scholarly journals Refinement of noninvasive methods for diagnosing precancer and cancer of oral mucosa in general dental practice

2021 ◽  
Author(s):  
MA Postnikov ◽  
AG Gabrielyan ◽  
DA Trunin ◽  
OI Kaganov ◽  
VP Kirillova ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Histopathological Examination ◽  
Early Stage ◽  
Main Group ◽  
Control Group ◽  
Noninvasive Methods ◽  
Medical Histories ◽  
Clinically Significant ◽  
Pathology Reports ◽  
Original Index

The search for and the application of available noninvasive methods for early diagnosis of oral mucosa (OM) neoplasia is a clinically significant problem. The aim of this study was to evaluate the effectiveness of the original score-based algorithm for assessing clinical data generated by a conventional and an autofluorescencebased examination in diagnosing OM cancer and assessing indications for a biopsy. We analyzed 134 medical histories and pathology reports of patients with oral neoplasia. The patients were assigned to 2 groups: the control group included 63 patients who underwent a standard visual and tactile examination with history taking and then were referred for an incisional biopsy followed by a histopathological examination of the specimens. In the main group consisting of 71 patients, a standard visual and tactile examination was complemented by an autofluorescence-based examination and the original score-based algorithm with the original index of required histopathological verification (RHV) were used to assess indications for a biopsy. In both groups, the most commonly affected site was the tongue (72.4%). The histopathological examination revealed that 28 patients from the main group and 14 patients from the control group had OM cancer (р = 0.051). Histologically, early-stage cancer was diagnosed in 17 patients from the main group and in 4 patients from the control group (р = 0.004). The proposed algorithm allowed us to effectively (in 90% of cases) diagnose precancer and cancer and avoid unnecessary biopsies.

Tumor expression of hypoxia-inducible factor and antimicrobial peptides in oral fluid for prediction of after-surgery suppurative complications in patients with oral mucosa cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17530-e17530
Author(s):  
Ekaterina Komarova ◽  
Oleg Ivanovich Kit ◽  
Vladimir Kononenko ◽  
Aleksey Yurievich Maksimov ◽  
Victoria V. Pozdnyakova ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Protein A ◽  
Hypoxia Inducible Factor ◽  
Infectious Complications ◽  
Main Group ◽  
Control Group ◽  
Comprehensive Treatment ◽  
Microbial Infection ◽  
Tumor Tissues ◽  
Tumor Expression

e17530 Background: It is believed that hypoxia-inducible factor (HIF-1α) hyperactivity promotes synthesis of protective factors and increases bacterial growth-inhibitory activity, provides enhancement methods of the congenital immune response to microbial infection. Methods: Lactoferrin and α-defensin were detected in saliva of 41 patients with oral mucosa (OM) cancer (T2N0-2M0) before a comprehensive treatment; enzyme immunoassay (EIA) method was used. A level of hypoxia-inducible factor (HIF-1α) was evaluated by EIA method in tumor tissues after surgical treatment. The patients were divided into two groups according to an after-surgery period: the main group (n = 16) had after-surgery suppurative complications. An after-surgery period proceeded without infectious complications in patients of a control group (n = 25). Results: It was found that Lactoferrin content in saliva statistically was significantly higher by 36,4% (p < 0,05) (3,0±0,24 µg/ml against 2,2±0,19 µg/ml) if to draw a comparison between the main group and the control group with respect to development of suppurative complications and absence of a inter-group difference according to α-defensin concentration (4,1±0,35 pg/ml against 3,8±0,19 pg/ml). HIF-1α expression index in the main group (8,4±0,79 CU/mg protein in a well) exceeded this index by 18,3% (p < 0,05) in the control group (7,1±0,79 CU/mg protein). A positive correlation between HIF-1α expression and Lactoferrin content (R = 0,53 at р = 0,0001) was detected in patients with OM cancer. Conclusions: Detected HIF-1α hyperexpression in tumor tissues and Lactoferrin content in saliva, as well as their interaction allows suggesting significance of these factors for their progression prediction in patients with OM cancer in case of after-surgery suppurative complications.

Randomized phase III trial evaluating the role of erythropoietin in the prevention of chemotherapy-induced anemia.

