scholarly journals Assessment of tear secretion and tear film instability in cases with pterygium and normal subjects

2013 ◽  
Vol 5 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Narayani Roka ◽  
SP Shrestha
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Strong Relationship ◽  
Normal Subjects ◽  
Controlled Study ◽  
Control Group ◽  
P Value ◽  
Tear Secretion ◽  
Schirmer’S Test ◽  
Significant Difference

Introduction: Dry eye is a common disorder affecting a significant percentage of the population. Materials and methods: This study is a prospective, hospital-based, case-controlled study conducted between January 2009 and May 2010. Seventy-six pterygium cases and 152 age-and- sex matched controls presenting to the OPD of Manipal Teaching Hospital were included. The TBUT Schirmer’s test and basal tear secretion were estimated in all patients. A TBUT of less than 10 seconds and a Schirmer’s test of less than 10 mm were considered abnormal. Results: Pterygium was bilateral in 15 (19.7 % ) and unilateral in 61 (80.3 %) patients. Ninety-two (92.1 %) pterygium patients reported either one or more of the six dry eye symptoms. Redness was the most common (67 %) symptom reported. The mean Schirmer’s test I, mean basal secretion and mean TBUT values were 16.19 mm, 10.01 mm and 10.56 seconds in pterygium cases and 20.22 mm,13.25 mm and 26.25 seconds in the control group respectively. There was a statistically significant difference in the dry eye results between the pterygium cases and the control group (p value < 0.05). The odds ratio between pterygium and dry eye was 3.28. Dry eye was present in 26 % of the normal patients and in 54 % of the pterygium cases. Conclusion: There is a strong relationship between dry eye and pterygium. Nepal J Ophthalmol 2013; 5(9):16-23 DOI: http://dx.doi.org/10.3126/nepjoph.v5i1.7816

scholarly journals Xerosis meter-an electro-physiological device for quick screening of dry eyes

1970 ◽  
Vol 1 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Y Gupta ◽  
M Gupta ◽  
R Maheshwari ◽  
T Mittal
Keyword(s):  
Dry Eye ◽  
Large Population ◽  
Control Group ◽  
P Value ◽  
Schirmer Test ◽  
Schirmer’S Test ◽  
Group I ◽  
Significant Difference ◽  
Break Up ◽  
Group Ii

Aim: To study the role of ‘Xerosis Meter' in screening of dry eye cases in a large population and compare its results with Schirmer's test and tear break-up time. Materials and method: In a cross sectional study with a control group dry eye was evaluated with Xerosis Meter, Schirmer test and tear film break-up time (TBUT). Cases included in the study were divided into two groups. Group I (Control Group) comprised of asymptomatic patients while Group II (Test Group) had patients showing symptoms and signs of dry eye. The Group II was further divided into two subgroups. Group IIa had cases showing positive result with either of the two tests Schirmer test or TBUT. Group IIb had cases which showed positive results with Xerosis Meter but normal results with the other two tests. Statistics: All the observations were statistically analyzed using SPSS version 11.5 software. The results obtained were compared statistically using unpaired t-test and chi-square test. The p value of < 0.05 was considered as significant. Results: There was a statistically significant difference between the means of Xerosis Meter, Schirmer test and TBUT of the two groups: Group I and Group IIa (p value < 0.001). On comparing Group I and Group IIb the difference was found to be statistically significant with Xerosis Meter (p value < 0.001). The sensitivity and specificity of Xerosis Meter were 85.7% and 80.2% respectively. This was higher than that of the Schirmer's test (81.3% and 74.9%) and TBUT (73.2% and 68.7%). Conclusion: The "Xerosis Meter" is an effective alternate in screening of dry eye cases. It is more effective than the TBUT and as effective as the Schirmer's test in detecting both the normal and dry eye patients. DOI: 10.3126/nepjoph.v1i2.3687 Nep J Oph 2009;1(2):123-128

scholarly journals Clinical correlation between dry eye and pterygium: a study done at government medical college Jammu, Jammu and Kashmir, North India

