scholarly journals Assessment of the Stigma Level of Patients with Chronic Hepatitis B and C in Students of Different Universities

2017 ◽  
Vol 16 (3) ◽  
pp. 72-77
Author(s):  
S. V. Baramzina ◽  
O. M. Bruhovich ◽  
E. O. Okulova

The purpose: to study the level of stigmatization and attitude towards patients with chronic hepatitis В (ChHB) and chronic hepatitis C (ChHC) among students of medical and non medical university. Materials and methods. Anonymous questioning was conducted among 194 senior students of two institutions of higher education in the city of Kirov: 96 people from the Kirov State Medical University (group 1) and 98 from the Vyatka State University (group 2) in 2016. The original questionnaire included 16 questions about the socio- The demographic status of the respondent, the epidemiology of HCV and HBV-infection, and the attitude towards patients with ChHB and ChHC. Results. As a result of the study, the presence of stigmatizing devices of different severity in patients with ChHB and ChHC in both groups was revealed. It was established that the level of stigmatization and potential discrimination of patients with ChHC and ChHB in students of non-medical specialties was significantly higher compared to medical students. Respondents of the 2nd group did not sufficiently orientate themselves in the issues of epidemiology of ChHB and ChHC, which led to a negative attitude towards these patients and elements of discrimination. However, in the course of the study, it was noted that one-third of students with medical training, well aware of the ways of transmission of HB/HC-virus, also feared household contacts with such patients. In the course of the work it was shown that significantly more stigmatization and discrimination were manifested in relation to ChHB patients in comparison with ChHC and only in the respondents of the 2nd group. Conclusions. Thus, the study revealed the presence of stigmatizing settings of varying severity in patients with ChHB and ChHC in both groups. It was established that the level of stigmatization and potential discrimination of patients with ChHC and ChHB in students of non-medical specialties was significantly higher compared with medical students.To overcome this problem, it is necessary to conduct planned sanitary education among students without medical training, to deepen the knowledge of students of the medical university, since patients with ChHB and ChHC should not be discriminated.

2014 ◽  
Vol 13 (4) ◽  
pp. 322-324
Author(s):  
Diogo Guilherme de Vasconcelos Gonçalves ◽  
Guilherme Zanini Rocha ◽  
José Augusto Malheiros ◽  
Paula Martins ◽  
Aluízio Augusto Arantes Junior ◽  
...  

Objective: The BHTRM Project aims at studying the epidemiology of TRM in the city of Belo Horizonte and providing the means to monitor these patients. Method: To assess the efficacy and solvability of the project, two groups of patients treated at the João XXIII Hospital were compared in two distinct periods. Group 1 - from May 1, 2011 to July 31, 2011, months of project initiation and Group 2 - from December 1, 2012 to February 28, 2013. Results: Despite the 34% increase in the number of assisted patients, there is a 30% drop in the average number of days of hospitalization, as well as a decrease in the average days waiting for surgery of patients requiring surgical treatment, from 10.9 to 4.84, a drop of 56%. Conclusion: BHTRM Project is a useful tool in public health management. It optimizes the treatment of patients with spinal trauma by decreasing the time between admission and surgery. Also provides active monitoring of patient care and ensures better integration of rehabilitation care.


2019 ◽  
Author(s):  
ADEM KOSE

Abstract Background Irrational antibiotic use can adversely affect treatment outcomes or even lead to increased antimicrobial resistance. We aimed to determine antimicrobial prescribing habits and to evaluate the level of theoretical knowledge of rational antibiotic use and awareness about antimicrobial resistance among the senior students of medical faculty and the family physicians in Malatya province in Turkey. Methods This study was cross-sectional research and was carried out between dates of 01 February-30 April 2019, in Malatya province. Power analysis was calculated as minimum 240 participants when considering a proportion difference of 0.18 between the groups, a type I error of 0.05 and a type II error of 0.20. A total 225 senior students in Inonu University Medical Faculty (Group 1) and 230 actively-working family physicians in Malatya primary healthcare services who were found eligible (Group 2) were included in to this study. A questionnaire form was prepared including seven sections and thirty questions. All of the participants were interviewed face to face. Before the questions, the purpose of the study and the contents of the questions were explained to participants. Qualitative data were analyzed by Pearson chi-square test. A p<0.05 value was considered to be statistically significant. Results The group 1 had a tendency to apply to specialist physician when starting to themselves antibiotic treatment, they were more cautious when making antibiotic decision, and their theoretical knowledge level was better. They argued that penal sanctions could be more effective by developing strict use policies to raise awareness of resistance to antibiotics. The group 2 had higher self-confidence and it was also concluded that forgot their theoretical antibiotic knowledge over time and could not follow the novel information because of the intensity of working life. Both groups stated that post-graduation trainings could be used effectively for reducing the antibiotic resistance. Conclusion This study highlighted the need for immediate action of training and corrective actions and might create awareness to determine the difference in theoretical knowledge levels and behavior models of physicians before and after graduation and to reduce higher use rates to lower levels. Key words: Antimicrobial resistance, antibiotic, awareness, rational use