1997 ◽  
Vol 15 (7) ◽  
pp. 2715-2721 ◽  
Author(s):  
L Del Mastro ◽  
M Venturini ◽  
R Lionetto ◽  
O Garrone ◽  
G Melioli ◽  
...  
Keyword(s):  
Early Stage ◽  
Cost Effective ◽  
Additional Treatment ◽  
Phase Iii ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Clinically Significant ◽  
Few Data ◽  
To Receive

PURPOSE Although erythropoietin (EPO) is known to be useful in treating chemotherapy-induced anemia, few data are available on its potential preventive role. The aim of this study was to evaluate the ability of EPO in preventing the development of clinically significant anemia in patients treated with chemotherapy. PATIENTS AND METHODS Sixty-two early-stage breast cancer patients undergoing accelerated adjuvant chemotherapy were randomized to receive EPO 150 U/kg three times a week or no additional treatment. Chemotherapy consisted of six cycles of cyclophosphamide 600 mg/m2, epirubicin 60 mg/m2, and fluorouracil 600 mg/m2 (CEF) intravenously on day 1, every 2 weeks with the support of granulocyte colony-stimulating factor (G-CSF), 5 microg/kg subcutaneously from day 4 to day 11. RESULTS Throughout the six cycles of chemotherapy, EPO-treated patients maintained stable values of hemoglobin, whereas control patients developed a progressive anemia. At the end of chemotherapy, the mean (+/- SD) hemoglobin decrease in the control group was 3.05 g/dL (+/- 1.0; 95% confidence interval [CI], 2.6 to 3.5), whereas in the EPO group it was 0.8 (+/- 1.4; 95% CI, 0.3 to 1.4). Clinically significant anemia (hemoglobin < or = 10 g/dL) occurred in 16 patients (52%; 95% CI, 33 to 69) in the control arm and in no patient (0%; 95% CI, 0 to 14) in the EPO arm (P = .00001). CONCLUSION EPO prevents anemia in patients undergoing chemotherapy. Further trials are required to identify subsets of patients in which the preventive use of this drug could be cost-effective.

scholarly journals RISK FACTORS FOR CORONARY ARTERIES DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 20 (1) ◽  
pp. 95-99
Author(s):  
V.M. Zhdan ◽  
V.G. Lebid ◽  
H.S. Khaimenova ◽  
Yu.A. Isheikina
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Diseases ◽  
General Population ◽  
Coronary Arteries ◽  
Rheumatic Diseases ◽  
Health Care Professionals ◽  
Early Stage ◽  
Main Group ◽  
Control Group ◽  
X Rays

Now health care professionals who manage patients and stick to holistic patient-cantered approach are facing the problem of “polymorbidity”. The most common conditions complicating rheumatic diseases are cardiovascular diseases, interstitial lung disease, osteoporosis, chronic kidney disease, malignancies and depression. Despite the success in treatment of rheumatoid arthritis, the mortality rate in this category of patients remains higher than in the general population. This is associated with the acceleration of atherosclerosis progression and the early-age onset of coronary arteries disease. Therefore, rheumatoid arthritis is considered as a predictor of coronary arteries disease. The incidence of myocardial infarction, heart failure, and sudden coronary death in patients with rheumatoid arthritis is found to be 3 to 5 times higher than in the general population. The purpose of the present study was to estimate and evaluate comorbidity status in patients with rheumatoid arthritis. The study was performed at the at the Regional Medical and Diagnostic Centre of Rheumatologic Diseases, M.V. Sklifosovskyi Poltava Regional Clinical Hospital, which is the clinical base of the Department of Family Medicine and Therapy, Ukrainian Medical Stomatological Academy. The study included 135 patients with rheumatoid arthritis aged 32 – 65, who made up the main group. The control group consisted of 30 patients without autoimmune diseases, inflammatory conditions and other diseases in acute phase. All patients stated the consent to participate in the study in writing. During the study, all the participants passed through clinical examination including blood tests, urine tests, blood biochemistry, electrocardiography, echocardiography, X-rays of the joints, and ultrasound examinations (by using an apparatus of class “Radmir ultima”). 68.2% of the patients in the main group suffering from rheumatoid arthritis were found out to have different comorbidities compared with the control group. Cardiovascular diseases and especially coronary arteries disease were detected in 42.3% of cases and found out as the most prevalent comorbid diseases in the patients with rheumatoid arthritis. We also revealed the high prevalence of dyslipidemia (73, 4% of cases). It is necessary to underline that 75% of patients in the main group were diagnosed to have even 2 or more comorbidities. According to the results obtained, the majority of the patients suffering from rheumatoid arthritis have comorbidities, which can seriously affect the course of rheumatic diseases and influence the treatment. Management of patients with rheumatoid arthritis and comorbid conditions should be supported by rheumatologists, family doctors, internists in order to evaluate all polymorbidities in their interactions and to provide proper assistance for patients in making their therapeutic course decisions. Of course, this requires novel data from experts to improve diagnostic and treatment approaches of rheumatoid arthritis in its early stage.

