Evaluation of 86 Patients Whom Death While Being Followed up with Pre-Diagnosis of Covid-19

The Coronavirus-19 pandemic continues at full speed, and the number of patients who die from Covıd-19 is increasing. It was aimed to evaluate the demographic information and laboratory findings of 86 patients who died while being followed up in our hospital with a pre-diagnosis of Covıd-19. Identifying these characteristics of deceased patients will be essential to guide clinicians in identifying critically ill patients. Data on demographic information, comorbidities, time from hospitalization to death, molecular test results, thorax CT findings, biochemical findings, culture, antibiotic susceptibility, and the given treatments of the cases were collected from the electronic system Kastamonu Training and Research Hospital. While the RT-PCR test of 21 of the cases was positive, in 9 of the cases, control PCR tests were negative after a while. The CT results of 18 of the 21 initially RT-PCR positive cases were compatible with Covid-19, and the CT result of 3 could not be reached. When the blood test results of the cases were examined, neutrophil increase, white blood cell increase, lymphocyte reduction, and inflammatory markers increase were determined. A total of 43 bacterial growths were found in 21 cases. It has been observed that deaths in patients who were followed up with the pre-diagnosis of Covıd-19 generally occur in older people, males, and those with underlying diseases. It was thought that the cause of death could be underlying diseases, pathologies caused by inflammation, and secondary bacterial infections in addition to viral infection. Clinicians should be more careful about elderly patients, patients with secondary bacterial infections, or patients with neutrophilia, lymphopenia.

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Evaluation Of Clinical, Laboratory And Radiological Findings In Pediatric Covid-19 Cases And Their Relation With RT-PCR Result

10.22541/au.161248601.18537576/v1 ◽

2021 ◽

Author(s):

Muhammet Asena ◽

ilyas yolbaş ◽

murat Kanğın

Keyword(s):

Computed Tomography ◽

Respiratory Distress ◽

Clinical Laboratory ◽

Age Groups ◽

Age Group ◽

Test Results ◽

Rt Pcr ◽

Radiological Findings ◽

Laboratory Findings ◽

Pcr Test

Background: The pandemic of the new coronavirus disease (COVID-19) continues to be a major health problem globally. In this study, clinical findings, radiological findings, laboratory findings and polymerase chain reaction (PCR) test results were evaluated according to age groups in pediatric patients with COVID-19. Methods: In this study, PCR (+) and PCR (-) 278 cases diagnosed with COVID-19 between March 15, 2020 and September 30, 2020 were assessed considering clinical symptoms, radiological and laboratory findings and RT-PCR test results. Results: 43.9% of the cases consisted of RT-PCR (+) and 56.1% of RT-PCR (-) cases. Fever was observed at the rate of 64.7%, cough 53.2%, respiratory distress 12.2%, myalgia 24.5%, diarrhea 12.9%, chest X-ray findings 48.2% and computed tomography findings 43.6%. Diarrhea and cough, alanine aminotransferase, aspartate aminotransferase, leukocyte and lymphocyte elevation were determined as significantly higher in younger age group cases, while high myalgia and neutrophilia was observed in older age group children (p <0.05). Fever, high CRP, leukocytosis frequency, high neutrophil, were significantly higher in PCR(-) cases and the frequency of respiratory distress, high lymphocyte and chest computed tomography findings in PCR(+) cases (p <0.05). Conclusion: COVID-19 infection may indicate different nonspecific clinical, laboratory and radiological findings in children according to both adults and pediatric age groups. In addition, the results of the PCR test may give erroneous results in cases due to conditions such as fever, respiratory distress, high CRP, leukocytosis, high neutrophil and CT finding. Keywords: pediatric, COVID-19, RT-PCR

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Association of Underlying Diseases and Clinical Characteristics with Mortality in Patients with 2019 Novel Coronavirus in Iran

Archives of Clinical Infectious Diseases ◽

10.5812/archcid.104621 ◽

2020 ◽

Vol 15 (5) ◽

Author(s):

Mohammadhossein Zamanian ◽

Zohre Foroozanfar ◽

Zhila Izadi ◽

Samira Jafari ◽

Hossein Derakhshankhah ◽

...

