scholarly journals Bax Expression of Throphoblast Cells did not Differ between Early and Late Onset Preeclampsia

2021 ◽  
pp. 126-129
Author(s):  
Made Ariyana ◽  
Diah R. Hadiati ◽  
Irwan T. Rachman ◽  
Dewajani Purnomosari
Keyword(s):  
Protein Expression ◽  
Gestational Age ◽  
Early Onset ◽  
Clinical Characteristics ◽  
Late Onset ◽  
Placental Tissue ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Bax Protein ◽  
Study Population

Objective: To compare Bax protein expression in throphoblast cells of early and late onset PE. Methods: A cross sectional study involving 36 cases of early onset PE and 36 cases of late onset PE was conducted. Bax protein expression was evaluated from sample of placental tissue collected from the study population and calculated using H-Score. Data on age, number of parity, gestational age, body mass index was collected from the medical records. Expression of Bax was compared using Mann-Whitney test. Results: There was no difference in the clinical characteristics (age, number of parity, BMI, SBP, DBP, and MAP) between the two groups. There was no difference in the expression of Bax protein between the early and late onset PE (mean H-score early vs. late onset PE: 1.48 vs 1.46, p=0.814, Mann Whitney U test). Clinical characteristics of the study population also did not correlate with the Bax expression (R for number of parity: 0.052, age: 0.009, gestational age: -0.014, BMI: 0.063, all p values were >0.05, linear regresion). Conclusion: There is no difference in the expression of Bax protein of throphoblast cells between early and late onset PE. Keyword: apoptosis, BAX, early onset, late onset, preeclampsia   Abstrak Tujuan: Untuk membandingkan ekspresi protein Bax dalam sel trofoblas pada preeklamsia (PE) onset dini dan lambat. Metode: Sebuah studi potong lintang yang melibatkan 36 kasus PE onset dini dan 36 kasus PE onset lambat dilakukan. Ekspresi protein Bax dievaluasi dari sampel jaringan plasenta yang dikumpulkan dari populasi studi dan dihitung menggunakan skor-H. Data usia, jumlah paritas, usia kehamilan, indeks massa tubuh dikumpulkan dari rekam medis. Ekspresi Bax dibandingkan menggunakan uji Mann-Whitney. Results: Tidak terdapat perbedaan pada karakteristik klinis (usia, jumlah paritas, IMT, TDS, TDD, dan MAP) antara kedua kelompok. Tidak terdapat perbedaan dalam ekspresi protein Bax antara PE onset dini dan lambat (rata-rata H-skor PE onset dini dan lambat: 1.48 vs 1.46, p = 0.814, uji Mann Whitney U). Karakteristik klinis populasi studi juga tidak berkorelasi dengan ekspresi Bax (R untuk jumlah paritas: 0,052, usia: 0,009, usia kehamilan: -0,014, BMI: 0,063, nilai p dari semua variable tersebut adalah sebesar >0,05, dengan menggunakan regresi linier). Kesimpulan: Tidak terdapat perbedaan dalam ekspresi protein Bax pada sel trofoblas antara PE onset dini dan lambat. Kata kunci: apoptosis, BAX, onset dini, onset lambat, preeklamsia

scholarly journals Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

2021 ◽  
Author(s):  
Maria del Carmen Moleon ◽  
Estrella Martinez-Gomez ◽  
Marisa Flook ◽  
Andreina Peralta-Leal ◽  
Juan Antonio Gallego ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Cross Sectional Study ◽  
Cytokine Profile ◽  
Sectional Study ◽  
Meniere Disease ◽  
Cross Sectional ◽  
Menière Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profile in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early onset MD (EOMD, <35 years old), and 39 with late onset MD (LOMD, > 50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p=0.004) and a higher prevalence of migraine than LOMD (p=0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3 and CXCL4 were different between patients with MD or migraine and controls.

