scholarly journals Cullin 1 is not associated with late-onset preeclampsia

Author(s):  
Tjam Diana Samara ◽  
Isabella Kurnia Liem ◽  
Ani Retno Prijanti ◽  
Andrijono Andrijono

Background<br />Late-onset preeclampsia (PE) is preeclampsia occurring after 34 weeks of gestational age or later.  Cullin 1 (CUL1), a proangiogenic protein, is expressed in the placenta, where an imbalance between proangiogenic and antiangiogenic proteins during gestation can cause disturbance of trophoblast invasion. This defect results in vascular ischemia that may produce preeclampsia. The objective of this study was to determine the correlation between CUL1 as proangiogenic factor and late-onset preeclampsia. <br /><br />Methods<br />This study was of analytical observational cross-sectional design and involved 44 preeclampsia patients with ³34 weeks of gestational age (late-onset PE). The CUL1 level in the subjects’ sera, taken before they gave birth, and in homogenates of their placenta, obtained per vaginam or by cesarean section, were examined by the ELISA technique.  Statistical analysis was performed with the Spearman correlation test with significant p value of &lt;0.05.<br /><br />Results<br />Median maternal age was 31 years and median gestational age was 37 weeks.  Median serum CUL1 was 41.78 pg/mL and median placental homogenate CUL1 was 32.24 pg per milligram of total placental tissue protein. There was no significant correlation between serum CUL1 level and late-onset preeclampsia (r=-0.281; p=0.065). There was also no significant correlation between placental CUL1 level and late-onset preeclampsia (r=-0.166; p=0.281).<br /><br />Conclusion<br />Serum CUL1 and placental CUL1 were not correlated with late-onset preeclampsia. However, this study indicated that low serum CUL1 tends to prolong gestational age in preeclampsia.

2017 ◽  
Vol 4 (2) ◽  
pp. 133
Author(s):  
Yolla Yollanda Wulandari ◽  
Herawati Herawati ◽  
Anggi Setyowati

ABSTRAKDukungan sosial keluarga merupakan strategi koping penting yang dimiliki keluarga saat mengalami stres. Stres adalahsegala situasi dimana tuntutan non spesifik mengharuskan seorang individu untuk berespons atau melakukan tindakan. Tujuan untuk mengetahui hubungan dukungan sosial keluarga dengan tingkatstresanggotakeluargayangmerawatpasiengangguanjiwadi wilayah kerja Puskesmas Banjarbaru. Metode penelitian ini adalah observasionalanalitik dengan menggunakan rancangan cross sectional. Pengumpulan data dilakukan dengan menggunakan kuesioner dukungan sosial keluarga dan kuesioner tingkatstres. Hasil penelitian menunjukan bahwa sebagian besar yaitu sebanyak 25 responden (78,13%) memiliki dukungan sosial keluarga baik, dukungan sosial keluarga cukup sebanyak 6 responden (18,75%) dan dukungan sosial keluarga kurang sebanyak 1 responden (3,13%). Tingkat stres responden menunjukkan bahwa keseluruhan yaitu sebanyak 18 responden (56,25%) memiliki tingkatstress sedikitrendahdari rata-rata. Analisis data hasil penelitian ini menggunakan uji korelasispearman dengan nilai p value 0,041< 0,05, ada hubungan negatif dengan kekuatan rendah antara dukungan sosial keluarga dengan tingkatstresanggotakeluargayang merawatpasiengangguanjiwa di wilayah kerja Puskesmas Banjarbaru dengan nilai r = -0,363.Kata-kata kunci: dukungan sosial keluarga, tingkatstres, gangguanjiwa.ABSTRACTFamily social support is a very important coping strategy of a family by the time of experiencing stress. Stress refers to any situation when non specific demand requires an individual to respond or to act. Objective to know the correlation between family social support and stress degree of family member in treating mental disorder patient in the work region of Banjarbaru Puskesmas. Methods this is an observation analytic study using cross sectional design and the data is collected by means of giving questionnaires on family social support and stress degree. Results the study indicates that most of the respondents, namely 25 respondents (78.13%) have good family social support, and 6 respondents (18.75%) have sufficient family support and only 1 respondents (3.13%) has less family social support. The respondents stress degree shows that generally, namely 18 respondents (56.25%) have stress degree a little bit lower than the average. The data analysis of the study has applied spearman correlation test with p value 0.041 <0.05, there is a negative correlation with the low power between the family social support and the stress degree of family member in treating patient with mental disorder in the work region of Banjarbaru Puskesmas with r value = -0,363.Keywords: family social support, stress degree, mental disorders.