2017 ◽  
Vol 5 (7) ◽  
pp. 3087
Author(s):  
Angli Manhas ◽  
Dinesh Gupta ◽  
Aditi Gupta ◽  
Dinesh Kumar ◽  
Rameshwar S. Manhas ◽  
...  
Keyword(s):  
Dry Eye ◽  
Rose Bengal ◽  
North India ◽  
Control Group ◽  
Clinical Correlation ◽  
Tear Secretion ◽  
Schirmer’S Test ◽  
Staining Score ◽  
Department Of Ophthalmology ◽  
Significant Difference

Background: To study the prevalence of dry eye among the patients of pterygium and to find the clinical correlation between dry eye and pterygium.Methods: The study was conducted at postgraduate department of Ophthalmology of GMC Jammu over a period of one year. 90 pterygium patients and 180 age and sex matched controls presenting to the eye OPD of GMC Jammu were included in the study. The TBUT, Schirmer’s test, basal tear secretion and Rose Bengal staining score were estimated in all patients. A TBUT of less than 10 seconds, a Schirmer’s test of less than 10mm, basal tear secretion of less than 10mm, Rose Bengal staining score of more than 3 were considered abnormal.Results: Redness 57 (63.33%) was the most frequently occurring symptom in pterygium patients followed by cosmosis 49 (54.44%). The mean TBUT, mean Schirmer’s, mean basal secretion and mean Rose Bengal staining score values were 9.88±3.39 seconds, 13.17±4.57mm, 10.11±4.81mm and 3.27±1.85 in pterygium patients and 14.22±3.99 seconds, 16.40±5.21mm, 12.19±5.05mm and 2.49±1.86 in the control group respectively. There was a statistically significant difference in the dry eye results between the pterygium patients and control groups (p<0.001). The odd’s ratio between dry eye and pterygium was 3.83, dry eye was present in 53 pterygium patients.Conclusions: The prevalence of dry eye in pterygium patients was 58.89% which suggests that there is a strong positive clinical correlation between dry eye and pterygium.

scholarly journals Effect of oral contraceptives on tear film in reproductive age group women

2018 ◽  
Vol 7 (3) ◽  
pp. 860
Author(s):  
Amita Sharma ◽  
Surabhi Porwal ◽  
Manoj Tyagi
Keyword(s):  
Oral Contraceptives ◽  
Tear Film ◽  
Reproductive Age ◽  
Hormonal Contraceptives ◽  
Control Group ◽  
Study Group ◽  
Age Group ◽  
Tear Secretion ◽  
Schirmer’S Test ◽  
Reproductive Age Group

Background: According to WHO 2009, 60-70% women use one of the method of contraception. 8.8% to 15.4% women use oral contraceptives. Objective of present study was to investigate the effect of oral contraceptives on androgen profile and tear film parameters in females within child bearing age.Methods: Present study involve 100 healthy women between 20-45 years, who presented in family planning clinic. Two groups were made according to the use of oral contraceptive pills. Study group consist of 50 women who were on OCPs (Oral contraception pills) and 50 as control group were not taking any hormonal contraceptives. Serum testosterone and DHEA levels of all subjects was done by Enzyme Immuno Assay on blood samples which were collected during 3th to 7th day of menstrual cycle. Quantitative test for tear secretion was done by Schirmer’s test. Stability of tear film was measured by Tear Breakup time (TBUT). Statistical analysis was done to determine the correlation between use of OCPs and androgen profile and tear film parameters.Results: Present results shows decreased androgen levels in women taking oral contraceptives as compared with age matched women who were not taking oral contraceptives. Tear secretion was significantly reduced in study group as indicated by decreased Schirmer’s test values in study group as compared to control group, the tear film stability was also significantly decreased in women taking oral contraceptives.Conclusions: Present study suggest that androgen profile decrease in women taking oral contraceptives. These results support that use of oral contraceptives may be an important etiological factor in pathogenesis of dry eye disease reproductive age group women.

scholarly journals A Controlled Study on the Correlation between Tear Film Volume and Tear Film Stability in Diabetic Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Iman M. Eissa ◽  
Noha M. Khalil ◽  
Heba A. El-Gendy
Keyword(s):  
Anterior Segment ◽  
Tear Film ◽  
Controlled Study ◽  
Control Group ◽  
Diabetic Patients ◽  
Film Stability ◽  
Duration Of Diabetes ◽  
Significant Difference ◽  
Tear Meniscus ◽  
Tear Meniscus Height