scholarly journals Perbedaan Berat Lahir Bayi Pasien Preeklampsia Berat / Eklampsia Early dan Late Onset di RSUP Dr. M. Djamil Padang

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Rizka Amelia ◽  
Ariadi Ariadi ◽  
Syaiful Azmi
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Early Onset ◽  
Late Onset ◽  
Severe Preeclampsia ◽  
Large For Gestational Age ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

AbstrakPreeklampsia dan eklampsia tidak hanya berdampak bagi ibu, tetapi juga terhadap janin yang dikandungnya, seperti hambatan pertumbuhan janin intrauterin yang dapat dilihat dari berat lahir bayi tersebut. Ibu dengan preeklampsia berat/ eklampsia early onset cenderung melahirkan bayi dengan berat lahir Kecil untuk Masa Kehamilan (KMK), sementara yang  late onset cenderung melahirkan bayi dengan berat lahir Sesuai untuk Masa Kehamilan (SMK) atau bahkan Besar untuk Masa Kehamilan (BMK). Tujuannya penelitian ini adalah menentukan perbedaan berat lahir bayi pasien preeklampsia berat/ eklampsia early dan late onset. Penelitian ini dilaksanakan dari Oktober 2012 sampai Juli 2013 di bagian Rekam Medik RSUP Dr. M. Djamil Padang. Jenis penelitian yang digunakan adalah observasional analitik dengan desain cross sectional. Hasil penelitian menunjukkan bahwa angka kejadian preeklampsia berat/ eklampsia early onset adalah 26,1% dan yang late onset sebanyak 73,9%. Bayi KMK lebih banyak dilahirkan oleh ibu preeklampsia berat/ eklampsia early onset (16,67%) dibandingkan dengan yang  late onset (7,35%). Setelah dilakukan analisis melalui uji chi-square, disimpulkan bahwa tidak ada perbedaan berat lahir bayi antara pasien preeklampsia berat/eklampsia early dan late onset secara signifikan (p>0,05).Kata kunci: preeklampsia berat/eklampsia early onset, preeklampsia berat/eklampsia late onset, berat lahir bayi AbstractPreeclampsia and eclampsia are not only effect to mother, but also influent to the fetus, such as intrauterine fetal growth retardation  which can be seen as baby's birth weight. Mothers with early onset severe preeclampsia / eclampsia tend to give birth small for gestational age  babies, while the late onset tend to give birth normal birth weight or large for gestational age babies. The objective of this study was to determine the differentiation between baby's birth weight of early and late onset severe preeclampsia/ eclampsia. The research was conducted from October 2012 to July 2013 at the medical records department of general hospital center Dr. M. Djamil Padang. The type of this research was observational analytic with cross sectional design. The results showed that the incidence of early onset severe preeclampsia/ eclampsia was 26.1% and late onset was 73.9%. Small for gestational age babies born from mothers with early onset severe preeclampsia/ eclampsia (16.67%) is more than the late onset (7.35%). After analyzed by chi square test, it was concluded that there was no differentiation between baby's birth weight of early and late onset severe preeclampsia/ eclampsia significantly (p> 0,05).Keywords: early onset severe preeclampsia/eclampsia, late onset severe preeclampsia/eclampsia, baby’s birth weight

scholarly journals Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali

2018 ◽  
Vol 146 (3) ◽  
pp. 354-358
Author(s):  
B. Kone ◽  
Y. S. Sarro ◽  
M. Maiga ◽  
M. Sanogo ◽  
A. M. Somboro ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Disease Burden ◽  
Cross Sectional Study ◽  
Pulmonary Infections ◽  
Sectional Study ◽  
Cross Sectional ◽  
Global Spread ◽  
Study Population ◽  
The Impact ◽  
Culture Positive

