scholarly journals The comparative evaluation of complex drugs based on fipronil for ectoparasitosis of dogs and cats

2021 ◽  
Vol 4 (2) ◽  
pp. 52-57
Author(s):  
O. L. Tishyn ◽  
I. D. Yuskiv ◽  
L. L. Yuskiv ◽  
Zn. M. Perih ◽  
O. M. Bogach
Keyword(s):  
Side Effects ◽  
Ixodes Ricinus ◽  
Clinical Examination ◽  
Dermacentor Reticulatus ◽  
Control Groups ◽  
Reference Drug ◽  
Pulex Irritans ◽  
Experimental Drug ◽  
And Control ◽  
Otodectes Cynotis

The article presents data on the effectiveness of new domestic antiparasitic drug “Insectostop for dogs and cats” in comparison to the reference drugs “Burdi Fipro for dogs” and “Burdi Fipro for cats” that is used for therapeutic and prophylactic purposes against ectoparasitosis of dogs and cats of different breeds. According to the results of the research, the parasitism of fleas of Ctenocephalus canis, C. felis and Pulex irritans species and parasitiform mites of the Ixodes ricinus and Dermacentor reticulatus species and sarcoptiform mites of the species Otodectes cynotis were detected on experimental animals. Clinically, this was inspected by redness, inflammation of the skin, itching reflex, the emergence of papules on the skin, scales. Based on the results, it was found that 8 hours after usage of the experimental drug “Insectostop for dogs and cats” its effectiveness in syphonapterosis of dogs was 87.9 %, and after usage of the reference drug “Bourdie Fipro for dogs” – 86.9 %, and in experiments on cats, the effectiveness of the experimental drug for siphonapterosis in cats was 92.4 %, and the reference drug “Bourdie Fipro for cats” – 90.3 %. Starting from the first and third days after usage of drugs on the fur of dogs and cats of the experimental and control groups, parasitological studies did not reveal fleas of the species Ctenocephalus canis, C. felis and Pulex irritans. So starting from the first day, the experimental and reference drugs showed 100 % effectiveness during the siphonapterosis in dogs and cats. During the ixodidosis of dogs, it was found that at the 8-th hour after usage of the experimental drug “Insectostop for dogs and cats” its effectiveness was 82.9 %, and after usage of the reference drug “Bourdie Fipro for dogs” – 81.3 %. At the 24-th hour after usage of the experimental drug, its effectiveness was 97.6 %, and after usage of the reference drug – 95.9 %. At the 72nd hour of the experiment, no adult representatives of the species Ixodes ricinus and Dermacentor reticulatus were found on the fur of dogs of these groups. Thus, at 72 hours after usage of the experimental and reference drug, they showed 100 % efficiency on adult Ixodes mites. During the Otodectesis of dogs it was found that on the 7th day, effectiveness of the experimental drug was 75.6 %, on the 14th day – 98.1 % and after usage of the reference drug “Bourdi Fipro for dogs” its effectiveness on the 7th day was 73.5 %, and on the 14th – 98.3 %. At 21-st days after treatment of animals with drugs as a result of clinical examination and parasitological examination of dogs mites of the species Otodectes cynotis were not detected. In experiments on cats, on the 7th day after usage of experimental drug, its effectiveness during Otodectesis of cats was 76.9 %, and after usage of reference drug – 77.1 %. As a result of clinical examination and parasitological study of the experimental and control groups of animals on the 14th day after treatment of the auricles of cats with mites of the species Otodectes cynotis was not detected. Thus, usage of both drugs promotes the release of Otodectesis in dogs from parasites on the 21st day of the experiment, and cats – on the 14th day. Tests have shown that the experimental drug “Insectostop for dogs and cats” (100 ml of the drug contains the active substance: fipronil – 10 g) does not cause skin irritation, dermatitis, seborrhea, allergic and other side effects, that the drug is well tolerated by dogs and cats and doesn’t give any side effects and changes of clinical condition of animals.

scholarly journals THE COMPARATIVE EVALUATION OF COMPLEX MEDICINES, BASED ON IMIDACLOPRIDE IN ECTOPARASITOSIS OF DOGS AND CATS

