scholarly journals Outbreaks of COVID-19 in Medical organizations

2021 ◽  
Vol 20 (5) ◽  
pp. 89-97
Author(s):  
Y. I. Sisin ◽  
A. A. Golubkova ◽  
I. I. Kozlova ◽  
N. A. Ostapenko
Keyword(s):  
High Frequency ◽  
Average Duration ◽  
Significant Proportion ◽  
Total Duration ◽  
General Information ◽  
Community Acquired Pneumonia ◽  
Epidemiological Features ◽  
Sources Of Infection ◽  
Coronavirus Infection ◽  
Spread Of Infection

Relevance. Prevention of the outbreak of a new coronavirus infection in medical organizations (MO) is one of the tasks facing the Rospotrebnadzor service and practical health care. Analysis of the causes and conditions of the spread of SARS-CoV-2 in the MO allows us to determine the most effective measures to contain the infection and prevent the occurrence of subsequent diseases in the focus.The aim is to characterize the epidemiological features of a new coronavirus infection during its nosocomial spread in medical organizations based on the analysis of outbreak incidence.Materials and methods. The data of the reporting forms «General information on patients with positive COVID-19», «General information on patients with community-acquired pneumonia with positive COVID-19» (138 pieces of information), copies of «Acts of epidemiological investigation of foci of infectious (parasitic) diseases with the establishment of a causal relationship» (57 pieces of information), copies of extraordinary reports on an emergency of a sanitary and epidemiological nature (57 pieces of information) were analyzed. The work uses epidemiological and statistical methods of research.Results. When analyzing 57 COVID-19 outbreaks in 30 medical organizations, it was found that the outbreak incidence was more often registered in multidisciplinary hospitals – 70.2% compared to 12.3% in specialized organizations of noninfectious profile, 10.5% of outbreaks were in polyclinics, 1.8% at emergency medical stations. The total number of people affected by the spread of the infection was 961, with a small proportion of children (15 people or 1.7%). Among those who fell ill with the spread of infection in the foci, the share of employees of medical organizations was 62.6%, including doctors – 16.6%, middle and junior medical workers-50.6% and 11.3%, respectively, and other categories – 21.5%. In nosocomial outbreaks of COVID-19, the focality index corresponded to 16.9, and the average duration of the focus was 32.4 days. The construction of the so-called «combined» outbreak diagram in the course of the epidanalysis allowed us to establish its total duration, which was 71 days, with the peaks of morbidity within the outbreak at intervals of 3–7 days, the greatest number of cases in the 1st and 8th days, and the gradual «extinction» of its activity in dynamics.Conclusions. The outbreak of COVID-19 in medical organizations usually occurred when there was an epidemic problem with COVID-19 in the territory. The peculiarity of nosocomial outbreaks was a significant proportion of adults (98.3%), mainly employees of medical organizations, who were often active sources of infection, as well as the involvement of structural units and hospitals for adults in the epidemic process, a high frequency of etiological interpretation of outbreaks (95.9%), a significant proportion of asymptomatic forms of infection and carrier, and the complexity of differential diagnosis of cases of out – of-hospital and nosocomial infection. The patterns of occurrence and spread of morbidity in medical organizations can be used in practical anti-epidemic work.

Evaluation of the effectiveness of preventive and anti-epidemic measures to prevent the spread of COVID-19 among patients and medical personnel of an antitubercular hospital during the pandemic

2021 ◽  
pp. 8-14
Author(s):  
Temirov Nemat Moidunovich ◽  
Mamyrova Kanykey Kanybekovna ◽  
Abdimomunova Begimay Toktobolotovna ◽  
Satybaldieva Ayzirek Topchubaevna ◽  
Zholdoshev Saparbay Tezekbaevich
Keyword(s):  
High Efficiency ◽  
Medical Personnel ◽  
Hospital Staff ◽  
Protective Equipment ◽  
Tuberculosis Control ◽  
Control Center ◽  
Adequate Ventilation ◽  
Sources Of Infection ◽  
Coronavirus Infection ◽  
Spread Of Infection

