Antimicrobial Resistance is a Global Problem

2018 ◽  
Vol 2 (4) ◽  
pp. 6-19
Author(s):  
A.G. Salmanov ◽  
V.V. Trokhymchuk ◽  
O.M. Verner ◽  
O.O. Lugach
Keyword(s):  
Public Health ◽  
Health Care ◽  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Animal Health ◽  
Antibiotic Use ◽  
Modern Medicine ◽  
Full Spectrum ◽  
The Public ◽  
Treatment Action

Infectious agents resistance to antimicrobials remains a challenging open problem of health care around the world. As a result, treatment-induced infections pose a serious threat to public health in general. This problem has become so important that the overwhelming majority of countries consider it a threat to the national security. Resistance to antimicrobials threatens to offset the very fundamentals of modern medicine and the sustainability of the public health system effective global response to a permanent infectious diseases threat. Today, antimicrobial resistance issues can be tackled provided that one implements an effective One Health approach (the principle of human and animal health interrelation), assuming that there is a coordination between different sectors and subjects, including experts in medicine, veterinary medicine, agriculture, ecology, and well-informed consumers. To ensure effectiveness of treatment, action is urgently needed to counteract the further development and spread of antibiotic resistance, which is driven by antibiotic use in all sectors. Since this resistance has no ecological, sectoral or geographical borders, its appearance in one sector affects resistance in other sectors. National authorities, veterinarians, physicians, patients and farmers all have key roles in preserving the power of antibiotics. The prevention and containment of antibiotic resistance therefore requires addressing all risk factors for the development and spread of antibiotic resistance across the full spectrum of conditions, sectors, settings (from health care to use in food-animal production) and countries. This article explores the options for prevention and containment of antibiotic resistance in the food-chain through national coordination, including the regulation and reduction of antibiotic use in food animals, training and capacity building, surveillance of resistance trends and antibiotic usage, promotion of knowledge and research, and advocacy and communication to raise awareness of the issues. The article suggests possible ways for adopting a holistic, intersectoral, multifaceted approach to this growing problem.

scholarly journals Perceptions of Antibiotic Use and Resistance: Are Antibiotics the Dentists’ Anxiolytics?

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 735
Author(s):  
Julie Dormoy ◽  
Marc-Olivier Vuillemin ◽  
Silvia Rossi ◽  
Jean-Marc Boivin ◽  
Julie Guillet
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Qualitative Method ◽  
Oral Surgery ◽  
Antibiotic Use ◽  
Public Health Issue ◽  
Clinical Factors ◽  
Structured Interviews ◽  
Health Crisis ◽  
The Public

Background: Antibiotic resistance is a global health crisis. The aim of this study was to explore dentists’ perceptions of antibiotic resistance. Methods: A qualitative method was used. Seventeen dentists practising in the Nancy (Lorraine, France) region were surveyed. They were general practitioners or specialised in oral surgery, implantology, or periodontology. The practitioners took part in semi-structured interviews between September 2019 and July 2020. All of the interviews were transcribed in full and analysed thematically. Results: Four major themes have been selected: attitudes of the dentists in regard to the guidelines, clinical factors that influence prescriptions, non-clinical factors that influence prescriptions, and the perception of antibiotic resistance. The dentists stated that they were very concerned regarding the public health issue of antibiotic resistance. However, they often prescribe according to their own interests and habits rather than according to the relevant guidelines. Conclusions: Although dentists are generally well aware of antibiotic resistance, they often do not adequately appreciate the link between their prescribing habits and the phenomenon of antibiotic resistance. Regular updating of practitioners’ knowledge in this regard is necessary, but patients and the general public should also be made more aware of the issue.

scholarly journals Anthropogenic Activities and the Problem of Antibiotic Resistance in Latin America: A Water Issue

Water ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 2693
Author(s):  
Delfina C. Domínguez ◽  
Luz María Chacón ◽  
D’Janique Wallace
Keyword(s):  
Antibiotic Resistance ◽  
Latin America ◽  
Antimicrobial Resistance ◽  
Latin American ◽  
Anthropogenic Activities ◽  
Antibiotic Use ◽  
Modern Medicine ◽  
Resistant Bacteria ◽  
Beta Lactam ◽  
Water Ecosystems

Antibiotics revolutionized modern medicine and have been an excellent tool to fight infections. However, their overuse and misuse in different human activities such as health care, food production and agriculture has resulted in a global antimicrobial resistance crisis. Some regions such as Latin America present a more complex scenario because of the lack of resources, systematic studies and legislation to control the use of antimicrobials, thus increasing the spread of antibiotic resistance. This review aims to summarize the state of environmental antibiotic resistance in Latin America, focusing on water resources. Three databases were searched to identify publications on antimicrobial resistance and anthropogenic activities in relation to natural and artificial water ecosystems. We found that antibiotic resistant bacteria, mainly against beta lactam antibiotics, have been reported in several Latin American countries, and that resistant bacteria as well as resistant genes can be isolated from a wide variety of aquatic environments, including drinking, surface, irrigation, sea and wastewater. It is urgent to establish policies and regulations for antibiotic use to prevent the increase of multi-drug resistant microorganisms in the environment.