Correction of antioxidant protection of the oral mucosa in chronic pancreatitis

2019 ◽  
Vol 24 (3) ◽  
pp. 274-279
Author(s):  
Ya. A. Lavrovskaya ◽  
I. G. Romanenko ◽  
O. M. Lavrovskaya
Keyword(s):  
Chronic Pancreatitis ◽  
Oral Mucosa ◽  
Catalase Activity ◽  
Oral Fluid ◽  
Comparison Group ◽  
Malonic Dialdehyde ◽  
Main Group ◽  
Laboratory Research ◽  
Control Group ◽  
Inflammatory Processes

Relevance: inflammatory processes in the oral mucosa are often found in diseases of the gastrointestinal tract, which is explained by the common functions and unity of all parts of the digestive system.Purpose – to study the effect of the studied drugs on the state of antioxidant-prooxidant systems of the oral mucosa in patients with chronic pancreatitis.Materials and methods: we examined 118 patients, of whom 62 were men (mean age 39.6 ± 16.4 years) and 56 women (mean age 40.3 ± 15.7 years); of these, 34 patients (control group) are practically healthy people without somatic pathology and 84 patients with chronic pancreatitis who were divided into two groups. The first (main) group - 46 people who, in addition to the drug therapy prescribed by the gastroenterologist, were prescribed the drug “Multiflora” 1 tablet 1 time per day with meals for 30 days. Also, the patients of the main group, after each meal, rinsed their mouths with “Enoant” food concentrate at a dilution of 1: 5 and applied it inside with 1 tablespoon 2 times a day, diluted with water in a ratio of 1: 5. The second (comparison group) - 38 people who, in addition to treatment of chronic pancreatitis, were treated with the oral mucosa according to the generally accepted method - prescribed fluconazole 150 mg 1 time a day, rinsing with 2% borax solution in glycerol after eating for 14 days. Unstimulated oral fluid of the examined patients served as the material for the study. In all groups, the activity of the catalase enzyme was determined by the method of S.V. Girina (1999), the level of malonic dialdehyde (MDA activity by reaction with thiobarbiturate acid to form a trimethine complex) and antioxidant-prooxidant index of unstimulated oral fluid by the method of А.P. Levitsky (2010). Laboratory research was carried out at the time of the initial examination before the start and on the 30th day of treatment.Results: in the comparison group after treatment, an increased concentration of malondialdehyde in the oral fluid, as well as reduced indicators of the API index and catalase activity confirm the presence of inflammatory processes in the oral mucosa. The application of the proposed therapeutic complex to patients of the main group significantly reduces the concentration of malondialdehyde in the oral fluid, proving its anti-inflammatory effect on the oral mucosa. An increase in the antioxidant-prooxidant index and an increase in catalase activity indicates an increase in the body’s defenses in patients of the main group.Conclusion: the use of the proposed therapeutic complex in patients with inflammatory diseases of the oral mucosa suffering from chronic pancreatitis contributes to the elimination of inflammatory and degenerative processes and the restoration of the normal level of protective systems in the oral mucosa.

scholarly journals Immediate results of surgical treatment of peripheral hepatic cholangiocarcinoma in elderly and senile patients

2020 ◽  
Vol 87 (9-10) ◽  
pp. 48-53
Author(s):  
O. Yu. Usenko ◽  
O. V. Hrynenko ◽  
A. І. Zhylenko ◽  
O. O. Popov ◽  
A. V. Husiev
Keyword(s):  
Surgical Treatment ◽  
International Study ◽  
Main Group ◽  
Control Group ◽  
Results Of Treatment ◽  
Peripheral Cholangiocarcinoma ◽  
Acute Pulmonary Thromboembolism ◽  
Clinically Significant ◽  
Selection Of