Author(s):  
Yi-Wen Huang ◽  
Chao-Wei Hsu ◽  
Sheng-Nan Lu ◽  
Ming-Lung Yu ◽  
Chien-Wei Su ◽  
...  

Abstract Background Ropeginterferon alfa-2b is a novel mono-pegylated interferon that has only one major form as opposed to 8–14 isomers of other on-market pegylated interferon, allowing injection every two or more weeks with higher tolerability. It received European Medicines Agency and Taiwan marketing authorization in 2019 and 2020, for treatment of polycythemia vera. This phase I/II study aimed to have preliminary evaluation of safety and efficacy in chronic hepatitis B. Methods Thirty-one HBeAg-positive and 31 HBeAg-negative were stratified by HBeAg status and randomized at 1:1:1 ratio to q2w ropeginterferon alfa-2b 350 μg (group 1), q2w 450 μg (group 2) or q1w PEG-IFN alfa-2a 180 μg (group 3). Each patient received 48-week treatment (TW48) and 24-week post-treatment follow-up (FW24). Results The baseline demographics were comparable among the three groups, except for mean HBeAg in HBeAg-positive patients (2.90, 2.23, 2.99 log10 S/CO, respectively). Cumulative HBeAg seroconversion rate at follow-up period was 27.3% (3/11), 36.4% (4/11), and 11.1% (1/9) with time to HBeAg seroconversion starting from TW24, TW16, and TW48 in group 1, 2, and 3, respectively. The rate of HBV DNA < 2000 IU/mL and HBsAg levels < 1500 IU/mL at FW24 were comparable in all groups. Ropeginterferon alfa-2b (group 1 & 2) had numerically lower incidence of rash (9.5% and 4.5%) as compared to PEG-IFN alfa-2a (36.8%). Ropeginterferon alfa-2b 350 μg (group 1) had more ALT elevation (38.1%), however the rate was comparable in group 2 (9.1%) and group 3 (10.5%). Conclusion In this preliminary study, ropeginterferon alfa-2b, although in only half the number of injections, is as safe and effective as pegylated interferon alfa-2a for chronic hepatitis B. Graphic abstract


2014 ◽  
Vol 58 (3) ◽  
pp. 1730-1737 ◽  
Author(s):  
Jeong-Hoon Lee ◽  
Yuri Cho ◽  
Dong Hyeon Lee ◽  
Minjong Lee ◽  
Jeong-ju Yoo ◽  
...  

ABSTRACTThe efficacy of entecavir (ETV) treatment in chronic hepatitis B (CHB) patients who were exposed to lamivudine (LAM) but had no detectable LAM resistance (LAM-R) is not well evaluated. In this study, we aimed to evaluate whether the probability of developing genotypic resistance to ETV in LAM-exposed patients with or without LAM-R is comparable to that in antiviral-naive patients. This retrospective cohort study included 500 consecutive patients with CHB who started ETV monotherapy at a single tertiary hospital in Korea. The patients were divided into three groups: nucleos(t)ide analogue (NA)-naive patients (group 1,n= 142), patients who were previously exposed to LAM and had no currently or previously detected LAM-R (group 2,n= 233), and patients with LAM-R when starting ETV (group 3,n= 125). The overall median ETV treatment duration was 48.7 months. The probabilities of virologic breakthrough were significantly increased not only in group 3 (hazard ratio [HR] = 14.4,P< 0.001) but also in group 2 (HR = 5.0,P< 0.001) compared to group 1. Genotypic ETV resistance (ETV-R) developed more frequently in group 2 (HR = 13.0,P= 0.013) as well as group 3 (HR = 43.9,P< 0.001) than in group 1: the probabilities of developing ETV-R in groups 1, 2, and 3 were <1.0%, 8.0%, and 28.2%, respectively, at month 48. The results of this study indicate that ETV-R occurred more frequently in LAM-exposed patients, even though they had no detectable LAM-R, than in NA-naive patients. Therefore, LAM-exposed CHB patients, regardless of the presence or absence of LAM-R, should be monitored more cautiously for the development of ETV-R during ETV monotherapy.


