Alpha-lipoic acid did not affect lipid profile and blood pressure in critically ill patients: A randomized, double-blind clinical trial

2021 ◽  
pp. 1-9
Author(s):  
Azam Mohamadi ◽  
Amir Reza Moravejolahkami ◽  
Gholamreza Askari ◽  
Mohammad Javad Tarrahi ◽  
Mohammadreza Hajiesmaeili ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Critically Ill ◽  
Lipoic Acid ◽  
Critically Ill Patients ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Alpha Lipoic Acid ◽  
Double Blind ◽  
Significant Difference

BACKGROUND: Some researchers suggested a positive effect of Alpha-Lipoic Acid (ALA) on Blood Pressure (BP) and lipid profile. OBJECTIVE: The aim of this study was to determine the efficacy of ALA for improving BP and lipid profile in critically ill patients. METHODS: In the present study, eighty patients (aged 18–80 years old) were randomly assigned to receive daily either ALA (600 mg/day) or placebo for eight weeks. Systolic BP (SBP), Diastolic BP (DBP), Triglyceride (TG), Total cholesterol (TC), Low Density Lipoprotein (LDL), and High Density Lipoprotein (HDL) were measured before and after intervention. RESULTS: LDL decreased significantly in the ALA group (110.6±34.9 vs. 107.9±33.4 mg/dl; P <  0.05). There was also a significant difference in terms of HDL in both groups (Δ= +1.8 vs. Δ= –0.3 mg/dl; P <  0.05). A marginal non-significant reduction was also observed for SBP. There were no significant differences in other variables between the two groups. CONCLUSIONS: ALA supplementation did not improve the BP and some serum lipid markers in critically ill patients. Larger and longer trials will be needed to determine efficacy of ALA.

Effect of Hydroxychloroquine on the Lipid Profile of Patients with Sjögren Syndrome

2014 ◽  
Vol 41 (5) ◽  
pp. 902-908 ◽  
Author(s):  
Michail P. Migkos ◽  
Theodora E. Markatseli ◽  
Chrisoula Iliou ◽  
Paraskevi V. Voulgari ◽  
Alexandros A. Drosos
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Sjögren Syndrome ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Entire Group ◽  
Sjogren Syndrome ◽  
Significant Difference ◽  
Changes Over Time

Objective.Many studies have highlighted the hypolipidemic action of hydroxychloroquine (HCQ). We investigated the effect of HCQ on the lipid profile of patients with Sjögren syndrome (SS).Methods.The present retrospective observational study included 71 female patients with SS treated with HCQ. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol, triglycerides (TG), and atherogenic index (TC/HDL) were measured at baseline, after 6 months, and 1, 3, and 5 years after initiation of HCQ treatment. Analysis to investigate changes over time was performed in the entire patient group and in the separate subgroups: those receiving (21 patients) and those not receiving (50 patients) hypolipidemic treatment.Results.For the entire group of patients a statistically significant decrease in TC was noted (levels before treatment 220 ± 41 mg/dl, and at 5 yrs 206 ± 32 mg/dl, p = 0.006). A statistically significant difference was observed in the levels of HDL (57 ± 14 mg/dl vs 67 ± 17 mg/dl, p < 0.001) and in atherogenic index (4.0 ± 1.3 vs 3.3 ± 0.9, p < 0.001). Patients not receiving a hypolipidemic agent during the same period demonstrated a decrease in TC (214 ± 40 mg/dl vs 208 ± 34 mg/dl, p = 0.049), an increase in HDL levels (55 ± 15 mg/dl vs 67 ± 18 mg/dl, p < 0.001), and a decrease in atherogenic index (4.0 ± 1.4 vs 3.3 ± 0.9, p < 0.001). In the subgroup of patients receiving hypolipidemic treatment, the respective changes in their lipid profile were not significant in the first years but became significant in the long term.Conclusion.Use of HCQ in patients with SS was related to a statistically significant decrease in TC, an increase in HDL, and improvement in the atherogenic index.

scholarly journals Metabolic evaluation in overweight and obese cats and association with blood pressure

2017 ◽  
Vol 48 (1) ◽  
Author(s):  
Vanessa Danielle de Freitas ◽  
Alessandra Ramos Castilho ◽  
Luciana Auxiliadora Viebrantz da Conceição ◽  
Valéria Régia Franco Sousa ◽  
Adriane Jorge Mendonça ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Metabolic Evaluation ◽  
Morphometric Measurements ◽  
Metabolic Alterations ◽  
Significant Difference

