scholarly journals B-Type Natriuretic Peptide as Prognostic Marker in Newly Diagnosed Acute Coronary Syndrome Patients

2015 ◽  
Vol 14 (1) ◽  
pp. 1-5
Author(s):  
Jakia Sultana Shila ◽  
Shirin Akter Begum ◽  
Md Aminul Haque Khan ◽  
Noortaj Begum ◽  
Md Matiur Rahman ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Natriuretic Peptide ◽  
Morbidity And Mortality ◽  
Newly Diagnosed ◽  
Good Recovery ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
Group I ◽  
Increased Risk ◽  
Group Ii

Background: B-type Natriuretic Peptide (BNP) a neurohormone synthesized in ventricular myocardium and released into the circulation in response to ventricular dilatation and pressure overload, is a current biomarker used for identifying patients at high risk of Acute Coronary Syndrome (ACS). High level of BNP is associated with an increased risk of Major Adverse Cardiac Events (MACE) including new or progressive heart failure and myocardial infarction. The objective of this study was to assess the prognosis of newly diagnosed ACS patients by using plasma BNP level. Methods: This study was conducted in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) in collaboration with National Institute of Cardiovascular Disease (NICVD) from January 2013 to December 2013. Total 100 newly diagnosed ACS patients, aged 30 to 70 years, irrespective of sex who reported within 24 hours of onset of symptoms were enrolled in this study by purposive and convenient sampling. Plasma BNP level of selected study subjects was measured within 24 hours of onset of symptoms. Then subjects were grouped on the basis of their empirical cut-off value of plasma BNP concentration Group I having plasma BNP level <135 pg/mL and Group II having plasma BNP level 135 pg/mL. Results: Of 100 ACS patients, 86 were male and 14 were female with the mean age 49.61±10.28 years and the age range of 30 to 70 years. Among 26 patients in Group I, good recovery, morbidity and mortality were 22 (84.6%), 4 (15.4%) and zero and among 74 patients in Group II good recovery, morbidity and mortality were 18 (24.3%), 53 (71.6%) and 3 (3.0%) respectively. Differences in outcome between groups were statistically significant (P=0.001). Above the empirical cut-off value of BNP (135 pg/mL) good prognosis was for 18 (24.3%) and bad prognosis was for 56 (75.7 %) patients and relative risk 3.48 in 95% CI (2.25-5.36). Conclusion: It can be concluded from this study that higher baseline plasma BNP concentration is associated with more adverse clinical outcomes in ACS patients. Since the baseline plasma BNP concentrations at the onset of event shows incremental prognostic value, so plasma BNP can be used clinically as a biomarker of prognosis in ACS patients.DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22870 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 1-5

scholarly journals Elevated Level of Plasma B-Type Natriuretic Peptide (BNP) as a Prognostic Marker in Patients with Acute Coronary Syndrome

2019 ◽  
Vol 46 (2) ◽  
pp. 32-37
Author(s):  
Dilshad Parvin ◽  
Md Nasir Uddin ◽  
Md Shahjahn Kabir ◽  
Afsana Ahmed ◽  
SM Rahat Hossain ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Logistic Regression ◽  
Odds Ratio ◽  
Binary Logistic Regression ◽  
Prognostic Indicator ◽  
Morbidity And Mortality ◽  
Coronary Syndrome ◽  
Group I ◽  
Group Ii ◽  
Age Range