scholarly journals Combating Antimicrobial Resistance Through Student-Driven Research and Environmental Surveillance

2021 ◽  
Vol 12 ◽  
Author(s):  
Erica R. Fuhrmeister ◽  
Jennifer R. Larson ◽  
Adam J. Kleinschmit ◽  
James E. Kirby ◽  
Amy J. Pickering ◽  
...  
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Modern Medicine ◽  
Classroom Research ◽  
Public Health Issue ◽  
Environmental Surveillance ◽  
Immune Systems ◽  
Institutional Participation ◽  
Common Barriers

Emerging resistance to all classes of antimicrobials is one of the defining crises of the 21st century. Many advances in modern medicine, such as routine surgeries, are predicated on sustaining patients with antimicrobials during a period when their immune systems alone cannot clear infection. The development of new antimicrobials has not kept pace with the antimicrobial resistance (AR) threat. AR bacteria have been documented in various environments, such as drinking and surface water, food, sewage, and soil, yet surveillance and sampling has largely been from infected patients. The prevalence and diversity of AR bacteria in the environment, and the risks they pose to humans are not well understood. There is consensus that environmental surveillance is an important first step in forecasting and targeting efforts to prevent spread and transmission of AR microbes. However, efforts to date have been limited. The Prevalence of Antibiotic Resistance in the Environment (PARE) is a classroom-based project that engages students around the globe in systematic environmental AR surveillance with the goal of identifying areas where prevalence is high. The format of PARE, designed as short classroom research modules, lowers common barriers for institutional participation in course-based research. PARE brings real-world microbiology into the classroom by educating students about the pressing public health issue of AR, while empowering them to be partners in the solution. In turn, the PARE project provides impactful data to inform our understanding of the spread of AR in the environment through global real-time surveillance.

Production of polyclonal antibody for ciprofloxacin detection in Brazilian livestock

2003 ◽  
Vol 2003 ◽  
pp. 84-84
Author(s):  
S.P. Gobbo ◽  
C. Longo ◽  
I.C.S. Bueno ◽  
K.M.R. Duarte ◽  
C.F. Meirelles
Keyword(s):  
Public Health ◽  
Veterinary Medicine ◽  
Antimicrobial Resistance ◽  
Polyclonal Antibody ◽  
Polyclonal Antibodies ◽  
Antibiotic Use ◽  
Feed Additive ◽  
Human Consumption ◽  
The Public ◽  
Significant Question

The antibiotic use to increase the animal production can result in residual concentrations in products as meat, eggs and milk, exceeding the acceptable doses for human consumption. In Brazil nowadays, 14 antibiotics are employed as feed additive, however there are about 121 drugs used in Veterinary Medicine that contain antibiotics in their formulation. Due to amplitude and frequency of the antimicrobial resistance, it can be considered an emergent and significant question for the public health and an alert for the necessity of a global control about the use of those antibiotics. The immunoassays allow the diagnosis of these antibiotics with accessible costs and presenting good results. The aim of this work was to produce polyclonal antibodies for ciprofloxacin detection using ELISA.

scholarly journals Public Health Literacy, Knowledge, and Awareness Regarding Antibiotic Use and Antimicrobial Resistance during the COVID-19 Pandemic: A Cross-Sectional Study

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1107
Author(s):  
Suhaib M. Muflih ◽  
Sayer Al-Azzam ◽  
Reema A. Karasneh ◽  
Barbara R. Conway ◽  
Mamoon A. Aldeyab
Keyword(s):  
Antibiotic Resistance ◽  
Health Literacy ◽  
Antimicrobial Resistance ◽  
Online Survey ◽  
Public Awareness ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Modern Medicine ◽  
Sectional Study ◽  
Cross Sectional

Multi-drug-resistant (MDR) organisms pose a global threat to modern medicine, which has grown as a result of irrational antibiotic use and misuse. This study aimed to assess general public knowledge in Jordan and awareness of antibiotics and antibiotic resistance during the COVID-19 pandemic. A cross-sectional study was carried out utilizing the WHO multicountry public awareness survey. The study population was composed mainly of social media users, and a total of 1213 participants completed the online survey. According to the findings, more than half of the participants were well versed in antibiotic use and resistance. Those with adequate health literacy were found to better understand antibiotics (OR = 1.37, p = 0.017) and antibiotic resistance (OR = 1.46, p = 0.003). The vast majority (88.5%) recognized at least one antibiotic resistance term; however, 53.2% believed that antibiotic resistance is a problem in other nations. The participants in this study reported using antibiotics incorrectly, believing that they were treating sore throats, colds, and flu. The participants were well aware of antibiotic resistance solutions and their consequences on health. Age, education, health literacy, and antibiotic knowledge were found to be substantially (p < 0.05) associated with greater awareness of antibiotic resistance. The findings highlight the need for antimicrobial resistance education campaigns, health literacy, and antibiotic stewardship initiatives.

