scholarly journals An unusual association of disseminated staphylococcal infection in dengue fever

2021 ◽  
pp. 391-394
Author(s):  
Sruthi Haridas ◽  
Renoy A Henry ◽  
Abhishek C Menon ◽  
Anup Menon ◽  
L Sasikala ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Dual Infection ◽  
Denv Infection ◽  
Staphylococcal Infection ◽  
Healthy Male ◽  
Unusual Association ◽  
Host Innate Immunity ◽  
Igm Deficiency ◽  
Expanded Dengue Syndrome

Dengue fever is an important mosquito-borne disease with a highly variable clinical spectrum, ranging from self-limiting mild illness to expanded dengue syndrome (EDS). While the immune-pathogenesis of dengue virus (DENV) infection had been studied thoroughly, the exact mechanism remains elusive. The transient suppression of host innate immunity by DENV might be the likely reason for dengue-associated co-infections and/or superinfections. In addition, the dual infection can worsen the clinical outcome of Dengue fever. We are reporting a case of disseminated staphylococcal infection in a 31-year-old healthy male with a recent dengue infection. Blood culture showed methicillin-sensitive Staphylococcus aureus. Selective IgM deficiency has been proved in this patient, which might explain, the occurrence of disseminated staphylococcal septicemia. This case report highlights the importance of early detection of atypical features and the emerging entity called EDS

Study of Cardiac Manifestation in Patients with Seropositive Dengue Fever and to Find Correlation with Subclinical Cardiac Involvement

2021 ◽  
Vol 8 (12) ◽  
pp. 28-33
Author(s):  
Rishad Ahmed
Keyword(s):  
Dengue Fever ◽  
Cardiac Involvement ◽  
Randomized Study ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Denv Infection ◽  
Left Ventricular ◽  
High Grade Fever ◽  
Plasma Leakage ◽  
Cardiac Manifestation

Objective: The main objective of the present study was to observe the electrocardiogram (ECG) changes in dengue fever and to find correlation with subclinical cardiac involvement. Methods: This was an observational, prospective, non-randomized study. High grade fever for one to five days diagnosed as dengue infection later confirmed by dengue tests (NS1, IgG and IgM ELISA) were included in this study. Prior to the commencement of the study informed consent was taken from all the participants. With 12 lead ECG taken during the febrile phase of dengue fever randomly selected serologically confirmed cases of dengue fever were evaluated at an interval of 24 hrs. for a total of five days. On the day of admission when the patient was afebrile, echocardiography was done. Plasma leakage was diagnosed by presence of any one of four: subcutaneous oedema (pedal oedema, facial puffiness) or pleural effusion or pericardial effusion or ascites. Result: A total 80 patients who were admitted to hospital during study periods due to symptoms of dengue fever and IgM dengue positive status were included in this study. Among this total population of 80 patients (N=80) 48 were male and 32 were female. Out of these, majority were diagnosed as DF 52 (65%), 23 (29%) were diagnosed as DHF and rest only 5 (6%) were diagnosed as DSS. Total 54 patients were found to have normal ECG among which 35 were having dengue fever, 16 were having DHF and 3 were having DSS. Total 2 patients were diagnosed to have left ventricular hypertrophy among which one had dengue fever and rest two had DHF. ST depression was observed in total 7 patients in which 5 were had dengue fever and 2 were had DHF. Relative bradycardia was found in 14, tall t waves in 2 and ventricular ectopics in 1 patient (table 2). Abnormal ECG findings were compared using Chi-square test and were found to be statistically significant (P < 0.05) in dengue fever and DHF. There was statistically significant correlation between ECG abnormalities and abdominal pain and mucosal bleed. The presence of plasma leakage were observed among 77 (96.3%) patients. Proportion of echocardiography abnormalities were higher among patients with plasma leak 6 (30%) as compared to without plasma leak 9 (15%), this difference was not found to be statistically significant Conclusion: In all type of Dengue infections incidence of cardiac involvement was quite high. Due to the overlapping clinical manifestations such as capillary leak associated with DENV infection, tachycardia, pulmonary edema, and hypotension as well as due to the low index of clinical suspicion cardiac involvement in dengue fever is often underdiagnosed. Keywords: Cardiac manifestation, dengue infection, echocardiography, electrocardiography.

scholarly journals 1405. Clinical and laboratory features of fatal dengue fever in children: a case-control study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S710-S711
Author(s):  
Dolores E Freire ◽  
Jeniffer D Olaya ◽  
Michael Hawkes
Keyword(s):  
Dengue Fever ◽  
Case Control Study ◽  
Dengue Infection ◽  
Healthcare Providers ◽  
Case Control ◽  
Warning Signs ◽  
Total Leukocyte Count ◽  
Retrospective Case ◽  
Time To Death ◽  
Control Study