Author(s):  
Tjam Diana Samara ◽  
Heri Wibowo ◽  
Isabella Kurnia Liem ◽  
Ani Retno Prijanti ◽  
Andrijono Andrijono

BACKGROUNDPreeclampsia (PE) is one of the most common pregnancy complications worldwide. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Among the various factors that influence pro and antiangiogenic factors in trophoblast invasion of PE are E-cadherin and matrix metalloproteinase-9 (MMP-9). The current classification scheme differentiates PE into two variants early-onset (EO) and late-onset (LO) PE. The aim of this study was to compare MMP-9 and E-cadherin expression between early- (EO) and late-onset (LO) PE. METHODSThis study used a cross-sectional design involving 26 women with gestational age <34 weeks (EO) and 38 women with gestational age ≥34 weeks (LO) from PE patients. Placentas born to preeclamptic mothers were taken in the form of small pieces of the maternal side to measure the levels of MMP-9 and E-cadherin by the ELISA method. Statistical analysis was assessed using the Mann Whitney and independent t-test with a significant p value <0.05. RESULTSSemiquantitative proteinuria levels were significantly higher in EO-PE group compared to LO-PE group (p=0.000). Mean E-cadherin levels were significant lower in the EO-PE group (125.94 ± 54.22 pg/mg) compared to LO-PE group (157.95 ± 54.12 pg/mg) (p=0.024). However, there was no significance difference in median MMP-9 levels between EO-PE group and LO-PE group (p=0.376). CONCLUSIONThis study demonstrate that E-cadherin had lower levels in preeclampsia patients who gave birth <34 weeks. This study indicated that lower levels of e-cadherin can lead to early delivery in preeclampsia patients.


Background: Parkinson disease (PD) has motor manifestations namely resting tremor, rigidity, bradykinesia and postural instability. In addition, non-motor symptoms such as psychiatric symptoms such as depression, anxiety, hallucinations, psychosis, delusions and sleep. Accompanying depression is the most common nonmotor symptom in Parkinson's. Depression in Parkinson's occurs in about 40% of patients and on average there is major depression and minor depression. Objective: To determine the relationship of severity with depression in Parkinson's patients. Method: This study used a cross sectional design. Sampling was conducted at H. Adam Malik General Hospital Medan and network hospital. The study sample was taken as many as 25 subjects consecutively, with primary data sources obtained from all patients who had been diagnosed with Parkinson's disease based on the UKPD Society Bank's Clinical Criteria for Probable Parkinson's Disease criteria. Data analysis using the Spearman correlation test. Results: The demographic characteristics of the study subjects were 19 (76%) men and 6 people (24%) women, with the oldest age being 77 years and the youngest 49 years, mean age was 61.52 ± 6.97 years. The majority of the patients are senior high school, self-employed, and the Batak ethnic group. There is a significant relationship between the MDS-UPDRS subscale and the level of depression in Parkinson's patients with a p value <0.05. Conclusion: There is a significant relationship between severity and depression in Parkinson's patients.


2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Maria M. Pontoh ◽  
Hendri Opod ◽  
Cicilia Pali