Author(s):  
V. O. Sitnikova ◽  
О. M. Nadvorna ◽  
О. V. Kashiyan

Preterm labor is one of the most current problems of modern medicine. Preterm labor is defined as the birth of a child in the gestation period less than 37 full weeks of gestation and is the second most common cause (after congenital anomalies) of neonatal mortality [3]. The highest percentage of morbidity and mortality occurs in children born to gestational age less than 32 weeks, although the proportion of these newborns is 16 % of all preterm infants [4]. Preterm labor is a polyetiology problem that depends on many factors. One of the major problems is the formation of placental dysfunction, which manifests itself by morphofunctional changes in the placenta associated with violation of uterine-placental circulation. The aim of the study – to obtain the peculiarities of placentas’ histological condition in women with burdent anamnesis and preterm labor with different Apgar point scale of newborn. Materials and Methods. A total of 19 placentas of women with preterm labor were observed in Maternal Hospital No. 5 of Odesa, Ukraine. We studed their residence areas, obstetrical and gynacology anamnesis, current pregnancy and labor anamnesis. We exa­mined the ultrasound datas of the newborns, studied their anthropometric, Apgar scale and histology of placentas’ datas. All interviewed women were devided into two groups: less than 35 years old – 12 women of the group 1 and more than 35 years old – 7 women, it was the group 2. The average age of the examined groups was 31.3 years old. Statistical datas processing was carried out by using the Fisher angular transformation. The degree of probability (P) between two comparative values was considered to be statistically valid when P<0.05. The research results showed that all elder women were married, lived in ecoregions of the city, had more often revolved to artificial reproductive technologies, had singleton gestation compared to younger group of patients. Newborns of women afer 35 had better points of Apgar scale and no one had IUGR compared to newborns of the younger women. Signs of placenta dysfynction were detected in placentas of both groups of women. Conclusions. In our investigation the women of different age groups with preterm labor had signs of placenta dysfunction but women after 35 years had better datas of newborn babies according to Apgar scale and absence of IUGR. Probably, it is connected with residency, official marriage and better preconceptional preparation in this group.


New Medicine ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Maja Stańczyk ◽  
Ronald Lukashevich ◽  
Aleksandra Gorzkowska ◽  
Paulina Urbańska ◽  
Piotr Laskowski ◽  
...  

Introduction. Temporomandibular joint (TMJ) disorders are a common diagnostic problem. No universal radiological parameter of the analysis was introduced. Aim. Comparison of values of selected radiological parameters between asymptomatic patients and those with the TMJ arthropathy. Material and methods. Retrospective analysis of CT scans of patients of the Department of Dental and Maxillofacial Radiology and the Department of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw. Patients were divided into two groups: 1. without TMJ disorders, 2. with TMJ dysfunction symptoms. Following parameters of heads of mandible were analyzed bilaterally: shape, anteroposterior and lateromedial dimensions, the distance between lateral points of both heads (HL-HR), distance between a head and the mandibular fossa. The angle between the horizontal axis of the head of mandible and the line drawn by posterior points of heads of mandible was measured. Results. The most common type of the head of mandible in group 1 (40 patients; 13 women, 27 men) was convex (14 patients), in group 2 (16 patients; 14 women, 2 men) – plane (8 patients). Significant differences between groups were obtained for: GL-GP (group 1 – 120.35 mm, group 2 – 115.4 mm), dimensions of heads of mandible: lateromedial – 19.7 mm, 18.14 mm, anteroposterior – 8.03 mm, 7.04 mm for group 1 and 2, respectively. Conclusions. Computed tomography allowed for an accurate analysis of the TMJ components. Measurements of structures discussed in this work should be a part of the diagnosis of patients with TMJ dysfunction.