ABSTRACT: Obesity has been increasing in cats andis associated with metabolic and cardiovascular diseases. The association of these alterations can trigger the onset of metabolic syndrome (MS). Therefore, this study aimed to analyze the serum levels of glucose, fructosamine, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein (VLDL), andalanine aminotransferase of cats and to identify the possibility of MS,as well as to evaluate changes in arterial pressure. Thirty-seven cats were classified by ECC and morphometric measurements, namely, 15 obese, 12 overweight, and 10 controls. Nocat manifested MS. Only VLDL had a statistically significant difference (P<0.05) between groups. Therefore, obesity may not be associated with arterial hypertension, and more studies are needed to evaluate the metabolic alterations in overweight and obese cats.

scholarly journals Effects of Low Molecular Weight and Unfractionated Heparin on Lipoprotein Lipase and Lipid Profile in haemodialysis patients

2021 ◽  
Vol 3 (1) ◽  
pp. 56-59
Author(s):  
Ahmad Jan ◽  
Shah Jahan ◽  
Nighat Aziz ◽  
Sikandar Ali Khan ◽  
Asia Asia ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Lipid Profile ◽  
Lipoprotein Lipase ◽  
Low Density Lipoprotein ◽  
Age Distribution ◽  
Density Lipoprotein ◽  
P Value ◽  
Low Molecular Weight ◽  
Significant Difference ◽  
Study Population

Introduction: In haemodialysis patients, mortality from cardiovascular disease is much greater than in the general population. The current study aimed to evaluate the effects of two different types of heparin, low molecular weight heparins (LMWH) and high molecular weight heparin (HMWH), on lipid profile in patients undergoing haemodialysis.Material & Methods: A total of 60 patients on haemodialysis were selected from two main hospitals of Lahore, Pakistan and were divided into two major groups based on the type of heparin used. A 5 ml blood sample was taken from the dialysis machine to get the serum and was kept frozen at -20ºC for analysis of total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein. Comparison of lipoprotein lipase activity between groups were evaluated by using the student t-test. A P-value of ? 0.05 was considered statistically significant.Results: Gender wise distribution of study population (n=60) was 67% (n=40) males and 33% (n=20) females. The age distribution of individuals varied from 39-43 years. Moreover, use of HMWH was high in males (73%) as compared to female (27%) with an average age of 39 ± 12 years where duration of haemodialysis was 4.44 ± 2.83. A significant difference in LPL activity related to different times in all patients was observed. A clearer difference observed in case of LDL where LPL activity was markedly different in both groups. Our data showed that individuals using LMWH had less chances of dyslipidaemia as compared to those using HMWH.Conclusion: LMWH is a useful and safe anticoagulant during haemodialysis as compared to HMWH.

scholarly journals Lipid Profile in Alcoholic and Non Alcoholic Fatty Liver Patients

2020 ◽  
Author(s):  
Aakash Shahi ◽  
Narayan Gautam ◽  
Sanju Rawal ◽  
Uday Sharma ◽  
Archana Jayan
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Profile ◽  
Fatty Liver Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
P Value ◽  
Alcoholic Fatty Liver ◽  
Significant Difference ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Fatty liver disease is a common and major chronic liver disease. It has been implicated that patients have disorders of lipid metabolism and involved in the pathogenesis of fatty liver. Lipid profile plays a very important role in diagnosis of liver diseases hence it was designed to observe relationship between lipid profile and fatty liver disease (FLD) based on ultrasonography (USG).Method and methodology: This Cross-sectional and analytical study was undertaken in the Department of Internal Medicine with collaboration of Department of Radiology and Department of Biochemistry, Universal College of Medical Sciences-Teaching Hospital (UCMS-TH), Bhairahawa, Nepal from March 2019 to February 2020 in total 100 patients diagnosed with FLD by USG.Result: In 100 cases, the male to female ratio was 1.8:1. 56% of the total cases presented with alcoholic fatty liver disease (AFLD) while remaining 44% with non alcoholic fatty liver disease (NAFLD). The spectrum of lipid abnormality was observed with increased total cholesterol (TC), Low Density Lipoprotein (LDL), increased triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in AFLD cases as compared to NAFLD cases. However, it has been observed that TG/HDL and Non-HDL/HDL were higher in NAFLD as compared to AFLD. There was statistical significant difference in HDL (p-value: 0.019) between alcoholic fatty liver disease grade 1 (AFLG1) and non-alcoholic fatty liver disease grade 1 (NAFLG1). Moreover, it was observed statistical significant difference in HDL between AFLG2 and NAFLG2 (p-value: 0.012).Conclusion:Elevated level of TG and decreased HDL has been implicated in the precipitation of the occlusive vascular disease. These parameters in conjunction with Non-HDL/HDL and TG/HDL can be useful in early screening and monitoring of dyslipidemia in the fatty liver patients to prevent cardiovascular diseases.

scholarly journals Alterations of Lipid profile levels in 7,12-Dimethylbenz(a)anthracene induced ulcerative colitis rat model.

