subtype of leprosy by skin punch biopsy

2020 ◽  
Vol 13 (1) ◽  
pp. 4-8
Author(s):  
Suman Poudel ◽  
Sunita Ranabhat ◽  
Gita Pun
Keyword(s):  
Mycobacterium Leprae ◽  
Punch Biopsy ◽  
Lepromatous Leprosy ◽  
P Value ◽  
Histopathological Diagnosis ◽  
Cross Sectional ◽  
Moderate Agreement ◽  
Skin Punch Biopsy ◽  
Tuberculoid Leprosy ◽  
Granulomatous Diseases

Introduction: Leprosy is chronic granulomatous disease caused by Mycobacterium leprae. Clinically diagnosed cases of leprosy can be evaluated by punch biopsy. It can be classified according to Ridley and Jopling Classification. Objective: To study the different spectrum of leprosy and its Bacillary Index (BI), evaluate the agreement between clinical and histopathological diagnosis. Materials and Methods: This is a hospital based cross sectional retrospective study done for the period of 6 months from January to June 2019. The data were subjected to kappa analysis by using SPSS version 24 to see the agreement between clinical and histopathological diagnosis. Results: Out of 62 cases of clinically diagnosed cases of leprosy three (4.83%) cases turned out to be other granulomatous diseases. According to Ridley and Jopling classification, clinical and histopathological agreement was seen in 38 (61.29%) cases. Agreement of 100% was seen in Indeterminate leprosy (IL) and Borderline tuberculoid leprosy (BT). The BI was more in Lepromatous leprosy (LL), Borderline lepromatous (BL) whereas IL, BT and Tuberculoid leprosy (TT) showed less BI. Overall there was moderate agreement between clinical and histopathological diagnosis (kappa- 0.505) which was statistically significant (p value <0.05). Conclusion: There was moderate agreement between the clinical and histopathological diagnosis of subtype of leprosy. The Bacillary load was high in LL whereas least in TT and is determined by immune system.

scholarly journals V.V. ZENKOVSKY’S FUNDAMENTAL PSYCHOLOGICAL IDEAS IN THE EARLY EMIGRATION

2020 ◽  
pp. 461-485
Author(s):  
А.А. Костригин
Keyword(s):  
Child Psychology ◽  
Educational Process ◽  
General Psychology ◽  
Social Psychological ◽  
Psychological Phenomena ◽  
Psychological Science ◽  
Leading Role ◽  
The Social

Изучалась биография и творчество выдающегося отечественного психолога, философа и представителя российского психологического зарубежья В.В. Зеньковского (1881-1962 гг.). Рассмотрены его ранний период эмиграции и работа в г. Белграде (Королевство сербов, хорватов и словенцев) и г. Праге (Чехословакия) (1920-1926 гг.). Проанализированы фундаментальные психологические идеи В.В. Зеньковского в общей, детской и педагогической психологии, сформулированные им в его монографии «Психология детства» (1924 г.) и курсах лекций «Педагогическая психология» (1924 г.) и «Курс общей психологии» (1925 г.) (на основе архивных материалов). Рассмотрены также его научные концепции в области теории и методологии психологии (структура психологической науки, строение душевной жизни, о ведущей роли эмоциональной сферы в психике человека), детской психологии (педологические основы психологии ребенка, задачи и методы детской психологии, проблемы понимания и самостоятельности феномена детства, роль игры в биологическом, психическом и социальном развитии ребенка) и педагогической психологии (социально-психологические основы педагогической психологии, социально-психологические феномены педагогического процесса, классификация социальных ролей ученика и учителя, психология поведения класса). В.В. Зеньковский представляется как оригинальный теоретик и методолог психологии, разработчик основ изучения психики ребенка, создатель социально-психологического подхода в педагогической психологии. Его концепции этого периода могут быть востребованы в настоящее время при решении методологических вопросов психологии, социально-психологических проблем педагогики, проблем социального воспитания личности, при изучении развития психических процессов и личности ребенка. The author refers to the biography and work of the outstanding Russian psychologist, philosopher and representative of the Russian psychological abroad community V.V. Zenkovsky (1881-1962 y.). The early emigration period of his life and work in Belgrade (the Kingdom of Serbs, Croats and Slovenes) and Prague (Czechoslovakia) (1920-1926 y.) is considered. The author discusses the fundamental psychological ideas of V.V. Zenkovsky regarding general psychology, child psychology and pedagogical psychology, which he formulated at that time in his monograph “Psychology of Childhood” (1924) and lecture courses “Pedagogical Psychology” (1924) and “The Course of General Psychology” (1925) (based on archival materials). There are significant scientific concepts of V.V. Zenkovsky in the field of theory and methodology of psychology (the structure of psychological science, the structure of mental life, the leading role of the emotional sphere in the human psyche), child psychology (pedological foundations of child psychology, tasks and methods of child psychology, the problem of understanding and independence of the childhood phenomenon, the role of the game in biological, mental and social development of the child) and pedagogical psychology (social-psychological foundations of pedagogical psychology, social-psychological phenomena of educational process, the classification of social roles of student and teacher, the psychology of class behavior). V.V. Zenkovsky is presented as an original theoretician and methodologist of psychology, pedologist, developer of the basics of studying the child’s psyche and creator of the social-psychological approach in pedagogical psychology. Nowadays the analyzed concepts of the Russian psychologist can be demanded when solving methodological issues of psychology, social-psychological problems of pedagogics, problems of social education of a person, when studying and designing the development of child’s mental processes and personality.