The commonality of mechanisms and ways of transmission of new coronavirus infection and tuberculosis increases the risk of spreading pathogens and determines common preventive approaches. The aim of the work was to assess the effectiveness of preventive and anti-epidemic measures to prevent the spread of COVID-19 among patients and medical personnel of an antitubercular hospital during the pandemic. Given the specifics of TB hospital developed and implemented a complex of measures to prevent the spread of COVID-19, which includes the identification and isolation of sources of infection, disinfection of air and adequate ventilation, disinfection of surfaces, use of personal protective equipment. The article describes the group morbidity of COVID-19 patients in an antitubercular hospital, which was caused by the introduction of infection into the hospital by patients in the incubation period. Timely measures made it possible to localize the situation and prevent the widespread spread of infection. The complex of measures for the protection of medical personnel has shown its high efficiency, which was manifested in the absence of cases of illness of personnel working in the «red zone». The absence of a consistent epidemic spread of the new coronavirus infection COVID-19 among patients and hospital staff of the R.G. Bauer Jalal-Abad Regional Tuberculosis Control Center allows us to use the described experience of conducting preventive and anti-epidemic measures in medical organizations of this type.

scholarly journals Epidemiological features of community-acquired mycoplasma pneumonia

2021 ◽  
Vol 6 (3) ◽  
pp. 85-93
Author(s):  
E. A. Koshkarina ◽  
O. A. Strazhnova ◽  
M. A. Sharabakina ◽  
O. M. Chekanina ◽  
V. V. Krasnov ◽  
...  
Keyword(s):  
Detection Rate ◽  
Significant Proportion ◽  
Federal District ◽  
Community Acquired Pneumonia ◽  
Healthy Population ◽  
Upward Trend ◽  
Epidemiological Features ◽  
Mycoplasma Pneumonia ◽  
Nizhny Novgorod Region

Aim. To analyse an epidemic process of community-acquired mycoplasma pneumonia in the Volga Federal District and the Nizhny Novgorod Region.Materials and Methods. We retrospectively analysed statistical reporting forms and electronic databases for 2012-2019 which included 443 cases of community-acquired mycoplasma pneumonia (349 foci and 4 outbreaks). In 2020, we assessed aetiology of community-acquired pneumonia in hospitalized patients of all ages who were diagnosed with a radiologically confirmed pneumonia (152 cases). In 2021, we carried out a microbiological study of pneumonia-causing pathogens in the nasopharynx among the healthy population (325 cases).Results. Average long-term incidence of community-acquired pneumonia in Nizhny Novgorod Region for 2012-2019 was 3.4 per 100,000 population (95% CI = 0.3-6.5, p < 0.001), with a pronounced upward trend. In general, the aetiology of community-acquired pneumonia in the Nizhny Novgorod Region in 2019 was established at 25.81 ± 0.7% cases. M. pneumoniae accounted for 8.00 ± 0.43% cases (56.72 ± 2.53%) of all aetiologically defined communityacquired pneumonias. In children, the aetiology was determined in 93.1 ± 2.5% cases, of which M. pneumoniae accounted for 13.8 ± 3.5% cases (14.6 ± 3.74% of all community-acquired pneumonias).Conclusion. Mycoplasma pneumonia is responsible for a significant proportion of all community-acquired pneumonias in Nizhny Novgorod Region. Notably, there is a low detection rate of mycoplasma pneumonia in certain territories that might explain an uneven distribution of associated morbidity.

EPIDEMIOLOGICAL FEATURES OF THE COURSE OF COMMUNITY-ACQUIRED PNEUMONIA IN PATIENTS OF THE CITY OF SARATOV AND SARATOV OBLAST

2020 ◽  
Author(s):  
Е.A. Chumachkova ◽  
◽  
S.A. Portenko ◽  
E.S. Kazakova ◽  
O.V. Kedrova ◽  
...  
Keyword(s):  
Outpatient Treatment ◽  
Medical Records ◽  
Community Acquired Pneumonia ◽  
Saratov Oblast ◽  
Patient Gender ◽  
Epidemiological Features ◽  
Coronavirus Infection ◽  
Etiological Agents ◽  
The Moment ◽  
The City

The aim of the study was to identify the epidemiological features of the course of community-acquired pneumonia among patients in the city of Saratov and the Saratov region during the epidemic of a new coronavirus infection. The medical records of 129 patients of various ages with a confirmed diagnosis of community-acquired pneumonia, who were on inpatient and outpatient treatment, were analyzed. The study established the predominance of pneumonia caused by COVID-19, compared to pneumonia caused by other etiological agents, and the pattern of identification of mild, moderate and severe forms of the disease from the moment the first signs of the disease appear. The computed tomography of the chest organs was proved to be the most informative diagnostic method. The severity of the inflammatory process in the lungs was analyzed depending on the age of the patient, gender, and the presence of concomitant chronic diseases.