2017 ◽  
Vol 10 (4) ◽  
pp. 352
Author(s):  
Geetha Palaniswamy ◽  
Lakshman Kumar B ◽  
Indra U ◽  
Pavithra Sheetal B
Keyword(s):  
Ulcerative Colitis ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Intestinal Inflammation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Significant Difference

Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12 Dimethylbenz(a)anthracene induced ulcerative colitis.Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high density lipoprotein (HDL-C) and low density lipoprotein (HDL-C).Results: Ulcerative colitis rats exhibit low level of low density lipoprotein cholesterol and total cholesterol. No significant difference was observed in high density lipoprotein and triglycerides and significant difference was observed in phospholipids and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis.Conclusion: This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.Keywords: Ulcerative colitis, 7,12-Dimethylbenz(a)anthracene, Lipoprotein, Low-density lipoprotein, Phospholipids.

scholarly journals Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease

2018 ◽  
Vol 7 (5) ◽  
pp. 637-644 ◽  
Author(s):  
Lang Qin ◽  
Xiaoming Zhu ◽  
Xiaoxia Liu ◽  
Meifang Zeng ◽  
Ran Tao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Cushing’S Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cushing's Disease ◽  
Independent Association ◽  
Lipids Profile ◽  
Restricted Cubic Splines

Introduction The purpose of the study was to describe lipid profile and explore pathogenetic role of LDL-c on hypertension in patients with Cushing’s disease (CD). Hypertension is a common feature in patients with CD. Previous study found low-density lipoprotein cholesterol (LDL-c) uptake in vascular cells might be involved in vascular remodeling in patients with CD. Therefore, we evaluated the relationship between lipid profile and the blood pressure in patients with CD. Methods This retrospective study included 84 patients referred to Huashan Hospital for the evaluation and diagnosis of CD from January 2012 to December 2013. All subjects had detailed clinical evaluation by the same group of endocrinology specialists to avoid subjective influences. Results We found that high LDL-c patients had significant higher body mass index (BMI), systolic blood pressure (SBP), cholesterol (CHO), triglyceride (TG), and apolipoproteinB (apoB) (P < 0.05). An association was detected between SBP values and lipids profile including CHO, TG, LDL-c, apolipoproteinA (apoA), apoB and lipoprotein(a) (LP(a)). After adjustment for all covariates, the LDL-c remained positively associated with SBP. In patients with or without taking statins, patients with LDL-c ≥3.37 mmol/L had higher SBP than patients with LDL-c <3.37 mmol/L. Then, LDL-c was coded using restricted cubic splines (RCS) function with three knots located at the 5th, 50th and 95th percentiles of the distribution of LDL-c. Compared to individuals with 3.215 mmol/L of LDL-c, individuals with 4.0, 4.5 and 5.0 mmol/L of LDL-c had differences of 3.86, 8.53 and 14.11 mmHg in SBP, respectively. Conclusions An independent association between LDL-c and SBP was found in patients with CD. We speculate that LDL-c may be a pathogenic factor for hypertension in those patients.

Effects of different exercise loads on the thyroid hormone levels and serum lipid profile in swimmers

2018 ◽  
Vol 38 (1) ◽  
Author(s):  
Sayad Kocahan ◽  
Aykut Dundar
Keyword(s):  
Thyroid Hormone ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Positive Impact ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thyroid Stimulating Hormone ◽  
Lipid Profiles ◽  
Serum Lipid Profile ◽  
Significant Difference

Abstract Background The aim of this study was to investigate the effects of different exercise loads (short, medium and long swimming distances) on the thyroid hormone (THs) levels and serum lipid profiles of male professional swimmers. Materials and methods The participants in this study were 20 healthy male professional swimmers aged 18–22 years, who all competed at an elite level. The THs levels [thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4)] and serum lipid profile were also obtained. Results It was determined that the TSH and T4 values increased after exercise (p < 0.05). When compared to the pretest values, the increase in the TSH and T4 values following the L400 tests was statistically significant (p < 0.001 and p < 0.05). It was also determined that the changes in the cholesterol, high-density lipoprotein (HDL) and total glucose (TG) values were significant after exercise (p < 0.001). There was no significant difference between the groups in terms of the low-density lipoprotein (LDL) values (p = 0.07). According to the results, the cholesterol counts for the M200 and L400 groups were lower than the pretest counts (p < 0.001). When compared to the pretest values, the decrease in the HDL counts for the M200 and L400 groups was higher than the pretest HDL counts (p < 0.001 and p < 0.05, respectively). Further, the triglycerides counts for the M200 and L400 groups were higher than the pretest counts (p < 0.001). Conclusions Different exercise loads can have a positive impact on the physical health of swimmers via their lipid profiles and THs. Additionally, swimming exercise could be considered an efficient protective strategy against metabolic disorders, as it serves to balance the serum lipid levels.