2021 ◽  
Vol 13 (02) ◽  
pp. e96-e101
Author(s):  
Zachary C. Landis ◽  
John B. Fileta ◽  
Allen R. Kunselman ◽  
Joseph Sassani ◽  
Ingrid U. Scott

Abstract Purpose The aim of this article is to investigate the impact of a 1-minute video describing resident training with a cataract surgical simulator on patients' perceptions regarding resident involvement in cataract surgery and to identify factors associated with patient willingness to have cataract surgery performed by a resident. Design Cross-sectional survey. Methods An anonymous Likert-style survey was conducted among 430 consecutive adult patients who presented for eye examination at the Penn State Health Eye Center. The survey included questions regarding demographics, understanding of the medical training hierarchy, and patient willingness to have a resident perform their cataract surgery. There were six questions regarding patient willingness to have residents perform their cataract surgery and the second question in this set informs the patient that residents are supervised by an experienced cataract surgeon. Patients were randomly assigned to one of two groups: patients in Group 1 completed the survey only, while patients in Group 2 watched a 1-minute video describing resident training with a cataract surgical simulator prior to completing the survey. Results Four hundred fourteen of the 430 patients (96.3%) completed the survey. Overall, 24.7% (n = 102) of respondents expressed willingness to allow an ophthalmology resident to perform their cataract surgery, and that proportion increased to 54.0% (n = 223) if the patient was informed that the resident would be supervised by an experienced cataract surgeon. Patients in Group 2 were twice as likely compared with patients in Group 1 to express willingness to allow an ophthalmology resident to perform their cataract surgery (odds ratio 1.92 [1.18–3.11], p = 0.009). Conclusions A thorough informed consent process including information regarding attending supervision and a brief video detailing resident training with a cataract surgery simulator may increase patient willingness to allow resident participation in cataract surgery.


Author(s):  
Al Hariri Mahmoud Jоmaa ◽  
Svitlana Semenenko ◽  
Sergey Zaikov ◽  
Vasyl Popovych

Materials and methods: Sixty patients aged 18 to 85 years who were ill with acute bacterial rhinosinusitis were examined. the average age of which was 36 ± 2 years. The research was carried out on the basis of the ENT Department of the City Clinical Emergency Hospital and the Municipal Medical Diagnostic Center of the city of Vinnitsya. All patients were divided into two groups. 30 patients with acute bacterial rhinosinusitis included in the baseline therapy group 1 (group of comparison), which included: systemic antibiotic therapy (selective drugs - cephalosporins II-III generation), anti-inflammatory (topical corticosteroids, non-steroidal anti-inflammatory drugs), irrigation therapy, local decongestants and drugs with mucolytic, secretomotor and secretory effect. Group 2 (main group) consisted of 30 patients with a diagnosis of acute bacterial rhinosinusitis, the bacteriophage (sta- phylococcal or piophage) was added to the baseline therapy. Patients undergoing bacteriophage (staphylococcus or piophage) were injected as drops in the nose, 3-4 drops in each nasal passage three times a day for 7-10 days or after catheterization of the nasal sinus was washed with sterile 0.9% sodium chloride solution, after which was injected through a catheter of 3-5 ml of a bacteriophage into the sinus cavity once a day for 7-10 days. The level of secretory immunoglobulin A (sIgA) was determined using an enzyme-linked immunosorbent assay in nasal secret. The statistical processing of the results was carried out using the statistical computer program Statistica for Windows, v.12 using parametric and nonparametric methods for evaluating the results. Results: Prior to the median treatment, the concentration of sIgA in nasal washes in group 1 was 0.92 mg / L, the interquartile interval of P25-P75 was in the range of 0.74; 1.15 mg / l, and in group 2 - median 0.94 mg / L, P25-P75 - 0.75-1.10 mg / l (p> 0.05). It was found that standard therapy was accompanied by a probable increase The concentration of sIgA in the nasal secret in 7-10 days from the beginning of treatment was 2.1 times (p <0.001), compared to the indicator before treatment, while the rates before treatment and after 12 weeks were not statistically significantly different (p = 0.051). Against the background of combination therapy, which included a bacteriophage, there was a more pronounced increase in the level of sIgA - after 7-10 days in 3 times (p <0,001), in 12 weeks in 2,5 times (p <0,001), compared with the indicator before treatment. A comparison of the mean values of sIgA concentration in the nasal secret between the study groups revealed that in 7-10 days and 12 weeks, the concentration of sIgA in patients receiving a bacteriophage was 21.3% and 43.9% higher, respectively, than in patients in the base group therapy (p = 0.048 and p <0.001). It was established that modified therapy with the use of bacteriophage contributes to the prevention of chronic acute bacterial rhinosinusitis, which was 36.6% less frequent than in the basic therapy group without bacteriophage (CS: 0.18; 95% CI: [0.05-0, 58]).