Abstract: Nowadays, we can easily find people around us who are attracted to their own gender (homosexual). Some experts believe that the main cause is multifactorial; one of them is parenting style. This study aimed to obtain the relationship between parenting style and homosexual level. This was an observational analytical retrospective study with a cross sectional design. Samples were 76 members of the gays of X community in Manado obtained by using total sampling method. The instruments used were parenting style questionnaire and homosexual level questionnaire. Data were analyzed by using Spearman correlation test. The Spearman correlation test showed a p value = 0.039 (<α = 0.05) which indicated that there was a relationship between parenting styles and the level of homosexual with a correlation of 0.237 that belonged to the low category. It means that parenting styles affect the level of the homosexual. The better the parenting style, the less the homosexual behavior. Conclusion: There was a positive relationship between parenting style and the homosexuality level of gays of X community in Manado.Keywords: parenting style, homosexual levelAbstrak: Dewasa ini, sering dijumpai orang yang menyukai sesama jenis (homoseksual). Para ahli berpendapat bahwa penyebabnya multifaktorial; salah satu diantaranya ialah pola asuh orang tua. Penelitian ini bertujuan untuk mengetahui hubungan antara pola asuh orang tua dengan tingkat homoseksual seseorang. Jenis penelitian ini retrospektif observasional dengan rancangan potong lintang yang bersifat analitik. Sampel ialah anggota komunitas gay X dikota Manado yang berjumlah 76 orang, diperoleh dengan metode total sampling. Instrumen penelitian ialah kuesioner pola asuh dan kuesioner tingkat homoseksual. Data dianalisis menggunakan uji korelasi Spearman. Hasil uji korelasi Spearman mendapatkan nilai p = 0,039 (<α = 0,05) dengan nilai korelasi 0,237 yang termasuk dalam kategori rendah. penelitian mendapatkan adanya hubungan antara pola asuh orang tua dengan tingkat homoseksual pada gay dalam komunitas X di kota Manado. Semakin baik pola asuh yang diterapkan, semakin berkurang perilaku penyimpangan seksual seseorang. Simpulan: Terdapat hubungan positif antara pola asuh orang tua dengan tingkat homoseksual pada gay dalam komunitas X di Manado.Kata kunci: pola Asuh, tingkat homoseksual


e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 368
Author(s):  
Michelle Wilia ◽  
Mia A. Prasetya ◽  
Putri Rejeki

Abstract: Coronavirus disease 2019 (Covid-19) can cause respiratory problems and affect all ages. The nature of the transmission and the mortality rate of this viral infection bring about anxiety among health workers, inter alia, dentists because they have a high risk of contracting Covid-19. This study was aimed to determine the relationship between anxiety levels and the preparedness of dentists in facing the Covid-19 pandemic. This was an analytical study with a cross-sectional design. A quantitative study was conducted using a questionnaire that has been structured and tested for its validity and reliability. The questionnaire was divided into two parts, as follows: demographic data and levels of anxiety. Data were analyzed univariately and bivariately with the Spearman correlation test. There were 276 dentists in Bali as respondents who participated in this study. The results showed that the highest level of anxiety was moderate anxiety (54.3%) and there was a relationship between level of anxiety and the number of screening and patient settings with a p-value of 0.034 (p<0.05). In conclusion, there is a relationship between level of anxiety and the dentist's preparedness in the form of number of screening and patient setting to face the Covid-19 pandemic in Bali.Keywords: Covid-19; dentist; anxiety Abstrak: Coronavirus disease 2019 (Covid-19) dapat menyebabkan gangguan pernapasan dan menyerang segala rentang usia. Sifat transmisi dan tingkat mortalitas infeksi virus ini menye-babkan kecemasan di kalangan petugas kesehatan, salah satunya dokter gigi karena memiliki risiko tinggi tertular Covid-19. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kecemasan dan kesiapan dokter gigi dalam menghadapi pandemi Covid-19 di Bali. Jenis penelitian ialah analitik dengan desain potong lintang. Penelitian kuantitatif dilakukan menggunakan kuesioner yang telah disusun dan diuji validitas dan reliabilitasnya. Kuesioner dibagi menjadi dua bagian yaitu data demografi dan tingkat kecemasan dokter gigi. Hasil data dianalisis secara univariat dan bivariat menggunakan uji korelasi Spearman. Terdapat 276 dokter gigi di Bali yang berpartisipasi dalam penelitian ini. Hasil penelitian menunjukkan bahwa tingkat kecemasan paling tinggi ialah kecemasan sedang (54.3%) dan terdapat hubungan antara tingkat kecemasan dengan jumlah skrining dan pengaturan pasien dalam menghadapi pandemi Covid-19 di Bali dengan p=0,034 (p<0,05). Simpulan penelitian ini ialah terdapat hubungan antara tingkat kecemasan dengan kesiapan dokter gigi yang dinyatakan dalam jumlah skrining dan pengaturan pasien dalam menghadapi pandemi Covid-19 di Bali.Kata kunci: Covid-19; dokter gigi; kecemasan


