scholarly journals COMPARATIVE EFFICACY OF NEEM (AZADIRACHTA INDICA) AND METFORMIN HYDROCHLORIDE (COMET®) IN STREPTOZOTOCIN INDUCED DIABETES MELITUS IN RATS

1970 ◽  
Vol 8 (1) ◽  
pp. 75-80 ◽  
Author(s):  
AR Das ◽  
M Mostofa ◽  
ME Hoque ◽  
S Das ◽  
AK Sarkar
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Azadirachta Indica ◽  
Body Weight Gain ◽  
Diabetic Rats ◽  
Metformin Hydrochloride ◽  
Comparative Efficacy ◽  
Neem Leaves ◽  
Streptozotocin Induced Diabetes ◽  
Diabetes Melitus

The present study was investigated the comparative efficacy of extract of Neem (Azadirachta indica) and Metformin hydrochloride (Comet®) in respect of their hypoglycemic activity in Streptozotocin (STZ)-induced diabetic rats. Extract of Neem was administered @ 500 mg/kg body-weight (bwt) and 250 mg/kg bwt. Metformin hydrochloride @ 500 mg/kg bwt and 250 mg/kg daily orally for 21 days. Changes in the blood glucose level and body weight were measured and the results were compared statistically using Anova test. The extract of Neem leaves and Metformin hydrochloride showed significant (p<0.01) hypoglycemic effect and neem extracts at 250 mg/kg bwt showed more potent effects. The Neem extracts significantly (p<0.01) increased body weight @ 250 mg/kg. From this experiment it was observed that extracts of Neem leaves had hypoglycemic and body weight gain effect. For definite conclusion, details study is needed. DOI = 10.3329/bjvm.v8i1.8353 Bangl. J. Vet. Med. (2010). 8(1): 75-80

scholarly journals Comparative study of neem leaf (Azadirachta indica) suspension and toltrazuril against coccidiosis in Sonali chicken

2020 ◽  
Vol 17 (2) ◽  
Author(s):  
R. Roy ◽  
M. H. Hasan ◽  
F. B. Aziz ◽  
R. Islam ◽  
S. Sarkar
Keyword(s):  
Body Weight ◽  
Azadirachta Indica ◽  
Body Weight Gain ◽  
Treated Group ◽  
The Body ◽  
Total Leukocyte Count ◽  
Comparative Efficacy ◽  
Blood Constituents ◽  
Treatment Groups ◽  
Neem Leaves

Background: Coccidiosis is recognized as the parasitic disease with the greatest economic impact on poultry industries worldwide. Sonali chicken are commonly affected by coccidiosis in Bangladesh. Recently, the concerns about possible drug resistance have aroused great caution in the usage of drug in the animal industry. As an alternative herbal extracts are used and Neem leaves (Azadirachta indica) have anti-coccidial property. This study was conducted to evaluate the comparative efficacy of Neem leaves suspension and toltrazuril on coccidial load, blood constituents, growth performance of Sonali chicken infected with Eimeria tenella. Methods: The study was conducted in the laboratory and experimental shed under the department of physiology and pharmacology, HSTU, Dinajpur during, 2nd January to 3rd February, 2019. Eighty (80) Sonali chicken of seven days old were randomly divided into four groups named T0, T1 T2 and T3 and each group contained 20 birds. All groups were supplied E. tenella orally except T0 group and after 3 days T2 group was treated with Neem leaves suspension (5%) for 15 days and T3 groups was treated with toltrazuril (topzuril ®) solution (1 ml/lit) for 2 days. Results: Results showed that protozoal load decreased significantly (P<0.01) in T2 & T3 groups whereas increased significantly (P<0.01) in T0 and T1 group. The total erythrocyte count and hemoglobin in different treatment groups were similar and the differences were non-significant (P>0.05) statistically except total leukocyte count (TLC). The body weight of T0, T1, T2 and T3 group at day 30 were 432.65, 469.81, 548.81, 489.22 gm respectively which is statistically significant (P<0.01) and highest body weight gain was recorded from Neem leaves suspension treated group. Conclusion: Neem leaves suspension have significant effects on protozoal load, body weight and no significant effect on haematological parameters except TLC.