Purpose. To assess the tear film quantity and correlate it with the quality and stability of the tear film in diabetics and compare them to age matched controls.Introduction. Diabetes affects tear film parameters in multiple ways. Poor metabolic control and neuropathy are postulated factors. To further understand how diabetes affects tear film parameters this study was conducted.Subjects and Methods. Tear meniscus height was measured by anterior segment OCT, along with tear thinning time, a subtype of noninvasive tear break-up time, and blinking rate per minute which were all recorded for 22 diabetic patients. Correlations between these tear film parameters were studied and then compared to 16 age matched controls.Results. A statistically significant difference was found in blinking rate between the diabetic and the control group (P=0.002), with higher blinking rate among diabetics. All tear film parameters were negatively correlated with duration of diabetes. A positive correlation was found between tear film volume and stability.Conclusion. Diabetes affects the tear film in various ways. Diabetics should be examined for dry eye signs even in absence of symptoms which may be masked by associated neuropathy. Duration of diabetes has an impact on tear film status.

scholarly journals Assessment of the Impact of Varying Durations of Computer Usage on Dry Eye Parameters in Employees of a Tertiary Care Teaching Hospital of Uttar Pradesh, India

2020 ◽  
Author(s):  
Amit Kumar Jain ◽  
Dadan JI Pandey
Keyword(s):  
Dry Eye ◽  
Tertiary Care ◽  
Tear Film ◽  
Computer Usage ◽  
P Value ◽  
Daily Routine ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
The Impact

Introduction: Dry eye (keratoconjunctivitis sicca) is a common disorder of the tear film having multifactorial aetiology. Now-a-days, a large portion of population is affected with Dry Eye Disease (DED) because of substantial increase in usage of computers and digital devices. Aim: To evaluate the effect of varying durations of computer usage on parameters of DED. Materials and Methods: In this prospective study, total 120 participants were divided into two groups. Group I (n=58) included participants who used computer daily for less than six hours while group II (n=62) included those who used computer for more than six hours daily. Routine eye examination was done and dry eye parameters i.e., Ocular Surface Diseases Index (OSDI), Schirmer Test (ST) and Tear Film Break Up Time (TFBUT) were performed and analysed for any significant difference between groups I and II using unpaired t-test. SPSS 16.0 was used and p-value <0.05 was considered as statistically significant. Pearson’s correlation test was performed to analyse correlation of OSDI score with TFBUT and ST values. Results: Mean OSDI scores in group I and group II were 37.39±8.98 and 49.54±11.7 (p<0.001), respectively; while TFBUT values were 10.19±2.27 seconds and 8.12±2.9 seconds (p<0.001), respectively. ST values were 12.82±3.32 mm in group I and 10.80±3.86 mm in group II (p=0.0027). Significant inverse correlation between OSDI score and TFBUT values was found in both group I (r=-0.557, p<0.001) and group II (r=-0.439, p<0.001). Similarly, correlation of OSDI score with ST values in group I (r=-0.787, p<0.001) and group II (r=-0.320, p=0.011) was also inversely significant. On the basis of OSDI score, 38 (65.5%) participants in group I and 54 (87.08%) participants in group II had severe dry eye. According to TFBUT values 12 (20.68%) participants in group I and 29 (46.77%) participants in group II and as per ST values 17 (29.31%) participants in group I and 30 (48.38%) participants in group II had severe dry eye. Conclusion: Usage of computer or digital displays more than six hours per day is a potential cause for the development of severe DED.

scholarly journals A study of meibomian gland and tear film changes in patients with pterygium in a tertiary care centre

2021 ◽  
Vol 11 (2) ◽  
pp. 336-340
Author(s):  
Piyali Sarkar ◽  
Shilpi Sharma ◽  
Partha Pratim Pal ◽  
Pinaki Sengupta
Keyword(s):  
Pearson Correlation ◽  
Tertiary Care ◽  
Tear Film ◽  
Meibomian Gland ◽  
Categorical Variables ◽  
Control Group ◽  
P Value ◽  
Continuous Variables ◽  
Significant Difference ◽  
Expression Score

