scholarly journals β Cyclodextrin Nanocomplexes with Biologically Active Peptides from Hydrolysed Bovine Whey and Colostrum

2021 ◽  
Vol 12 (6) ◽  
pp. 8502-8514
Keyword(s):  
Body Weight Gain ◽  
Relative Weight ◽  
Fold Increase ◽  
Tetrahymena Pyriformis ◽  
Weight Coefficient ◽  
Biologically Active ◽  
Control Group ◽  
Active Peptides ◽  
Dairy Protein

β Cyclodextrin nanocomplexes with extensive whey and colostrum hydrolysates possessing acceptable flavor properties serve as potential sources of bioactive peptides. In this study, comparative characterization of dairy protein hydrolysates and their complexes with β cyclodextrin is presented. Antioxidant activity of studied samples was estimated by fluorometric method, the formation of clathrates with cyclic oligosaccharide was determined using thermogravimetric analysis. A significant decrease in bitterness of peptides included in cyclic oligosaccharides was established compared with samples of dairy hydrolysates. 2.1/1.3 fold increase in the antioxidant potential of β cyclodextrin clathrates with whey/colostrum hydrolysates was recorded versus unbound peptide fractions. According to toxicological tests on Tetrahymena pyriformis, the samples of whey hydrolysate and the resulting nanocomplex were referred to as non-toxic and slightly hazardous compounds, respectively. The dynamics of body weight gain and the relative weight coefficient of internal organs revealed no differences compared to the control group of Rattus norvegicus. The data on differentiation of blood cells, their death, and cytogenetic disorders demonstrated that a sample of cyclic oligosaccharides with whey peptides is non-toxic at the maximum dosages allowable for administration. β Cyclodextrin complexing with dairy peptides resulted in enhanced radical-reducing activity and improved flavor properties, making the clathrates promising and safe ingredients of special nutrition formulas.

New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids

1998 ◽  
Vol 41 (14) ◽  
pp. 2481-2491 ◽  
Author(s):  
Maria Sandberg ◽  
Lennart Eriksson ◽  
Jörgen Jonsson ◽  
Michael Sjöström ◽  
Svante Wold
Keyword(s):  
Amino Acids ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Chemical Descriptors

scholarly journals Effect of Biologically Active Additive on the Quality of Grown Calves

2021 ◽  
pp. 67-72
Author(s):  
А.И. Фролов ◽  
О.Б. Филиппова ◽  
А.Н. Бетин ◽  
В.И. Дорохова
Keyword(s):  
Pathogenic Bacteria ◽  
Body Weight Gain ◽  
Biologically Active ◽  
Stress Factors ◽  
Control Group ◽  
Klebsiella Pneumonia ◽  
Feed Supplement ◽  
Growing Period ◽  
Body Resistance

Изучена эффективность применения синбиотической кормовой добавки, повышающей резистентность организма животных и усиливающей реакцию адаптации к воздействию стресс-факторов окружающей среды. Бактерицидное действие кормовой добавки-синбиотика позволило полностью исключить возникновение заболеваний у телят желудочно-кишечного тракта, способствуя нормализации микробиоценоза кишечника. Количество условно-патогенных бактерий Klebsiella pneumonia в составе кишечной микрофлоры уменьшилось в 10 раз по сравнению с образцами контрольной группы (104 против 105 КОЕ/г). Телята, получавшие добавку-синбиотик, по валовому приросту живой массы за период выращивания превышали контрольных на 8%. В контрольной группе выявлены животные с признаками нарушения функции желудочно-кишечного тракта.Применение кормовой добавки- синбиотика в рационе опытных телят позволило получить дополнительный доход от условной реализации их валового прироста на 435,8 руб./гол. больше, чем от телят контрольной группы. Effectiveness of use of synbiotic feed supplement increasing animal body resistance and enhancing adaptation reaction to environmental stress factors effect has been studied. The bacterial effect of the synbiotic feed supplement made it possible to completely eliminate the occurrence of diseases in calves of the gastrointestinal tract, promoting to the normalization of intestinal microbiocenosis. The number of conditionally pathogenic bacteria Klebsiella pneumonia in the intestinal microflora decreased by 10 times compared to the control group samples (104 against 105 CFU/g). Calves received synbiotic additive were 8% higher than control calves in terms of gross body weight gain during the growing period. In the control group animals with signs of the digestive tract dysfunction were identified. The use of synbiotic feed supplement in the diet of experimental calves made it possible to obtain additional income from the conditional realization of their gross growth by 435.8 Rub/goal more than from the calves of the control group.