Keyword(s):

Heart Disease ◽

Clinical Characteristics ◽

Underlying Disease ◽

Test Results ◽

Rt Pcr ◽

Factors Associated ◽

History Of ◽

Novel Coronavirus ◽

Underlying Diseases ◽

Pcr Test

Objectives: The first case of 2019 novel coronavirus disease (COVID-19) was reported in Iran in February 2020. Here, we report the epidemiological and clinical characteristics of patients with COVID-19 and factors associated with mortality in these patients. Methods: A retrospective cohort study was conducted from February 22, 2020, to March 24, 2020, in Golestan Hospital in Kermanshah, Iran. Demographic data including underlying diseases and clinical data including the presenting symptoms, chest computed tomography (CT) scan, reverse transcription polymerase chain reaction (RT-PCR) test results, and outcomes were extracted from electronic medical records. Simple and multiple logistic regression methods were used to explore the factors associated with mortality. Results: Of 245 patients admitted with COVID-19, 155 (63.30%) were male. The mean age of the subjects was 54.68 ± 19.21. Forty-five (18.48%) patients had underlying diseases. Common symptoms were dyspnea (n = 137; 55.9%), cough (n = 93; 38.0%), and fever (n = 78; 31.8%). All patients had pneumonia with abnormal findings on chest CT scan (100%), and RT-PCR test results were positive in 87 (35.50%) patients. Of the total admitted cases, 38 (15.5%) patients died during hospitalization. An old age (OR = 1.09; 95% CI: 1.02 to 1.06), history of heart disease (OR = 5.07; 95% CI: 1.46 to 17.58), hypertension (OR = 5.82; 95% CI: 1.13 to 30.04), smoking (OR = 11.44; 95% CI: 1.01 to 29.53), history of at least one underlying disease (OR = 3.31; 95%CI: 1.54 to 7.09), and symptoms of decreased consciousness at the time of admission (OR = 24.23; 95% CI: 2.62 to 223.39) were associated with mortality. Also, the symptoms of cough (OR = 0.383; 95% CI: 0.17 to 0.88) and fever (OR = 0.278; 95% CI: 0.10 to 0.74) had a negative association with mortality. Conclusions: In the current study, factors including old age, smoking, symptoms of decreased consciousness, and underlying diseases such as heart disease, hypertension, and history of at least one underlying disease were associated with mortality. Factors associated with mortality should be considered so that we can better manage patients with COVID-19.

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Comparison of Clinical, Radiological and Laboratory Findings in Discharged and Dead Patients With COVID-19 in Ilam Province, West of Iran

10.21203/rs.3.rs-1049149/v1 ◽

2021 ◽

Author(s):

Mohammad Reza Kaffashian ◽

Maryam Shirani ◽

Maryam Koupaei ◽

Nourkhoda Sadeghifard ◽

Iraj Ahmadi ◽

...

Keyword(s):