Objective. To estimate immediate results of surgical treatment of peripheral cholangiocarcinoma in elderly and senile patients. Materials and methods. In 2004-2018 yrs period in the Department of Transplantation and Surgery of the Liver of the Shalimov National Institute of Surgery and Transplantology 84 patients, suffering peripheral cholangiocarcinoma, were radically operated: 31 (36.9%) patients older than 60 yrs (the main Group), and 53 (63.1%) patients, younger than 60 yrs (control Group). Results. Postoperative clinically significant (IIIa-IV degree in accordance to classification of Clavien-Dindo) complications during 90-days of postoperative period were noted in 29.1% patients of the main Group and in 32.1% patients of a control Group (p=0.262), postoperative hepatic insufficiency, in accordance to The International Study Group of Liver Surgery criteria, - in 16.1 and 22.6% accordingly (p=0.473); reoperation was performed in 9.6 and 9.4% patients, accordingly (p=0.973). The causes of postoperative lethality in 2 patients of the main Group were an acute myocardial infarction (1) and an acute pulmonary thromboembolism (1). Conclusion. Hepatic resection is characterized by satisfactory immediate results of treatment of peripheral cholangiocarcinoma in elderly and senile patients, if performed in highly-specialized multidisciplinary centre and thorough selection of patients.

scholarly journals Identification of the site for biopsy in oral mucosa cancer diagnostics

2020 ◽  
Vol 5 (3) ◽  
pp. 181-185
Author(s):  
Andrei E. Orlov ◽  
Aleksei G. Gabrielyan ◽  
Oleg I. Kaganov ◽  
Mikhail A. Postnikov ◽  
Dmitrii A. Trunin ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Green Light ◽  
Light Filter ◽  
Cancer Diagnostics ◽  
Main Group ◽  
Control Group ◽  
Incisional Biopsy ◽  
Biopsy Procedure ◽  
Significant Difference ◽  
Histological Verification

Objective to refine the method of incisional biopsy in the diagnosis of oral mucosa cancer using the auto-fluorescent stomatoscopy. Materials and method.The study was conducted on the base of the Samara Regional Clinical Oncology Center. The inclusion criterion for patients was the diagnose of the oral mucosa cancer of various localization. Patients were divided into 2 groups. The main group included patients (n=43), who were being diagnosed for cancer with the help of optimized incisional biopsy of the oral mucosa formations, using the "AFS-400" autofluorescence complex and glasses with a green light filter for identification. The patients of the control group (n=46) received the standard biopsy procedure under direct vision. Results.The first incisional biopsies revealed cancer in 25 (54%) patients of the control group and in 36 (84%) patients of the main group. A histological verification of the diagnosis was necessary in 7 (16%) patients of the main group and required the second biopsy. In the control group, for the same purpose, 17 (37%) patients underwent the second biopsy and 4 (9%) patients required the third biopsy procedure. Exophytic-papillary forms of cancer were the most complex for histological verification. The primary biopsy of these cases was effective in 16 (37%) patients in the main group and in 8 (17%) patients in the control group (p = 0.036). In patients with initial stages of cancer (I-II), with the first incision biopsy, the histological verification of cancer was achieved in 16 (37%) cases in the main group and in 8 (17%) cases in the control group (p = 0.036). Conclusion.The use of the "AFS-400" autofluorescent complex and glasses with a green light filter for incisional biopsy of oral mucosal formations allows histological verification of cancer with the first biopsy in 84% of cases, including in stages I - II in 16 (37%) cases and in exophytic papillary forms in 16 (37%) cases. The significant difference was registered for the similar indicators of the control group (p = 0.036).

scholarly journals Oral Stereognosis in Patients with Completely Edentulous Jaws

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Volodymyr Sarapuk ◽  
Mykola Rozhko
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Main Group ◽  
Control Group ◽  
Tactile Sensitivity ◽  
Edentulous Jaws

Thirty patients with completely edentulous jaws (the main group) and 30 patients without denture defects and treated oral cavity (the control group) were examined in order to study oral stereognosis. Standard Н. Landt sets were used. The rate of tactile assessment of the objects shape in the oral cavity of the patients with completely edentulous jaws was established to decrease by 2.6 times on average in comparison with the control group, and the percentage of correctness of the sample determination decreased by 44.4%. After one month of prosthodontic treatment of the patients with completely edentulous jaws with the use of complete laminar dentures, the rate of tactile assessment of the objects’ shape increased by 18.3% and the index of the correctness of the sample determination increased by 31.5%. The results of the oral stereognosis study showed that the duration of collecting and analysis of receptor signals of oral mucosa in the patients with completely edentulous jaws was longer than in the patients without denture defects. However, the tactile sensitivity of the oral mucosa had the ability to recover in one month after prosthodontic treatment with complete laminar dentures. 

scholarly journals Clinical and immunological features of metabolic phenotype of osteoarthritis