PROGRESS OF RESEARCH IN NUTRITIONAL THERAPY FOR NEW CORONAVIRUS INFECTION (NARRATIVE REVIEW)

2020 ◽  
Vol 7 (11) ◽  
pp. 7-19
Keyword(s):  
Theoretical Study ◽  
Animal Experiments ◽  
Nutrient Status ◽  
Nutritional Therapy ◽  
Review Of The Literature ◽  
Global Concern ◽  
Coronavirus Infection ◽  
Spread Of Infection ◽  
Development Methods ◽  
Positive Effect

Objective: In this review, we highlight the importance of an optimal nutrient status to strengthen the immune system during the COVID-19 crisis, focusing on the most relevant constituents that reduce inflammation and Provide a holistic perspective nutritional therapy the new coronavirus (covid-19) to assist researchers and improving areas for future response plans to deal with these diseases, and to provide a summary of the nutrients that help stop their development. Methods: This is a theoretical study conducted through a comprehensive review of the literature and research in the research engines (PubMed), (Read) and (ELSEVIER) and other new studies published in Chinese; we obtained information nutritional treatment who contributed to increasing the immunity of patients, due to the lack of treatment for this disease. Results: Until now no effective drug for the treatment of new coronavirus, pneumonia (covid-19) has been found. The development of vaccines is still in animal experiments. Recommendations and measures to control the spread of infection and nutritional therapy are still the only way to prevent the spread of covid-19 virus. Because, People relied only on treatments that were effective on previous viruses, for example those that have been used during the SARS and MERS epidemics. Discussion: The Covid-19 virus remains a global concern and more research is needed to control it. In addition, people need to know the nutrition ingredients that have a positive effect on increasing the immunity of the human body.

scholarly journals The impact of theory-based messages on COVID-19 vaccination intentions: a structured summary of a study protocol for a randomised controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ben Young ◽  
Marie Kotzur ◽  
Lauren Gatting ◽  
Carissa Bonner ◽  
Julie Ayre ◽  
...  
Keyword(s):  
Online Survey ◽  
Controlled Trial ◽  
Significant Proportion ◽  
General Information ◽  
School Level ◽  
Text And Image ◽  
Post Intervention ◽  
Full Protocol ◽  
The Impact ◽  
Illness Coherence

Abstract Objectives Uptake of vaccination against COVID-19 is key to controlling the pandemic. However, a significant proportion of people report that they do not intend to have a vaccine, often because of concerns they have about vaccine side effects or safety. This study will assess the impact of theory-based messages on COVID-19 vaccination intention, drawing on the Necessity-Concerns framework to address previously reported beliefs and concerns about COVID-19 vaccination, and assess whether hypothesised variables (illness coherence, perceived necessity and concerns) mediate change in vaccination intention. Trial design Prospective, parallel two-arm, individually randomised (1:1) trial. Participants Adults aged over 18 years, living in Scotland and not vaccinated for COVID-19. A quota sampling approach will be used with the aim of achieving a nationally representative sample on gender, region and ethnic group, with oversampling of individuals with no educational qualifications or with only school-level qualifications. Intervention and comparator Intervention: Brief exposure to online text and image-based messages addressing necessity beliefs and concerns about COVID-19 vaccination. Comparator: Brief exposure to online text and image-based messages containing general information about COVID-19 and COVID-19 vaccination. Main outcomes Primary outcome: Self-reported intention to receive a vaccine for COVID-19 if invited, immediately post-intervention. Secondary outcomes: Self-reported COVID-19 illness coherence, perceived necessity of a COVID-19 vaccine and concerns about a COVID-19 vaccine, immediately post-intervention. Randomisation Quasi-randomisation performed automatically by online survey software, by creating a variable derived from the number of seconds in the minute that the participant initiates the survey. Participants starting the survey at 0-14 or 30-44 seconds in the minute are allocated to the intervention and 15-29 or 45-59 seconds to the comparator. Blinding (masking) Participants will not be blinded to group assignment but will not be informed of the purpose of the study until they have completed the follow-up survey. Investigators will be blinded to allocation as all procedures will be undertaken digitally and remotely without any investigator contact with participants. Numbers to be randomised (sample size) A total of 1,094 will be randomised 1:1 into two groups with 547 individuals in each. Trial Status Protocol version number 1.0, 26th February 2021. Recruitment status: Not yet recruiting, set to start April 2021 and end April 2021. Trial registration ClinicalTrials.gov, NCT04813770, 24th March 2021. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.