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2014 ◽  
Vol 9 (1) ◽  
pp. 13-17 ◽  
Author(s):  
CM Reza ◽  
ASMA Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameter total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/uhj.v9i1.19505 University Heart Journal Vol. 9, No. 1, January 2013; 13-17

scholarly journals Supplementation with Low Doses of a Cod Protein Hydrolysate on Glucose Regulation and Lipid Metabolism in Adults with Metabolic Syndrome: A Randomized, Double-Blind Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1991 ◽  
Author(s):  
Caroline Jensen ◽  
Hanna Fjeldheim Dale ◽  
Trygve Hausken ◽  
Jan Gunnar Hatlebakk ◽  
Ingeborg Brønstad ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Composition ◽  
Lipid Profile ◽  
Protein Hydrolysate ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Postprandial Glucose ◽  
Double Blind Study ◽  
Double Blind ◽  
Glucose Levels

The risk of cardiovascular diseases and type 2 diabetes mellitus are increased in subjects with metabolic syndrome (MetS), and hydrolyzed fish protein may have favorable effects on metabolic health. Here, we investigated the effect of 8 weeks supplementation with 4 g of cod protein hydrolysate (CPH) on glucose metabolism, lipid profile and body composition in individuals with MetS in a double-blind, randomized intervention study with a parallel-group design. Subjects received a daily supplement of CPH (n = 15) or placebo (n = 15). Primary outcomes were serum fasting and postprandial glucose levels. Secondary outcomes were fasting and postprandial insulin and glucagon-like peptide 1 (GLP-1), fasting lipid concentrations and body composition. No difference was observed between CPH and placebo for insulin, glucose or GLP-1 after 8 weeks intervention. Fasting triacylglycerol decreased in both the CPH group and placebo group, with no change between groups. Fasting total cholesterol and low-density lipoprotein cholesterol decreased significantly within both groups from baseline to study end, but no difference was observed between the two groups. In conclusion, supplementing with a low dose of CPH in subjects with MetS for 8 weeks had no effect on fasting or postprandial levels of insulin, glucose or GLP-1, lipid profile or body composition.

scholarly journals Study of Lipid Profile in Newly Diagnosed Hypertensive Patients

2014 ◽  
Vol 6 (2) ◽  
pp. 112-115
Author(s):  
MAK Akanda ◽  
KN Choudhury ◽  
MZ Ali ◽  
LA Sayami ◽  
RM Huda
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Newly Diagnosed ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
The Mean ◽  
Lipid Parameters

Back ground: Hypertension is one of the most important modifiable risk factors for cardiovascular disease (CVD) and stroke. Dyslipidemia is closely associated with hypertension. Dyslipidemia and hypertension are the commonest risk factors for CVD. The aim of the present study was to compare different lipid parameters among newly diagnosed hypertensive patients with normotensive subjects in Bangladesh and find out the relationship. Methods: This study was a cross sectional study in which 42 newly diagnosed hypertensive patients who were on no antihypertensive medication and 42 subjects with normal blood pressure (normotensive) were enrolled for compare. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by Enzymatic colorimetric test. Results: The mean systolic blood pressure of hypertensive and normotensive were 154.6±22.5 vs111.50±3.42 mmof.Hg and mean diastolic blood pressure were 93.2±5.20 vs 71.44± 3.21mm of Hg. The mean of SBP and DBP of hypertensive patients was found to be higher than normotensive (p< 0.05). There was significant increase in different lipid levels namely TC 199.4±44.5 vs188.7±37.9 mg/dl, TG155.9±88.8 vs 121.9±73.2 mg/dl and LDLc 119.8±35.6 vs112.7±28.6 mg/dl in hypertensive patients as compared to normotensive (p<0.05). However there was no significant difference in HDLc level. BMI and waist circumference showed significant association in hypertensive patients (p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia, BMI and waist circumference. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/cardio.v6i2.18350 Cardiovasc. j. 2014; 6(2): 112-115

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