Electronic Medical Records ◽

Medical Records ◽

Clinical Symptoms ◽

Rt Pcr ◽

Laboratory Findings ◽

Treatment Regimens ◽

Special Profile ◽

Radiological Images ◽

Global Threat ◽

Underlying Diseases

Abstract Objective: COVID-19 is the last global threat which WHO confirmed it as a pandemic on March 11, 2020. In the Middle East, Iran was the first country where the SARS-Cov-2 was detected. The epidemiological and economic challenges of Iran make this country a particularly relevant subject of study. In the current study, we aimed to evaluate the clinical, radiological and laboratory findings in hospitalized COVID-19 confirmed cases in Ilam province, west of Iran.Material and methods:Overall, 2204 hospitalized RT-PCR confirmed patients with COVID-19 were considered in this study. Electronic medical records, including clinical symptoms, radiological images, laboratory findings, and the comorbidities of patients with COVID-19 were collected and analyzed. In addition, the medication regimens used in these patients were evaluated. The patients were classified in discharged and died groups according to their outcomes. Then, clinical, radiological and laboratory findings as well as treatment regimens and underlying diseases were compared in these two groups.Results:Among the patients, 1209 (54.85%) were male and 995 (45.14%) were female. Pneumonia, dyspnea and cough, were the most common clinical data in both discharged and died groups. Among the comorbidities, COPD, and cancer were significantly more common in the dead patients than in the living. The results of laboratory tests showed that blood creatinine, BUN, ESR, Na+, WBC, and neutrophil count have increased in deceased group compared to the survivors. However, the lymphocyte count decreased in deceased patients. The evaluation of radiographs demonstrated that there were significant correlations between bilateral pneumonia, ground glass opacity, bilateral patchy shadowing, and pleural effusion with death. Conclusion:The current investigation indicated the special profile of COVID-19 in west of Iran. Discharged and dead patients with COVID-19 had distinct clinical, radiological and laboratory features, which were separated by principle component analysis. Identifying these characteristics of the disease would translate into the implementation of practical measures to improve results.

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FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study

10.1101/2020.10.15.20213108 ◽

2020 ◽

Author(s):

Samuel G. Urwin ◽

B. Clare Lendrem ◽

Jana Suklan ◽

Kile Green ◽

Sara Graziadio ◽

...

Keyword(s):