The working of the urology department during the COVID-19 epidemic

2020 ◽  
Vol 10 (4) ◽  
pp. 301-307
Author(s):  
Ekaterina V. Kul’chavenya ◽  
Denis P. Kholtobin ◽  
Alexander I. Neymark
Keyword(s):  
Medical Center ◽  
Total Duration ◽  
World Health ◽  
Medical Attention ◽  
Malignant Neoplasms ◽  
City Hospital ◽  
Strict Adherence ◽  
Number Of Patients ◽  
Coronavirus Infection ◽  
Research Institute

Introduction. In March 2020, the World Health Organization declared the outbreak of the novel coronavirus infection (COVID-19) a pandemic. The pandemic also significantly affected all academic, scientific and educational activities. Material and methods. We compared the work of the urological departments of the private (Medical Center Avicenna, Novosibisk) and municipal (City Clinical Hospital No. 11, Barnaul) clinics, as well as the urogenital department of the Novosibirsk Research Institute of Tuberculosis of the Ministry of Healthcare of Russia for 6 months of calm 2019, and the first half of 2020, which coincided with the start of the COVID-19 coronavirus pandemic. Results. In March 2020, the urogenital department of the Novosibirsk Research Institute of Tuberculosis of the Ministry of Healthcare of Russia was redesigned into an observational one. In the first half of 2020, patients with malignant neoplasms, varicocele, chronic pyelonephritis, hydronephrosis, dropsy of the testicular membranes and with phimosis/paraphimosis were admitted to the urology department of the City Hospital No. 11 in Barnaul in the first half of 2020. On the contrary, statistically significant in 2020 the number of patients admitted for kidney abscess and acute prostatitis prevailed. It can be assumed that, due to the tense epidemic situation, patients postponed seeking medical attention until their condition required emergency intervention. In the Medical Center Avicenna (Novosibirsk) in the first half of 2020 the number of visits to the pediatric urologist significantly decreased, the inpatient and average bed-day decreased. On the contrary the total duration of the patients' stay in the day hospital has significantly increased, which is logically explained by the epidemic situation; there was a statistically significant decrease in the number of most operations and outpatient procedures. Conclusion. The new coronavirus infection has affected all spheres of human life, to a maximum extent on medicine. In the first six months, no unified approaches to the management of urological patients in epidemic conditions were developed; clinics worked according to internal standards. Our analysis showed that strict adherence to sanitary and hygienic standards and the implementation of anti-epidemic measures allows us to provide urological care to patients in full-even in such unfavorable conditions.

High cytokine levels and cytokine storm in the novel coronavirus infection

2021 ◽  
pp. 38-47
Author(s):  
Maksim Leonidovich Maksimov ◽  
Albina Ayratovna Zvegintseva ◽  
Lyudmila Yurievna Kulagina ◽  
Albina Zainutdinovna Nigmedzyanova ◽  
Elvina Ramisovna Kadyseva
Keyword(s):  
Peripheral Blood ◽  
High Frequency ◽  
The Novel ◽  
Cytokine Storm ◽  
The Public ◽  
Systemic Inflammatory Reaction ◽  
Scientific World ◽  
Cytokine Levels ◽  
Coronavirus Infection ◽  
Novel Coronavirus

A review article is based on current foreign sources. The level of cytokines in the peripheral blood can be increased in many diseases, but in some cases there may be an excess of their normal concentration in tens, hundreds or more times with the development of a peculiar clinical picture, which is based on a systemic inflammatory reaction. In the literature this condition has received the figurative name «cytokine storm», which highlights an extremely violent reaction of the immune system with an unknown (often unfavorable) outcome. Close attention of the scientific world and the public to the problem of extremely high levels of cytokines in the peripheral blood (hypercytokinemia) was drawn due to the high frequency of the cytokine storm in the novel coronavirus infection.

Clinical and epidemiological features of community-acquired pneumonia during an epidemic of respiratory viral infection

2021 ◽  
Vol 31 (4) ◽  
pp. 490-498
Author(s):  
N. I. Izmozherova ◽  
A. A. Popov ◽  
E. R. Prokopeva ◽  
A. A. Kuryndina ◽  
E. I. Gavrilova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Streptococcus Pneumoniae ◽  
Causative Agent ◽  
Community Acquired Pneumonia ◽  
Influenza Viruses ◽  
X Rays ◽  
Imaging Data ◽  
Cross Sectional ◽  
Epidemiological Features ◽  
Working Age

