Hyperthyroidisme pada Kehamilan

Hyperthyroidism is defined by abnormally high levels of thyroid hormones caused by increased synthesis and secretion of thyroid hormones from the thyroid gland. Physiological changes in pregnancy affect the function of the thyroid gland. The sharp increase in human chorionic gonadotropin (hCG) from early pregnancy stimulates the thyroid gland to increase thyroid hormone production. hCG is a glycoprotein synthesized and released from the placenta, and stimulates the TSH receptor due to its structural similarity to TSH. Normal pregnancy produces a number of important physiological and hormonal changes that alter thyroid function. These changes mean that laboratory tests of thyroid function should be interpreted with caution during pregnancy. Thyroid function tests change during pregnancy due to the influence of two main hormones: human chorionic gonadotropin (hCG), the hormone measured in pregnancy tests and estrogen, the main female hormone. The treatment of choice in pregnancy is antithyroid drugs (ATD). These drugs are effective in controlling maternal hyperthyroidism, but they all cross the placenta, thus requiring careful management and control during the second half of pregnancy taking into account the risk of fetal hyperthyroidism or hypothyroidism. An important aspect in early pregnancy is that the main side effect of taking ATD at 6-10 weeks of gestation is birth defects which can develop after exposure to the types of ATD available and may be severe. This review focuses on the management of overt hyperthyroidism in pregnancy, including the etiology and incidence of the disease, how the diagnosis is made, the consequences of untreated or inadequately treated disease, and finally how to treat overt hyperthyroidism in pregnancy. This review discusses the etiology, pathophysiology, and initial evaluation of hyperthyroidism in pregnancy, followed by a discussion of its treatment, management, and complications.

Identifikasi Potensi Bahaya dan Risiko Keselamatan dan Kesehatan Kerja pada Pabrik Tahu House Of Tofu

Occupational Health and Safety (K3) is generally defined as the science of anticipating, recognizing, evaluating and controlling hazards arising in or from the workplace that may interfere with the health and well-being of workers, taking into account the possible impact on the environment and the surrounding community. The scope is quite broad, covering a large number of disciplines and many hazards in the workplace and the environment.The International Labor Organization (ILO) released data in 2020 that globally, more than 2.78 million people die from workplace-related accidents or diseases, which means one death every fifteen seconds Measures and strategies designed to prevent, control, reducing or eliminating occupational hazards and risks have been developed and implemented over the years to keep pace with technological and economic changes. Work and industrial accidents are all caused by preventable factors that can be eliminated by applying known and available measures and methods. This is indicated by the continued decline in accident rates in industrialized countries. Therefore, the implementation of prevention strategies offers significant human and economic benefits. However, occupational accidents and diseases are still too frequent and their cost in terms of human suffering and economic burden continues to be significant. This study discusses the level of occupational accidents and occupational diseases obtained by conducting a walk-through survey at the tofu factory "House Of Tofu" which is located at Way Halim Permai Bandar Lampung. Identification of occupational safety and health is carried out by means of a Walk Through Survey using Hazard Identification, Risk Assessment, and Determining Control techniques. The results show that there are still many potential Occupational Safety and Health Hazards and Risks at the House Of Tofu Tofu Factory that have not been identified and have a negative impact on the workers in it. Interventions against potential hazards must be carried out by employers to reduce the number of work accidents.