Acute coronary syndrome (ACS), a life-threatening manifestation of coronary artery disease, ranges from unstable angina (UA) to acute myocardial infarction (AMI). To reduce the morbidity and mortality resulting from acute coronary syndrome, we should have to find out some predictor or prognostic indicator. A prognostic indicator should be available at the time of initial patient’s evaluation, in order to maximize the potential benefits of early risk assessment. This study designed to evaluate plasma BNP as a prognostic tool in patients with acute coronary syndrome. A prognostic cohort study was carried out with 90 (ninety) acute coronary syndrome patients on the basis of their clinical and laboratory criteria with age range of 30 to 90 years in the department of biochemistry, BSMMU, in collaboration with department of cardiology, NICVD, BSMMU and BIRDEM. Plasma BNP concentrations were measured on enrollment and then grouping of the study subjects were done on the basis of their empirical cut off value of plasma BNP concentration. All the patients were free from heart failure, renal disease, thyroid disease and hepatic disorder. Main outcomes were mortality, morbidity and survival after hospital discharge with or without any disability. All the subjects were categorized into two and to see the significance between two groups in relation to age and sex Unpaired –t test and Chi square test were done. Finally, Binary logistic regression was done. Among 90 acute coronary syndromes patients, there were 74(82.2%) male and 16(17.8%) female with mean age of the study population 51.8 years and the age range of 30 t0 90 years. Among enrolled patients, 24 (26.7%) were NSTEMI and 66 (73.3%) were STEMI that includes 29 (32.2%) anterior MI, 21 (23.3%) inferior MI, 16 (17.8%) other varieties of MI. All the study subjects were grouped into two on the basis of empirical cut off value of plasma BNP 640pg/ml on enrollment. Group I with plasma BNP level less than 640pg/ml includes 57 (63.3%) subjects and group II with plasma BNP more than 640pg/ml includes 33 (36.7%) subjects. Among group I (n=57) good recovery, morbidity and mortality found to be in 41(71.9%), 15(26.3%) and 1(1.8%) patients and those in group II (n=33) found in 6(18.2%), 19(57.6%) and 8(24.2%) patients respectively. Keeping the group I in reference category binary logistic regression analysis done, showing odds ratio 11.5 with p- value 0.000. The odds ratio 11.5 indicates that there is 11.5 times higher chance of getting bad outcome in ACS patients having higher plasma BNP concentrations. Bangladesh Med J. 2017 May; 46 (2): 32-37

scholarly journals Study of Lipid Profile and Coronary Angiographic Pattern in Young Bangladeshi Patients with Acute Coronary Syndrome

1970 ◽  
Vol 1 (2) ◽  
pp. 183-188 ◽  
Author(s):  
AR Khan ◽  
AAS Majumder
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Older Age ◽  
Age Group ◽  
Coronary Angiogram ◽  
Coronary Syndrome ◽  
Group I ◽  
Younger Age ◽  
Group Ii

Background: Majority of the patients of coronary heart disease (CHD) in our country are above 40 years of age but a good number of patients belong to the age under 40, the most valuable and productive period of life during which they can devote themselves to uplift their family, society and country and can participate in nation building activities.3,4 The number of young individuals falling into the spectrum of CHD is increasing everywhere However, this age trend is peculiar in relation to the western age incidence.5 Our objective was to investigate the lipid profile and coronary angiographic pattern in young Bangladeshi patients with acute coronary syndrome and also to find out the relationship between dyslipidemia and coronary artery disease in this age group. Methods: This observational study was carried out in National Institute of Cardiovascular Diseases (NICVD) during the period of January 2000 to December 2000. A brief history was recorded on the date of admission and fasting lipid profile was done within 24 hours of admission. Other associated major risk factors were looked for and recorded accordingly. After stabilization oh the acute condition patient was prepared for coronary angiogram and informed consent was taken. Accordingly elective CAG was done. Among them total 64 patients of ACS, underwent coronary angiogram in the cath lab of NICVD, were selected randomly of which of which 32 patients were up to the age 40 years (Group- I) and 32 were above 40 years of age (Group-II). Patient of ACS of either sex having no age limitation were included without prior history of Percutaneous Coronary Intervention or Coronary Artery Bypass Graft surgery. The findings were reviewed and scrutinized carefully by two interventional cardiologists. In doubtful cases third expert reviewed the CD. If a consensus was not reached due to technical or visual error, the case wais discarded from the study. Details of CAG findings i.e. site and number of diseased vessels, location, morphology and pattern of lesion were studied and recorded accordingly. Results: The prevalence of dyslipidaemia and positive family history were more in group I than group II. Younger age group has less favorable lipid profile than older age group having raised total cholesterol in 31.3 percent cases, low HDL in 12.5 percent cases and raised LDL in 31.3 percent cases, while in older age group, it was 21.8, 25.0, 0 and 18.7 percent, respectively. CAG study of the patients showed that no vessel involvement was more common in group I than group II (21.9% vs 12.5%), but triple vessel disease was more common in group II (12.5% vs 21.8%). Single vessel and double vessel diseases were similar in both the groups. Involvement of LAD was slightly more in-group I than group II (68.8% vs 65.6%) and involvement of LCX and RCA were less in group I than group II (21.9% vs 34.3%, and 43.8% vs 78.1%, respectively). Diffuse LAD and RCA lesions were more in group II (36.4% vs 52.4% and 42.9% vs 48.0%, respectively), but diffuse LCX lesion was more in group I (42.9 vs 36.4%). Multiple irregular lesions are more common in older age group (53.1%) than younger age group (28.1%). Conclusion: The younger age group has less favorable lipid profile than older age group having raised total cholesterol, decreased HDL and raised LDL. CAG findings show that most of the lesions are present in LAD (having less impressive LVEF) as like as in older age group, but older age group has more multiple irregular lesions. Prevalence of >2 lesions in one coronary artery was more in group I (31 vs. 25%) but difference was not statistically significant. Keywords: Lipid profile, Coronary angiogram, Younger patients, Acute Coronary Syndrome. DOI: http://dx.doi.org/10.3329/cardio.v1i2.8237 Cardiovasc. j. 2009; 1(2): 183-188