To find out the correlation of Meibomian gland and Tear film dysfunction with pterygium. Institution based prospective cross sectional study. 70 (seventy) patients with unilateral primary progressive nasal Pterygium and 70 healthy adults without any ocular pathology were selected as comparison group from the Ophthalmology outpatient department of Calcutta National Medical College and hospital, Kolkata for a duration of 6 months from January 2020 to June 2020. Meibomian gland dysfunction was measured by meibomian gland expression score and lid margin abnormality score. Tear film changes were measured by Ocular Surface Disease Index (OSDI) Score , Tear break up time (TBUT), Tear meniscus height(TMH), Schirmer’s test 1 (ST1) and Corneal flourescein staining in both pterygium and control group and comparisons were done to find out the significance in differences. The Categorical variables were analyzed with the help of Pearson Chi square test, Spearman rho Correlation, Man Whitney U Test and the continuous variables were analyzed with the help of Independent T test and Pearson Correlation coefficient. The level of significance was considered as 95% of confidence interval i.e. P value &#60;0.05. OSDI score, TBUT, meibomian gland expression score, lid margin abnormality score and corneal fluoresce in staining were significantly higher in pterygium group than others (p&#60;0.05) whereas TMH values although showed differences between the two groups but were not statistically significant. ST1 were normal in pterygium group though had significant difference with control. Meibomian gland function was altered in patient with Pterygium which is also associated with uncomfortable ocular symptoms due to tear film abnormalities.

scholarly journals Effects of Aerobic Exercise on Tear Secretion and Tear Film Stability in Dry Eye Patients

2021 ◽  
Author(s):  
Chao Sun ◽  
Xiaofan Chen ◽  
Yanming Huang ◽  
Huan Zou ◽  
Wei Fan ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Aerobic Exercise ◽  
Dry Eye ◽  
Tear Film ◽  
Normal Subjects ◽  
Oxidative Stress Marker ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability ◽  
Before And After

Abstract Background: To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients.Methods: Firstly we observed Schirmer Ⅰ test and 6 tear compositions detected by ELISA in 34 eyes of dry eye patients and 34 eyes of normal subjects before and after AE. Then we observed 30 eyes of dry eye patients and 30 eyes of normal subjects before and after AE, the evaluated variables included tear meniscus height (TMH), first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness (LLT), number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity.Results: In dry eye group, compared with baseline, Schirmer Ⅰ test at 0 minutes after AE increased significantly (P < 0.001), F-NITBUT and A-NITBUT at every time point after AE prolonged significantly (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 minutes after AE decreased significantly (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001), visual acuity at 10 and 20 minutes after AE improved significantly (P = 0.017, P = 0.021). The overall oxidative stress marker 8-hydroxy-2’-deoxyguanosine at 0 minutes after AE decreased significantly compared with baseline (P = 0.040).Conclusion: AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020, http://www.chictr.org.cn/showproj.aspx?proj=57282

scholarly journals Multicenter Study of Intense Pulsed Light for Patients with Refractory Aqueous-Deficient Dry Eye Accompanied by Mild Meibomian Gland Dysfunction

2020 ◽  
Vol 9 (11) ◽  
pp. 3467
Author(s):  
Reiko Arita ◽  
Shima Fukuoka ◽  
Takanori Mizoguchi ◽  
Naoyuki Morishige
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Meibomian Gland ◽  
Intense Pulsed Light ◽  
Meibomian Gland Dysfunction ◽  
Control Group ◽  
Pulsed Light ◽  
Lipid Layer ◽  
Film Stability ◽  
Schirmer’S Test