2020 ◽  
Vol 22 (2) ◽  
pp. 327-334
Author(s):  
V. S. Shirinsky ◽  
N. Yu. Kalinovskaya ◽  
K. Yu. Filatova ◽  
I. V. Shirinsky
Keyword(s):  
Short Form ◽  
Main Group ◽  
Metabolic Phenotype ◽  
Control Group ◽  
Low Grade ◽  
Sf 36 ◽  
Patient Health ◽  
Clinically Significant ◽  
New Treatments ◽  
Low Grade Inflammation

Forty women with gonarthrosis were included in this study. The main group consisted of 19 patients having osteoarthritis (OA) with metabolic syndrome (MS), the control group consisted of 21 patients with OA but without MS. It was found that metabolic phenotype of gonarthrosis, i.e. OA with concomitant MS, was different from OA without MS in terms of pain measured with visual analogue scale (VAS) (65 mm in the main group vs 47 mm in control group, р = 0.001) and other OA symptoms in accordance with Knee Osteoarthritis Outcome Scale (KOOS) (43.2 points in the main group vs 76.1 points in the control group, р = 0.001). These main distinguishing features were associated with low quality of life measured with non-specific questionnaire Short Form -36 (SF-36) (30 points in the main group and 40 points in the control) and clinically significant signs of depression, detected with Patient Health Questionnaire-9 (PHQ-9) (12 points in the main group and 7 points in the control group). The metabolic phenotype of gonarthrosis was characterized with laboratory features of low-grade systemic inflammation as evidenced by increased CRP (11.4 mg/ml in the main group vs 3.2 mg/ml in the control group, р = 0.03), IL-6 (2.6 pg/ml in the main group vs 0.7 pg/ml in the control group, р = 0.001), IL-18 (196.6 pg/ml in the main group vs 61.4 pg/ml in the control group, р = 0.001) in the peripheral blood serum, as well as increase in antibodies against Col2 (27.1 ng/ml in the main vs 5.5 ng/ml in the control group, р = 0.01) , and dyslipidaemia — increase in LDL-cholesterol (5.5 mmol/l in the main group vs 5.9 mmol/l in the control group, р = 0.032) and triglycerides (2.026 mmol/l in the main group and 1.36 mmol/l in the control gropu, р = 0.02). In conclusion, MS-associated OA phenotype occurs due to pathogenetic similarities between OA and MS (syntropy) based on systemic low grade inflammation. This OA phenotype is not well studied and needs further research to develop new treatments targeting these two comorbid disorders as a single disease.

Prevention of inflammatory changes in the denture-bearing mucous membrane

2021 ◽  
Vol 21 (3) ◽  
pp. 211-215
Author(s):  
A. S. Peremyshlenko ◽  
A. K. Iordanishvili ◽  
P. A. Mushegyan ◽  
A. G. Sirak ◽  
A. A. Dolgalev
Keyword(s):  
Mucous Membrane ◽  
Oral Mucosa ◽  
Functional Condition ◽  
Main Group ◽  
Control Group ◽  
Adaptation Period ◽  
Denture Adhesive ◽  
Denture Stomatitis ◽  
Edentulous Patients ◽  
Inflammatory Changes

Relevance. Advanced clinical and cytological studies have not been conducted yet to examine denture adhesive effect on the prevention of inflammatory changes in the mucous membrane of the prosthetic bed, and thus, the prevention of denture-related stomatitis. Purpose: to assess the clinical and functional condition of the oral mucosa beneath the denture during the adaptation period using a denture adhesive cream to prevent inflammation of the denture bed mucous membrane.Materials and methods. The study clinically and cytologically (washing, scraping) assessed the condition of oral mucosa beneath complete acrylic dentures on days 14-16 and 28-30 of the adaptation period in 15 fully edentulous patients (main group), who used an adhesive cream after they were delivered their dentures, and in 21 fully edentulous patients (control group) who did not use the cream during the denture adaptation period. All the patients were elderly.Results. At different times of the adaptation period, the study more frequently detected inflammatory changes in the denture-bearing mucosa in subjects who did not use the denture adhesive cream. The cytological study confirmed the results of the oral clinical examination, as, at the end of the adaptation period, the number of cellular elements and various microorganisms was significantly lower in the main group than in the controls, which proved the effectiveness of the denture adhesive cream for the prevention of denture stomatitis.Conclusions. Regardless of sex, patients with complete acrylic dentures, who used a denture adhesive cream, had a lower bacterial accumulation on the prosthetic bed and inflammatory changes during the adaptation period, which allowed us to recommend the adhesive cream for the prevention of denture stomatitis.

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

Sign in / Sign up

Export Citation Format

Share Document