scholarly journals RISK FACTORS FOR CORONARY ARTERIES DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 20 (1) ◽  
pp. 95-99
Author(s):  
V.M. Zhdan ◽  
V.G. Lebid ◽  
H.S. Khaimenova ◽  
Yu.A. Isheikina
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Diseases ◽  
General Population ◽  
Coronary Arteries ◽  
Rheumatic Diseases ◽  
Health Care Professionals ◽  
Early Stage ◽  
Main Group ◽  
Control Group ◽  
X Rays

Now health care professionals who manage patients and stick to holistic patient-cantered approach are facing the problem of “polymorbidity”. The most common conditions complicating rheumatic diseases are cardiovascular diseases, interstitial lung disease, osteoporosis, chronic kidney disease, malignancies and depression. Despite the success in treatment of rheumatoid arthritis, the mortality rate in this category of patients remains higher than in the general population. This is associated with the acceleration of atherosclerosis progression and the early-age onset of coronary arteries disease. Therefore, rheumatoid arthritis is considered as a predictor of coronary arteries disease. The incidence of myocardial infarction, heart failure, and sudden coronary death in patients with rheumatoid arthritis is found to be 3 to 5 times higher than in the general population. The purpose of the present study was to estimate and evaluate comorbidity status in patients with rheumatoid arthritis. The study was performed at the at the Regional Medical and Diagnostic Centre of Rheumatologic Diseases, M.V. Sklifosovskyi Poltava Regional Clinical Hospital, which is the clinical base of the Department of Family Medicine and Therapy, Ukrainian Medical Stomatological Academy. The study included 135 patients with rheumatoid arthritis aged 32 – 65, who made up the main group. The control group consisted of 30 patients without autoimmune diseases, inflammatory conditions and other diseases in acute phase. All patients stated the consent to participate in the study in writing. During the study, all the participants passed through clinical examination including blood tests, urine tests, blood biochemistry, electrocardiography, echocardiography, X-rays of the joints, and ultrasound examinations (by using an apparatus of class “Radmir ultima”). 68.2% of the patients in the main group suffering from rheumatoid arthritis were found out to have different comorbidities compared with the control group. Cardiovascular diseases and especially coronary arteries disease were detected in 42.3% of cases and found out as the most prevalent comorbid diseases in the patients with rheumatoid arthritis. We also revealed the high prevalence of dyslipidemia (73, 4% of cases). It is necessary to underline that 75% of patients in the main group were diagnosed to have even 2 or more comorbidities. According to the results obtained, the majority of the patients suffering from rheumatoid arthritis have comorbidities, which can seriously affect the course of rheumatic diseases and influence the treatment. Management of patients with rheumatoid arthritis and comorbid conditions should be supported by rheumatologists, family doctors, internists in order to evaluate all polymorbidities in their interactions and to provide proper assistance for patients in making their therapeutic course decisions. Of course, this requires novel data from experts to improve diagnostic and treatment approaches of rheumatoid arthritis in its early stage.

scholarly journals FRI0443 CLINICAL CHARACTERISTICS AND RELATED FACTORS OF COMMON RHEUMATIC DISEASES COMPLICATED WITH TUBERCULOSIS INFECTION

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 819.1-819
Author(s):  
L. Long ◽  
G. Tang ◽  
Y. Han ◽  
Q. Peng ◽  
J. Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Weight Loss ◽  
Risk Factor ◽  
High Risk ◽  
Rheumatic Diseases ◽  
Clinical Characteristics ◽  
Control Group ◽  
Average Dose ◽  
Systemic Lupus ◽  
Infection Group

