scholarly journals THE FEATURES OF THE CLINIC AND DIAGNOSIS OF INTRAUTERINE PNEUMONIA IN NEWBORNS (LITERATURE REVIEW)

ASJ. ◽  
2021 ◽  
Vol 1 (56) ◽  
pp. 43-48
Author(s):  
L. Levchenko ◽  
H. Sargsyan ◽  
S. Cherkasova
Keyword(s):  
Literature Review ◽  
Clinical Features ◽  
Premature Infants ◽  
Clinical Picture ◽  
Clinical Manifestations ◽  
Etiological Factors

This article focuses on the variety of clinical manifestations of intrauterine pneumonia in newborns, including premature infants. The clinical picture of early and late intrauterine pneumonia is presented. The features of the methods of examination of the respiratory organs, such as percussion and auscultation in newborns, are given. The article presents the material of the course of pneumonia which is based on etiological factors and manifested by specific clinical features. The main methods of diagnosis of intrauterine pneumonia such as instrumental and laboratory which is used in newborns are indicated

On the clinical course of multiforme exudative erythema of the oral cavity (literature review)

2020 ◽  
Vol 25 (1) ◽  
pp. 71-74
Author(s):  
A. I. Bulgakova ◽  
Z. R. Hismatullina ◽  
M. V. Zatsepina ◽  
J. A. Kudryavtseva
Keyword(s):  
Literature Review ◽  
Oral Cavity ◽  
Mucous Membrane ◽  
Oral Mucosa ◽  
Erythema Multiforme ◽  
Clinical Picture ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Timely Diagnosis ◽  
Mucous Membranes

Relevance. Multiform exudative erythema is a polyetiological disease, which is characterized by damage not only to the skin, but also to the mucous membranes, mainly the mucous membrane of the oral cavity. The article reviews the literature on the clinical course of multiform exudative erythema of the oral cavity.Purpose. Study the clinical course of erythema multiforme.Materials and methods. We conducted a review of studies of the etiology, pathogenesis, prevalence of erythema multiforme according to domestic and foreign authors, and also reflected the identification of various forms and clinical manifestations of this disease.Results. The analysis of clinical manifestations of erythema multiforme exudative in the oral cavity, the most common symptoms and manifestations on the oral mucosa.Conclusion. The clinical picture of lesions of the oral mucosa in multiform exudative erythema is very diverse, which is important for the timely diagnosis of the disease.

scholarly journals Keratosis Lichenoides Chronica – a Case Report and Literature Review

2014 ◽  
Vol 6 (3) ◽  
pp. 120-137
Author(s):  
Mirjana Paravina ◽  
Predrag Cvetanović ◽  
Miloš Kostov ◽  
Slađana Živković ◽  
Ivana Dimovski ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Literature Review ◽  
Rare Disease ◽  
Clinical Picture ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Poor Response ◽  
Unknown Etiology ◽  
Distinct Entity

Abstract Keratosis lichenoides chronica represents a distinct entity, a rare disease of unknown etiology and pathogenesis, with clinical manifestations which, although typical, require extensive differential diagnosis. The course of the disease is chronic, progressive, and it is resistant to various treatment options, so despite variations in the clinical picture it is really easier to diagnose than to treat. This is a case report of a male patient in whom the diagnosis of keratosis lichenoides chronica was based on typical clinical picture, repeated biopsies and histopathological findings, course of the disease and poor response to any therapy.

scholarly journals MORBUS HANSEN MULTIBASILER RELAPS DENGAN REAKSI ERITEMA NODOSUM LEPROSUM BULOSA PADA SEORANG ANAKMORBUS HANSEN MULTIBASILER RELAPS DENGAN REAKSI ERITEMA NODOSUM LEPROSUM BULOSA PADA SEORANG ANAK

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Damayanti Tangkidi ◽  
Oktavia R. L. Sondakh ◽  
Renate T. Kandou
Keyword(s):  
Clinical Features ◽  
Intravenous Injection ◽  
Clinical Picture ◽  
Laboratory Tests ◽  
Clinical Manifestations ◽  
Severe Reaction ◽  
One Year ◽  
Erythematous Plaques ◽  
Multibacillary Leprosy