scholarly journals Persea Americana L. (Avocado) Fruit Mesocarp intake in Experimental Diabetic Rats: Impacts and Implication of Mode of Consumption

2021 ◽  
Vol 4 (7) ◽  
pp. 01-06
Author(s):  
Magnus Michael Chukwudike Anyakudo ◽  
Ifeoluwa Adekunle Adediji
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Diabetic Rats ◽  
Persea Americana ◽  
Avocado Fruit ◽  
Mode Of Consumption

Background: Few epidemiological data exist on the effects of the mode of consumption of avocado on diet quality, weight management, and lipoglycemic profile in diabetic condition and other metabolic disease risk factors. Objectives: This study investigated the metabolic, lipoglycemic, and anthropometric impacts of avocado fruit mesocarp intake and the implication of its mode of consumption on body weight gain, lipid profile, glycemic tolerance and control in male diabetic Wistar rats. Method: Twenty one (21) adult male Wistar rats (150-220g) were randomly categorized into three experimental groups (n = 7, each): Diabetic control fed with normal diet (DC); Diabetic rats fed with avocado supplemented diet (DSA); Diabetic rats treated with aqueous mesocarp extract of avocado (DAE). Diabetes was inducted with 150 mg/dL, alloxan monohydrate solution intraperitoneally. Animals were fed according to the experimental design with water ad libitum for six weeks. Body weights and fasting blood glucose (FBG) concentrations were measured twice weekly. LP and OGTT were conducted. Microsoft Excel and statistical SPSS program version 22 were used for data analysis. Results are expressed as mean ± SEM. Comparison between groups were made using Students’t-test and one way ANOVA. Results: Consumption of avocado mesocarp caused significant reduction in mean body weight gain (DSA: 13.75%; DAE: 10.17%; P value < 0.05) and blood glucose concentrations (DSA: 9.48%; DAE: 21.0%; P = 0.002) with significant improvement in glycemic tolerance and lipid profile (DAE > DSA) over the control. Peaked glycemic responses occurred at 30 minutes of glucose challenge in DSA and DAE groups. Conclusion: Avocado fruit mesocarp intake reduced body weight gain and blood sugar with improved lipid profile and glycemic tolerance in experimental diabetic rats while the mode of consumption influenced its potential impacts.

scholarly journals Antidiabetic effects of Catharanthus roseus, Azadirachta indica, Allium sativum and glimepride in experimentally diabetic induced rat

1970 ◽  
pp. 99-102 ◽  
Author(s):  
M Mostofa ◽  
ME Choudhury ◽  
MA Hossain ◽  
MZ Islam ◽  
MS Islam ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Dose Rate ◽  
Catharanthus Roseus ◽  
Azadirachta Indica ◽  
Allium Sativum ◽  
Body Weight Gain ◽  
Antidiabetic Activity ◽  
Herbal Preparations

Catharanthus roseus (Nyantara), Azadirachta indica (Neem), Allium sativum (Garlic) are medicinal plants, used in Ayurveda for treating various diseases, one of which is diabetes mellitus. In the present study of 12 months period from January to December 2007, aqueous extract of this plants were prepared and blood glucose lowering effect and improvement of body weight gain in Streptozotocin (50 mg/kg bwt i.p.) induced diabetic rats were measured and compared with that of a patent drug glimepride in the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh. Rats were administered Catharanthus roseus, Azadirachta indica, Allium sativum extracts at the dose rate of 1g/kg, 500 mg/kg and 1g/kg bwt orally for 14 days, respectively. Blood glucose level and body weight was measured by Glucotrend kit and Electronic balance and that compared with a patent drug Glimepride at a dose rate of 100 mg/kg bwt. The data were compared statistically by using student's unpaired t-test. The herbal preparations of these plants significantly increased body weight gain and decreased blood glucose as compared with the patent drug. The present study clearly indicated the significant antidiabetic activity of Catharanthus Roseus, Azadirachta indica and Allium sativum and supports the traditional usage of the herbal preparations by Ayurvedic physicians for the therapy of diabetics. Key words: Catharanthus roseus, Azadirachta indica, Allium sativum, Glimepride, Streptozotocin, diabetic rat DOI = 10.3329/bjvm.v5i1.1324 Bangl. J. Vet. Med. (2007). 5 (1 & 2): 99-102

