scholarly journals The Role of Matrix Metalloproteinase9 (MMP9) in Endometriosis

Author(s):  
Amalia Amalia ◽  
Nusratuddin Abdullah ◽  
Umar Malinta

Objective: To investigate the role of MMP-9 expression in endometriosis. Methods: The study was conducted from October 2015 to March 2016, an observational study with cross-sectional design. Samples are all endometriosis patients who underwent laparoscopic surgery in Dr. Wahidin Sudirohusodo Hospital and several other hospitals in Makassar. Samples were stored and fixed in the Grand Medika Histopathology Laboratory Makassar for examination the expression of MMP-9 using immunohistochemical methods. Conducted an analysis of 50 samples, of which 11 samples of stage II, 21 stage III samples, and 18 samples of stage IV. The data obtained and analyzed statistically using Mann Whitney and Chi Square test with a significance level of p <0.05. Results: The results reported rankings mean the expression of MMP-9 in stage I-II = 16.68, stage III-IV 27.99 (p = 0.013). There were differences in the expression of MMP-9 based on the stage. Stage I-II endometriosis had a more positive 2 expression of MMP-9 (45.5%), stage III-IV endometriosis have more positive 3 expression of MMP-9 (59.0%). The results of chi square test (p = 0.043). Conclusion: Higher expression of MMP-9 is significantly associated with higher degree of endometriosis. Keywords: matrix metalloproteinase-9, stages of endometriosis

2017 ◽  
Vol 4 (3) ◽  
pp. 360
Author(s):  
Efi Isnayni

Immunization is the government's efforts to reduce children mortality, because immunization is an effective primary prevention to reduce infectious diseases. But the sufficient immunization number is still far to achieve the targets specified. There are many factors influence such as parents and families. The purpose of this study was to analyze the connection of the mothers’ knowledge with family roles (nuclear family and non-core family) alongside of basic immunization status. This research was an observational analytic study using cross sectional design. The sampling used cluster random sampling. Sampling in this research were 46 mothers of infants aged 9-12 month in community health center of  Pucuk Lamongan. Analysis of the data used was the chi-square test with significance level α of 0.05. The results showed a connection between mothers’ knowledge (p = 0.027), the role of the nuclear family (p = 0.007), and the role of non-core family (p = 0.020) with basic  immunization status. There is no connection between family’s income with basic  immunization status. (p = 0.725). The  conclusions  of the results this study of the mother's knowledge, the role of the nuclear family and non-core family has an important part to increase basic immunization coverage . As to develop KIE complete for mothers about basic immunization which should be obtained for infant. Motivate parents and family to always apply completeness of  basic  immunization, and  utilize the health care that has been provided to maintain the health of her infant. Keywords: basic immunization, role of family, nuclear-noncore


2017 ◽  
Vol 4 (3) ◽  
pp. 360
Author(s):  
Efi Isnayni

Immunization is the government's efforts to reduce children mortality, because immunization is an effective primary prevention to reduce infectious diseases. But the sufficient immunization number is still far to achieve the targets specified. There are many factors influence such as parents and families. The purpose of this study was to analyze the connection of the mothers’ knowledge with family roles (nuclear family and non-core family) alongside of basic immunization status. This research was an observational analytic study using cross sectional design. The sampling used cluster random sampling. Sampling in this research were 46 mothers of infants aged 9-12 month in community health center of  Pucuk Lamongan. Analysis of the data used was the chi-square test with significance level α of 0.05. The results showed a connection between mothers’ knowledge (p = 0.027), the role of the nuclear family (p = 0.007), and the role of non-core family (p = 0.020) with basic  immunization status. There is no connection between family’s income with basic  immunization status. (p = 0.725). The  conclusions  of the results this study of the mother's knowledge, the role of the nuclear family and non-core family has an important part to increase basic immunization coverage . As to develop KIE complete for mothers about basic immunization which should be obtained for infant. Motivate parents and family to always apply completeness of  basic  immunization, and  utilize the health care that has been provided to maintain the health of her infant. Keywords: basic immunization, role of family, nuclear-noncore


2022 ◽  
Vol 7 (2) ◽  
pp. 150-160
Author(s):  
Putri Rahmadani ◽  
Besral Besral ◽  
Masrizal Masrizal