scholarly journals SOCIO-CULTURAL FEATURES OF SPEAKERS’ COMMUNICATIVE BEHAVIOR IN DIFFERENT SOCIAL ROLES AND THEIR TRANSLATION INTO UKRAINIAN

2020 ◽  
Vol 11 (87) ◽  
Author(s):  
Myroslava Lohvynenko ◽  
Keyword(s):  
Social Roles ◽  
Social Role ◽  
Communicative Behavior ◽  
Communication Situations ◽  
The Social ◽  
The Individual ◽  
Cultural Features ◽  
Linguistic Means

The article is a study of the features of the individual’s communicative behavior, when implementing different social roles. By analyzing the concept of the social role and status, author puts forward the classification of the most frequent social roles represented by an individual in formal and informal communication situations (that of a father, lecturer, friend, colleague, employer, employee, consultant). The work is based on the number of studied and investigated dialogical fragments, where one character appears in different social roles and uses various language means. Having considered typical communicative situations, the author also singles out linguistic and extra-linguistic means which mark the changes of speaker’s social roles, namely: elevated, sarcastic, polite, sad, ironic, joyful, neutral, strict, humorous, angry, contemptuous, intrusive, friendly, confident and other tones as well as smile, frown and raised eyebrows, laugh, direct eye contact, pointing finger, pointing the hand etc. At the next stage of the analysis the author reveals the language means that mark the changes of the speaker's social roles as well as outlines the difficulties, connected with their translation into Ukrainian. Translation of the dialogical fragments was studied in order to find out types of rendition of the means that indicate realization of different social roles by the speaker. Non-verbal communication was also researched, aiming to find out correlation between the social role of the speaker and the means, used by the speaker, according to his social role. As a result, the paper presents the analysis of such means of translation as transliteration, transcription, antonymous, descriptive, and contextual tracing, literal types of translation as well as their dependence on the social role of the speaker. So the components of intercourse let communicative behavior of the individual to be comprehensively considered. Thereby, the results of the study, their representation in per cents, as well as examples of the communicative situations and their analysis, are represented in the following article.

scholarly journals Memory in Linguistic Narrative vs. Postmodern Multitasked Multimedia Art Memory

2018 ◽  
Vol 1 (2) ◽  
pp. 101
Author(s):  
Vesna Srnic ◽  
Emina Berbic Kolar ◽  
Igor Ilic
Keyword(s):  
Short Term Memory ◽  
Social Role ◽  
Procedural Memory ◽  
Short Term ◽  
The Social ◽  
Multimedia Art ◽  
The Media

<p><em>In addition to the well-known classification of long-term and short-term memory, we are also interested in distinguishing episodic, semantic and procedural memory in the areas of linguistic narrative and multimedial semantic deconstruction in postmodernism. We compare the liveliness of memorization in literary tradition and literature art with postmodernist divisions and reverberations of traditional memorizations through human multitasking and performative multimedia art, as well as formulate the existence of creative, intuitive and superhuman paradigms.</em></p><em>Since the memory can be physical, psychological or spiritual, according to neurobiologist Dr. J. Bauer (Das Gedächtnis des Körpers, 2004), the greatest importance for memorizing has the social role of collaboration, and consequently the personal transformation and remodelling of genomic architecture, yet the media theorist Mark Hansen thinks technology brings different solutions of framing function (Hansen, 2000). We believe that postmodern deconstruction does not necessarily damage memory, especially in the field of human multitasking that utilizes multimedia performative art by means of anthropologization of technology, thereby enhancing artistic and affective pre&amp;post-linguistic experience while unifying technology and humans through intuitive empathy in society.</em>