Effect of Honey & Olive Oil Supplemented Bio-Yoghurt Feeding on Lipid Profile, Blood Glucose and Hematological Parameters in Rats

2019 ◽  
Vol 15 (2) ◽  
pp. 140-147
Author(s):  
Magdy M. Ismail ◽  
El-Tahra M. Ammar ◽  
Abd El-Wahab E. Khalil ◽  
Mohamed Z. Eid
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Olive Oil ◽  
Body Weight Gain ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background and Objective: Yoghurt, especially bio-yoghurt has long been recognized as a product with many health benefits for consumers. Also, honey and olive oil have considerable nutritional and health effects. So, the effect of administration of yoghurt made using ABT culture and fortified with honey (2 and 6%), olive oil (1 and 4%) or honey + olive oil (2+1 and 6+4% respectively) on some biological and hematological properties of rats was investigated.Methods:The body weight gain, serum lipid level, blood glucose level, serum creatinine level, Glutamic Oxaloacetic Transaminase (GOT) activity, Glutamic Pyruvic Transaminase (GPT) activity, leukocytes and lymphocytes counts of rats were evaluated.Results:Blending of bio-yoghurt with rats&#039; diet improved body weight gain. Concentrations of Total plasma Cholesterol (TC), High-Density Lipoprotein cholesterol (HDL), Low-Density Lipoprotein cholesterol (LDL), Very Low-Density Lipoprotein cholesterol (VLDL) and Triglycerides (TG) significantly lowered in plasma of rats fed bio-yoghurt. Levels of TC, LDL, VLDL, and TG also decreased in rat groups feed bio-yoghurt supplemented with honey and olive oil. LDL concentrations were reduced by 10.32, 18.51, 34.17, 22.48, 43.30% in plasma of rats fed classic starter yoghurt, ABT yoghurt, ABT yoghurt contained 6% honey, ABT yoghurt contained 4% olive oil and ABT yoghurt contained 6% honey + 4% olive oil respectively. The blood glucose, serum creatinine, GOT and GPT values of rats decreased while white blood cells and lymphocytes counts increased by feeding bioyoghurt contained honey and olive oil.Conclusion:The findings enhanced the multiple therapeutic effects of bio-yoghurt supplemented with honey and olive oil.

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mohamed Eddouks ◽  
Farid Khallouki ◽  
Robert W. Owen ◽  
Morad Hebi ◽  
Remy Burcelin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats

1985 ◽  
Vol 106 (2) ◽  
pp. 225-231 ◽  
Author(s):  
A.-M. Mendes ◽  
R. J. Madon ◽  
D. J. Flint
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Insulin Receptor ◽  
Body Weight Gain ◽  
Serum Insulin ◽  
Insulin Binding ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Receptor Concentration

ABSTRACT Cortisol implants in normal and diabetic rats reduced body weight, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in isolated adipocytes, whilst insulin sensitivity was unchanged. In normal but not diabetic rats these changes were accompanied by increased serum glucose and insulin concentrations. In contrast, progesterone implants in normal and diabetic rats increased body weight gain, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in adipose tissue, again without affecting insulin sensitivity. Progesterone did not affect serum insulin concentrations in normal or diabetic rats but accelerated the decline in serum glucose concentrations which occurred during an overnight fast in diabetic rats. The results suggest that (1) cortisol inhibits lipogenesis in adipose tissue without affecting insulin sensitivity, (2) cortisol reduces insulin binding in adipose tissue without a requirement for hyperinsulinaemia, which might itself indirectly lead to down-regulation of the insulin receptor, and (3) in diabetic rats progesterone stimulates lipogenesis in adipose tissue without any increase in food intake or serum insulin concentrations suggesting that progesterone may have a direct anabolic role in adipose tissue. J. Endocr. (1985) 106, 225–231