Background: The measles rubella (MR) immunization coverage rate in Padang City is only 30.82%, still far below Indonesia's national target of 95%. The coverage of measles rubella immunization at the Rawang Health Center is around 62.1%. This study aims to determine the role of health workers in the success of measles rubella immunization in the Rawang Public Health Center, Padang City. Methods: This study used a cross sectional design. The study was conducted in October 2018-July 2019. The research population is mothers who have children aged 12-59 months (toddlers) as many as 1807 respondents. The sampling method is proportional random sampling with a sample of 87 respondent. Data was collected by interview using a questionnaire. Results: The results showed that 37.9% of children under five had not been immunized against measles rubella and 44.8% of health workers had an unfavorable role. The results of the chi-square test showed a significant relationship  between  the role of officers in  the success of measles rubella immunization  (p-value=0.020). Recommendation: It is hoped that health workers can increase health promotion activities regarding the risks due to children not being immunized against measles rubella and intensify door-to-door programs in the implementation of measles rubella immunization


2020 ◽  
Vol 10 (1) ◽  
pp. 1238-1245
Author(s):  
Suzana Indragiri ◽  
Liha Salihah

Salah satu upaya pencegahan kecelakaan tenaga kerja adalah dengan mengharuskan memakai Alat Pelindung Diri (APD) yang memenuhi syarat, yaitu nyaman dalam penggunaan, tidak menghalangi dalam proses bekerja, dan memberikan perlindungan efektif terhadap jenis-jenis bahaya. Dalam meningkatkan kepatuhan  penggunaan APD pada pekerja juga diperlukan adanya faktor pengawasan yang berfungsi sebagai pengendalian pelaksanaan setiap kegiatan yang  merupakan usaha pencapaian tujuan yang telah ditentukan. Pengawasan ini pada dasarnya adalah pengawasan terhadap proses dan hasil serta orang yang melakukan pekerjaan. Tujuan penelitian ini adalah untuk mengetahui Hubungan pengawasan dan kelengkapan dengan tingkat kepatuhan penggunaan alat pelindung diri (APD) pada pekerja produksi area bagging off  di PT Japfa Comfeed Indonesia Tbk. Unit Cirebon tahun 2018. Rancangan dalam penelitian ini adalah pendekatan kuantitatif dengan desain cross sectional. Populasi penelitian adalah seluruh Pekerja produksi area bagging off  PT Japfa Comfeed Indonesia Tbk. Unit Cirebon yang berjumlah 55 orang pada bulan Mei 2018. Jumlah sampel menggunakan total sampling karena jika jumlah populasi kurang dari 100 maka seluruh populasi dijadikan sampel penelitian. Metode pengumpulan data menggunakan data primer berupa observasi dan wawancara dan instrumen pengumpulan data menggunakan kuesioner. Data dianalisis dengan menggunakan Uji Chi Square pada tingkat kemaknaan 5% (0,05). Hasil uji statistik didapatkan bahwa ada hubungan antara pengawasan dengan kepatuhan penggunaan APD diperoleh p value sebesar 0,049. Dan ada hubungan antara kelengkapan APD terhadap kepatuhan penggunaan APD diperoleh p value sebesar 0,001.Kata kunci : ABSTRACTOne effort to prevent workplace accidents is to require that you wear Personal Protective Equipment (PPE) that meets the requirements, which is comfortable in use, does not hinder the work process, and provides effective protection against types of hazards. In increasing the compliance of PPE usage to workers, it is also necessary to have a supervisory factor that functions as a control for the implementation of each activity which is an effort to achieve the stated goals. This supervision is basically the supervision of the process and results and the people who do the work. The purpose of this study was to determine the relationship of supervision and completeness with the level of compliance with the use of personal protective equipment (PPE) on workers producing bagging off areas at PT Japfa Comfeed Indonesia Tbk. Cirebon Unit in 2018.The design in this study is a quantitative approach with cross sectional design. The study population was all workers producing bagging off areas of PT Japfa Comfeed Indonesia Tbk. The Cirebon unit which numbered 55 people in May 2018. The number of samples uses total sampling because if the population is less than 100 then the entire population is used as a sample. Data collection method uses primary data in the form of observation and interviews and data collection instruments using questionnaires. Data were analyzed using Chi Square Test at a significance level of 5% (0.05).Statistical test results showed that there was a relationship between supervision with compliance with PPE obtained p value of 0.049. And there is a relationship between the completeness of PPE to the APD usage compliance obtained p value of 0,001.


2021 ◽  
Vol 6 (3) ◽  
Author(s):  
Pasionista Vianitati ◽  
Maria Yulita Meo

Objective:  The aim of this study to find out the relationship between public knowledge about health protocols and prevention measures for Covid-19 transmission in the Sikka Regency area.Methods:  This type of research is analytic observational with cross sectional design. A questionnaire was given to measure public knowledge about health protocols and an observation sheet to see the behavior of the community to prevent Covid-19 transmission. The sample in the study was 147 people using purposive sampling technique. Data analysis used Chi-Square with a significance level of α = 0.05.Results:  of this study were obtained public knowledge about the health protocol for the prevention of Covid-19 transmission was in a good category of 53.7% and most people made efforts to prevent Covid-19 transmission by 5M as much as 62.6%. And the results of statistical tests using the Chi Square test obtained pvalue = 0.029 <α = 0.05.Conclusion:  there is a significant relationship between public knowledge about health protocols and measures to prevent Covid-19 transmission in the Sikka Regency area. Therefore, all forms of health education to the public related to Covid-19 must continue to be carried out and carry out tiered evaluations related to the implementation of health protocols and it is hoped that the community will be more obedient to implementing health protocols to prevent Covid-19 transmission through 5M measures.