Clinical to Histopathological Correlation of the Diagnosis of Dementia

1991 ◽  
Vol 3 (S1) ◽  
pp. 69-74 ◽  
Author(s):  
I. Alafuzoff ◽  
A.-L. Rönnberg ◽  
S. Asikainen-Gustafsson
Keyword(s):  
Clinical Diagnosis ◽  
Clinical Investigation ◽  
Clinical Signs ◽  
University Hospital ◽  
Vascular Lesions ◽  
Cortical Atrophy ◽  
Histopathological Diagnosis ◽  
Exact Nature ◽  
Histopathological Correlation ◽  
Diagnostic Decision

Between January 1988 and December 1989, 1,600 autopsies were performed at Huddinge University Hospital, representing approximately 40% of the 4,000 deceased patients. In 40% (647) of the autopsy cases, patients showed clinical signs of CNS dysfunction.Of these cases, 58% (380) were subject to neuropathological evaluation, including both macro- and microscopic examination. Only macroscopic examination by general pathologists was performed on the remaining cases. Clinical signs of dementia were seen in 10% (169 cases) of the autopsied patients. Neuropathological evaluations were performed on 70% (118) of these patients. Of these, 60% (70) showed degenerative changes and 36% (43) vascular alterations. Macroscopic examinations alone were performed in 30% of the cases. Of these, signs of severe cortical atrophy were seen in 21%, vascular lesions in 12%, and no macroscopic changes in 67%. The completeness of clinical and postmortem examinations of the 169 demented patients was variable. Approximately 40% of the patients lacked any diagnostic decision. In approximately 50% of the cases with diagnostic decision, the clinical diagnosis correlated with the histopathological diagnosis. This low correlation between the clinical diagnosis and the exact nature of the disease was primarily based on the variable completeness of the clinical examinations. In order to improve this situation, it is important to perform both a complete clinical investigation and a neuropathological verification of the nature of the disease.

scholarly journals A clinico pathological correlation in leprosy in a tertiary care teaching institution

2019 ◽  
Vol 5 (4) ◽  
pp. 870
Author(s):  
Ramesh A. ◽  
Sampath V. ◽  
Shvedha M.
Keyword(s):  
Clinical Diagnosis ◽  
Tertiary Care ◽  
Clinical Information ◽  
Lepromatous Leprosy ◽  
Female Ratio ◽  
Histopathological Findings ◽  
Medical College ◽  
Number Of Patients ◽  
One Year ◽  
Madras Medical College

<p class="abstract"><strong>Background:</strong> Leprosy is a chronic infectious granulomatous disease caused by <em>Mycobacterium leprae</em>. The disease primarily affects peripheral nervous system, the skin and certain other tissues. It is a spectral disease which is classified into five groups based on clinical, histopathological and bacteriological and immunological criteria as tuberculoid (TT), borderline tuberculoid (BT), mid-borderline (BB), borderline lepromatous (BL), lepromatous (LL) according to Ridley-Jopling classification. Adequate clinical information combined with histopathology and bacteriological index is helpful not only in classification of different types of leprosy, but also useful for management of cases.The objective of the study was to correlate clinical diagnosis with histopathological findings of leprosy.</p><p class="abstract"><strong>Methods:</strong> A retrospective study was conducted for one year from January to December 2018 in Leprosy clinic, Department of Dermatology, Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai. The histopathological findings were compared with clinical diagnosis.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total number of cases attended leprosy clinic from January 2018 to December 2018 was 167 cases, among those 49 clinically diagnosed cases were included in the study. Out of 49 cases, maximum number of patients belonged to 30-50 years age group. Male to female ratio was 3.9: 1. Hypopigmented, hypoaesthetic patches were commonly seen. Clinically as well as histopathologically BT leprosy was common.The maximum histological correlation seen in lepromatous leprosy (100%) followed by BT (80%).</p><p class="abstract"><strong>Conclusions:</strong> The study emphasises the role of skin biopsy in confirming the clinical diagnosis of leprosy and also as a therapeutic guide.</p>

scholarly journals Współistnienie języków na ziemiach byłego Wielkiego Księstwa Litewskiego w świetle prac Jana Karłowicza

2015 ◽  
Vol 37 ◽  
pp. 41-51
Author(s):  
Elżbieta Koniusz
Keyword(s):  
Nineteenth Century ◽  
The Social ◽  
Linguistic Interference ◽  
History Of ◽  
Polish Language ◽  
Grand Duchy Of Lithuania ◽  
Bilingualism And Multilingualism ◽  
Grand Duchy