Laboratory Test ◽

Diagnostic Accuracy ◽

Bacterial Infections ◽

Point Of Care ◽

Test Accuracy ◽

Test Results ◽

Standard Laboratory ◽

Rt Pcr ◽

Accuracy Study ◽

Test Result

AbstractBackgroundPoint-of-care (POC) tests for COVID-19 could relieve pressure on isolation resource, support infection prevention and control, and help commence more timely and appropriate treatment. We aimed to undertake a systematic review and pooled diagnostic test accuracy study of available individual patient data (IPD) to evaluate the diagnostic accuracy of a commercial POC test (FebriDx) in patients with suspected COVID-19.MethodsA literature search was performed on the 1st of October 2020 to identify studies reporting diagnostic accuracy statistics of the FebriDx POC test versus real time reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2. Studies were screened for risk of bias. IPD were sought from studies meeting the inclusion and exclusion criteria. Logistic regression was performed to investigate the study effect on the outcome of the RT-PCR test result in order to determine whether it was appropriate to pool results. Diagnostic accuracy statistics were calculated with 95% confidence intervals (CIs).Results15 studies were screened, and we included two published studies with 527 hospitalised patients. 523 patients had valid FebriDx results for Myxovirus resistance protein A (MxA), an antiviral host response protein. The FebriDx test produced a pooled sensitivity of 0.920 (95% CI: 0.875-0.950) and specificity of 0.862 (0.819-0.896) compared with RT-PCR, where there was an estimated true COVID-19 prevalence of 0.405 (0.364-0.448) and overall FebriDx test yield was 99.2%. Patients were tested at a median of 4 days [interquartile range: 2:9] after symptom onset. No differences were found in a sub-group analysis of time tested since the onset of symptoms.ConclusionsBased on a large sample of patients from two studies during the first wave of the SARS-CoV-2 pandemic, the FebriDx POC test had reasonable diagnostic accuracy in a hospital setting with high COVID-19 prevalence, out of influenza season. More research is required to determine how FebriDx would perform in other healthcare settings with higher or lower COVID-19 prevalence, different patient populations, or when other respiratory infections are in circulation.Trial registrationThis work was based on a pooled analysis of anonymised data from two previous studies; the CoV-19POC study, described by Clark et al. (9), the “Southampton study” [ISRCTN:14966673, date registered: 18/03/2020]; and a study described by Karim et al. (13) the “Kettering study”.Lay summaryTests to diagnose COVID-19 are crucial to help control the spread of the disease and to guide treatment. Over the last few months, tests have been developed that can detect the SARS-CoV-2 virus which causes COVID-19. These tests use complex machines in pathology laboratories accepting samples from large geographical areas. Sometimes it takes days for test results to come back. So, to reduce the wait for results, new portable tests are being developed. These point-of-care (POC) tests are designed to work close to where patients require assessment and care such as hospital emergency departments, GP surgeries or care homes. For these new POC tests to be useful, they should ideally be as good as standard laboratory tests so patients get their result quickly and can benefit from the best, safest care.In this study we looked at published research into a new test, FebriDx, which can detect the presence of any viral infection, including infections due to the SARS-CoV-2 virus, as well as bacterial infections which can have similar symptoms. The FebriDx result was compared with that obtained on the same patient’s throat and nose swab and using the standard COVID-19 viral laboratory test. We were able to analyse data from two studies with a total of 523 adult patients who were receiving emergency hospital care with symptoms of COVID-19 during the early stage of the UK pandemic. Almost half of the patients were diagnosed as positive for SARS-CoV-2 virus using standard laboratory COVID-19 viral tests.Our analysis demonstrated that the FebriDx POC test agreed 94 out of 100 times with the standard laboratory test results when FebriDx diagnosed the patient as free from COVID-19. However, FebriDx agreed only 82 out of 100 times with the standard laboratory test when FebriDx indicated that the patient had a COVID-19 infection. These differences have important implications for how these tests could be used. As there were far fewer FebriDx false results when the results of the FebriDx test were negative (6 out of 100) than when the results of the FebriDx test were positive (18 out of 100), we can have more confidence in a negative test result using FebriDx at the POC than a positive FebriDx result.Overall, we have shown that the FebriDx POC test performed quite well during the first wave of the COVID-19 pandemic when compared with laboratory tests, especially when the POC test returned a negative test. For the future, this means that the FebriDx POC test might be helpful in making a rapid clinical decision whether to isolate a patient with COVID-19-like symptoms arriving in a busy emergency department. However, our results indicate it would not completely replace the need to conduct a confirmatory laboratory test in certain cases.There are limitations to our findings. For example, we do not know if FebriDx will work in a similar way with patients in different settings such as in the community or care homes. Similarly, we do not know whether other viral and bacterial infections which cause similar COVID-19 symptoms, and are more common in the autumn and winter months, could influence the FebriDx test accuracy.

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Comparison of Rapid Antibody Test and Thorax Computed Tomography Results in Patients who Underwent RT-PCR with the Pre-Diagnosis of COVID-19

10.22541/au.161380936.65092255/v1 ◽

2021 ◽

Author(s):

İlker Kızıloglu ◽

Aslı Şener ◽

Neslihan Siliv

Keyword(s):

Computed Tomography ◽

Emergency Department ◽

Predictive Value ◽

Antibody Test ◽

Nasopharyngeal Swab ◽

Test Results ◽

Rt Pcr ◽

Hospital Data ◽

Thorax Ct ◽

Rapid Antibody

Introduction: In this study, it is planned to compare the RT-PCR test, which is the gold standard in the diagnosis of COVID-19, with Thorax computed tomography (CT) and rapid antibody test results. Methods: Patients who were admitted to the emergency service of İzmir Çiğli Training and Research Hospital between 01.04.2020 and 31.05.2020 and who were suspected of having COVID-19 infection were included in the study. The medical records of the patients were retrospectively analyzed through the hospital data processing database. Age, gender, hospitalization, status of home quarantine, real-time reverse transcription-polymerase chain reaction (RT-PCR), thorax CT and rapid antibody test results of the patients were examined. The relationship between RT-PCR, thorax CT and rapid antibody test results were compared statistically. Results: A total of 181 patients, 115 (63.5%) male and 66 (36.5%) female, with an average age of 56.4 ± 18.06 years were included in the study. The nasopharyngeal swab PCR result obtained at the first admission of the patients to the emergency department was positive in 71 (39.2%) patients. Thorax CT was performed in 173 (95.6%) patients who applied to the emergency department, and 112 (64.7%) of them had findings that could be compatible with COVID-19. According to the thorax CT findings in patients, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting COVID-19 infection were respectively; 76.1%, 43.1%, 48.2% and 72.1% (ĸ: 0.176, p <0.001). In our study, the mortality rate for COVID-19 was found to be 2.8%. Conclusion: Rapid antibody test and thorax CT examinations were found to have low diagnostic value in patients who admitted to the emergency department of our hospital and whose first RT-PCR SARS-CoV-2 test was positive. Studies involving larger patient groups are needed for their use alone in diagnosis and screening.