2021 ◽  
Vol 22 (1) ◽  
pp. 228-235
Author(s):  
O. L. Tishyn ◽  
I. D. Yuskiv ◽  
Zn. M. Perih ◽  
O. M. Bogach
Keyword(s):  
Body Surface ◽  
Dermacentor Reticulatus ◽  
Control Group ◽  
Average Intensity ◽  
Reference Drug ◽  
Pulex Irritans ◽  
Ctenocephalides Canis ◽  
Experimental Drug ◽  
And Control ◽  
Experimental Group

The article represents data on the effectiveness of the new domestic anti-parasitic medicine «Animal VetLine antiparasitic drops for dogs and cats spot-on» in comparison to the reference-medicine «Advantage@» when used for the therapeutic and prophylactic purposes for ectoparasites of dogs and cats of different breeds. According to the results of clinical examination and parasitological examination of animals, parasitism of fleas of the Ctenocephalides canis, Ctenocephalides felis, Pulex irritans species at the intensity of invasion (II) from 5 to 8 specimens/10 cm2, lice Linognathus setosus at II from 1 to 3 specimens/10 cm2 of body surface, and parasitic mites of the Ixodes ricinus, Dermacentor reticulatus species at II from 8 to 12 specimens per animal in addition in dogs. Based on the obtained results for the study of the effectiveness of the «Animal VetLine antiparasitic drops for dogs and cats spot-on» in comparison with the reference drug «Advantage@» medicine, during the infection of dogs and cats by Ctenocephalides canis, Pulex irritans and Ctenocephalides felis fleas, Linognathus setosus lice, mites of the Ixodes ricinus, Dermacentor reticulatus species, was found that on the second day of treatment in the experimental and control groups of animals there was a sharp increase in the number of dead insects, ectoparasites and Ixodes mites, and on the fifth day of the study no live fleas were detected, lice and ticks. At the same time, on the second day after the usage of the experimental and reference drug, their extensile effectivity during the linognatosis of dogs and cats and syphonapterosis of cats was 100.0 %. In the experimental and control groups of dogs on the second day after usage of the experimental drug and the reference drug, the average intensity of invasion of Ctenocephalides canis and Pulex irritans decreased to 1.2±0.4 ectoparasite insects per 10 cm2 of body surface in the experimental group and to 1.4±0.4 insect ectoparasites per 10 cm2 of body surface in the control group of animals, ie the intensity of the experimental drug was 82.1 %, and the reference drug 78.5 %. The results show that the rate of intensification of the drug for exodidosis of dogs in the experimental group on the second day was – 75.0 %, and the control – 68.0 %. However, the average intensity of mite infestation of the family Ixodidae was in the experimental group 2.5±0.15 specimens per animal, and in the control group 3.0±0.21 specimens per animal, respectively. It was found that the experimental drug had no toxic effects and was well tolerated by animals no changes in clinical signs during use were detected.

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

THE APPLICATION OF STATISTICAL METHODS IN EVALUATING THE RESULTS OF CLINICAL FINDINGS OF THE DRUG BOVHUALONIDASE AZOXIMER IN CATS WITH UROLOGICAL DISEASES

2020 ◽  
pp. 212-218
Author(s):  
А. V. Nazarova ◽  
◽  
B. S. Semenov ◽  
Т. Sh. Kuznetsova ◽  
◽  
...  
Keyword(s):  
Relative Risk ◽  
Side Effects ◽  
Risk Reduction ◽  
Absolute Risk ◽  
Control Group ◽  
Control Groups ◽  
Saint Petersburg ◽  
Number Of Patients ◽  
And Control ◽  
Experimental Group

In the period from November 2018 to August 2020, we conducted a randomized blind placebo-controlled confirmatory clinical trial in parallel groups on the basis of network of veterinary clinics in Saint Petersburg and Saint Petersburg state university of veterinary medicine. The purpose of the study: to evaluate the effectiveness of Bovhualonidaze azoximer(BA) in patients subjected to surgical intervention on the urethra and bladder, to prevent postoperative complications and relapses of the underlying disease. The frequency of complications was taken as an indicator of effectiveness. 80 cats were evaluated according to the criteria for inclusion in the study, after evaluation and randomization, 53 patients (24 and 29 cats in the experimental and control groups, respectively) who had indications for surgery on the urethra and/or bladder were included in the study. After the withdrawal of some patients, 38 cats were analyzed (17 and 23 cats in the experimental and control groups, respectively). Animals in the experimental group received BA drugs in addition to conventional therapy, and animals in the control group received placebo. The rate of complications in the experimental group was 11.8 %, in the control group-61.9 %. The relative risk was 19.0 %, and the relative risk reduction was 80.9 %. The chance of developing complications in the animals of the experimental group is 12.2 times lower than in animals of the control group.. Absolute risk reduction — 50.1 %, and the number of patients to be treated — 2 patients. The confidence interval for the risk of side effects of BA drugs in cats was 0.0-10.1 %. Based on the results of our clinical study, we proved that the use of BA drugs is effective for preventing complications during surgical interventions on the urethra and bladder, and the risk of side effects when using BA drugs in cats is insignificant