Background:Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and syndrome(SS) are common rheumatic diseases with high incidence. Patients with those rheumatic diseases are at high risk of tuberculosis (TB) infection. However, manifestations can be atypical and easily confused with those of rheumatic disease itself. For those patients, diagnosis is usually much more difficult and further make treatment delayed. Sometimes it may lead to mistreatment. Therefore, it is important to recognize the clinical characteristics of those patients.Objectives:To explore the clinical characteristics and high risk factors of common systemic rheumatism complicated with tuberculosis infection.Methods:A total of 3,906 cases of RA, SLE, and SS common systemic rheumatism diagnosed in the People’s Hospital of Sichuan Province from January 2007 to January 2017 were collected with carefully exclusion with other infectious diseases and neoplastic disease. One hundred and five patients with TB were included as infection group, including 42 cases of RA, 41 cases of SLE, and 22 cases of SS. In the control group, 84 patients with RA, 82 patients with SLE, and 44 patients with SS were randomly selected from the corresponding rheumatoid non-infected patients hospitalized during the same period.Results:Fever was the most common symptom among 42 cases of RA, 41 cases of SLE, and 22 cases of SS with TB, accounting for 83.3%, 92.7%, and 68.2%, respectively. Cough, weight loss or fatigue was less common. For 41 cases of SLE and 22 cases of SS with TB, the proportion of pulmonary was 46.3%, 59.01%, respectively.In TB infection group, 27 cases of RA, 21 cases of SLE, and 13 cases of SS with TB had two or more chest CT findings, accounting for 59%, 57%, 62%, respectively. Lesions located in the posterior or posterior segment which TB usually affected were 9 cases(33.3%),9cases(42.9%),6cases(27.2%),respectively.The daily average dose of hormones within 1 year in TB infection group was higher than that in the control group (P<0.05). For SLE patients, lower counts of CD4+TL were found in TB infection group (P<0.05), while no such differences were found in RA and SS group.Conclusion:Patients with RA who have TB infection are mainly pulmonary TB. For SLE and SS patients, the chance of pulmonary tuberculosis and extra-pulmonary tuberculosis is similar.Symptoms of RA, SLE, SS with TB, such as fever, cough, weight loss, fatigue, are similar with the primary disease or other infection. Chest imaging is diversity. It is difficult to diagnose.Daily average dose of hormone within one year may be a common risk factor for RA, SLE and SS patients with TB. Decreased CD4+TL may also be a risk factor for SLE patients with TB.References:[1]Cantini F, Nannini C, Niccoli L, et al. Risk of Tuberculosis Reactivation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Receiving Non-Anti-TNF-Targeted Biologics[J]. Mediators of Inflammation, 2017, 2017(6):1-15.[2]Ruangnapa K, Dissaneewate P, Vachvanichsanong P. Tuberculosis in SLE patients: rare diagnosis, risky treatment.[J]. Clinical & Experimental Medicine, 2015, 15(3):429-432.[3]Manuela D F, Bruno L, Martina S, et al. Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections[J]. International Journal of Molecular Sciences, 2017, 18(2):293-315.[4]Disseminated tuberculosis masquerading as a presentation of systemic lupus erythematosus.Li JC, Fong W, Wijaya L, Leung YY.Int J Rheum Dis. 2017 Oct 2. doi: 10.1111/1756-185X.13195.[5]Handa R, Upadhyaya S, Kapoor S, et al. Tuberculosis and biologics in rheumatology: India – A special situation[J]. International Journal of Rheumatic Diseases, 2017, 51(2):115.Disclosure of Interests:None declared

scholarly journals Sanator rehabilitation of patients after stenting of coronary arteries

2019 ◽  
Vol 18 (2) ◽  
pp. 76-80
Author(s):  
Lira T. Gilmutdinova ◽  
Elena N. Galimulina ◽  
Azat A. Bagautdinov ◽  
Elvira R. Faizova ◽  
Bulat R. Gilmutdinov
Keyword(s):  
Performance Improvement ◽  
Coronary Arteries ◽  
Blood Lipid ◽  
Functional Independence ◽  
Main Group ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Blood Lipid Profile ◽  
Dry Air