scholarly journals Agro-Environmental Determinants of Leptospirosis: A Retrospective Spatiotemporal Analysis (2004−2014) in Mahasarakham Province (Thailand)

2021 ◽  
Vol 6 (3) ◽  
pp. 115
Author(s):  
Jaruwan Viroj ◽  
Julien Claude ◽  
Claire Lajaunie ◽  
Julien Cappelle ◽  
Anamika Kritiyakan ◽  
...  
Keyword(s):  
Public Health ◽  
Animal Health ◽  
Spatiotemporal Analysis ◽  
Health Concern ◽  
Intersectoral Collaboration ◽  
The Public ◽  
Additive Modeling ◽  
The One ◽  
And Control ◽  
Northeastern Thailand

Leptospirosis has been recognized as a major public health concern in Thailand following dramatic outbreaks. We analyzed human leptospirosis incidence between 2004 and 2014 in Mahasarakham province, Northeastern Thailand, in order to identify the agronomical and environmental factors likely to explain incidence at the level of 133 sub-districts and 1,982 villages of the province. We performed general additive modeling (GAM) in order to take the spatial-temporal epidemiological dynamics into account. The results of GAM analyses showed that the average slope, population size, pig density, cow density and flood cover were significantly associated with leptospirosis occurrence in a district. Our results stress the importance of livestock favoring leptospirosis transmission to humans and suggest that prevention and control of leptospirosis need strong intersectoral collaboration between the public health, the livestock department and local communities. More specifically, such collaboration should integrate leptospirosis surveillance in both public and animal health for a better control of diseases in livestock while promoting public health prevention as encouraged by the One Health approach.

scholarly journals Cultural mediators are needed to fulfill Right to health for all

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M Magnusson ◽  
I-Z Jama
Keyword(s):  
Public Health ◽  
Health Care ◽  
Life Style ◽  
Right To Health ◽  
Healthy Life ◽  
The Public ◽  
Cultural Mediators ◽  
Healthy Life Style ◽  
The Right ◽  
Health Planner

Abstract The Right to health framework supports available, accessible and acceptable health care of high quality for all (AAAQ). Health of migrants often worsen in the new country. AAAQ may be hindered by poverty, discrimination, health cares' shortcomings and misunderstandings, respectively. Advocating for marginalised groups' Right to health include action. Interventions based on shared influence, participation and control need to be launched. Cultural mediators (CM), i.e. persons that are knowledgeable in both cultures and with networks in migrant groups help overcome lingual problems, lack of trust and uneven power relations. This resource needs to be further examined. How can a CM strengthen AAAQ in a public health setting? Women with Somalian origin living in an underserved neighborhood in Sweden contacted the Public Health Unit of a local hospital, asking for support for a health focused group-activity. Weight loss after delivery was a primary concern. Women gathered monthly 2018-19. The objective was to support healthy life style habits drawing on issues raised by the women. The intervention was conducted by group talks, led by the CM and a public health planner. Methods were based on Social Cognitive Theory focusing on self-efficacy. The CM recruited women, helped them to find the venue, encouraged them to trust the public health planner and broadened perspectives to include female genital mutilation, children's food, how to seek care and workforce issues. Trust developed over time. 70 women participated. Reported gains were raised awareness of ones' rights, increased self-efficacy in relation to food, physical activity and how to support children to a healthy life style. Support for a healthy lifestyle was made more available, accessible and acceptable by the cooperation with the CM, as was the quality of the support. A CM bridges distances regarding spoken language, trust and cultural understanding. S/he puts forward perspectives and needs from the group in question Key messages The Right to health framework highlights areas that need to be in focus when advocating for health equity. Health care workers in settings with many migrants should strive to include cultural mediators in planning, execution and evaluation of interventions.

scholarly journals Antimicrobial multidrug resistance in the era of COVID-19: a forgotten plight?

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Eric Pelfrene ◽  
Radu Botgros ◽  
Marco Cavaleri
Keyword(s):  
Public Health ◽  
Multidrug Resistance ◽  
Regulatory Network ◽  
One Health ◽  
Animal Health ◽  
Antibiotic Use ◽  
Economic Conditions ◽  
Main Body ◽  
The One ◽  
The Relationship

Abstract Background Antimicrobial resistance (AMR) is a growing global problem to which the ongoing COVID-19 pandemic may further contribute. With resources deployed away from antimicrobial stewardship, evidence of substantial pre-emptive antibiotic use in COVID-19 patients and indirectly, with deteriorating economic conditions fuelling poverty potentially impacting on levels of resistance, AMR threat remains significant. Main body In this paper, main AMR countermeasures are revisited and priorities to tackle the issue are re-iterated. The need for collaboration is stressed, acknowledging the relationship between human health, animal health and environment (“One Health” approach). Among the stated priorities, the initiative by the European Medicines Regulatory Network to further strengthen the measures in combatting AMR is highlighted. Likewise, it is asserted that other emerging health threats require global collaboration with the One Health approach offering a valuable blueprint for action. Conclusion The authors stress the importance of an integrated preparedness strategy to tackle this public health peril.

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