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Devi Muji Rahayu ◽  
Firdaus S.Kep., Ns., M.Kes

Introduce: The events that often occurs in toddler is inability to perform the toilet training. It is because the parents are less active in their role. The purpose of this study is to know the relationship of parental role with the ability of toilet training for toddler in Permata Bunda Early childhood education at RW 01 of Jati Selatan 1 village Sidoarjo. Study design is analytic with cross-sectional approach. The population were all parents and toddler. Number of sample were 24 respondents taken by simple random sampling technique. Data were collected by questionnaire and observation. The independent variable is role of parents and the dependent variable is the ability of toddler performed toilet training. The data obtained were processed by SPSS 17.0 use chi-square test with significance level α (0.05). The results of study of role of parents indicate that a half of parents (50%) had lack of parental roles and the capabilities of toilet training for the toddler mostly (54.2%) were not able to perform toilet training. Based on chi-square test found p = 0.001 < 0.05, which means that H0 is rejected so there is relationship of parental role with the ability of toilet training for toddler. Conclusions of this study is the better role of parents, the better the ability of the child. Suggested to parents to understand the learning readiness of children in toilet training so it can maximize child learning and toilet training capabilities.


2021 ◽  
Vol 2 (5) ◽  
pp. 44-51
Author(s):  
Sulfianti Sulfianti ◽  
Hasliana Haslan

The kind of research that was utilized in this study was an analytical questionnaire. In this study, a cross-sectional design was employed to collect data. Sixty-six individuals were included in the samples that fulfilled the requirements. The findings revealed that 1) the midwife's attitude toward promoting exclusive breastfeeding at the UPT Puskesmas (Community Health Center) Mare had no impact on the outcomes of the study. The results of the chi square test revealed that the p-value was 0,089, indicating that the hypothesis was correct (0,05). There is an association between midwife assistance and an increase in exclusive breastfeeding at the University of Puskesmas Mare, according to the findings of the chi square test (p-value =0,007 for exclusive breastfeeding at the UPT Puskesmas Mare) (0,05). The rise in exclusive breastfeeding at the UPT Puskesmas Mare may be attributed to the midwifery program, according to the findings. The results of the chi square test reveal that the p-value is 0,0002, which indicates a significant difference (0,05). 4) Midwife assistance had a 12,7-fold higher impact on the rise in exclusive breastfeeding, with a p-value of 0.028 0.05 for the effect of midwife support. The midwife program, on the other hand, had a moderate impact on the rise in exclusive breastfeeding, with a p-value of 0,038 0.05 and a moderate effect of 11,1 times on the increase in exclusive breastfeeding.


2020 ◽  
Vol 8 (2) ◽  
pp. 981-990
Author(s):  
Suzana Indragiri ◽  
Hendri Firnanda