The results of sanatorium rehabilitation of 56 patients (men) after stenting of the coronary arteries in the conditions of a specialized sanatorium are presented. Patients of the main group used a rehabilitation complex based on physical training in combination with dry air carbon dioxide baths, patients in the control group received a basic complex. A more effective effect of the developed complex with respect to the positive dynamics of clinical and hemodynamic parameters, blood lipid profile, increase in physical performance, improvement of quality of life parameters, decrease in the level of functional independence in patients of the main group, in contrast to patients against the background of the basic complex, was established.

scholarly journals Level of N-terminal fragment of brain natriuretic peptide progenitor and atherosclerotic damage of brachocephalic arteries in patients with rheumatoid arthritis with inefficiency and/or injurability of basic anti - inflammatory treatment

2019 ◽  
Vol 91 (5) ◽  
pp. 34-39
Author(s):  
E V Gerasimova ◽  
T V Popkova ◽  
A V Martynova ◽  
E I Markelova ◽  
D S Novikova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Natriuretic Peptide ◽  
Prognostic Significance ◽  
Atherosclerotic Lesion ◽  
Control Group ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Traditional Risk Factors

The high prognostic significance of the concentration of the N-terminal - pro-B-type natriuretic peptide (NT-proBNP) in the development of cardiovascular diseases (CVD) was identified for rheumatoid arthritis (RA) and general populations. Aim: to investigate the significance of NT-proBNP level in patients (pts) with RA with the ineffectiveness and/or intolerance of basic anti - inflammatory therapy; compare the level of NT-proBNP with atherosclerotic lesion of the brachiocephalic arteries (BCA), traditional risk factors and inflammatory markers. Materials and methods. The investigation enrolled 28 pts (24women/4men) with the lack of efficacy/resistance and/or intolerance of basic anti - inflammatory drugs (DMARDs); median age was 55 [46; 61] years, median disease duration 114 [60; 168] month; DAS28 6,2 [5.1; 7.0]; SDAI 35.0[23.9; 51.0], CDAI 30.0[21.0; 42.0], serum positivity for rheumatoid factor (RF) (100%)/anti - cyclic citrullinated peptide antibodies (ACCP) (86%). The study did not include RA pts with congestive heart failure. High incidence of traditional risk factors was found in RA pts: arterial hypertension - in 75%, dyslipidemia - 61%, smoking - 17%, overweight - 61%, family history of cardiovascular diseases - 36%, hypodynamia - 68%. Coronary artery disease was diagnosed in 11% RA pts. Lack of efficacy of 3 or more DMARDs was found in 46% of pts, intolerance to previous therapy with DMARDs - in 54% pts. 47% were receiving methotrexate (20 [18; 25] mg/week), 11% - leflunomide, 7% - sulfasalazine, 46% - glucocorticoids, 75% - non - steroidal anti - inflammatory drugs. The control group consisted of 20 healthy donors, comparable to pts by age and sex. Serum levels of of NT-proBNP were measured using electrochemiluminescence method Elecsys proBNP II (Roche Diagnostics, Switzerland). The determination of the intima - media thickness (IMT) BCA were assessed from duplex scanning. Atherosclerotic lesion of BCA was assessed by the presence of atherosclerotic plaque (IMT ≥1.2 mm). Results. NT-proBNP concentrations in RA pts proved to be higher (78.7 [41.4; 101.3] pg/ml) than those in the control group (55.3 [36.6; 67.3] pg/ml, p100 pg/ml - 1 group (n=6) and ≤100 pg/ml - 2 group (n=22). Groups of RA pts did not differ in gender, age, activity of RA, frequency of detection of traditional risk factors. Atherosclerotic lesion of the BCA was detected in 3 (50%) pts of the 1 group and in 8 (36%) pts of the 2 group (p>0.05). In RA pts the level of NT-proBNP correlated with age (r=0.39; p