scholarly journals Safety and efficacy study: Short-term application of radiofrequency ablation and stereotactic body radiotherapy for Barcelona Clinical Liver Cancer stage 0–B1 hepatocellular carcinoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245076
Author(s):  
Feiqian Wang ◽  
Kazushi Numata ◽  
Atsuya Takeda ◽  
Katsuaki Ogushi ◽  
Hiroyuki Fukuda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Side Effects ◽  
Liver Cancer ◽  
Stereotactic Body Radiotherapy ◽  
Control Group ◽  
Control Groups ◽  
Short Term ◽  
Safety And Efficacy ◽  
And Control

Aim To evaluate the safety and efficacy of the administration of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in the short term to the same patients in Barcelona Clinical Liver Cancer (BCLC) stages 0–B1. Methods From April 2014 to June 2019, we retrospectively reviewed BCLC stage 0–B1 patients with fresh hepatocellular carcinoma (HCC) lesions that were repeatedly treated by RFA (control group, n = 72), and by RFA and subsequent SBRT (case group, n = 26). Propensity score matching (PSM) was performed to reduce the selection bias between two groups. Recurrence, survival, Child–Pugh scores and short-term side effects (fever, bleeding, skin change, abdominal pain and fatigue) were recorded and analyzed. Results After PSM, 21 patients remained in each group. Seventeen and 20 patients in the case and control groups experienced recurrence. For these patients, the median times to progression and follow-up were 10.7 and 35.8 months, respectively. After PSM, the 1-year progression-free survival rate in case and control groups were 66.7% and 52.4%, respectively (P = 0.313). The inter-group overall survival (OS) was comparable (3 and 5-year OS rates in case groups were 87.3% and 74.8%, while rates in control groups were 73.7% and 46.3%, respectively; P = 0.090). The short-term side effects were mild, and the incidence showed no inter-group difference. The 1-year rates of the Child–Pugh score deterioration of ≥2 in case and control groups were 23.8% and 33.3% (P > 0.05), respectively. Conclusion The short-term administration of RFA and SBRT to the same BCLC stage 0–B1 patients may be feasible and effective because of their good prognosis and safety.

scholarly journals Safety of Intravitreal Injection of Stivant, a Biosimilar to Bevacizumab, in Rabbit Eyes

2020 ◽  
Author(s):  
Alireza Lashay ◽  
Hooshang Faghihi ◽  
Ahmad Mirshahi ◽  
Hassan Khojasteh ◽  
Alireza Khodabande ◽  
...  
Keyword(s):  
Intravitreal Injection ◽  
Histological Analysis ◽  
Intravitreal Bevacizumab ◽  
Saline Control ◽  
Control Group ◽  
Control Groups ◽  
Reference Drug ◽  
Future Studies ◽  
Significant Difference ◽  
And Control

Purpose: To evaluate the safety of intravitreal injection of Stivant, a biosimilar to bevacizumab, in rabbits using electrophysiological and histological analysis. Methods: Both eyes of 41 New Zealand albino rabbits were injected with 0.1 mL (2.5 mg) of Stivant. The rabbits were scheduled to be sacrificed 1, 2, 7, 14, and 28 days after injection for histopathological evaluations. Clinical examinations and electroretinography (ERG) were performed at baseline and just before sacrificing the rabbits. Fourteen separate rabbits received a reference drug (Avastin) and were considered as the control group. Furthermore, three other rabbits received the same volume of saline (saline control group). Rabbits of both control groups were sacrificed four weeks after injection. ERG was performed 1, 2, 7, 14, and 28 days after injections. Results: No significant difference was observed in a- and b-wave amplitudes and latency after intravitreal Stivant injection between baseline and different time points. Moreover, there was no statistically significant difference in wave amplitudes and latency between the Stivant and control groups. The histology of rabbit eyes of the Stivant and control groups after intravitreal injections was not distinguishable. Conclusion: The biosimilar Stivant, up to a dose of 2.5 mg, did not appear to be toxic to the retina in albino rabbits. These results suggest that this drug could be a safe and inexpensive alternative to intravitreal bevacizumab. The efficacy of these injections was not investigated in this study and needs to be evaluated in future studies.

Safety of intraoperative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection: A randomized, multicenter, prospective, phase III IOCCRC trial (IOCCRC).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15002-e15002
Author(s):  
Rong-xin Zhang ◽  
Jun-zhong Lin ◽  
Gong Chen ◽  
Li-ren LI ◽  
Zhen-hai LU ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Side Effects ◽  
Cancer Patients ◽  
Surgical Resection ◽  
Control Group ◽  
Control Groups ◽  
Safety And Efficacy ◽  
Colorectal Cancer Patients ◽  
And Control ◽  
Intraoperative Chemotherapy

e15002 Background: The safety and efficacy of intraoperative chemotherapy in colorectal cancer have not yet been extensively investigated. This randomized control trial was designed to compare the safety and efficacy of intraoperative chemotherapy in combination with surgical resection to those of traditional surgical resection alone. Patients and Methods: From January 2011 to January 2016, 696 colorectal cancer patients were enrolled in this study: 341 patients were randomly assigned to the intraoperative plus surgery group to receive intraoperative chemotherapy (portal vein, intraluminal, and intraperitoneal chemotherapy plus surgical resection), whereas 344 patients were randomized to the control group to undergo surgery alone. Eleven patients withdrew consent. Surgical complications and side effects of intraoperative chemotherapy were compared between the two groups. Results: Intraoperative chemotherapy did not increase the rate of surgical complications, and no severe chemotherapy-associated side effects were observed. There were no significant differences in the length of hospital stay (8.31 vs. 7.98 days, P = 0.138), length of surgery (170.4 vs. 167.0 min, P = 0.526), length of antibiotic use (2.28 vs. 2.15 days, P = 0.322), or length of drain usage (6.37 vs. 6.16 days, P = 0.387) between the intraoperative chemotherapy and control groups. Four patients in each of the intraoperative chemotherapy and the control groups experienced anastomotic leakage and underwent a second operation (1.2% vs. 1.2%, P = 0.99). There were no deaths within 90 days after surgery in the chemotherapy group, whereas one patient died in the control group (0% vs. 0.3%, P = 0.99). Intraoperative chemotherapy did not decrease the rate of patients who received postoperative adjuvant chemotherapy between the intraoperative group and control group (29.3% vs. 30.2%, P = 0.795). Conclusions: Intraoperative chemotherapy can be safely performed during colorectal surgery; however, follow-up is necessary for a better assessment of its efficacy. Register Number: NCT01465451. Clinical trial information: NCT01465451.

Using of collars “Neoterika Protecto 12” against ixodid ticks in dogs and cats

2018 ◽  
Vol 12 (1) ◽  
pp. 59-63
Author(s):  
M.V. Arisov ◽  
G.B. Arisova ◽  
E.A. Koshkarev ◽  
I.A. Stepanova
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Ctenocephalides Felis ◽  
Ixodid Ticks ◽  
Control Groups ◽  
Different Ages ◽  
Antiparasitic Drugs ◽  
Instructions For Use ◽  
And Control

The purpose of the research: to study the effectiveness of the insectoacaricidal collars “Neoterika Protecto 12” against Ixodid ticks in dogs and cats. Materials and methods. In the experiment 86 dogs and 24 cats of different ages and breeds, free from ectoparasites, were used. 30 days before the experiment, the animals were not treated with antiparasitic drugs and they did not use insectoacaricidal collars for three months. All animals were divided into experimental and control groups. The animals of the experimental groups “Neoterika Protecto 12” were used according to the instructions for use. Animals of the control groups did not receive the collar. Inspection of animals for mites was carried out regularly for 6 months. Studies were conducted on the territory of the Moscow, Ryazan and Nizhny Novgorod regions. Results and discussion. For 6 months ectoparasites on the skin-coat of animals is not fixed. Side effects after use of the collar were not observed. When studying animals of control groups for 6 months found attached Ixodid ticks, as well as fleas Ctenocephalides felis and C. canis. After ectoparasites were found in control animals, the collars were also put on the animals, previously removing the ticks, and continued to observe for 6 months. No ectoparasites were found on the skin-coat. The high prophylactic and therapeutic efficacy of collars “Neoterika Protecto 12” was established against ectoparasites, including ticks, during 6 months.

scholarly journals Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys

2018 ◽  
Vol 62 (9) ◽  
Author(s):  
Nicanor Obaldia ◽  
Wilbur K. Milhous ◽  
Dennis E. Kyle
Keyword(s):  
Plasmodium Vivax ◽  
Papua New Guinea ◽  
Drug Combination ◽  
Drug Efficacy ◽  
Chloroquine Resistance ◽  
Control Groups ◽  
Content Type ◽  
Efficacy Trials ◽  
Experimental Drug ◽  
And Control

ABSTRACT Chloroquine-resistant (CQR) vivax malaria has emerged as a threat to the malaria elimination agenda. The objective of this study was to assess if a combination of chloroquine (CQ) and prochlorperazine was able to reverse CQ resistance of the Plasmodium vivax AMRU-1 strain from Papua New Guinea in infected Aotus monkeys. For this purpose, in two independent experimental drug efficacy trials, a total of 18 Aotus monkeys infected with blood obtained from donor animals were randomly assigned to treatment and control groups and orally administered CQ at 10 mg/kg or prochlorperazine at 20 mg/kg, alone or in combination, for five consecutive days. Reversal of CQR was achieved in animals that received the drug combination, whereas neither drug alone produced cures. This same drug combination reverses CQR in P. falciparum and could be an alternative for treatment in humans with chloroquine-resistant P. vivax infections.

scholarly journals Monitoring of vector-borne diseases in the west part of Ukraine

2019 ◽  
Vol 21 (96) ◽  
pp. 14-18 ◽  
Author(s):  
V. A. Levytska ◽  
A. B. Mushinsky
Keyword(s):  
Ixodes Ricinus ◽  
Dermacentor Reticulatus ◽  
Ixodid Ticks ◽  
Vector Borne Diseases ◽  
Candidatus Neoehrlichia Mikurensis ◽  
West Part ◽  
Western Ukraine ◽  
Vector Borne ◽  
And Control ◽  
Neoehrlichia Mikurensis

During recent years, infectious and invasive animal diseases caused by viruses, bacteria, and protozoa and transmitted by ticks have been a new problem in medical and veterinary practice. Many of these diseases are zoonoses and lead to the disability and mortality of humans and animals. Ixodes ricinus and Dermacentor reticulatus are species of ticks that are commonly attack animals and humans in Europe. These ticks are spread throughout the EU and are involved in the transmission of a large number of vector-borne diseases. To date, relatively limited data on the circulation of tick-borne diseases and their transmission in western Ukraine are presented. The purpose of this study was to monitor the types of ixodid ticks, as well as to identify pathogens in ticks collected from the environment in urban parks and from dogs and cats. A total of 215 ticks (22 Ixodes ricinus and 193 Dermacentor reticulatus) collected in two regions of Lviv and Ivano-Frankivsk were investigated. Pathogens, namely, Rikettsia spp., Candidatus Neoehrlichia mikurensis, Anaplasma phagocytophilum and Bartonella spp., were detected in 64.0% of the I. ricinus ticks. Overall, 18.2% of I. ricinus ticks were positive for Rikettsia spp., 54.5% for Candidatus Neoehrlichia mikurensis, 9.1% for A. phagocytophilum and Bartonella spp. confirmed in 4.5% of the studied ticks. Mixed infestations were found in 5 samples of I. ricinus DNA, representing 22.7%. In addition, 74.6% of D. reticulatus ticks were infested with these pathogens. Overall, 30.0% of D. reticulatus ticks were positive for Rikettsia spp., Candidatus Neoehrlichia mikurensis was confirmed in 54.9%, A. phagocytophilum in 1.6%, and Bartonella spp. in 6.2% of the studied ticks. Mixed infestations were found in 35 D. reticulatus DNA samples, representing 18.1%. The prevalence of Rikettsia spp. in two regions of Lviv and Ivano-Frankivsk, among the studied ticks was 28.8%, Bartonella spp. – 6.0%, A. phagocytophilum – 2.3%, Candidatus Neoehrlichia mikurensis – 54.9%. Our data indicate the presence of pathogens in urban populations of ticks of I. ricinus and D. reticulatus in west part of Ukraine. Monitoring of tick-borne diseases is an important tool in the prevention and control of infections transmitted to humans and animals.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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