scholarly journals The Effectiveness of Bioadditive Use in the Diets of Heifers of a Covering Age

2020 ◽  
Author(s):  
А.И. Фролов ◽  
А.Н. Бетин
Keyword(s):  
Body Weight Gain ◽  
Food Supplement ◽  
Biologically Active ◽  
Farm Animals ◽  
Control Group ◽  
Copper Zinc ◽  
Feeding Technology ◽  
Positive Effect ◽  
Experimental Group ◽  
Active Substances

Жизненно важными микроэлементами для жвачных животных являются медь, цинк, марганец, железо, кобальт, йод, селен. Микроэлементы, в которых атом металла соединён и защищён белковыми молекулами, улучшают воспроизводительные качества самок за счёт повышения оплодотворяемости, уменьшения эмбриональной смертности, улучшения состояния мочеполовой системы или повышения интенсивности функционирования яичников. Поэтому в настоящее время актуальными являются разработка и внедрение в технологию кормления сельскохозяйственных животных наиболее эффективных препаратов с необходимыми биологически активными веществами. На основании проведённого исследования дано практическое обоснование использования в технологии кормления тёлок отечественной кормовой биодобавки на основе гидролизата соевого белка, витаминов и микроэлементов. Установлено её положительное действие на некоторые функции органов и систем животных. Экспериментально доказана эффективность её применения для оптимизации обменных процессов и повышения воспроизводительных функций тёлок. Так, биохимическим исследованием образцов крови подопытных животных установлено, что количество кальция и фосфора в крови у тёлок опытной группы по сравнению с контролем было достоверно выше на 2,35 и 2,9% соответственно. Эритропоэтическая фракция была более выражена у молодняка опытной группы. У тёлок опытной группы время от начала скармливания препарата до первой выраженной охоты и осеменения, по сравнению с контрольными животными, сократилось на 16%, а период от начала скармливания препарата до плодотворного осеменения – на 25,7%. Количество тёлок, пришедших в охоту и осеменённых в первый месяц, в опытной группе по сравнению с контрольной было на 43% больше. Оплодотворяемость тёлок опытной группы за учётный период составила 95%, что на 20% больше, чем у животных контрольной группы. Включение в рацион тёлок биодобавки в дозе 100 мл/гол. позволило получить дополнительно на 8,5% больше валового прироста живой массы по отношению к их аналогам. The vital trace nutrients for ruminants are copper, zinc, manganese, iron, cobalt, iodine, selenium. Microelements in which a metal atom is jointed and protected by protein molecules improve the reproductive qualities of females by increasing fertility, reducing embryonic mortality, improving the state of the genito-urinary system or increasing the intensity of ovarian functioning. Therefore the development and implementation of the most effective preparations with the necessary biologically active substances in the technology of feeding farm animals is currently relevant. On the ground of conducted research a practical substantiation of the use of domestic food supplement based on the hydrolyzate of soy protein, vitamins and trace nutrients in the feeding technology of heifers is given. Its positive effect on some functions of animal organs and systems has been established. The effectiveness of its application to optimize metabolic processes and increase the reproductive functions of heifers has been experimentally proven. Thus a biochemical blood samples analysis of experimental animals found that the amount of calcium and phosphorus in the blood of the heifers of the experimental group compared with the control was significantly higher by 2.35 and 2.9% respectively. The erythropoietic fraction was more defined in the young experimental group. In heifers of the experimental group the time from the beginning of feeding the drug to the first defined heat and insemination compared with control animals decreased by 16% and the period from the beginning of feeding the drug to prolific insemination – by 25.7%. The number of heifers that came to the heat and inseminated in the first month in the experimental group was 43% higher than the control group. The impregnation capacity of the heifers of the experimental group during the record period was 95% which is 20% more than in animals of the control group. Inclusion in the diet of heifers bioadditive at a dose of 100 ml / goal allowed obtaining additionally 8.5% more the gross body weight gain relative to their analogs.