Abstract: The clinical manifestations of ENL bullous reaction are generally in the form of nodes and erythematous plaques, but in a severe reaction, bullae, ulcerations, and necrosis may occur. Relapses occur one year or more after the RFT whilst the symptoms emerge slowly and gradually. We reported a case of multibacillary leprosy relapse with ENL bullous reaction in a 14-year-old boy. The clinical picture consisted of reddish nodes and thickening red plaques since 10 days before admission to the hospital, followed by fluid-filled blisters associated with fever. The dermatological status showed multiple erythematous nodes and plaques, as well as multiple bullae. The laboratory tests indicated AFB (+), MI 6.5%, and BI 4+. The patient was stated as RFT after 1 year of MDT-MB treatment. The patient was treated with methylprednisolone 1x40 mg intravenous injection for 10 days, followed by oral methylprednisolone 4 mg in reduced dosage. Conclusion: This case was diagnosed as MHMB relapse with ENL bullous reaction based on the anamnesis, clinical features such as multiple erythematous nodules and plaques with bullae, and laboratory tests. Treatment with corticosteroids and MDT-MB resulted in good improvement.Keywords: ENL bullous reaction, relapseAbstrak: Manifestasi klinis reaksi ENL bulosa umumnya berupa nodi dan plak eritematosa, namun pada reaksi berat dapat berupa bula, ulserasi, dan nekrosis. Relaps terjadi 1 tahun atau lebih setelah RFT, dimana gejala timbul lambat dan bertahap. Kami melaporkan suatu kasus MHMB relaps dengan reaksi ENL bulosa pada seorang anak berusia 14 tahun. Gambaran klinis didapatkan bentol kemerahan dan bercak merah meninggi sejak 10 hari lalu, kemudian timbul lepuh berisi cairan disertai demam badan. Status dermatologis generalisata ditemukan nodul dan plak eritematosa multipel serta bula multipel. Pemeriksaan laboratorium menunjukkan BTA (+), MI 6,5%, dan BI 4+. Pasien dinyatakan RFT setelah 1 tahun pengobatan MDT-MB. Pasien diobati dengan metilprednisolon injeksi 1x40 mg intravena selama 10 hari, dilanjutkan dengan metilprednisolon oral 4mg dengan dosis diturunkan. Lesi bulosa pada kusta merupakan manifestasi dari reaksi ENL berat dengan MI dan BI yang tinggi. Simpulan: Pada kasus ini, diagnosis MHMB relaps dengan reaksi ENL bulosa ditegakkan berdasarkan anamnesis, gambaran klinis berupa nodul dan plak eritematosa multipel disertai bula, dan pemeriksaan laboratorik. Pengobatan dengan kortikosteroid dan MDT-MB memberikan hasil yang baik.Kata kunci: reaksi ENL bulosa, relaps

scholarly journals Acute and chronic dysimmune polyneuropathies in the context of the COVID-19 pandemic: pathogenesis, features of the clinical picture, diagnosis and therapy (literature review)

2021 ◽  
Vol 11 (2) ◽  
pp. 17-27
Author(s):  
A. E. Khrulev ◽  
N. A. Shiyanova ◽  
S. N. Sorokoumova ◽  
D. S. Kasatkin ◽  
V.  N. Grigoryeva ◽  
...  
Keyword(s):  
Nervous System ◽  
Differential Diagnosis ◽  
Literature Review ◽  
Peripheral Nervous System ◽  
Clinical Features ◽  
Clinical Picture ◽  
Specific Therapy ◽  
Diagnosis And Management ◽  
Current Information ◽  
Mechanisms Of Development

Dysimmune polyneuropathies are the etiologically heterogeneous group of diseases with autoimmune damage to the peripheral nervous system. The rarity of these diseases doesn’t exclude the possibility of their development or exacerbation in patients infected with SARS‑CoV‑2, which will require timely differential diagnosis and urgent specific therapy. The article summarizes current information on the mechanisms of development, clinical features, diagnosis and management of acute and chronic dysimmune polyneuropathies in the context of the COVID‑19 pandemic.

scholarly journals CURRENT ISSUES OF ETIOPATHOGENESIS, CLINICAL PICTURE, DIAGNOSIS AND TREATMENT OF MULTIPLE SCLEROSIS (LITERATURE REVIEW AND OWN DATA)

2017 ◽  
Vol 25 (2) ◽  
pp. 316-327
Author(s):  
L. V. Lorina ◽  
A. O. Burshinov
Keyword(s):  
Multiple Sclerosis ◽  
Literature Review ◽  
Clinical Picture ◽  
Demyelinating Disease ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment ◽  
Immunomodulatory Drugs ◽  
Internal And External Factors ◽  
Brain And Spinal Cord

The article provides a literature review on contemporary aspects of etiopathogenesis, clinical picture, diagnosis and treatment of multiple sclerosis (MS). MS is one of the most socially significant problems of modern neurology. MS has been proven to be a multifactorial disease, which develops as a result of both internal and external factors. In the early stages of this disease there is damage to the axons, therefore MS is not only considered an autoimmune demyelinating disease, but also neurodegenerative. The disease is characterized by a variety of clinical manifestations. The variety of neurological symptoms is due to a multiplicity of foci of demyelination and their localization in brain and spinal cord. Neuroimaging methods play an important role in the modern diagnosis of MS. Management of patients with a diagnosis of MS involves compulsory and long-term basic therapy with immunomodulatory drugs that change the course of multiple sclerosis.

Clinical manifestations, diagnosis and treatment of HIV infection of stage 4 (severely symptomatic stage) in the practice of a health professional

2020 ◽  
pp. 27-34
Author(s):  
A. Nikitina ◽  
A. Rusanova ◽  
A. Zhilenkova
Keyword(s):  
Hiv Infection ◽  
Health Professional ◽  
Clinical Picture ◽  
Clinical Manifestations ◽  
Significant Problem ◽  
Diagnosis And Treatment ◽  
Modern World ◽  
Infected People ◽  
Stage 4 ◽  
Future Practice

HIV infection is a significant problem in the modern world, because there are more and more infected people every year. This article will consider: the clinical picture, diagnosis and treatment of this disease in different countries. Based on these data, the following conclusions will be made to help doctors in their future practice correctly approach the diagnosis and treatment of patients with this disease.