AbstractThe global spread of non-tuberculous mycobacteria (NTM) may be due to HIV/AIDS and other environmental factors. The symptoms of NTM and tuberculosis (TB) disease are indistinguishable, but their treatments are different. Lack of research on the epidemiology of NTM infections has led to underestimation of its prevalence within TB endemic countries. This study was designed to determine the prevalence and clinical characteristics of pulmonary NTM in Bamako. A cross-sectional study which include 439 suspected cases of pulmonary TB. From 2006 to 2013 a total of 332 (76%) were confirmed to have sputum culture positive for mycobacteria. The prevalence of NTM infection was 9.3% of our study population and 12.3% of culture positive patients. The seroprevalence of HIV in NTM group was 17.1%. Patients who weighed <55 kg and had TB symptoms other than cough were also significantly more likely to have disease due to NTM as compared to those with TB disease who were significantly more likely to have cough and weigh more than 55 kg (OR 0.05 (CI 0.02–0.13) and OR 0.32 (CI 0.11–0.93) respectively). NTM disease burden in Bamako was substantial and diagnostic algorithms for pulmonary disease in TB endemic countries should consider the impact of NTM.

scholarly journals Fetal Foot Length and Femur/ Foot Length Ratio: Significance in Nepalese Context

2012 ◽  
Vol 1 (1) ◽  
pp. 15-22 ◽  
Author(s):  
KS Joshi ◽  
SB Marahatta ◽  
S Karki ◽  
S Tamrakar ◽  
NC Shrestha
Keyword(s):  
Linear Relationship ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Length Ratio ◽  
Normal Infant ◽  
Cross Sectional ◽  
Femur Length ◽  
Foot Length ◽  
Final Study ◽  
Study Population

Aim: 1. To assess relationship between fetal foot length and gestation age and develop a nomogram. 2. To assess relationship between fetal foot length and femur length. Meterials and Method: Cross sectional study. Fetal foot length was taken from the skin edge overlying calcaneus to the distal end of the longest toe on either plantar or the sagittal view in 860 singleton pregnant women between 15 and 40 weeks’ gestation. Normal case was defined as normal sonographic findings during examination and normal infant examination at birth or both. Final study population constituted 779 healthy fetuses. The relationship between gestational age to foot length was analyzed by simple linear regression. Correlation of fetal foot length with gestational age and femur length were also obtained. Results: A nomogram for fetal foot length was obtained. There is linear relationship between foot length and gestational age [foot length (mm)=2.494xGestational age (weeks)-15.46] with significant correlation (r=0.970 and p=0.000) and between foot length and femur length [foot length(mm)=1.049xfemur length (mm)+0.648] with significant correlation (r=0.980 and P=0.000). Femur length/ Foot Length ratio was 0.9 and 1.0 in most of the cases. Conclusion: Nomogram was obtained for fetal foot length at various gestational ages in our population. There is linear relationship and good correlation between foot length and gestational age and foot length and femur length. Fetal foot length can be used as an alternative fetal parameter to assess gestational age. Femur length/ Foot Length ratio is fairly constant throughout gestation. DOI: http://dx.doi.org/10.3126/njr.v1i1.6317 Nepalese Journal of Radiology Vol.1(1): 15-22

scholarly journals Risk Factors Associated with Neonatal Jaundice: A Cross-Sectional Study from Iran

2018 ◽  
Vol 6 (8) ◽  
pp. 1387-1393 ◽  
Author(s):  
Sayed Yousef Mojtahedi ◽  
Anahita Izadi ◽  
Golnar Seirafi ◽  
Leila Khedmat ◽  
Reza Tavakolizadeh
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Neonatal Jaundice ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Predisposing Factors ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Significant Relationships ◽  
Study Population