Abstract Background Dengue fever (DF) is a mosquito-borne illness that causes significant morbidity and mortality in tropical climates. This study compared the clinical features of fatal DF cases to severe non-fatal, and non-severe controls in Ecuador. Methods Retrospective case-control study of children (1 month to 15 years) hospitalized with serologically-confirmed DF in Guayaquil, Ecuador from 2013 to 2017. Cases of severe, fatal (SF) DF were compared to two control groups: (1) severe DF survivors (SS); and (2) patients with dengue with warning signs (DWS), matched 3:1 to cases for age, sex, and admission date. Observational trial profile Results 1051 patients were admitted with suspected DF and 552 were IgM-positive. Patients were classified as SF (n=11), SS (n=30), or DWS (n=511) (Figure1). Among SF cases, median age was 9.6 years (IQR 5.5-11), 7 (64%) were male, and median time to death was 1.5 days (IQR 0.8-4.0). (Table 1) SF cases had a median of 3 (Range 0-5) encounters with healthcare providers prior to presentation, compared to 2 (Range 0-5, p=0.02) for SS and 2 (Range 0-3, p=0.02) for DWS. Physical findings more common in SF cases than controls included: higher weight, tachycardia, tachypnea, delayed capillary refill, and hepatomegaly (p&lt; 0.05 for all comparisons). Neurological manifestations were more prevalent in the SF group: 9/11 (82%) patients compared to 15/30 (50%, p=0.09) in SS and 7/33 (21%, p&lt; 0.01) in DWS. Total leukocyte count (7.8x103/µL versus 4.5x103/µL, p=0.03) and absolute neutrophil count (5.1x103/µL versus 2.1x103/µL, p=0.03) were higher in SF cases than DWS controls. Fewer SF patients received intravenous dextrose than SS controls (27% versus 70%, p=0.03) (Table 2). Admission characteristics of children with dengue fever Management and outcome Conclusion Delayed recognition by healthcare workers, higher weight, vital sign abnormalities, hepatomegaly, neurological symptoms, leukocytosis, neutrophilia, and lack of dextrose in intravenous solutions were associated with mortality in children with DF. These findings have implications for optimizing the diagnosis and management of severe pediatric dengue infection. Disclosures All Authors: No reported disclosures

scholarly journals Multi-Tissue Transcriptomic-Informed In Silico Investigation of Drugs for the Treatment of Dengue Fever Disease

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1540
Author(s):  
Beatriz Sierra ◽  
Ana Cristina Magalhães ◽  
Daniel Soares ◽  
Bruno Cavadas ◽  
Ana B. Perez ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Dengue Fever ◽  
In Silico ◽  
Serotonin Receptor ◽  
Neglected Tropical Diseases ◽  
Dengue Infection ◽  
Severe Dengue ◽  
Functional Evaluation ◽  
Atpase Inhibitor ◽  
Serotonin Receptor Antagonist

Transcriptomics, proteomics and pathogen-host interactomics data are being explored for the in silico–informed selection of drugs, prior to their functional evaluation. The effectiveness of this kind of strategy has been put to the test in the current COVID-19 pandemic, and it has been paying off, leading to a few drugs being rapidly repurposed as treatment against SARS-CoV-2 infection. Several neglected tropical diseases, for which treatment remains unavailable, would benefit from informed in silico investigations of drugs, as performed in this work for Dengue fever disease. We analyzed transcriptomic data in the key tissues of liver, spleen and blood profiles and verified that despite transcriptomic differences due to tissue specialization, the common mechanisms of action, “Adrenergic receptor antagonist”, “ATPase inhibitor”, “NF-kB pathway inhibitor” and “Serotonin receptor antagonist”, were identified as druggable (e.g., oxprenolol, digoxin, auranofin and palonosetron, respectively) to oppose the effects of severe Dengue infection in these tissues. These are good candidates for future functional evaluation and clinical trials.

scholarly journals Infectious Disease Relational Data Analysis Using String Grammar Non-Euclidean Relational Fuzzy C-Means

2021 ◽  
Vol 18 (15) ◽  
pp. 8153
Author(s):  
Apiwat Budwong ◽  
Sansanee Auephanwiriyakul ◽  
Nipon Theera-Umpon
Keyword(s):  
High Risk ◽  
Dengue Fever ◽  
Policy Development ◽  
Dengue Infection ◽  
Prevention Policy ◽  
Fuzzy C Means ◽  
North East ◽  
B Virus ◽  
North And South ◽  
Better Than