2020 ◽  
Vol 2 (1) ◽  
pp. 1-11
Author(s):  
Yarshynta Aprilia Marshanty

Stress is one of the body's response due to unbalanced demands and abilities. The workers group is one group that has the potential for stress. The impact of stress caused is very likely to affect work. The purpose of this study was to examine the relationship between mental workload and individual factors (work period, age) with stress at aquaculture company in Banyuwangi. This research was an observational study with cross sectional design. The sample of this research is 36 samples and it is a total population. The purpose of this study was to determine the correlation between variables, the research data were analyzed using the Spearman correlation test. The results showed that the majority of workers have a mental workload with a high category, stress conditions for workers are mostly in the low stress category In conclusion, there is no relationship between mental workload (p value = 0,123) and work period (p value = 0,096) with stress. However, there is a relationship between age and stress (p value = 0,023) and this relationship is negative (correlation coefficient = -0.281). Recommendations for companies are to pay attention to workload owned by workers, both mental and physical workloads, create health programs for workers, including physical and mental health, create a healthy and comfortable work environment, and create good relationships between workers and introduce stress management to workers, so the workers are able to prevent the adverse effects of stress that might be experienced.


Author(s):  
Made Ariyana ◽  
Diah R. Hadiati ◽  
Irwan T. Rachman ◽  
Dewajani Purnomosari

Objective: To compare Bax protein expression in throphoblast cells of early and late onset PE. Methods: A cross sectional study involving 36 cases of early onset PE and 36 cases of late onset PE was conducted. Bax protein expression was evaluated from sample of placental tissue collected from the study population and calculated using H-Score. Data on age, number of parity, gestational age, body mass index was collected from the medical records. Expression of Bax was compared using Mann-Whitney test. Results: There was no difference in the clinical characteristics (age, number of parity, BMI, SBP, DBP, and MAP) between the two groups. There was no difference in the expression of Bax protein between the early and late onset PE (mean H-score early vs. late onset PE: 1.48 vs 1.46, p=0.814, Mann Whitney U test). Clinical characteristics of the study population also did not correlate with the Bax expression (R for number of parity: 0.052, age: 0.009, gestational age: -0.014, BMI: 0.063, all p values were >0.05, linear regresion). Conclusion: There is no difference in the expression of Bax protein of throphoblast cells between early and late onset PE. Keyword: apoptosis, BAX, early onset, late onset, preeclampsia   Abstrak Tujuan: Untuk membandingkan ekspresi protein Bax dalam sel trofoblas pada preeklamsia (PE) onset dini dan lambat. Metode: Sebuah studi potong lintang yang melibatkan 36 kasus PE onset dini dan 36 kasus PE onset lambat dilakukan. Ekspresi protein Bax dievaluasi dari sampel jaringan plasenta yang dikumpulkan dari populasi studi dan dihitung menggunakan skor-H. Data usia, jumlah paritas, usia kehamilan, indeks massa tubuh dikumpulkan dari rekam medis. Ekspresi Bax dibandingkan menggunakan uji Mann-Whitney. Results: Tidak terdapat perbedaan pada karakteristik klinis (usia, jumlah paritas, IMT, TDS, TDD, dan MAP) antara kedua kelompok. Tidak terdapat perbedaan dalam ekspresi protein Bax antara PE onset dini dan lambat (rata-rata H-skor PE onset dini dan lambat: 1.48 vs 1.46, p = 0.814, uji Mann Whitney U). Karakteristik klinis populasi studi juga tidak berkorelasi dengan ekspresi Bax (R untuk jumlah paritas: 0,052, usia: 0,009, usia kehamilan: -0,014, BMI: 0,063, nilai p dari semua variable tersebut adalah sebesar >0,05, dengan menggunakan regresi linier). Kesimpulan: Tidak terdapat perbedaan dalam ekspresi protein Bax pada sel trofoblas antara PE onset dini dan lambat. Kata kunci: apoptosis, BAX, onset dini, onset lambat, preeklamsia


2018 ◽  
Vol 1 (2) ◽  
pp. 58
Author(s):  
Setia Budi ◽  
Ria Dila Syahfitri

The rate of stroke incidence is about 200 per 100,000 people throughout the world. This study aims to determine the Relation Suffer Stroke With Independence Level In Neurology Polyclinic TK II DR Ak Gani Palembang Year Hospital 2017. The research method used is descriptive quantitative with cross sectional design that is done by interviewing techniques with questionnaires on 42 respondents with Accidental sampling technique. This research was conducted in August 2017. Data analysis used is univariate data analysis and bivariate data analysis with one way anova test result. The results of univariate analysis showed that the duration of the respondents suffering from stroke was between 2.10 years to 3.38 years. Also found that most respondents were at the level of independence f; independent, except bathing, dressing, moving, and one other function with a total of 12 respondents. The results showed that there was a significant relationship between the long suffering stroke with the level of independence with the value of p value 0.025. For that the need for rehabilitation to patients and families of patients in order to help improve the independence of stroke patients in doing their daily activities. Keywords : Long Suffer Stroke, Level of Independence