Kesehatan Mental Mahasiswa Fakultas Kedokteran Di Masa Pandemi COVID-19

December 2019, COVID-19 was first reported in Wuhan, Hubei Province, China. March 11, 2020, the World Health Organization declared COVID-19 a worldwide pandemic. The COVID-19 pandemic has focused attention on the mental health of the various affected populations, medical students being one of the more vulnerable groups. Therefore, this literature review aims to find out how the mental health of Faculty of Medicine students during the COVID-19 pandemic, so that it can be used as learning material to always maintain mental health stability. The method used in this study is a literature review and literature search which was carried out by collecting several electronic journals such as PubMed, NCBI and Google Scholar. Conducted by reviewing journals related to the mental health of medical faculty students during the COVID-19 pandemic. This study involved 49 library sources from 2018-2020. From 7,143 students, 0.9% of them experienced severe anxiety, 2.7% moderate, and 21.3% experienced mild anxiety. In addition, delay in academic activities is a risk factor for experiencing symptoms of anxiety. 40% of students also experience financial difficulties, in terms of e-learning platforms, this problem is a challenge for medical students because financial and social factors can be an obstacle to the development and implementation of effective online learning programs. Future research is urgently needed to provide a better explanation of the tips needed for students in adapting to the changes that occur in order to lead a mentally healthy life in the midst of the COVID-19 pandemic.

Faktor Risiko Terjadinya Coronavirus Disease 2019 pada Pasien dengan Komorbid Diabetes Melitus

Corona virus disease 2019 (COVID-19) is an infectious disease severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The clinical scope of Covid-19 varies, from asymptomatic, mild symptoms, to clinical conditions characterized by acute respiratory failure. The most common comorbidities in patients with COVID-19 were hypertension (HTN) (56.2%), followed by diabetes mellitus (DM) (30.1%), and chronic kidney disease (CKD) (17.5%). Several studies suggest that diabetes is one of the main risk factors for COVID-19. Therefore, this literature review aims to determine the risk factors for the occurrence of COVID-19 in patients with diabetes mellitus so that it can be used as a consideration for controlling risk factors and better treatment of COVID-19 patients with comorbidities. The method used in this research is literature review and literature search is carried out through the NCBI, PubMed, and Google Scholar databases. This research involves as many as 24 library sources from 2020-2021. Several studies have shown that diabetes mellitus is a major risk factor for COVID-19. This condition is associated with several macrovascular and microvascular complications that ultimately impact the patient's survival. Diabetes which is a hyperinflammatory condition that can increase susceptibility to COVID-19 with possible mechanisms of chronic inflammation, hypercoagulable state, and activation of the renin-angiotensin-aldosterone system (RAAS) and dysregulation of the sympathetic nervous system. Future research is urgently needed to provide a better understanding of the pathophysiological mechanisms underlying the association between COVID-19 and diabetes, and their clinical management

Hubungan Antara Komitmen Organisasi Dan Kepuasan Kerja Dengan Organizational Citizenship Behavior (OCB) Pada Perawat di Rumah Sakit Umum Wisma Rini Pringsewu

In the hospital industry, the performance of nurses is very important in the success in the hospital. It is necessary for the workforce to be able to work optimally and the role of Organizational Citizenship Behavior (OCB). OCB is a behavior of an employee that is not formally regulated and can improve the performance of the organization. Some of the factors that affect OCB are organizational commitment and job satisfaction. Therefore, this study aims to find out the relationship of organizational commitment and job satisfaction with OCB. Data collection in this study used OCB scale, organizational commitment, and job satisfaction. Sampling using total sampling, with a sample number of 100 nurses at the public hospital Wisma Rini Pringsewu. Data analysis using multiple linear regression analysis with the help of SPSS 22.0 for windows. The results showed that Deviation From Linearity between OCB and Organizational Commitment of 0.707 and between OCB and Job Satisfaction of 0.602, where the value of each variable is p>0.05s so that it indicates there is a linear relationship, and can be continued with hypothetical tests. It is known that the first hypothesis is that the relationship between organizational commitment and job satisfaction is positively correlated with ocb variables with the significance of p<0.01 and p<0.05 received. The conclusion is that there is a relationship between organizational commitment and job satisfaction with Organizational Citizenship Behavior (OCB)

Hubungan Karakteristik Gambaran Radiografi Toraks Distribusi Lesi Paru dengan Prognosis Pasien COVID-19