BACKGROUND: Neonatal jaundice is one of the main causes of the patient's admission in the neonatal period and is potentially linked to morbidity.AIM: This study aimed to determine the possible risk factors for neonatal jaundice.METHODS: We investigated the case of infants who were admitted to the neonatal department of Ziyaeian hospital and Imam Khomeini Hospital for jaundice. Simple random sampling was used to evaluate variables related to maternal and neonatal predisposing factors based on the medical records and clinical profiles. All variables in this study were analysed using SPSS software.RESULTS: In this study, about 200 mothers and neonates were examined. Our findings depicted that mother's WBC, Hb, PLT, and gestational age were associated with jaundice (P < 0.05). Furthermore, there were significant relationships between different degrees of bilirubin with TSH, T4 levels and G6PD (P < 0.05). In fact, TSH, T4 levels and G6PD were found to be linked to neonatal hyperbilirubinemia. The risk factors for jaundice in our study population comprise some predisposing factors such as WBC, Hb, PLT, gestational age, TSH, and T4 levels, as well as G6PD. Neonates at risk of jaundice are linked to some maternal and neonatal factors that can provide necessary interventions to reduce the burden of the disease. Therefore, identification of associated factors can facilitate early diagnosis, and reduce subsequent complications.CONCLUSION: Neonatal jaundice should be considered as the main policy in all health care settings of the country. Therefore, identification of factors affecting the incidence of jaundice can be effective in preventing susceptible predisposing factors in newborns and high-risk mothers.

scholarly journals Cullin 1 is not associated with late-onset preeclampsia

2019 ◽  
Vol 38 (1) ◽  
pp. 4
Author(s):  
Tjam Diana Samara ◽  
Isabella Kurnia Liem ◽  
Ani Retno Prijanti ◽  
Andrijono Andrijono
Keyword(s):  
Gestational Age ◽  
Late Onset ◽  
Placental Tissue ◽  
Trophoblast Invasion ◽  
P Value ◽  
Cross Sectional ◽  
Median Serum ◽  
Spearman Correlation Test ◽  
Elisa Technique ◽  
Cross Sectional Design

Background<br />Late-onset preeclampsia (PE) is preeclampsia occurring after 34 weeks of gestational age or later.  Cullin 1 (CUL1), a proangiogenic protein, is expressed in the placenta, where an imbalance between proangiogenic and antiangiogenic proteins during gestation can cause disturbance of trophoblast invasion. This defect results in vascular ischemia that may produce preeclampsia. The objective of this study was to determine the correlation between CUL1 as proangiogenic factor and late-onset preeclampsia. <br /><br />Methods<br />This study was of analytical observational cross-sectional design and involved 44 preeclampsia patients with ³34 weeks of gestational age (late-onset PE). The CUL1 level in the subjects’ sera, taken before they gave birth, and in homogenates of their placenta, obtained per vaginam or by cesarean section, were examined by the ELISA technique.  Statistical analysis was performed with the Spearman correlation test with significant p value of &lt;0.05.<br /><br />Results<br />Median maternal age was 31 years and median gestational age was 37 weeks.  Median serum CUL1 was 41.78 pg/mL and median placental homogenate CUL1 was 32.24 pg per milligram of total placental tissue protein. There was no significant correlation between serum CUL1 level and late-onset preeclampsia (r=-0.281; p=0.065). There was also no significant correlation between placental CUL1 level and late-onset preeclampsia (r=-0.166; p=0.281).<br /><br />Conclusion<br />Serum CUL1 and placental CUL1 were not correlated with late-onset preeclampsia. However, this study indicated that low serum CUL1 tends to prolong gestational age in preeclampsia.

scholarly journals 2396

2017 ◽  
Vol 1 (S1) ◽  
pp. 37-37
Author(s):  
Sarah Youssof ◽  
Carol Romero-Clark
Keyword(s):  
Muscular Dystrophy ◽  
Disease Duration ◽  
Outcome Measure ◽  
Late Onset ◽  
Objective Measure ◽  
Cross Sectional Study ◽  
Barium Swallow ◽  
Cross Sectional ◽  
Study Population ◽  
The Relationship