Investigating Diseases and Chemicals in COVID-19 Literature with Text Mining (Preprint)

2020 ◽  
Author(s):  
Amir Karami ◽  
Brandon Bookstaver ◽  
Melissa Nolan
Keyword(s):  
Text Mining ◽  
Literature Review ◽  
Topic Modeling ◽  
Large Scale ◽  
Clinical Manifestations ◽  
International Health ◽  
Research Papers ◽  
Strategic Plans ◽  
Funding Agencies ◽  
The Relationship

BACKGROUND The COVID-19 pandemic has impacted nearly all aspects of life and has posed significant threats to international health and the economy. Given the rapidly unfolding nature of the current pandemic, there is an urgent need to streamline literature synthesis of the growing scientific research to elucidate targeted solutions. While traditional systematic literature review studies provide valuable insights, these studies have restrictions, including analyzing a limited number of papers, having various biases, being time-consuming and labor-intensive, focusing on a few topics, incapable of trend analysis, and lack of data-driven tools. OBJECTIVE This study fills the mentioned restrictions in the literature and practice by analyzing two biomedical concepts, clinical manifestations of disease and therapeutic chemical compounds, with text mining methods in a corpus containing COVID-19 research papers and find associations between the two biomedical concepts. METHODS This research has collected papers representing COVID-19 pre-prints and peer-reviewed research published in 2020. We used frequency analysis to find highly frequent manifestations and therapeutic chemicals, representing the importance of the two biomedical concepts. This study also applied topic modeling to find the relationship between the two biomedical concepts. RESULTS We analyzed 9,298 research papers published through May 5, 2020 and found 3,645 disease-related and 2,434 chemical-related articles. The most frequent clinical manifestations of disease terminology included COVID-19, SARS, cancer, pneumonia, fever, and cough. The most frequent chemical-related terminology included Lopinavir, Ritonavir, Oxygen, Chloroquine, Remdesivir, and water. Topic modeling provided 25 categories showing relationships between our two overarching categories. These categories represent statistically significant associations between multiple aspects of each category, some connections of which were novel and not previously identified by the scientific community. CONCLUSIONS Appreciation of this context is vital due to the lack of a systematic large-scale literature review survey and the importance of fast literature review during the current COVID-19 pandemic for developing treatments. This study is beneficial to researchers for obtaining a macro-level picture of literature, to educators for knowing the scope of literature, to journals for exploring most discussed disease symptoms and pharmaceutical targets, and to policymakers and funding agencies for creating scientific strategic plans regarding COVID-19.

scholarly journals Pediatric COVID-19 and the Factors That May Mitigate Its Clinical Course

2020 ◽  
Vol 10 (01) ◽  
pp. e137-e140
Author(s):  
Mosaad Abdel-Aziz ◽  
Nada M. Abdel-Aziz ◽  
Dina M. Abdel-Aziz ◽  
Noha Azab
Keyword(s):  
Clinical Features ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Angiotensin Converting Enzyme 2 ◽  
Compulsory Vaccination ◽  
Specific Factors ◽  
Novel Coronavirus ◽  
Radiographic Data

AbstractThe clinical manifestations of novel coronavirus disease 2019 (COVID-19) vary from mild flu-like symptoms to severe fatal pneumonia. However, children with COVID-19 may be asymptomatic or may have mild clinical symptoms. The aim of this study was to investigate clinical features of pediatric COVID-19 and to search for the factors that may mitigate the disease course. We reviewed the literature to realize the clinical features, laboratory, and radiographic data that may be diagnostic for COVID-19 among children. Also, we studied the factors that may affect the clinical course of the disease. Fever, dry cough, and fatigue are the main symptoms of pediatric COVID-19, sometimes flu-like symptoms and/or gastrointestinal symptoms may be present. Although some infected children may be asymptomatic, a recent unusual hyperinflammatory reaction with overlapping features of Kawasaki's disease and toxic shock syndrome in pediatric COVID-19 has been occasionally reported. Severe acute respiratory syndrome-coronvirus-2 (SARS-CoV-2) nucleic acid testing is the corner-stone method for the diagnosis of COVID-19. Lymphocyte count and other inflammatory markers are not essentially diagnostic; however, chest computed tomography is highly specific. Factors that may mitigate the severity of pediatric COVID-19 are home confinement with limited children activity, trained immunity caused by compulsory vaccination, the response of the angiotensin-converting enzyme 2 receptors in children is not the same as in adults, and that children are less likely to have comorbidities. As infected children may be asymptomatic or may have only mild respiratory and/or gastrointestinal symptoms that might be missed, all children for families who have a member diagnosed with COVID-19 should be investigated.

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