Author(s):  
Rubiyati Rubiyati

ABSTRACT Antenatal Care is the care given to pregnant woman to monitor, support maternal health and maternal detect, whether normal or troubled pregnant women. Aki in Indonesia amounted to 359 in 100.000 live births. The purpose of the study was to determine the relationship between age and education in the clinic Budi Mulia Medika 2014. This study used a survey method whit cross sectional analytic. This is the overall study population of women with gestational age ≥36 weeks who come to visit the clinic Budi Mulia Medika Palembang on February 10 to 18. The study sample was taken in non-random with the technique of “accidental smapling “ with respondents who happens to be there or variable. The obtained using univariate and bivariate analysis using Chi-Square test statistic. The results of the univariate analysis showed that 83,3% of respondents did according to the standard prenatal care, high risk age 40,0 %, 60,0% lower risk of age, higher education 70,0%, 30,0% low education. Bivariate analysis showed that there was no significant relationship betwee age and pregnancy tests wit p value= 0,622, and significant relationship between education and prenatal care with p value= 0,019. From the results of this study are expected to need to increase outreach activities to the community about the importance of examination of pregnancy according to gestational age in an effort to reduse maternal mortality.   ABSTRAK Antenatal Care merupakan pelayanan  yang di berikan pada ibu hamil untuk memonitor, mendukung kesehatan ibu dan mendeteksi ibu, apakah ibu hamil normal atau bermasalah. Di Indonesia AKI berjumlah 359 per 100.000 kelahiran hidup. Tujuan penelitian adalah untuk mengetahui hubungan antara usia dan pendidikan dengan pemeriksaan kehamilan di klinik budi mulia medika tahun 2014. Penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional. Populasi penelitian ini adalahseluruh ibu dengan usia kehamilan ≥ 36 minggu yang dating berkunjung ke Klinik Budi Mulia Medika pada tanggal 10-18 Februari. Sampel penelitian ini di ambil secara non random dengan tekhnik ‘’ Accidental Sampling’’ dengan responden yang kebetulan ada atau tersedia. Data yang di peroleh menggunakan analisis univariat dan bivariat menggunakan uji statistik Chi-Square. Hasil analisis univariat ini menunjukan bahwa 83,8% responden melakukan pemeriksaan kehamilan sesuai standar, 16,7% tidak melakukan pemeriksaan kehamilan sesuai standar, usia resiko tinggi 40,0%, usia resiko rendah 60,0%, pendidikan tinggi 70,0 %, pendidikan rendah 30,0 %. Analisis bivariat menunjukan bahwa tidak ada hubungan bermakna antara usia dengan pemeriksaan kehamilan dengan p value =0,622, ada hubunngan bermakana antara pendidikan dengan pemeriksaan kehamilan dengan p value = 0,019. Dari hasil penelitian ini di harapkan perlu meningkatkan kegiatan penyuluhan kepada masyarakat tentang pentingnya dilakukan pemeriksaan kehamilan sesuai dengan umur kehamilan sebagai upaya menurunkan angka kematian ibu.    


2016 ◽  
Vol 1 (1) ◽  
pp. 21-30
Author(s):  
Imelda Derang

Intelligence is the ability to apply the knowledge and experiences that have been gained into the effort tasks are challenging and flexible book. Behaviour is an action that involves aspects of affective, cognitive, and psychomotor. Goal: This study aims to determine the relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Method: This study uses correlation with cross sectional design. The study population was all students / i Ners Level II STIKes Santa Elisabeth Medan as 65. The samples used were 65 respondents, the sampling technique in this research is using purposive sampling. The instrument of this study using questionnaire and observation sheets by using product moment test person. Result: Intelligence students as many as 30 people (46.2%) classified as having an average level of intelligence. A total of 32 people (49.2%) classified as well-behaved students. Person product moment test results obtained p value = 0.172 where a significant level of p> 0.05 so that this value proves that the absence of a relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Conclusion: Recommended for institutions, motivating students in balancing the behavior and intelligence. 


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