Predictors of atherosclerosis in rheumatoid arthritis

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 353-359 ◽  
Author(s):  
Ahmad ◽  
Garg ◽  
Dhar ◽  
Srivastava ◽  
Biswas ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Disease Duration ◽  
Early Stage ◽  
Subclinical Atherosclerosis ◽  
Disease Onset ◽  
Intima Media Thickness ◽  
Qt Dispersion ◽  
Control Group ◽  
Age And Sex

Background: Atherosclerosis is emerging as an important complication of rheumatoid arthritis (RA), with coronary artery disease being projected as the major cause of mortality in these patients.This study was undertaken to evaluate the presence of subclinical atherosclerosis and to identify the risk factors of atherosclerosis in patients with RA. Patients and methods: All consecutive in- and out-patients of rheumatoid arthritis (n = 100) irrespective of the disease duration were included in the study. A group of 100 age and sex matched controls were also studied. Increased carotid intima media thickness (beyond the 75th percentile for age and sex), presence of plaques, ankle brachial pressure index and QT dispersion were deemed as non-invasive measures of atherosclerotic burden. Results: Fifty patients (50.0 %) with RA had evidence of subclinical atherosclerosis as compared to the control group (n = 11, 11 %); plaques were observed in 26 patients. Eighteen (36 %) of these developed this evidence within 1 - 5 years of disease onset. Low HDL levels among the conventional risk factors and advanced patient age, longer disease duration, greater number of involved joint areas, steroid use and indices of inflammation in particular in RA, were associated with subclinical atherosclerosis. Sustained inflammation was observed throughout the sub-group with atherosclerosis irrespective of the disease duration. Conclusions: RA is a pro-atherogenic state with the process of atherosclerosis initiated in the early stage of the disease. Besides the traditional risk factors, sustained inflammation contributes to atherogenesis.

P-450 Effects of rheumatoid arthritis and methotrexate therapy on ovarian reserve in infertile women

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
G Vlasova ◽  
S Perminova
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Ovarian Reserve ◽  
Small Sample Size ◽  
Genetic Material ◽  
Main Group ◽  
Small Sample ◽  
Control Group ◽  
Proliferating Cells ◽  
Number Of Patients

Abstract Study question Do patients with infertility and rheumatoid arthritis (RA) treated with methotrexate (MTX) have ovarian reserve alterations? Summary answer Women with infertility and RA treated with MTX were found to have statistically significant decrease of ovarian reserve. What is known already Rheumatoid arthritis (RA) is one of the most prominent inflammatory diseases affecting women of child-bearing age [Brouwer J. et al, 2014]. RA and its treatment may interfere with the female reproductive physiology. The vast majority of patients with RA are treated with methotrexate (MTX) which is a folate antagonist that inhibits DNA synthesis. MTX, which is the anchor drug in RA, targets actively proliferating cells including the oocytes and granulosa cells which may impair the ovarian reserve [Min Tun Kyaw et al, 2020]. Study design, size, duration A prospective case-control study that enrolled 72 female patients with infertility was conducted in the 2-year time period of September 2018 to October 2020. Participants/materials, setting, methods The main group comprised 32 patients with infertility and RA; the control group consisted of 40 women with infertility only. Patients with RA were stratified into subgroups based on whether or not they received MTX. To investigate ovarian reserve measurement of serum anti-Müllerian hormone (AMH) was used. The level of AMH was evaluated concerning RA duration and activity, as well as the age at initiation of MTX therapy, dosage, and treatment duration. Main results and the role of chance The mean age of the study population was 36±3 years. The duration of RA was 4 [3;11] years. The low disease activity based on DAS28-ESR (disease activity score based on 28 joints using the erythrocyte sedimentation rate) prevailed(56.2%). In the main group 19(59.4%) women received MTX therapy. The MTX dosage was 15 [15;20]mg /wk, the duration of MTX therapy by the day of inclusion in the study was 18.7[1;15]months. The AMH level was significantly lower in the main group (2.1 n /ml vs 2.73ng /ml, p = 0.043). The number of patients with decreased ovarian reserve (AMH level&lt;1.0ng/ml) significantly prevailed in the group of patients with RA (25% vs 5%, p = 0.015). When assessing the AMH level in patients with RA who received MTX (n = 19) and patients in the control group, there was a tendency towards a decrease in the indicator in the first subgroup, but no statistically difference was found (p = 0.074). Correlation analysis of the dependence of AMH level on the patient age showed the most significant decrease in AMH in the patients with RA receiving MTX compared to the patients with RA who did not, and compared to all patients with RA regardless of the therapy received (rs=-0.563)(p &lt; 0.05). Limitations, reasons for caution The lack of statistically significant data in certain cases may be due to the small sample size. Wider implications of the findings RA and MTX administration are associated with a significant decrease in AMH levels. The age of initiation of the therapy is negatively correlated with the AMH level. In this regard, patients with already compromised reproductive function who are planning to receive MTX should be advised to preserve the genetic material. Trial registration number 567890