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The transmission rapidly from human to human via aerosol droplets and direct contact, accelerating the spread of SARS-CoV-2 in various parts of the world. Chest radiograph can be used to monitor the development of pulmonary disorders due to COVID-19, a reference for medical personnel in screening for patients who are suspected of being infected to COVID-19, and to study the prognosis of patients COVID-19 as well. The aims of this study was to determine the relationship between the characteristics of the distribution of chest radiograph lesions and the prognosis of COVID-19 patients in Bandar Lampung City in 2020. This study was a descriptive analytic study with a retrospective approach. Analysis of the data used are univariate analysis and bivariate analysis using the Spearman correlation test. The results of statistical tests using the Spearman Correlation Test showed that there was a relationship between the characteristics of the distribution of chest radiograph lesions and the prognosis of patients who were confirmed positive for COVID-19 in Bandar Lampung City in 2020, p-value = 0.001 (r = 0.203 weak relationship) on the chest radiograph features of involvement lung, p-value = 0.002 (r = 0.188 weak relationship) on the chest radiograph distribution of lesions from top to bottom, and p-value = 0.030 (r = 0.135 weak relationship) on the chest radiograph distribution of central to peripheral lesions. The conclusion of this study is that there is a significant relationship between the characteristics of the distribution of chest radiograph lesions and the prognosis of COVID-19 patients in Bandar Lampung City in 2020.

HUBUNGAN USIA DAN PARITAS TERHADAP KEJADIAN PRE EKLAMPSIA DI RSD BALUNG JEMBER

One of the contributors to maternal and infant mortality is the incidence of preeclampsia that occurs during pregnancy. The cause of preeclampsia is still unknown, but it is suspected that age and parity are one of the triggers for this occurrence. Women of childbearing age who are nulliparous with extreme age under the age of less than 20 years and women with the age of more than 35 years are most commonly found to have preeclampsia. The design in this study is analytic with a cross sectional approach. The population of all mothers giving birth in the delivery room of RSD Balung Jember was 3594 in 2019. The number of samples taken using non-random sampling by purposive sampling was finally obtained by 97 respondents. In this study, the independent variables were maternal age and parity, while the dependent variable was the incidence of preeclampsia. The instrument used is medical records. The data is processed by editing, coding, processing and cleaning processes. Data were analyzed using multiple logistic regression. The results of the chi-square test for the age variable obtained that the Pearson chi-square value was 0.019 and the p value = 0.000 <0.05 from these results Ho was rejected, and the parity variable the Pearson chi- square value was 0.019 and the p value = 0.000 <0.05 from these results Ho is rejected. In conclusion, there is a relationship between age and preeclampsia, and there is a relationship between parity and preeclampsia.

Hubungan KEK dengan Anemia Gravidarum pada Ibu Riwayat BBLR

KEK (Chronic Energy Deficiency) is a condition of the mother suffering from lack of calories and protein (malnutrition) that lasts chronic (chronic) at risk of causing complications in the mother one of which is anemia gravidarum. Anemia in pregnancy is a decrease in Hb levels, so that the carrying capacity of oxygen for the needs of vital organs in the mother and fetus is reduced. The purpose of this study is to determine the relationship of KEK with anemia gravidarum in mothers with low birth weigth history. The correlation analytic research design is a case control study approach, the population is 68 mothers with low birth weight history, using simple random sampling technique, the sample is calculated using Slovin formula, the number of 58 low birth weight history mothers fulfills the inclusion criteria. The research instrument used observation sheets to look at secondary data on cohorts of pregnant women, data analysis using the chi square test obtained a p value of 0, 001 means that p <0.05 indicates the relationship of KEK with anemia gravidarum in women with low birth weight history with a close relationship is sufficient. The value of the Contingency Coefficient in the Chronic Energy Deficiency variable is 0.39, which means that the relationship between KEK and anemia gravidarum is sufficient. The Odds Ratio (OR) value in the Chronic Energy Deficiency variable is 6.9, which means that pregnant women with nutritional status of Chronic Energy Deficiency have a 6.9 times greater risk of anemia during pregnancy than those who are not. Inadequate nutritional needs have a greater risk of anemia during pregnancy and the risk of giving birth to Low Birth Weight Babies. Researchers suggest providing counseling to women of adolescence, women of childbearing age and especially pregnant women so that they can add more information about the importance of nutritional status in pregnant women, the dangers of anemia during pregnancy and also the importance of consuming blood booster tablets during pregnancy. So that it is expected to reduce the incidence of anemia pregnant women case and low birth weight history.