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Testing applicability of international guidelines in treatment of sepsis

Medicinski pregled ◽

10.2298/mpns14s2024p ◽

2014 ◽

Vol 67 (suppl. 2) ◽

pp. 24-30

Author(s):

Vedrana Petric ◽

Sandra Mikic ◽

Sinisa Sevic ◽

Danijela Stankovic-Baricak ◽

Nevena Drljevic ◽

...

Keyword(s):

Infectious Diseases ◽

Clinical Experience ◽

Bacterial Infections ◽

Test Results ◽

Clinical Protocols ◽

C Reactive Protein ◽

Laboratory Findings ◽

International Guidelines ◽

Mean Values ◽

Reactive Protein

Introduction. The Department of Infectious Diseases adopted new internal clinical protocols for initial adequate antimicrobial therapy of bacterial infections in January, 2013. Protocols were made up on the basis of European (British National Formulary) and the American (Sanford) guidelines for treatment of bacterial infections. The aim of our study was to investigate the efficiency of new clinical protocols based on international guidelines in treatment of bacteria induced sepsis and to compare it with the efficiency of the existing guidelines, which are based on the use of antibiotics according to clinical experience of the doctors. Material and Methods. The study included 109 patients diagnosed with bacteria-induced sepsis, who were treated at the Department of Infectious Diseases in the period from 1 January, 2012 to 31 December, 2013. Data were collected from the medical records. The patients were divided into two groups. The first group included 54 patients diagnosed with sepsis who were treated empirically. The second group consisted of 55 patients treated according to the new internal protocols. The efficiency of treatment in both groups of patients was monitored by laboratory findings (leukocyte count, C-reactive protein, fibrinogen, sedimentation, procalcitonin), and temperatures, measured on the first and seventh day of hospitalization. For statistical analysis, we used the ?2 test. Results. After the applied treatment, there was a statistically significant decrease in the mean values of C-reactive protein P and procalcitonin on the seventh day of treatment in both groups of patients. The most frequently applied therapy was triple antibiotic therapy - ceftriaxone, ciprofloxacin and metronidazole, in both groups. Conclusion. Treatment of bacteria-induced sepsis according to internationally accepted protocols for treatment of bacterial infections is as effective as treatment of sepsis according to the clinical experience of doctors.

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Screening COVID-19 with Chest CT in Preference to RT-PCR: Based on Mortality Analysis

10.21203/rs.3.rs-31338/v1 ◽

2020 ◽

Author(s):

Yuanlong Xie ◽

Minhao Wu ◽

Chong Zhang ◽

Yufan Zhu ◽

Kun Li ◽

...