Menurut PT Jamsostek (Persero) yang saat ini telah berubah menjadi Badan Penyelenggara Jaminan Sosial (BPJS) Ketenagakerjaan, sepanjang tahun 2014 jumlah pesertanya yang mengalami kecelakaan kerja sebanyak 129.911 orang. Kurangnya kesadaran para pekerja untuk senantiasa menggunakan APD dipengaruhi oleh beberapa faktor yang mempunyai pengaruh yang cukup besar terhadap tindakan penggunaan alat pelindung diri pada pekerja. Tujuan penelitian ini adalah untuk mengetahui hubungan faktor determinan perilaku dengan penggunaan Alat Pelindung Diri (APD) pada pekerja pemboran PT. PDSI (RIG 38.2/D1000-E) di Desa Kaplongan Lor Kecamatan Karangampel Kabupaten Indramayu Tahun 2017. Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross sectional. Populasi dalam penelitian ini adalah seluruh karyawan di PT. PDSI (RIG 38.2/D1000-E) di Desa Kaplongan Lor Kecamatan Karangampel Kabupaten Indramayu tahun 2017 dengan jumlah 50 responden. Jumlah sampel sebanyak 34 sampel responden yang diambil menggunakan proportional random sampling. Instrument menggunakan kuesioner. Data dianalisis secara statistik menggunakan  uji Chi Square pada tingkat kemaknaan 5% (0,05). Hasil uji statistik didapatkan bahwa ada hubungan antara pengetahuan, ketersediaan APD, kenyamanan APD, peraturan dan pengawasan, serta tidak ada hubungan antara sikap dan pelatihan dengan penggunaan APD pada pemboran PT. PDSI (RIG 38.2/D1000-E) di Desa Kaplongan Lor Kecamatan Karangampel Kabupaten Indramayu Tahun 2017.Kata Kunci : Pengetahuan, Sikap, Ketersediaan APD, Perilaku Penggunaan APD   ABSTRACTAccording to PT Jamsostek (Persero), which has been transformed into Social Security Agency (BPJS) Employment, throughout 2014 the number of participants injured at work as much as 129 911 people. Lack of awareness of the workers to always use PPE is influenced by several factors that have a considerable influence on the action the use of personal protective equipment to workers. The purpose of this study was to determine Relation Determinant factor with the Behaviour of the use of Personal Protective Equipment (PPE) on Drilling PT. PDSI (RIG 38.2 / D1000-E) in the village of Kaplongan Lor, Karangampel District of Indramayu Regency in 2017. This study uses a quantitative approach to the cross-sectional design. The population in this study were all employees at PT. PDSI (RIG 38.2 / D1000-E) in the village of Kaplongan Lor Karangampel District of Indramayu regency in 2017 with a total of 50 respondents. The total sample of 34 respondents in a sample taken using proportional random sampling. Instrument using a questionnaire. Data were statistically analyzed using Chi Square test at the 5% significance level (0.05). Results of statistical test showed that there is a relationship between knowledge, availability of APD, APD comfort, regulation and supervision, and there is no relationship between attitude and training with the use of PPE in the Drilling PT. PDSI (RIG 38.2 / D1000-E) in the village of Kaplongan Lor Karangampel District of Indramayu Regency in 2017.Keywords : Knowledge, Attitude, availability of APD, Behavior use of PPE


2019 ◽  
Vol 3 (2) ◽  
pp. 53-62
Author(s):  
Marniati ◽  
Nurlina ◽  
Safruddin

Pulmonary tuberculosis is a direct infectious disease caused by TB (Mycobacterium Tuberculosis) bacteria. The level of compliance with the use of pulmonary TB drugs is very important and requires a long time that is 6-8 months, because if treatment is not carried out regularly or is not compliant and does not correspond to the specified time then there will be resistance (resistance) of tuberculosis germs against drugs Widespread Anti Tuberculosis (OAT) or Multi Drugs Resistance (MDR). The purpose of this study was to determine the relationship between motivation, attitudes, the role of supervisors taking medication (PMO) in TB sufferers. The design of the study used an Analytical Observational design using the Cross-Sectional approach. The population in this study were all TB sufferers in Bulukumba District with a sampling technique using cluster sampling. The number of samples in this study were 60 respondents. Data were obtained through questionnaire sheets made by researchers to respondents. Data analysis used Fisher's alternative Chi-square Test, with significance level α = 0.05. The results of the data analysis show that the motivation variable p = 0.023, the attitude variable p = 0.012, and the role of the supervisor for taking medication (PMO) p = 0.017. So it can be concluded that there is a relationship between motivation, attitude, the role of supervisors taking medication (PMO) with adherence to taking medication in TB patients in Bulukumba Regency.


2020 ◽  
Vol 1 (3) ◽  
pp. 190-196
Author(s):  
Yunitasari ◽  
Nopi Sani ◽  
Arti Febriyani ◽  
I Nengah Budiarta

Abnormalities lip and palate or cleft lip commonly called congenital abnormality or labioschizis is a gap between the right and/or left lip. The incidence of cleft lip with or without cleft palate is one per 700-1000 births worldwide and Asians have the highest risk. Infant death or disability, even the mother died during childbirth in pregnancy aged 35 years and over. Giving birth at the age of 35 years and over, babies who are born susceptible to genetic abnormalities. The purpose of this study was to determine the relationship between maternal age of  ≥35 years with labioschizis incident. This study used cross-sectional design: Retrospective, data was collected from the medical records during the period 1 January 2018 to 31 December 2018. The number of samples of 138 respondents, data was analyzed using the chi-square test with a significance level of ρvalue < 0.05. The results showed that most respondents had labioschizis namely 65.9%, while 34.1% of respondents experienced palatoschizis and labiognatoschizis. The lives of most mothers with children experiencing labioschizis are ≥35 years of age is 57.1%. The results of the study there was no correlation between a maternal age ≥ 35 years with the incidence labioschizis with value 0.793 ρvalue means sig >0.05. However, based on the data that researchers get the respondent with maternal age of 35 years tend to have labioschizis, meaning that the older a pregnant woman would be more risk of having babies with labioschizis.


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