Statistical analysis in infectious diseases is becoming more important, especially in prevention policy development. To achieve that, the epidemiology, a study of the relationship between the occurrence and who/when/where, is needed. In this paper, we develop the string grammar non-Euclidean relational fuzzy C-means (sgNERF-CM) algorithm to determine a relationship inside the data from the age, career, and month viewpoint for all provinces in Thailand for the dengue fever, influenza, and Hepatitis B virus (HBV) infection. The Dunn’s index is used to select the best models because of its ability to identify the compact and well-separated clusters. We compare the results of the sgNERF-CM algorithm with the string grammar relational hard C-means (sgRHCM) algorithm. In addition, their numerical counterparts, i.e., relational hard C-means (RHCM) and non-Euclidean relational fuzzy C-means (NERF-CM) algorithms are also applied in the comparison. We found that the sgNERF-CM algorithm is far better than the numerical counterparts and better than the sgRHCM algorithm in most cases. From the results, we found that the month-based dataset does not help in relationship-finding since the diseases tend to happen all year round. People from different age ranges in different regions in Thailand have different numbers of dengue fever infections. The occupations that have a higher chance to have dengue fever are student and teacher groups from the central, north-east, north, and south regions. Additionally, students in all regions, except the central region, have a high risk of dengue infection. For the influenza dataset, we found that a group of people with the age of more than 1 year to 64 years old has higher number of influenza infections in every province. Most occupations in all regions have a higher risk of infecting the influenza. For the HBV dataset, people in all regions with an age between 10 to 65 years old have a high risk in infecting the disease. In addition, only farmer and general contractor groups in all regions have high chance of infecting HBV as well.

scholarly journals Micafungin Inhibits Dengue Virus Infection through the Disruption of Virus Binding, Entry, and Stability

2021 ◽  
Vol 14 (4) ◽  
pp. 338
Author(s):  
Yen-Chen Chen ◽  
Jeng-Wei Lu ◽  
Chia-Tsui Yeh ◽  
Te-Yu Lin ◽  
Feng-Cheng Liu ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Early Stage ◽  
Quantitative Polymerase Chain Reaction ◽  
Enterovirus 71 ◽  
Denv Infection ◽  
Immunofluorescence Assay ◽  
Dependent Manner ◽  
Virus Binding ◽  
Virus Serotype

Dengue fever is an arbovirus disease caused by infection with the dengue virus (DENV). Half of the world’s population lives under the threat of dengue fever, however, researchers have yet to develop any drugs that are clinically applicable to this infection. Micafungin is a member of the echinocandins family of anti-fungal drugs, capable of blocking the synthesis of β-1,3-D-glucan in the walls of fungal cells. Previous studies have demonstrated the effectiveness of Micafungin against infections of enterovirus 71 (EV71) and chikungunya virus (CHIKV). This is the first study demonstrating the effectiveness of micafungin in inhibiting the cytopathic effects of dengue virus serotype 2 (DENV-2) in a dose-dependent manner. Time-of-addition assays verified the inhibitory effects of micafungin in pre-treated, co-treated, and full-treatment groups. Binding and entry assays also demonstrated the effectiveness of micafungin in the early stage of DENV-2 infection. The virucidal efficacy of micafungin appears to lie in its ability to destroy the virion. Molecular docking assays revealed the binding of micafungin to the envelope protein of DENV-2, thereby revealing the mechanism by which micafungin affects the early stage of DENV infection and the stability of DENV. Two other micafungin analogs, caspofungin and anidulafungin, were also shown to have the antiviral effects on DENV-2. Finally, immunofluorescence assay (IFA) and reverse-transcription quantitative polymerase chain reaction (RT-qPCR) confirmed the broad anti-DENV ability of micafungin against dengue virus serotypes 1, 3, and 4 (DENV-1, DENV-3, and DENV-4). Taken together, these results demonstrate the potential of micafungin and its analogs as candidates for the development of broad-spectrum treatments for DENV infection.