Keyword(s):

Mortality Rate ◽

Virus Disease ◽

Chest Ct ◽

Test Results ◽

Rt Pcr ◽

Number Of Patients ◽

Significant Difference ◽

The Mean ◽

Mortality Analysis ◽

Pcr Test

Abstract Corona Virus Disease 2019 (COVID-19) became the outbreak of infectious diseases emergency worldwide. It remains unknown whether the RT-PCR test results was associated with the prognosis of COVID-19 patients or not. In this study, a total number of 495 patients with typical chest CT feature and symptom consistent with COVID-19 were retrospectively included from Jan 23, 2020 to Feb 26, 2020. 186 (37.58%), 32 (6.46%) and 277 (55.96%) COVID-19 patients had initial positive, suspected and negative RT-PCR results, respectively. The mean age was 58.55 years and 254(51.3%) were older than 60 years. 60.00% (297/495), 22.02% (109/495) and 17.98% (89/495) of COVID-19 patients were common, severe and critically type, respectively. There were no significant differences of age, gender, time from onset to hospitalization and severity classification in the patients with initial positive and negative RT-PCR result. The mortality rate of patients with positive and negative were 7.14% and 7.94%. Patients with initial negative or initial positive RT-PCR results had no significant difference of mortality rate (c2=4.079, p=0.130). The number of patients with lymphocyte ratios under the normal level was significantly larger in patients with initial negative RT-PCR results (59/92) compared with the patients with initial positive result (86/167), p=0.033. COVID-19 patients with positive or negative RT-PCR results had no significant difference in severity and mortality. Chest CT may be a more effective tool to screen COVID-19 in preference to RT-PCR.

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Multi-dimensional Visualisation of Laboratory Findings and Functional Test Results for Analysing the Clinical Course of Disease in Medicine

Methods of Information in Medicine ◽

10.1055/s-0038-1634604 ◽

1995 ◽

Vol 34 (03) ◽

pp. 302-308 ◽

Cited By ~ 7

Author(s):

C. J. Luz ◽

W. Giere ◽

R. Lüdecke ◽

D. Jonas ◽

A. J. W. Goldschmidt

Keyword(s):

Clinical Course ◽

Test Results ◽

Geometrical Figure ◽

Laboratory Findings ◽

Course Of Disease ◽

Quantitative Examination ◽

Ward Rounds ◽

Patient’S History ◽

Graphical Primitive ◽

Computerized Medical Record

Abstract:The illustration of a patient’s history by a graphical primitive is discussed. Illustration technology is presented which simultaneously represents quantitative examination findings (e. g., laboratory values) and qualitative findings (e. g., from function diagnostics) by a single geometrical figure. Depending on the medical results, this figure takes on characteristic forms which can be identified as patterns typical for a specific disease. The procedure developed is integrated in a user interface which is implemented in the form of a computerized medical record for use on a pentop computer. This portable computer assists the physician during ward rounds, supplies additional, intelligence-based information, serves quality control, and streamlines working procedures making them more efficient.

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Perbedaan sensitivitas tetes telinga antibiotik terhadap Pseudomonas aeruginosa pada otitis media supuratif kronik

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v42i2.22 ◽

2012 ◽

Vol 42 (2) ◽

Author(s):

Anton Budhi Darmawan ◽

Dwi Utami Anjarwati

Keyword(s):