scholarly journals The Effect of Diet with Fermented Soybean Meal on Blood Metabolites and Redox Status of Chickens

2020 ◽  
Vol 20 (2) ◽  
pp. 599-611
Author(s):  
Iwona Sembratowicz ◽  
Robert Chachaj ◽  
Magdalena Krauze ◽  
Katarzyna Ognik
Keyword(s):  
Soybean Meal ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Hdl Cholesterol ◽  
Fold Increase ◽  
Redox Status ◽  
Blood Metabolites ◽  
Control Group ◽  
Fermented Soybean Meal ◽  
Fermented Soybean

AbstractThe aim of the study was to determine whether replacing soybean meal with 3% or 6% fermented soybean meal would positively affect blood metabolites and redox status of broiler chickens. The experiment was carried out on 600 broiler chickens assigned to three experimental groups of 200 chickens each (10 replications of 20 individuals each). In the control group, soybean meal (SBM) was the main source of dietary protein, whereas the remaining groups were fed diets in which soybean meal was partially replaced with 3% or 6% fermented soybean meal (FSBM-3%, FSBM-6%). The fermentation of the SBM contributed to an increase of Lactobacillus, content of crude protein, methionine and lysine, and especially over a 30-fold increase in the concentration of lactic acid. The inclusion of 3% or 6% share of FSBM in the diet of chickens contributed to an increase in total antioxidant potential (FRAP) and plasma total glutathione content. In blood of chickens receiving FSBM an increase of total protein and HDL cholesterol content, aspartate aminotransferase activity and a decrease in urea content were noted. In addition to the positive effect on protein and lipid metabolism as well as antioxidant defence, the diet with a 6% share of FSBM improved body weight gain of chickens. In conclusion, it can be suggested that introducing 6% share of FSBM in place of FSM is more justified.

Characterization of the thermolysin-like cleavage of biologically active peptides by Xenopus laevis peptide hormone inactivating enzyme

Biochemistry ◽  
1993 ◽  
Vol 32 (23) ◽  
pp. 5959-5966 ◽  
Author(s):  
Carine Joudiou ◽  
Krishnamurti de Morais Carvalho ◽  
Gisela Camarao ◽  
Hamadi Boussetta ◽  
Paul Cohen
Keyword(s):  
Xenopus Laevis ◽  
Peptide Hormone ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides

Effects of nickel supply on the fattening performance and several biochemical parameters of broiler chickens and rabbits

2004 ◽  
Vol 52 (2) ◽  
pp. 185-197 ◽  
Author(s):  
A. Bersényi ◽  
S. Gy. Fekete ◽  
M. Szilágyi ◽  
Erzsébet Berta ◽  
L. Zöldág ◽  
...  
Keyword(s):  
Growth Performance ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Fatty Infiltration ◽  
Relative Weight ◽  
Dietary Supplementation ◽  
The Body ◽  
White Female ◽  
Control Group ◽  
Crude Fibre