DIAGNOSIS OF OSTEOPOROSIS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 93 (1) ◽  
pp. 8-10
Author(s):  
Kamila Abdushukurova ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
General Population ◽  
Rheumatic Diseases ◽  
Joint Disease ◽  
Diagnosis Of Osteoporosis

Rheumatoid arthritis (RA) is a chronic joint disease with erosive and destructive lesions of the peripheral joints. The incidence of RA is 10% for rheumatic diseases and 0.5-1.0% in the general population. Women get sick 3-6 times more often than men

scholarly journals Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study

2021 ◽  
pp. annrheumdis-2021-220647
Author(s):  
Victoria Furer ◽  
Tali Eviatar ◽  
Devy Zisman ◽  
Hagit Peleg ◽  
Daphna Paran ◽  
...  
Keyword(s):  
General Population ◽  
Disease Activity ◽  
Rheumatic Diseases ◽  
Messenger Rna ◽  
Vaccine Dose ◽  
Adult Patients ◽  
Control Group ◽  
Inflammatory Rheumatic Diseases ◽  
Igg Antibody ◽  
Antibody Levels

IntroductionVaccination represents a cornerstone in mastering the COVID-19 pandemic. Data on immunogenicity and safety of messenger RNA (mRNA) vaccines in patients with autoimmune inflammatory rheumatic diseases (AIIRD) are limited.MethodsA multicentre observational study evaluated the immunogenicity and safety of the two-dose regimen BNT162b2 mRNA vaccine in adult patients with AIIRD (n=686) compared with the general population (n=121). Serum IgG antibody levels against SARS-CoV-2 spike S1/S2 proteins were measured 2–6 weeks after the second vaccine dose. Seropositivity was defined as IgG ≥15 binding antibody units (BAU)/mL. Vaccination efficacy, safety, and disease activity were assessed within 6 weeks after the second vaccine dose.ResultsFollowing vaccination, the seropositivity rate and S1/S2 IgG levels were significantly lower among patients with AIIRD versus controls (86% (n=590) vs 100%, p<0.0001 and 132.9±91.7 vs 218.6±82.06 BAU/mL, p<0.0001, respectively). Risk factors for reduced immunogenicity included older age and treatment with glucocorticoids, rituximab, mycophenolate mofetil (MMF), and abatacept. Rituximab was the main cause of a seronegative response (39% seropositivity). There were no postvaccination symptomatic cases of COVID-19 among patients with AIIRD and one mild case in the control group. Major adverse events in patients with AIIRD included death (n=2) several weeks after the second vaccine dose, non-disseminated herpes zoster (n=6), uveitis (n=2), and pericarditis (n=1). Postvaccination disease activity remained stable in the majority of patients.ConclusionmRNA BNTb262 vaccine was immunogenic in the majority of patients with AIIRD, with an acceptable safety profile. Treatment with glucocorticoids, rituximab, MMF, and abatacept was associated with a significantly reduced BNT162b2-induced immunogenicity.

scholarly journals A Pilot Study: Hypertension, Endothelial Dysfunction and Retinal Microvasculature in Rheumatic Autoimmune Diseases