scholarly journals Inhibition ofα-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Abdulrahman L. Al-Malki
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Hydrolytic Enzyme ◽  
Positive Control ◽  
Diabetic Rats ◽  
Postprandial Hyperglycemia ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Albino Rats ◽  
Predisposing Factor

Postprandial hyperglycemia is a predisposing factor for vascular dysfunction and organ damage.α-glucosidase is a hydrolytic enzyme that increases the glucose absorption rate and subsequently elevates blood glucose levels. Garlic (Allium sativumL.) is a rich source of several phytonutrients, including thiosulfinate (THIO). The aim of this study was to evaluate the ability of THIO, a potent inhibitor of intestinalα-glucosidase, to reduce postprandial blood glucose. Male albino rats were randomly assigned to five different groups (n=10/group). Group 1 served as the control group. Groups 2–5 were injected intraperitoneally with a single dose of streptozotocin (STZ) to induce diabetes. Group 2 comprised untreated diabetic rats. Groups 3 and 4 contained diabetic rats that were given THIO orally (20 mg/kg body weight/day and 40 mg/kg body weight/day, resp.). Group 5 was the positive control having diabetic rats treated orally with acarbose (10 mg/kg body weight/day; positive control). Diabetic rats treated with THIO displayed a significant blood glucose reduction (p<0.001and < 0.01 by analysis of variance, resp.) and a significant elevation in insulin compared with that of untreated rats. THIO is an effective noncompetitive intestinalα-glucosidase inhibitor that promotes hypoglycemic action (p<0.001) in STZ-injected rats. THIO is a promising agent for the management of postprandial hyperglycemia.

scholarly journals Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats

2004 ◽  
Vol 47 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Ricardo Galletto ◽  
Vera Lúcia Dias Siqueira ◽  
Edilene Bega Ferreira ◽  
Arildo José Braz Oliveira ◽  
Roberto Barbosa Bazotte
Keyword(s):  
Body Weight ◽  
Blood Level ◽  
Serum Lipids ◽  
Body Weight Gain ◽  
Acute Effect ◽  
Diabetic Rats ◽  
The Body ◽  
Hypolipidemic Effect ◽  
Gymnema Sylvestre ◽  
Water Ingestion

In this study we investigated the antidiabetic and hypolipidemic potential of dried powdered leaves of Gymnema sylvestre (GS). The acute effect of GS administered by oral gavage on glucose blood level of and lipids in non-diabetic and alloxan-diabetic rats were investigated in the following conditions: a) after a balanced meal; b) after the ingestion of 1000 mg/kg amylose or 1000 mg/kg glucose; c) after the ingestion of a mixture of 12 mL/kg soybean oil + 1% cholesterol (SOC). In addition, the effect of the treatment with GS during two (sub-acute) or four weeks (chronic) on body weight, food and water ingestion, glucose blood level and lipids in non-diabetic and alloxan-diabetic rats were measured. The dose of GS utilized in the majority of the experiments, i.e., 30 mg/kg, corresponds to that given to treat diabetes in Brazil. GS acutely did not influence the elevation of glycemia promoted by a balanced meal or by the administration of amylose or glucose; but promoted more intense (P<0.05) elevation of serum lipids after the administration of SOC. Moreover, the sub-acute and chronic treatment with GS in non-diabetic and alloxan-diabetic rats did not change: a) the body weight gain; b) food and water ingestion; c) the blood level of glucose and lipids. Thus we concluded that GS, at least in the form commercialized in the Brazil, i.e., dried powdered leaves, require further experimental and clinical trials before being recommended to treat diabetes and hyperlipidemia.

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