Co-existence of languages in the area of the former Grand Duchy of Lithuania in the light of the works of Jan KarłowiczThe article discusses the issues of the co-existence of languages in the former Grand Duchy of Lithuania and the consequences of the phenomenon as documented in the works of Jan Karłowicz – the outstanding scholar of the second half of the nineteenth century, an expert and researcher of the “Lithuanian” version of Polish language. The article emphasizes the fact that the research on languages in the area of The Grand Duchy of Lithuania and results of their co-existence goes back to the second half of the nineteenth century and Jan Karłowicz was the pioneer of this research. He was the first to observe the following phenomena of their co-existence: interference; bilingualism and multilingualism; prioritization of co-existing languages with the unique role of the Polish language in focusing various functions in the history of The Grand Duchy of Lithuania; the diversity of Polish with sociolinguistic classification of its provincia­lisms and their division in the view of their origin; and the dangers to the Polish language in the period of Russification. Karłowicz struggled with the lack of terminology to describe the linguistic phenomena characteristic for the area. The article focuses on the classification of provincial qualities of the “Lithuanian” Polish language executed by Karłowicz in the social and ethnolinguistic area; and on the presentation of the phenomenon of linguistic interference visible in the provincial vocabulary in The Grand Duchy of Lithuania collected in “Dictionary of Polish dialects” by Karłowicz. Сосуществование языков на территории бывшего Великого княжества Литовского в свете произведений Яна КарловичаЦель данной статьи – показать сосуществование языков на землях бывшего Великого княжества Литовского (ВКЛ) и последствий этого явления, засвидетельствованных в работах Яна Карловича, видного ученого второй половины девятнадцатого века, знатока и исследователя „литовского” польского языка. Автор статьи указывает на то, что изучение языков в Великом княжестве Литовском, последствиям их сосуществования относятся ко второй половине девятнадцатого века, а их первым исследователем был Карлович. Им впервые были отмечены такие проявления этого сосуществования, как языковая интерференция, билингвизм и многоязычие, иерархия сосуществующих языков и диалектов. Выделена особая роль польского языка, объединившего целый ряд функций в истории ВКЛ, дифференциация внутри польского языка, социолингвистическая классификация его диалектизмов и их деление по происхождению, угрозы для польского языка в период сильной русификации. Особое внимание автор статьи сосредоточил на классификации провинциальных особенностей „литовского” польского языка, осуществлённой Карловичем в социальном и этнолингвистическом плане, а также на проявлениях интерференции в провинциальной лексике, ведущей своё происхождение из Великого княжества Литовского, собранной в „Словаре польских диалектов” Карловича.

scholarly journals Study of glottic lesions in patients undergoing microlaryngeal surgery

2020 ◽  
Vol 6 (2) ◽  
pp. 277
Author(s):  
Vikrant Mittal ◽  
Manish Munjal ◽  
Rohit Verma ◽  
Parth Chopra ◽  
Hemant Chopra
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Detailed Examination ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Male Female Ratio ◽  
Male Preponderance ◽  
Vocal Nodules ◽  
Microlaryngeal Surgery

<p class="abstract"><strong>Background:</strong> Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.</p><p class="abstract"><strong>Methods:</strong> 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed.  </p><p class="abstract"><strong>Results:</strong> There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.</p><p class="abstract"><strong>Conclusions:</strong> In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.</p>

CRIMINOLOGICAL PERSONAL TRAITS OF AN OFFENDER

2018 ◽  
Author(s):  
Bohdan Holovkin ◽  
◽  
Maryna Kakhnova ◽  
Keyword(s):  
Domestic Violence ◽  
Social Role ◽  
Psychological Traits ◽  
Personal Traits ◽  
Legal Norms ◽  
The People ◽  
The Social ◽  
Illegal Acts

This article considers particular aspects of criminological personal traits of an offender. The author draws attention to the fact that in most countries of the world, including Ukraine, there is an exacerbation of the problem of domestic violence due to the COVID-19 pandemic, quarantine and isolation. Therefore, analysis of some particular aspects of the criminological personality traits of an offender is an urgent issue. In this article, the typical personal features of offenders were identified. The author classified people committing domestic violence by gender, age and educational level. The study identified negative traits of character that are common to the individuals committing domestic violence. The research of criminal law features that characterize the personality of an offender showed that the offender commits most of all illegal acts from this category individually. At the same time, most of the people who commit domestic violence have previous criminal experience and a criminal record. The analysis of socio-psychological characteristics of offenders revealed that latter tend to act in a socially dangerous way. It should be noted, that unfriendly relations become the most frequent motives for domestic violence. The analysis of the social role of people committing domestic violence allowed concluding that the latter tend to separate themselves from positively oriented social groups. They tend to perform negative social roles and functions, causing violations or deliberate disregard for legal norms, labour, family and other responsibilities. In the article, there is a classification of the different types of the offender’s personality by moral and psychological traits of the person. The findings of the research provide a typical criminological portrait of a person who commits domestic violence and outline the prospects for further research of this issue.

Sign in / Sign up

Export Citation Format

Share Document