2021 ◽  
Vol 10 (18) ◽  
pp. 4067
Author(s):  
Ahmed Mahdy ◽  
Martin Stradner ◽  
Andreas Roessler ◽  
Bianca Brix ◽  
Angelika Lackner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Autoimmune Diseases ◽  
Rheumatic Diseases ◽  
Control Group ◽  
Autoimmune Rheumatic Diseases ◽  
Retinal Microvasculature ◽  
Significant Difference

Background: The etiology of autoimmune rheumatic diseases is unknown. Endothelial dysfunction and premature atherosclerosis are commonly seen in these patients. Atherosclerosis is considered one of the main causes of cardiovascular diseases. Hypertension is considered the most important traditional cardiovascular risk. This case-control study aimed to investigate the relationship between autoimmune diseases and cardiovascular risk. Methods: This study was carried out in patients with rheumatoid arthritis, RA (n = 10), primary Sjögren syndrome, PSS (n = 10), and healthy controls (n = 10). Mean blood pressure (MBP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse wave velocity (PWV, an indicator of arterial stiffness) were assessed via a Vicorder device. Asymmetric dimethylarginine (ADMA) was measured via ELISA. Retinal photos were taken via a CR-2 retinal camera, and retinal microvasculature analysis was carried out. T-tests were conducted to compare the disease and control groups. ANOVA and ANOVA—ANCOVA were also used for the correction of covariates. Results: A high prevalence of hypertension was seen in RA (80% of cases) and PSS (40% of cases) compared to controls (only 20% of cases). Significant changes were seen in MBP (RA 101 ± 11 mmHg; PSS 93 ± 10 mm Hg vs. controls 88 ± 7 mmHg, p = 0.010), SBP (148 ± 16 mmHg in RA vs. 135 ± 16 mmHg in PSS vs. 128 ± 11 mmHg in control group; p = 0.007), DBP (77 ± 8 mmHg in RA, 72 ± 8 mmHg in PSS vs. 67 ± 6 mmHg in control; p = 0.010 in RA compared to the controls). Patients with PSS showed no significant difference as compared to controls (MBP: p = 0.240, SBP: p = 0.340, DBP: p = 0.190). Increased plasma ADMA was seen in RA (0.45 ± 0.069 ng/mL) and PSS (0.43 ± 0.060 ng/mL) patients as compared to controls (0.38 ± 0.059 ng/mL). ADMA in RA vs. control was statistically significant (p = 0.022). However, no differences were seen in ADMA in PSS vs. controls. PWV and retinal microvasculature did not differ across the three groups. Conclusions: The prevalence of hypertension in our cohort was very high. Similarly, signs of endothelial dysfunction were seen in autoimmune rheumatic diseases. As hypertension and endothelial dysfunction are important contributing risk factors for cardiovascular diseases, the association of hypertension and endothelial dysfunction should be monitored closely in autoimmune diseases.

scholarly journals DERMATOGLYPHS OF PATIENTS SUFFERING FROM RHEUMATIC DISEASES OF VARIOUS ETIOLOGIES

2021 ◽  
Vol 7 (73) (2) ◽  
pp. 104-116
Author(s):  
M. S. Nechaeva ◽  
V. N. Kalaev ◽  
E. V. Gosteva ◽  
E. A. Kalaeva ◽  
A. A. Sotnikov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Rheumatic Diseases ◽  
Genetic Diseases ◽  
Population Sample ◽  
Risk Groups ◽  
Genetic Component ◽  
Control Group ◽  
Special Role ◽  
Genetic Determination