Wegener’s granulomatosis with dengue fever: an unusual association

2011 ◽  
Vol 15 (3) ◽  
pp. e47-e49 ◽  
Author(s):  
Anirban GHOSH ◽  
Arnab BANERJEE ◽  
Sandip SAHA ◽  
Arindam PANDE ◽  
Biswadip GHOSH
Keyword(s):  
Dengue Fever ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Unusual Association

scholarly journals Oculogyric Crisis – Atypical Presentation in Patient with Dengue Fever

2021 ◽  
pp. 19-23
Author(s):  
Saurabh Rajkumar Jain ◽  
Jitendra D. Lakhani ◽  
Pramod R. Jha
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Neurological Complications ◽  
Oculogyric Crisis ◽  
Co Morbidity ◽  
Wide Range ◽  
Chief Complaints ◽  
Plasma Leakage ◽  
Multi Organ Dysfunction Syndrome ◽  
Rule Out

Here we are presenting a case of dengue fever presented with an atypical symptom of “oculogyric crisis” with features of multi organ dysfunction syndrome. Increased vascular permeability, plasma leakage, haemorrhagic manifestations, and thrombocytopenia are charecteristics of dengue fever.  A 19 year old male patient, with no co-morbidity came to Dhiraj hospital with chief complaints of  fever which was high grade & intermittent, it is associated with chills & rigours for 5 days. Also complain of abdominal pain over epigastric region, dull aching non radiating associated with decreased appetite since 5 days. Dengue infection has a wide range of clinical features. Neurological complications can occur in any spectrum of dengue infection.  The diagnosis of oculogyric crisis is majorly clinical and it requires a focused detailed history and detailed physical examination to find out possible triggers for the crisis and to rule out other reasons for abnormal eye movements.

scholarly journals Prospective study on the clinico-hematological profile of dengue fever patients in Navi Mumbai

2021 ◽  
Vol 8 (4) ◽  
pp. 569
Author(s):  
Prachi Sankhe ◽  
Priyanka Jadhav ◽  
Praveen Meduri
Keyword(s):  
Dengue Fever ◽  
Prospective Observational Study ◽  
Clinical Laboratory ◽  
Dengue Infection ◽  
Radiological Findings ◽  
Hematological Profile ◽  
Entire Duration ◽  
Wbc Count ◽  
Almost All ◽  
Biochemical Abnormalities

Background: It has been seen that epidemiology and clinical presentation of dengue infection differs significantly across geographical areas. The present study was done to study clinico-hematological profile of patients with dengue fever in Navi Mumbai, Maharashtra.Methods: This prospective observational study was conducted at a tertiary level teaching hospital in Navi Mumbai. All patients were observed over their entire duration of their hospital stay (up to 7 days). We included adult patients of both gender (males or females) who were admitted with clinically and serological diagnosed dengue fever, consenting to participate in the study.  The clinical, laboratory and radiological findings of the patients were noted.Results: All 80 patients presented with fever while 71.25% had myalgia. Retro-orbital pain, rash and vomiting was observed in 38%, 26% and 26% respectively, whereas 23.75% patients were having cough and bleeding from any site. Three fourths of the patients were diagnosed with dengue, 18.75% and 6.25% were diagnosed with DHF and DSS. respectively. Hepatosplenomegaly was increasing from day 1 (9%) to 6th (60%) and 7th (60%) day. Mean haemoglobin levels and haematocrit started increasing from second day onwards, while WBC count and platelet count increased gradually from first day onwards. Splenomegaly was diagnosed in 3.75% of patients while hepatosplenomegaly and fatty liver was observed in 8.75% and 2.5% respectively. There were two deaths, both were cases of DSS.Conclusions: Almost all the patients included in our study showed both haematological and biochemical abnormalities. 

scholarly journals Intraoperative Post Partum Hemorrhage in a Patient with Dengue Fever

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Usama Ahmed ◽  
Asiyah Aman
Keyword(s):  
Dengue Fever ◽  
Post Partum ◽  
Dengue Infection ◽  
Massive Hemorrhage ◽  
Anesthetic Induction ◽  
Post Partum Hemorrhage ◽  
Creative Commons ◽  
Perioperative Phase ◽  
Mild Fever ◽  
Open Access Article

A 33 year old obstetric patient with mild fever of undiagnosed etiology underwent emergency caesarean section under general anesthesia. She had platelet count of 98,000 per microliter and increased APTT of 37.8 s at the time of surgery. After uneventful anesthetic induction and delivery of fetus, slow and oozing type of bleeding led to massive hemorrhage. Patient remained vitally stable throughout perioperative phase and was extubated. Next day, patient’s dengue IgM antibody was reported positive. Neonate was well and his dengue test was negative. Pregnant women are at high risk of developing severe complications of dengue fever with unclear mechanisms related to impaired coagulation. Regional anesthesia may not have safe outcome due to dengue infection. doi: https://doi.org/10.12669/pjms.38.1.4519 How to cite this:Ahmed U, Aman A. Intraoperative Post Partum Hemorrhage in a Patient with Dengue Fever. Pak J Med Sci. 2022;38(1):---------.  doi: https://doi.org/10.12669/pjms.38.1.4519 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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