scholarly journals The Impact of Glyco-Metabolic Status in Patients Treated for Acute Coronary Syndrome

PRILOZI ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 37-50
Author(s):  
Marija Vavlukis ◽  
Biljana Zafirovska ◽  
Emilija Antova ◽  
Bekim Pocesta ◽  
Enes Shehu ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Glycemic Control ◽  
Morbidity And Mortality ◽  
Newly Diagnosed ◽  
Stress Hyperglycemia ◽  
Coronary Syndrome ◽  
Hospital Morbidity ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
The Impact

Abstract Objective: The aim of the study was to assess the prevalence of newly diagnosed diabetes in patients with acute coronary syndrome and estimate the relationship between stress hyperglycemia, glyco-regulation and newly diagnosed diabetes with hospital morbidity and mortality. Methods: This was an observational study which included all patients hospitalized due to acute coronary syndrome (January 2015 until April 2017) at the University Clinic of Cardiology in Skopje, Macedonia. We analyzed demographic, clinical, biochemical variables and hospital morbidity and mortality. Five investigated groups were compared using a single biochemical parameter glycated hemoglobin (HgbA1c) depending on the presence of known diabetes before the acute event: 0-without DM (HgbA1c <5.6%), 1-newly diagnosed pre-diabetes (HgbA1c 5.6-6.5%), 2-newly diagnosed diabetes (HgbA1c ≥ 6.5%), 3-known well controlled diabetes (HgbA1c <7%) and 4-known un-controlled diabetes (HgbA1c ≥7%). Results: 860 patients were analyzed. Impaired glucose metabolism was confirmed in 35% of patients, 9% of which were with newly diagnosed diabetes. Stress hyperglycemia was reported in 27.3% (3.6% were without diabetes). The highest values of stress hyperglycemia were reported in newly diagnosed and known un-controlled diabetes. In-hospital morbidity and mortality were 15% and 5% accordingly and the rate was highest in patients with newly diagnosed and known, but un-controlled diabetes. HgbA1c, stress hyperglycemia, and poor glycemic control have emerged as significant independent predictors of hospital morbidity and mortality in patients with acute coronary syndrome. Conclusion: High prevalence of newly diagnosed diabetes was observed in patients with acute coronary syndrome. Stress hyperglycemia and failure to achieve glycemic control are independent predictors of hospital morbidity and mortality.

scholarly journals THE EFFICIENCY OF ANTI-COAGULANTS APPLIED DURING TRANSCUTANEOUS CORONARY INTERVENTIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME WITHOUT ELEVATION OF ST SEGMENT

2017 ◽  
Vol 23 (2) ◽  
pp. 64-71
Author(s):  
T. P Chernigina ◽  
R. S Goloshchapov-Aksenov ◽  
Daniil A. Maksimkin ◽  
N. V Sturov ◽  
Z. Kh Shugushev
Keyword(s):  
Acute Coronary Syndrome ◽  
Cardiovascular Complications ◽  
Syntax Score ◽  
Femoral Access ◽  
Coronary Syndrome ◽  
Radial Access ◽  
Coronary Interventions ◽  
Group I ◽  
St Segment ◽  
Group Ii