Mutations and genetic diseases, caused by genome disorders, frequently manifest at the phenotypic level and, especially, at the dermatoglyphic level, that makes it possible to use dermatoglyphs as markers of any genetic diseases. Rheumatic diseases is a group of disorders, characterized by systemic conjunctive tissue damage, essentially, connected with immune system pathology. Systemic progressive disorganization of conjunctive tissue is morphological base for the whole group of rheumatic diseases. Rheumatoid arthritis and ankylosing spondylitis are multifactorial and difficult-to-diagnose in the early stages diseases, that indicates the need to identify markers, that allows to detect these diseases as early as possible. A special role in the pathogenesis of these diseases is assigned to the genetic component, while recent studies have highlighted the shares of genetic determination in the disease’s advance are somewhat differ. The goal of this research was to identify the features of dermatoglyphic patterns of patients with rheumatoid arthritis and ankylosing spondylitis. Finger dermatoglyphic drawings of patients suffering from ankylosing spondylitis, rheumatoid arthritis, and representatives of the general population sample were studied. Statistical data processing was performed using non-parametric Van der Waerden test. To establish predictors of these diseases, ROC analysis was used. In persones suffering from ankylosing spondylitis there were found more differences in finger patterns from the control group, than in patients with rheumatoid arthritis. So, the total ridge count and the intensity index of the patterns on the left arm of patients with ankylosing spondylitis were lower than in the control group. Peoples with ankylosing spondylitis had more predictors of pathology than patients with rheumatoid arthritis. The analysis of the results shows that the absence of radial loops on the right arm and double loops in the examined persons may indicate the probability of developing these diseases. All predictors of rheumatoid arthritis and ankylosing spondylitis were characterized by high sensitivity and low specificity, which makes them convenient markers for preliminary screening studies and the formation of risk groups for the development of these pathologies. However, it is not recommended to use these predictors for establishing a final diagnosis, since their low specificity will cause to a large number of false-positive results among the examined persons. Individuals with ankylosing spondylitis have more differences in fingerprints from the control group and more predictors of pathology than patients with rheumatoid arthritis. It can be assumed that the genetic component plays a more significant role in the pathogenesis of ankylosing spondylitis, and the formation of rheumatoid arthritis is more caused by environmental factors. Our study confirms the feasibility of considering dermatoglyphs as an additional genetic marker in clinical medicine. Dermatoglyphic indicators can be used in the formation of risk groups for inflammatory joint diseases for primary prevention, for solving a number of issues of medical and genetic consulting, which indicates the prospects of this research area.

scholarly journals Refinement of noninvasive methods for diagnosing precancer and cancer of oral mucosa in general dental practice

2021 ◽  
Author(s):  
MA Postnikov ◽  
AG Gabrielyan ◽  
DA Trunin ◽  
OI Kaganov ◽  
VP Kirillova ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Histopathological Examination ◽  
Early Stage ◽  
Main Group ◽  
Control Group ◽  
Noninvasive Methods ◽  
Medical Histories ◽  
Clinically Significant ◽  
Pathology Reports ◽  
Original Index

The search for and the application of available noninvasive methods for early diagnosis of oral mucosa (OM) neoplasia is a clinically significant problem. The aim of this study was to evaluate the effectiveness of the original score-based algorithm for assessing clinical data generated by a conventional and an autofluorescencebased examination in diagnosing OM cancer and assessing indications for a biopsy. We analyzed 134 medical histories and pathology reports of patients with oral neoplasia. The patients were assigned to 2 groups: the control group included 63 patients who underwent a standard visual and tactile examination with history taking and then were referred for an incisional biopsy followed by a histopathological examination of the specimens. In the main group consisting of 71 patients, a standard visual and tactile examination was complemented by an autofluorescence-based examination and the original score-based algorithm with the original index of required histopathological verification (RHV) were used to assess indications for a biopsy. In both groups, the most commonly affected site was the tongue (72.4%). The histopathological examination revealed that 28 patients from the main group and 14 patients from the control group had OM cancer (р = 0.051). Histologically, early-stage cancer was diagnosed in 17 patients from the main group and in 4 patients from the control group (р = 0.004). The proposed algorithm allowed us to effectively (in 90% of cases) diagnose precancer and cancer and avoid unnecessary biopsies.

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