Pseudomonas Aeruginosa ◽

Otitis Media ◽

Chronic Suppurative Otitis Media ◽

Test Results ◽

Sectional Study ◽

Suppurative Otitis Media ◽

Number Of Patients ◽

Significant Difference ◽

Cochran Test ◽

Post Hoc

Background: Chronic suppurative otitis media (CSOM) is one infectious disease of the middle ear, most commonly caused by Pseudomonas aeruginosa. A high number of patients come to the ENT outpatient clinic with active benign type of CSOM. The bacteria Pseudomonas aeruginosa is capable of producing biofilm which protects itself from penetration of antibiotics, and therefore creates resistance towards antibiotics and difficult to eradicate. Objective: The aim of this study was to compare the sensitivity levels of chloramphenicol, polymyxin-neomycin, cyprofloxacin and ofloxacine against Pseudomonas aeruginosa in patients with active benign type CSOM in ENT clinic. Method: The method used was across sectional study on 25 patients, from August 2010 until December 2010. Samples were taken withear swab and then put on sensitivity test to chloramphenicol, polymyxin-neomycin, cyprofloxacin andofloxacine using the diffusion disc method. The analysis used in this study was Cochran test. Results: Results showed a significant difference in sensitivity among chloramphenicol (38,70%), polymyxinneomycin(83,87%),cyprofloxacin(90,32%)andofloxacin(58,06%)withp=0,000(p<0,05).PostHocanalysisusing the Mc Nemar indicated that there were significant differences in sensitivity betweenpolymyxin-neomycin to chloramphenicol with p=0,000 (p<0,05), ciprofloxacin to chloramphenicol andciprofloxacin to ofloxacine with p= 0,002, but there were no significant differences between cyprofloxacinto polymyxin-neomycin with p=0,687, polymyxin-neomycin to ofloxacin p=0.057 and ofloxacin tochloramphenicol p=0,109. There were significant differences in antibiotic ear dropssensitivity to Pseudomonas aeruginosa in patients with active benign type of CSOM. Cyprofloxacin andpolymyxin-neomycin were more sensitive than ofloxacin and chloramphenicol. Keywords: Pseudomonas aeruginosa, active benign type of chronic suppurative otitis media, antibioticear drops. Abstrak : Latar belakang: Otitis media supuratif kronik (OMSK) merupakan penyakit infeksi kronik telinga tengah yang sering dijumpai di klinik THT. Penyebab tersering OMSK adalah bakteri Pseudomonasaeruginosa. Pseudomonas aeruginosa mempunyai kemampuan untuk membentuk biofilm yangmelindunginya dari penetrasi antibiotik sehingga menimbulkan resistensi terhadap antibiotik dan sulituntuk eradikasinya. Tujuan: Untuk mengetahui perbandingan tingkat sensitivitas kloramfenikol,polimiksin-neomisin, ciprofloksasin dan ofloksasin terhadap isolat Pseudomonas aeruginosa padapasien OMSK benigna aktif di klinik THT RSMS. Metode: Metode yang digunakan adalah crosssectional terhadap 29 pasien OMSK di klinik THT RSMS periode bulan Agustus 2010 - Desember2010. Pengambilan sampel dilakukan dengan swab telinga. Uji sensitivitas terhadap kloramfenikol,polimiksin-neomisin, ciprofloksasin dan ofloksasin dilakukan dengan metode cakram secara difusi.Analisis yang digunakan dalam penelitian ini adalah Cochran dan analisis post hoc. Hasil: Didapatkansensitivitas kloramfenikol sebesar 38,70%, polimiksin-neomisin sebesar 83,87%, ciprofloksasin sebesar90,32% dan ofloksasin sebesar 58,06% dengan p=0,01 (P<0,05), yang menunjukkan adanya perbedaansensitivitas yang bermakna antara kloramfenikol, polimiksin-neomisin, ciprofloksasin dan ofloksasinterhadap Pseudomonas aeruginosa. Analisis post hoc menggunakan Mc Nemar menunjukkan bahwaterdapat perbedaan sensitivitas yang bermakna antara tetes telinga polimiksin-neomisin terhadapkloramfenikol, dan ciprofloksasin terhadap kloramfenikol p=0,000 (p<0,05), serta terdapat perbedaanyang bermakna antara tetes telinga ciprofloksasin terhadap ofloksasin, p=0,002, tetapi tidak terdapatperbedaan yang bermakna antara ciprofloksasin terhadap polimiksin-neomisin, p=0,687, polimiksinneomisinterhadap ofloksasin p=0,057, dan kloramfenikol terhadap ofloksasin p=0,109. Kesimpulan:Terdapat perbedaan sensitivitas yang bermakna tetes telinga antibiotik terhadap Pseudomonas aeruginosa pada pasien OMSK benigna aktif. Ciprofloksasin dan polimiksin-neomisin tetes telinga mempunyai sensitivitas yang lebih baik dibanding ofloksasin dan kloramfenikol. Kata kunci: Pseudomonas aeruginosa, otitis media supuratif kronik, tetes telinga antibiotik

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