Pengaruh Pemberian Minuman Cokelat (Theobroma cacao L.) Terhadap Berat Basah Organ Hati Tikus Diabetes Melitus

Cacao (Theobroma cacao L.) is known to have enormous potential advantages because they contain vitamins A1, B1, B2, C, D, and E as well as minerals such as iron, zinc, phosphorus, magnesium, and copper. In addition, chocolate is also known to be rich in active antioxidant ingredients such as phenolic compounds, prociandin, and flavonoids which can reduce the bad effects of antioxidants in the body. giving chocolate to experimental animals and consumption interventions in humans can prevent and overcome the problem of several diseases, one of which is diabetes mellitus. The purpose of this study was to see the effect of giving cocoa powder drink to the wet weight of the liver in rats with diabetes mellitus. The research design used was experimental research using a completely randomized design with a post-test only control group design. The experimental sample used fifteen male white rats (Rattus norvegicus) Sprague Dawley strain. The experimental mice were divided into 5 groups, namely the negative control group (K-), namely normal rats without any treatment, the positive group, namely the diabetes mellitus (K +) group; treatment group 1 (KP1), treatment group 2 (KP2), treatment group 3 (KP3), namely the diabetes mellitus group of rats that were given the treatment of chocolate drink with a concentration of cocoa powder drink doses of 2%, 4% and 6%. Data analysis was performed using the One Way ANOVA test. Results: The results showed that the organ weight in the group K- = 10.46 ± 0.44; K + = 11.49 ± 0.39; KP1 = 9.95 ± 0.60; KP2 = 11.30 ± 0.60; KP3 = 11.09± 0.90. Statistical analysis showed that there was no significant difference for each treatment with a value of p = 0.077. The conclusions in the study regarding the effect of giving chocolate drink on the wet weight of the liver in rats with diabetes mellitus showed that giving cocoa powder with a concentration of 2%, 4% and 6% was not able to significantly affect the wet weight of the liver.

Paparan Informasi, Pengetahuan, Sikap tentang Pedoman Gizi Seimbang dan Status Obesitas pada Anak Sekolah di Sekolah Dasar Negeri Pulogebang 11 Pagi Jakarta Timur

Prevalence of obesity among school children aged 5-12 years old in Jakarta is remainly high, namely 14%. Indonesia Balance Nutrition Guideline (PGS) need to be applied everyday to tackle obesity. However, the exposure to PGS information, knowledge and attitude related to PGS among school children is still lacking. This study aims to identify the association between exposure to information, knowledge, and attitudes of PGS with obesity status among school children at SD Negeri Pulogebang 11 Pagi, East Jakarta. This is a quantitative study with a cross-sectional study design. This study was conducted in SDN Pulogebang 11 Pagi with a sample of 100 fourth-grade students. Variable in this study were exposure to information, knowledge, attitudes related PGS, and obesity status. Exposure to information, knowledge, and attitudes related PGS were taken by filling out the questionnaires by respondents. Obesity status was measured by measuring height and weight. Data was analyzed by using Fisher Exact test and Chi Square test. This study shows that the prevalence of obesity is 14%. School children who had never been exposed to PGS information were 34%. School children with ≤ median score of knowledge and attitudes were 61% and 58%. Other result shows that there was no significant association between exposure to information (p = 0.371), knowledge (p = 0.363), and PGS attitude (p = 0.513) with obesity status. Other factors, such as the role of parents, peers, and school, may influence children's behavior, as in eating behavior, physical activity, and lifestyle. The conclusion of this study is the prevalence of obesity is still high. To overcome this, intervention is not only carried out among school children, but also interventions related to PGS among parents and integration with school programs are needed.