Community-acquired pneumonia (CAP) is one of the most common lower respiratory tract diseases. An increase in the CAP incidence has been reported to be associated with epidemics of acute respiratory viral infections (ARVI).Aim. Аssess clinical and epidemiological features of CAP in patients admitted to hospital during an ARVI epidemic.Methods. A cross-sectional study included 208 patient records. Medical history, physical examination, laboratory and imaging data were analyzed. CAP severity was assessed by CRB-65 scale and the systemic inflammatory response syndrome (SIRS) criteria.Results. Most CAP patients (75%) were of active working age; all presented signs of ARVI upon admission. Nasal mucosa diagnostic smears have revealed type A influenza viruses: H1N1 – 5 (83.3%) and H3N2 – 1 (16.7%) cases. 195 (93.8%) patients were not vaccinated against influenza. X-rays showed that unilateral (81.7%) and lobular pneumonia (55.8%) were the most common CAP types. 93.2% patients had nonsevere CAP, according to CRB-65. But 88 (42.3%) subjects qualified for SIRS upon admission. Concomitant conditions as risk factors of an adverse course of CAP were present in 89 patients (42.8%). Sputum analysis, if available, most frequently identified Streptococcus pneumoniae (23 cases or 38.9%) as a causative agent. Antibacterial drugs (ABD) used to treat CAP were ceftriaxone 206 (99%), macrolides 188 (90.4%), and fluoroquinolones 94 (45.2%). The initial antibacterial treatment regimens were: 186 (89.4%) prescriptions of ceftriaxone + macrolides, 16 (7.7%) prescriptions of ceftriaxone alone, and 6 (2.9%) prescriptions of levofloxacin. A switch between ABDs was reported in 78 (37.5%) cases, including 61 switches to fluoroquinolones. The median ABD administration duration was 10 (8 – 13) days.Conclusion. Most of the hospitalized CAP patients were of working age and not vaccinated against influenza. Streptococcus pneumoniae was the most common causative agent. PCR (polymerase chain reaction) smear analysis was performed only in 6 patients with ARVI, which does not allow us to assess the role of viruses and viral-bacterial associations in the etiology of CAP. In spite of non-severe CAP, all hospitalizations were justified, due to multiple risk factors of unfavorable prognosis of CAP and epidemiological factors. Most patients received a combination of generation 3 cephalosporins and macrolides as the initial therapy for CAP.

Consensus ‘Interferon therapy for patients with influenza, SARS and COVID19’

2021 ◽  
pp. 51-58
Author(s):  
N. D. Yushchuk ◽  
I. V. Maev ◽  
A. L. Vertkin
Keyword(s):  
General Practitioner ◽  
Infectious Diseases ◽  
Secondary Prevention ◽  
Interferon Therapy ◽  
Viral Infections ◽  
Total Duration ◽  
Community Acquired Pneumonia ◽  
Outpatient Clinics ◽  
Primary Contact ◽  
Respiratory Viral Infections

According to the who, the share of acute respiratory viral infections (амма? and influenza) accounts for about 90–95% of all infectious diseases; in russia, influenza and arvi take up to 40% of the total duration of official disability, which determines the significance of this pathology. At the same time, the primary contact of the overwhelming majority of patients with suspected arvi and influenza occurs with a therapist or general practitioner of polyclinics. The proposed consensus of experts is intended to systematize the known approaches to the diagnosis, treatment and secondary prevention of influenza, acute respiratory viral infections and community-acquired pneumonia for their use at outpatient clinics. The schemes of using interferon therapy for arvi and influenza are considered in detail.

Epidemiological features of typhoid fever incidence in the uranium biogeochemical zone of the Kyrgyz Republic

2020 ◽  
pp. 8-17
Author(s):  
R. M. Toichuev ◽  
J. S. Zakirova ◽  
S. T. Joldoshev ◽  
R. A. Nadirbekova
Keyword(s):  
Typhoid Fever ◽  
Kyrgyz Republic ◽  
Immunological Reactivity ◽  
Complete Elimination ◽  
Radiation Factor ◽  
Environmental Objects ◽  
Epidemiological Features ◽  
Sources Of Infection ◽  
Clean Drinking Water ◽  
The Impact

The results of an epidemiological study of typhoid fever in the territory of the uranium biogeochemical zone of the Kyrgyz Republic are presented. The presence of a chronic focus of typhoid fever in the territory of the uranium biogeochemical province with high levels of morbidity has been established. The leading factor in transmission is water, primarily from the Mailuu-Suu river, which is also contaminated with radionuclides. The main feature of typhoid fever in the territory of the uranium biogeochemical province is the registration of cases of diseases throughout the year, which differs from non-polluted areas, where cases are detected only in the warm months. This feature can be associated with the impact of the radiation factor on the pathogen by increasing its resistance, and on the human body by reducing immunological reactivity. This assumption requires more detailed research. For the complete elimination of typhoid fever in the study area, comprehensive measures are required throughout the year, aimed at providing the population with clean drinking water, identifying sources of infection, including bacterial carriers, and their treatment, as well as monitoring bacteriological studies of environmental objects throughout the calendar year.

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