Author(s):  
A. Yu. Razumovsky ◽  
A. N. Smirnov ◽  
V. V. Kholostova ◽  
N. A. Al-Mashat ◽  
A. E. Stepanov ◽  
...  

Aim. The paper presents the experience of treatment of echinococcal cysts in children, which reflects most of the existing methods of treatment.Materials and methods. From 2010 to 2021, 81 patients with hepatic echinococcosis aged from 3 to 17 years (average 14.3 ± 1.3) were treated at the bases of the Department of Pediatric Surgeons of the Pirogov Russian State Medical University. All patients were examined according to the standard procedure, including: general clinical examination, examination of liver function, ultrasonography, chest X-ray, CT scan, blood test for IgG to echinococcus antigens. All children were divided into 2 groups according to the type of the surgery: in the group 1, 27 (33.3%) children underwent laparoscopic surgery; in the group 2, 54 (66.7%) children – laparotomy.Results. The treatment duration accounted 12.5 ± 3.1 days in group 1 and 9.2 ± 1.3 days in group 2 (p < 0.0067). In the group 1 the drainage duration was higher (6.8 ± 0.6) than in the group 2 (4.1 ± 0.3) (p < 0.03). Complications occurred in 7 patients, relapse of cysts – in 2 patients.Conclusion. Children with echinococcal cysts in Central Russia occur with a constant frequency and require to apply modern approaches in diagnosis and treatment. The classification and treatment protocol of echinococcosis, adopted by WHO, are easy-to-use and proves its effectiveness. There is no significant difference in germicidal agents’ effect on echinococcus and the effect on the development of relapse. The method of selection in the treatment of solitary and superficial cysts is laparoscopic interference with the mandatory application of a PAIR and a high-power aspirator. An important stage of the interference is the treatment of the fibrous capsule of the cyst, if it is impossible to completely remove it, with an argon-plasma coagulator.


Author(s):  
D. B. Giller ◽  
E. M. Glotov ◽  
O. Sh. Kesaev ◽  
A. A. Glotov ◽  
J. G. Imagozhev ◽  
...  

The purpose of the study was to improve quality of surgical treatable of destructive pulmonary tuberculosis in patients with diabetes.Materials and methods. D.B. Giller and employees of the Department of Phthisiopulmonology and Thoracic Surgery of the First Moscow State Medical University M.I. Sechenov performed operations on 200 patients with diabetes due to tuberculosis. Group 1 was mustered from 78 patients from 2004 to 2009. Group 2 was mustered from 122 patients from 2011 to 2017.Results. An analysis of the results showed that after 31 operations, 27 (13.5%) patients from both groups developed 33 complications. The second group (6,6 %) had fewer complications after surgery than the first group (24,4%) 3.7 times. The first group had more vulnerary and bronchopleural complications than the second group. 12 patients (15,4%) of the first group and 6 patients (4,9%) of the second group had bronchopleural complications (empyema, residual cavity, delayed expansion of the lung and intrapleural bleeding). 2 patients died in the hospital (30-day mortality was 0.66%) after 303 surgical intervention in both groups. 1 patient (0.9%) died after 106 surgical intervention in the first group. 1 patient (0.5%) died after 197 surgical intervention in the second group. The full effect was achieved in 75 (96.2%) patients in the first group and 114 (93.4%) in the second group. The survival value of patients of the second group was 100% after 1 year, 98% after 2 years, 98.8% after 3 years, 96.9% after 4 years, 95.2% after 5 years. The surgical treatable affected the occupational rehabilitation of patients from group 2. 61.5% of patients from group 2 became able to work after 1 year. 64.5% of patients from group 2 became able to work after 5 years.Conclusion. If doctors will use our tactics in patients with destructive pulmonary tuberculosis and diabetes, the risk of complications after surgery dropped and reactivation of tuberculosis will not occur.


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