OBJECTIVES/SPECIFIC AIMS: Oculopharyngeal muscular dystrophy (OPMD) is a rare, late-onset muscular dystrophy that causes severe swallowing impairment (dysphagia). Although promising therapies are in the pipeline, validated dysphagia outcome measures for use in OPMD trials have not been established. Videofluoroscopic swallow studies (VFSS) are considered the clinical gold standard for dysphagia assessment, yet the optimal objective measure of VFSS in OPMD is not known. Our aim was to investigate the utility of the Modified Barium Swallow Impairment Profile (MBSImP) as an objective measure of VFSS in OPMD patients. METHODS/STUDY POPULATION: This was a single-center, prospective, cross-sectional study. In total, 26 individuals with OPMD underwent VFSS and other measures of dysphagia including 50-mL water swallow time (ST). Validity was assessed by examining correlations with an OPMD Global Severity Score (GSS) and with dysphagia duration. RESULTS/ANTICIPATED RESULTS: The MBSImP demonstrated moderate correlations with GSS (Pearson r=0.52, p=0.006) and ST (r=0.39, p=0.049). The relationship between MBSImP and dysphagia duration appeared nonlinear, and levelled off with long dysphagia duration. In contrast, ST did not correlate significantly with GSS (r=0.27, p=0.18), nor with disease duration (r=0.05, p=0.83). DISCUSSION/SIGNIFICANCE OF IMPACT: Objective measurement of VFSS is a promising outcome measure in OPMD. With long disease duration, the MBSImP may not be sufficiently sensitive to detect disease progression. More sensitive measures for scoring dysphagia severity on VFSS should be explored for application to future s of OPMD.

scholarly journals A Cross-sectional Study of Psychiatric Comorbidity and Severity of Addiction in Patients with Early- and Late-Onset Alcohol Dependence

2020 ◽  
Vol 42 (4) ◽  
pp. 334-340
Author(s):  
Anamika Das ◽  
Sujita Kumar Kar ◽  
Pawan Kumar Gupta ◽  
Pronob Kumar Dalal
Keyword(s):  
Alcohol Dependence ◽  
Early Onset ◽  
Late Onset ◽  
Severity Index ◽  
Cross Sectional Study ◽  
Addiction Severity Index ◽  
Cross Sectional ◽  
Addiction Severity ◽  
Onset Group ◽  
Early Onset Group

Background: Alcohol use disorder is a serious health problem with high comorbidities. Early-onset alcohol use has been associated with greater impulsivity, increased severity of dependence, frequent alcohol withdrawal complications, externalizing symptoms, and antisocial behaviors. We aimed to evaluate the psychiatric comorbidities and severity of addiction in early- and late-onset alcohol dependence. Methods: This was a cross-sectional study. All patients fulfilling the diagnostic criteria of alcohol dependence as per International Classification of Diseases (10th edition) were included in it. Semi-Structured Assessment for Genetics of Alcoholism IV was applied to find the age of onset of dependence as per the lifetime frame and also to find comorbidities. Composite International Diagnostic Interview 3.0. was used to find other comorbidities. The severity of addiction was evaluated with Addiction Severity Index, 5th edition. All the sociodemographic and clinical parameters were compared between patients with the early- and late-onset alcohol dependence. Results: Out of the 112 patients screened, 57 met the selection criteria, 26 were with early-onset and 31 with late-onset alcohol dependence. The patients were all males. The patients with early-onset alcohol dependence had a higher family history (P = 0.006) and were nonearning (P = 0.002) in comparison to the group with late-onset dependence. The comorbidity among all patients was 59.6% and 84.2% in current and lifetime frames, respectively. It was significantly higher in the early-onset group, both for current (P = 0.015) and lifetime (P = 0.031) frames. On the domains of Addiction Severity Index 5th edition, the early-onset group had a more severe profile of addiction in all domains except the medical domain. Conclusion: Comorbidity is high among patients with alcohol dependence and is even higher for the early-onset group. The family history was higher in the early-onset group and they have more severe profile of substance use.

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