Broiler chicken and rabbit experiments were carried out to study the effects of nickel (Ni) supplementation on growth performance and Ni metabolism. ROSS cockerels and New Zealand White female rabbits were fed a diet containing Ni in concentrations of 0, 50 and 500 mg/kg in dry matter (DM). Dietary supplementation of 50 mg Ni/kg slightly improved the body weight gain (BWG) and had a beneficial effect on the feed conversion efficiency (FCE) in broiler chickens. However, Ni added at a level of 500 mg/kg significantly (P < 0.05) reduced the BWG by 10% and resulted in significantly (P < 0.05) worse (2.3 ± 0.2 kg/kg) FCE. The relative weight of the liver in cockerels was significantly (P < 0.05) decreased by Ni as compared to the control group (1.7 and 2.1% vs. 2.6%). The activity of AST and CHE enzymes was increased insignificantly by dietary supplementation of 500 mg Ni/kg, indicating damage of the liver parenchyma. The results of serum biochemistry were confirmed by a mild or moderate form of pathological focal fatty infiltration of the liver in broilers. Supplemental Ni of 50 mg/kg concentration resulted in non-significantly increased BWG in rabbits. Ni added to the diet at a level of 500 mg/kg reduced the digestibility of crude protein by 3-4% and that of crude fibre by 20-25% in rabbits. Approx. 98% of the ingested Ni was lost from the body via the faeces, 0.5-1.5% via the urine and approx. 1% was incorporated into the organs of rabbits. As a result of dietary supplementation of 50 and 500 mg Ni/kg, Ni accumulated in the kidneys (4.9 ± 0.5 and 17.1 ± 3.1 vs. 1.9 ± 0.3 mg/kg DM), ribs (10.3 ± 0.4 and 10.4 ± 0.6 vs. 9.1 ± 0.6 mg/kg DM), heart (1.4 ± 0.2 and 2.5 ± 0.4 vs. 1.0 ± 0.1 mg/kg DM) and liver (1.3 ± 0.1 and 2.2 ± 0.2 vs. 0.9 ± 0.05 mg/kg DM), as compared to the control animals. It can be stated that supplementation of the diet with 50 mg Ni/kg had slight but non-significant beneficial effects on the growth performance of broiler chickens and rabbits.

scholarly journals Effect of Feeding Moringa oleifera Leaf Meal with Multienzyme on Performance, Carcass Characteristics and Economics of Production of Broiler Chicks

2021 ◽  
Author(s):  
M.S. Meel ◽  
T. Sharma ◽  
Monika Joshi ◽  
M.L. Gurjar ◽  
S.K. Sharma ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Body Weight Gain ◽  
Antimicrobial Property ◽  
Relative Weight ◽  
Carcass Characteristics ◽  
Control Group ◽  
Broiler Chicks ◽  
Treatment Groups ◽  
Leaf Meal ◽  
Wide Range

Background: Moringa leaves have wide range of medicinal value including antimicrobial property. Therefore, it could be an alternative of antibiotic growth promoters in poultry but the presence of phytate and other anti-nutrients can reduce the bioavailability of certain nutrients. Enzymes may reduce anti-nutrients effect, break down non-starch polysaccharides (NSPs), reduce intestinal viscosity and ultimately improve digestibility of nutrients by improving gut performance. An experiment was conducted to assess the effect of supplementation of Moringa oleifera leaf meal with multienzyme on the performance, carcass characteristics and economics of broiler chicks. Methods: Day-old, 150 broiler chicks (Vencobb-400) were randomly allotted to five treatment groups. The T1 i.e. control group was fed on basal diet, while, T2, T3, T4 and T5 treatment groups were supplemented with 0.5%, 1.0%, 1.5% and 2.0% of moringa leaf meal in combination with multienzyme @ 50g/100kg feed in the basal broiler starter and finisher ration, respectively.Result: Body weight gain was higher (P less than 0.01) in broilers fed diet supplemented with 1.5% Moringa oleifera leaf meal (MOLM) and multienzyme at 3 or 6 weeks of age. The best feed conversion ratio (FCR) at the starter phase was recorded in the T2 group and over the entire period of the trial T4 treatment group had the best FCR. Significant increase in dressing yield percent and relative weight of giblet was observed in broilers fed diet with 1.5% level of moringa leaf meal and multienzyme. Supplementation of MOLM with multienzyme was profitable in terms of reduction in feed cost per kg gain. It was concluded that supplementation of Moringa oleifera leaf meal @ 1.5% with multienzyme at 50g/100Kg dose in the diet was effective in improving the performance and net profit in broiler chicks.

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