Aqueous-deficient dry eye (ADDE) and meibomian gland dysfunction (MGD) can be refractory to therapy. Intense pulsed light (IPL) was recently introduced as an effective treatment for MGD. We here evaluated the efficacy of IPL combined with MG expression (MGX) compared with MGX alone (n = 23 and 20, respectively) for patients with refractory ADDE with mild MGD at three sites. Symptom score, visual acuity (VA), noninvasive breakup time (NIBUT) and lipid layer thickness (LLT) of the tear film, lid margin abnormalities, fluorescein BUT (FBUT), fluorescein staining, tear meniscus height (TMH), meibum grade, meiboscore, and Schirmer’s test value were assessed at baseline and 1 and 3 months after treatment. LLT, plugging, vascularity, FBUT and NIBUT were improved only in the IPL-MGX group at three months compared with baseline. All parameters with the exception of VA, meiboscore, TMH, Schirmer’s test value were also improved in the IPL-MGX group compared with the control group at three months, as was VA in patients with central corneal epitheliopathy. Although IPL-MGX does not affect aqueous layer, the induced improvement in quality and quantity of the lipid layer may increase tear film stability and ameliorate symptoms not only for evaporative dry eye but for ADDE.

scholarly journals EVALUATION OF THE ROLE OF 1% CARBOXYMETHYLCELLULOSE AFTER PHACOEMULSIFICATION AMONG NORTH INDIAN POPULATION : A PROSPECTIVE, RANDOMIZED, PLACEBO CONTROLLED STUDY

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Shweta Sharma ◽  
Ashok Kumar Sharma ◽  
Hans Raj Sharma ◽  
Shivani Sharma
Keyword(s):  
Dry Eye ◽  
Conventional Therapy ◽  
Tear Film ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Intraocular Lens Implantation ◽  
Schirmer Test ◽  
Lens Implantation

Patients undergoing phacoemulsification with intraocular lens implantation present with dry eye symptoms postoperatively. The present study was done to evaluate the role of carboxymethylcellulose 1% added to conventional therapy to treat ocular discomfort and tear film instability in patients after cataract surgery. METHODS: A prospective, placebo controlled study of 150 patients with age-related cataract after undergoing phacoemulsification with intraocular lens implantation were postoperatively randomized to treatment with conventional therapy plus CMC 1% (study group, n = 75) or to conventional therapy plus 0.9% NaCl (control group, n = 75). Tear film breakup time (TBUT), schirmer test without anesthesia, lissamine green staining and ocular surface disease index (OSDI) scoring were done preoperatively (baseline) and postoperatively at 7 and 30 days.   Results A significant increase in TBUT in the study group as compared to the control group on both day 7 and day 30 was seen (p<0.0001). The OSDI score on day 30 decreased in study group but increased in control group. Schirmer test showed an increase in both the groups on day 7. Day 30 recorded a significant increase in the study group and a decrease in the control group (p<0.0001). Conclusion The present study thus concludes that dry eye can develop immediately after phacoemulsification with a peak on day 7. However, use of 1% carboxymethylcellulose stabilizes the tear film and thus prevents development of dry eye.

scholarly journals The Effectiveness of a Balanced Salt Solution on Dry Eyes in Comatose Patients: A Randomized Trial

2021 ◽  
Author(s):  
Hengameh sadeghi-hasanvand ◽  
Parastou Kordestani-Moghadam ◽  
Farnoosh irandoost ◽  
Seyed hadi ali ◽  
Tahereh Toulabi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Salt Solution ◽  
Control Group ◽  
Artificial Tears ◽  
Dry Eyes ◽  
Schirmer’S Test ◽  
Significant Difference ◽  
Time Test ◽  
The Mean ◽  
Breakup Time

Abstract Objective: Dry eye is one of the complications of hospitalization in ICUs. This study was conducted to assess the effectiveness of a Balanced Salt Solution (BSS) on dry eyes in comatose patients. This clinical trial was conducted in 2019 on 34 patients admitted to the ICUs. The control group received sterile eye ointment with artificial tears (2 drops every 6 hours) and a tape over the eye. The trial group also received BSS (2 drops every 6 hours) in the opposite eye over five days. The patients' dry eye was examined on first day and sixth day of the study using Schirmer’s Test (ST) and the Tear Breakup Time Test (TBUT). The data were analyzed in SPSS-21.Results: The results of the paired T-test based on ST and TBUT showed no significant change from first day one to sixth day in the BSS-receiving group (P>0.999 and P=0.187, respectively). Furthermore, no significant difference was observed between the two groups in the mean score of dry eye after eliminating the effect of the demographic and clinical variables (P=0.947). The administration of this solution by nurses seems to be an effective method for preventing the progression of dry eye in ICU patients.

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