The purpose of study. To evaluate efficiency of different coagulants used under transcutaneous coronary interventions in patients with acute coronary syndrome without elevation of ST segment.The methods. The sampling of 346 patients was randomized in two groups. In the group I (n=155) transcutaneous coronary intervention was implemented using bivalirudin and in group II (n = 191) - using unfractionated heparin. The additional randomization of patients of group I: in subgroup A (n = 77) infusion of bivalirudin continued during four hours after intervention and in subgroup B (n = 78) infusion was discontinued in X-ray operating room. The criteria of inclusion: patients with acute coronary syndrome without elevation of ST segment with multi-vascular affection of coronary channel (risk on SYNTAX score = 23-32); high and medium degree of risk according GRACE scale; absence of re-vascularization of myocardium in anamnesis. The criteria of exclusion: patients with very high risk according GRACE scale; affection of left coronary artery trunk. The results. During period of hospitalization, total rate of intra- and post-operative cardiovascular complications had no reliable differences in two groups and amounted to 7.1% and 8.4% correspondingly (p = 0.6423). The serious bleedings (BARC 3 and 5) occurred reliably more frequently in patients of group II. Also, the groups had no differences in rate of development of acute thrombosis of stents. In subgroup A reliably less frequently occurred serious cardiovascular complications as compared with patients of subgroup B (1,3% и 13% correspondingly; р = 0,001). At that, rate of bleeding reliably had no differences. At trans-radial access, in patients of group I rate of bleeding and cardiovascular complications amounted to 0% and 2.9% and at trans-femoral access these indices were reliably higher - 3,3% и 10% correspondingly (р < 0,001). In group II a similar tendency is noted: at trans-radial access these indices amounted to 6% and 4.6% and at trans-femoral - 33.7% and 11.9% correspondingly (р

Outcome of Patients Hospitalized with Acute Coronary Syndrome Fulfilling the Criteria of Metabolic Syndrome

2014 ◽  
Vol 15 (1) ◽  
pp. 31-35
Author(s):  
Mohammed Shahadat Hossain ◽  
Khan Abul Kalam Azad ◽  
Prodip Kumar Biswas ◽  
Md. Amir Hossain ◽  
Jayanta Kumar Saha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Acute Coronary Syndrome ◽  
Heart Block ◽  
Cardiovascular Complications ◽  
Coronary Syndrome ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
The Impact

The aim of the study was to assess the association of metabolic syndrome in patients with acute coronary syndrome and the impact of metabolic syndrome on clinical outcome. Total 210 ACS patients were included in this study and divided in group I & II on the basis of presence or absence of MS respectively. Among the study patients mean age in group I and group II was 52.99 ± 11.49 years and 53.34 ± 12.54 years respectively. Among the risk factors, hypertension (70%vs 15%), dyslipidemia (100 vs. 97%), diabetes mellitus (36.4% vs. 6%) were significant between two groups. Mean waist circumference recorded was 103.12 ± 4.15 in group I and 96.50 ± 6.43 in group II which was significant. Present study showed, in hospital outcome was worse in group I in comparison to group II and was significant, like cardiogenic shock (11% vs. 1%), LVF (28.2% vs. 16%), and CVD (5.45 vs. 0%). But there were no significant difference in heart block, tachyarrhythmia, cardiac arrest, reinfarction and death. Complications were far more in group I than in group II (14.5% vs. 52.0%) which was also highly significant. So, we conclude that the presence of MS in patients suffered from ACS was associated with a greater incidence of in-hospital cardiovascular complications and mortality.DOI: http://dx.doi.org/10.3329/jom.v15i1.19857 J Medicine 2014; 15: 31-35

scholarly journals Newly Diagnosed Diabetes and Stress Glycaemia and Its’ Association with Acute Coronary Syndrome

2015 ◽  
Vol 3 (4) ◽  
pp. 607-612 ◽  
Author(s):  
Gordana Kamceva ◽  
Marija Vavlukis ◽  
Darko Kitanoski ◽  
Sashko Kedev
Keyword(s):  
Acute Coronary Syndrome ