scholarly journals BREAST CANCER PROFILE IN VERY YOUNG WOMEN AT HAJI ADAM MALIK GENERAL HOSPITAL MEDAN

2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Nichitri Agina Ginting ◽  
Betty
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
General Hospital ◽  
Brca2 Mutation ◽  
Cross Sectional Study ◽  
Young Age ◽  
Brca1 And Brca2 ◽  
Cross Sectional ◽  
History Of ◽  
Grade 3

Abstract. Breast cancer is the most kind of cancer that happens to women, and it’s one of the cancer that can cause the major death in the world and in Indonesia. Breast cancer cases at age are very young tend to have lower percentages of old age, but have a bad prognosis. Family history of breast cancer because of the BRCA1 and BRCA2 mutation . Objective. The aim of this research is to study about breast cancer very young age profile in H. Adam Malik Medan General Hospital. From 2016-2018 based on age, family history and grading histology. Methods. In this descriptive research with cross-sectional study, the sample were collected from medical record of breast cancer patient in H. Adam Malik Medan General Hospital. This research use total sampling method and matched with inclusion and exclusion criteria. Results. Total of the sample is 160 subject. The majority of age group is 31-35 year’s old (81 subject or 51,0%). The majority of age menarche group is <12 year’s old (104 subject or 65,5%). Do not have family history (82 subject or 51,3%), and have a family history just found (78 subject or 48,8%). The majority of grading histology is grade 3 (68 subject or 42,5%). Conclusion. Sufferers of breast cancer at very young age is quite a lot with grade 3 on grading histology.Keyword: breast cancer, very young age, family history. Abstrak. Latar Belakang. Kanker payudara merupakan kanker yang paling sering terjadi pada wanita, dan merupakan salah satu kanker yang dapat menyebabkan kematian utama di dunia dan di Indonesia. Kasus kanker payudara pada usia sangat muda cenderung memiliki presentase yang lebih rendah diantara usia tua, namun memiliki prognosis yang lebih buruk. Riwayat keluarga pada kanker payudara dikarenakan adanya mutasi BRCA1 dan BRCA2. Tujuan. Mengetahui profil kanker payudara wanita pada usia sangat muda di Rumah Sakit Umum Pusat Haji Adam Malik Medan. Tahun 2016-2018 berdasarkan usia, riwayat keluarga dan grading histologi. Metode. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional. Penelitian ini dilakukan menggunakan data sekunder melalui data rekam medis penderita kanker payudara di Rumah Sakit Umum Pusat Haji Adam Malik Medan. Besar sampel ditentukan dengan metode total sampling dan disesuaikan dengan kriteria inklusi dan eksklusi. Hasil. Diperoleh total 160 sampel. Kelompok usia terbanyak adalah usia 31-35 tahun sebanyak 81 penderita (51,0%). Usia menarche terbanyak pada kelompok usia <12 tahun sebanyak 104 penderita (65,5%). Tidak memiliki riwayat keluarga sebanyak 82 penderita (51,3%), dan memiliki riiwayat keluarga ditemukan sebanyak 78 penderita (48,8%). Grading histologi terbanyak adalah grade 3 sebanyak 68 penderita (42,5%). Kesimpulan. Penderita kanker payudara pada usia sangat muda cukup banyak dengan grade 3 pada grading histologi.Kata Kunci: kanker payudara, usia sangat muda, riwayat keluarga

scholarly journals Social, Demographical, and Clinical Correlates of Stigma in Iranian Breast Cancer Women

2021 ◽  
Author(s):  
Hadi Zamanian ◽  
Mohammadali Amini-Tehrani ◽  
Mona Daryaafzoon ◽  
Zahra Jalali ◽  
Fatemeh Sabeghi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Chronic Diseases ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Background Data ◽  
Related Stigma ◽  
History Of

Abstract Background: This study aimed to assess the severity of disease-related stigma felt by Iranian women with breast cancer as well as to determine the contextual correlates of stigmatization.Methods: This cross-sectional study included 223 breast cancer patients between October-2014 and May-2015, in Tehran, Iran. Eligible patients were asked to provide background data and to complete Stigma Scale for Chronic Illness 8-item (SSCI-8) questionnaire. Binomial logistic regression analysis was employed to identify stigmatized (SSCI-8 > 8) and heavily stigmatized (SSCI-8 >10) groups.Results: A total of 58.3% (n=130) stated that they were stigmatized at least “rarely.” In the multi-variable models in the total sample, living with spouse, Turkic ethnicity, family history of chronic diseases were the significant associations of stigmatization, while no variable was found to be associated with heavily stigmatization. In the sub-sample having the data of spouse’s education (n=185), living with spouse, lower spouse’s education, and family history of chronic diseases were the significant correlates of stigmatization; while, in terms of heavily stigmatization, only the lower spouse’s education was the significant indicator.Conclusions: Stigmatization tails women with breast cancer especially those living with their poorly educated husbands which call for dyadic interventions.

scholarly journals Fatalism in breast cancer and performing mammography on women with or without a family history of breast cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Maryam Molaei-Zardanjani ◽  
Mitra Savabi-Esfahani ◽  
Fariba Taleghani
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Positive Family History ◽  
Screening Method ◽  
Cross Sectional Study ◽  
Data Collection Tool ◽  
Cross Sectional ◽  
History Of ◽  
The Mean ◽  
Spss Software

Abstract Background Breast cancer is the most prevalent cancer in women, and in those with a positive family history, it is important to perform mammography. One of the probable barriers in doing mammography is fatalism. Methods This is a descriptive/cross-sectional study conducted on 400 women residing in Isfahan, Iran, randomly selected in 2017. Sampling was done randomly among the enrolled women in Health Integrity System. The data collection tool was a questionnaire regarding the demographic-fertility information and fatalism. The data analysis was done by SPSS software. A P-value < 0.05 was considered statistically significant. Results The results showed that the mean rate of fatalism was 59.5 ± 23.2 in women with the experience of mammography, and 65.9±18.7 in women without the experience. Moreover, the mean rate of fatalism was 73.1±15.2 in subjects with a family history of breast cancer, and 59.3 ± 22.5 in those no family history related to this condition. Accordingly, fatalism was statistically significant associated (P < 0.001) with a family history of breast cancer and experience of mammography. There was no significant relationship between demographic information and fatalism (P > 0.05). Conclusion The results indicated that fatalism in women with no experience of mammography was higher than in those with a positive history. Regarding the necessity of mammography in women with a family history of breast cancer, the required interventions seem to be essential to changing the viewpoints of women regarding the importance and effect of mammography as a screening method for breast cancer.

scholarly journals Subjective cognitive complaints at age 70: associations with amyloid and mental health

2021 ◽  
pp. jnnp-2020-325620
Author(s):  
Ivanna M. Pavisic ◽  
Kirsty Lu ◽  
Sarah E. Keuss ◽  
Sarah-Naomi James ◽  
Christopher A. Lane ◽  
...  
Keyword(s):  
Family History ◽  
Trait Anxiety ◽  
Population Based ◽  
Cross Sectional Study ◽  
Subjective Cognitive Decline ◽  
Cross Sectional ◽  
Amyloid Pathology ◽  
History Of ◽  
Β Amyloid ◽  
Anxiety Depression

ObjectiveTo investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective cognition and family history of dementia in the Insight 46 study.MethodsCognitively unimpaired ~70-year-old participants, all born in the same week in 1946 (n=460, 49% female, 18% amyloid-positive), underwent assessments including the SCD-Questionnaire (MyCog). MyCog scores were evaluated with respect to 18F-Florbetapir-PET amyloid status (positive/negative). Associations with anxiety, depression, objective cognition (measured by the Preclinical Alzheimer Cognitive Composite, PACC) and family history of dementia were also investigated. The informant’s perspective on SCD was evaluated in relation to MyCog score.ResultsAnxiety (mean (SD) trait anxiety score: 4.4 (3.9)) was associated with higher MyCog scores, especially in women. MyCog scores were higher in amyloid-positive compared with amyloid-negative individuals (adjusted means (95% CIs): 5.3 (4.4 to 6.1) vs 4.3 (3.9 to 4.7), p=0.044), after accounting for differences in anxiety. PACC (mean (SD) −0.05 (0.68)) and family history of dementia (prevalence: 23.9%) were not independently associated with MyCog scores. The informant’s perception of SCD was generally in accordance with that of the participant.ConclusionsThis cross-sectional study demonstrates that symptoms of SCD are associated with both β-amyloid pathology, and more consistently, trait anxiety in a population-based cohort of older adults, at an age when those who are destined to develop dementia are still likely to be some years away from symptoms. This highlights the necessity of considering anxiety symptoms when assessing Alzheimer’s disease pathology and SCD.

scholarly journals Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Micro Rna ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

Impact of family history of metabolic traits on severity of non-alcoholic steatohepatitis related cirrhosis: A cross-sectional study

2017 ◽  
Vol 37 (9) ◽  
pp. 1397-1404 ◽  
Author(s):  
Ajeet S. Bhadoria ◽  
Chandan K. Kedarisetty ◽  
Chhagan Bihari ◽  
Guresh Kumar ◽  
Ankur Jindal ◽  
...  
Keyword(s):  
Family History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Metabolic Traits ◽  
Alcoholic Steatohepatitis ◽  
History Of

scholarly journals High Rate of Obesity-Associated Hypertension among Primary Schoolchildren in Sudan

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Zeena Salman ◽  
Gregory D. Kirk ◽  
Mark D. DeBoer
Keyword(s):  
Family History ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Sub Saharan Africa ◽  
High Rate ◽  
Cross Sectional ◽  
Primary Schoolchildren ◽  
History Of ◽  
Family History Of Hypertension

Cardiovascular disease (CVD) frequently has roots in childhood, including following childhood-onset hypertension. Incidence of CVD has increased in developing countries in East Africa during recent urbanization. Effects of these shifts on childhood hypertension are unclear. Our objectives were to (1) Determine the prevalence of hypertension among primary schoolchildren in Khartoum, Sudan; (2) Determine whether hypertension in this setting is associated with obesity. We performed a cross sectional study of 6-12y children from two schools randomly selected in Khartoum, Sudan. Height, weight, BMI, BP and family history of hypertension were assessed. Age-, height- and gender-specific BP curves were used to determine pre-hypertension (90–95%) and hypertension (>95%). Of 304 children, 45 (14.8%) were overweight; 32 (10.5%) were obese; 15 (4.9%) were pre-hypertensive and 15 (4.9%) were hypertensive. Obesity but not family history of hypertension was associated with current hypertension. In multiple logistic regression, adjusting for family history, children who were obese had a relative-risk of 14.7 (CI 2.45-88.2) for systolic hypertension compared to normal-weight children. We conclude that overweight and obesity are highly prevalent among primary schoolchildren in urban Sudan and are strongly associated with hypertension. That obesity-associated cardiovascular sequelae exist in the developing world at young ages may be a harbinger of future CVD in sub-Saharan Africa.

scholarly journals Prevalence of BRCA1 and BRCA2 Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study

2021 ◽  
pp. 849-861
Author(s):  
Sudeep Gupta ◽  
Senthil Rajappa ◽  
Suresh Advani ◽  
Amit Agarwal ◽  
Shyam Aggarwal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Family History ◽  
Newly Diagnosed ◽  
Brca1 And Brca2 ◽  
Brca Mutations ◽  
Fallopian Tube Cancer ◽  
Cross Sectional ◽  
Brca2 Mutations ◽  
Brca1 Brca2

PURPOSE There are deficient data on prevalence of germline mutations in breast cancer susceptibility genes 1 and 2 ( BRCA1/ BRCA2) in Indian patients with ovarian cancer who are not selected by clinical features. METHODS This prospective, cross-sectional, noninterventional study in nine Indian centers included patients with newly diagnosed or relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer. The primary objective was to assess the prevalence of BRCA1/ BRCA2 mutations, and the secondary objective was to correlate BRCA1/ BRCA2 status with clinicopathologic characteristics. Mutation testing was performed by a standard next-generation sequencing assay. RESULTS Between March 2018 and December 2018, 239 patients with a median age of 53.0 (range, 23.0-86.0 years) years were included, of whom 203 (84.9%) had newly diagnosed disease, 36 (15.1%) had family history of ovarian or breast cancer, and 159 (66.5%) had serous subtype of epithelial ovarian cancer. Germline pathogenic or likely pathogenic mutations in BRCA1 and BRCA2 were detected in 37 (15.5%; 95% CI, 11.1 to 20.7) and 14 (5.9%; 95% CI, 3.2 to 9.6) patients, respectively, whereas variants of uncertain significance in these genes were seen in four (1.7%; 95% CI, 0.5 to 4.2) and six (2.5%; 95% CI, 0.9 to 5.4) patients, respectively. The prevalence of pathogenic or likely pathogenic BRCA mutations in patients with serous versus nonserous tumors, with versus without relevant family history, and ≤ 50 years versus > 50 years, were 40 of 159 (25.2%; 95% CI, 18.6 to 32.6) versus 11 of 80 (13.8%; 95% CI, 7.1 to 23.3; P = .0636), 20 of 36 (55.6%; 95% CI, 38.1 to 72.1) versus 41 of 203 (20.2%; 95% CI, 14.9 to 26.4; P < .0001), and 20 of 90 (22.2%; 95% CI, 14.1 to 32.2) versus 31 of 149 (20.8%; 95% CI, 14.6 to 28.2; P = .7956), respectively. CONCLUSION There is a high prevalence of pathogenic or likely pathogenic germline BRCA mutations in Indian patients with ovarian cancer.

scholarly journals Study on Associated Risk Factors of Hypertension at Sipaghat of Sindhupalchowk District, Nepal

2017 ◽  
Vol 1 ◽  
pp. 73-82
Author(s):  
Naresh Manandhar
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Alcohol Consumption ◽  
Lifestyle Modification ◽  
Percent Level ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Family History Of Hypertension ◽  
Associated Risk Factors

Background: Hypertension is a progressive cardiovascular syndrome arising from complex and interrelated etiologies. Males have slightly higher prevalence than female in most of countries of Southeast-Asian region.Objective: The objective of study is to find out prevalence and the risk factors of hypertension at Sipaghat, Sindhulchowk, Nepal.Materials and Methods: A cross-sectional study was conducted at Sipaghat of Sindhupalchowk district in May 2016 and 260 persons were selected randomly. Results: The prevalence of hypertension was higher in male (25.4%) than female (17.4%). Mean age of study population was 42.08 years with standard deviation, 15.95 years. Variables namely age group, smoking, alcohol consumption and family history of hypertension were found to be significant at 5 percent level of significance. Alcohol consumption and smokers have more than two times higher chance of getting hypertension compared to alcohol non-consumer and nonsmoker with 95% confidence intervals were 1.08-4.80 and 1.21-6.10, respectively. Persons with family history of hypertension have 3.8 times more chance of getting hypertension compared to no family history of hypertension with 1.89-7.61 of 95% confidence interval.Conclusion: Lifestyle modification reduces blood pressure which prevents or delays the incidence of hypertension. Hypertension can be controlled and prevented by modifying the lifestyle. People should be advised to avoid modifiable risk factors of hypertension like smoking, consumption of alcohol and physical inactivity through health education programs.Nepalese Journal of Statistics, 2017, Vol. 1, 73-82

What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

2020 ◽  
Vol 31 (2) ◽  
pp. 33-44
Author(s):  
Simon Francis ◽  
Obadia V. Nyongole
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Positive Family History ◽  
Negative Attitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adult Men ◽  
History Of ◽  
One Year ◽  
High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

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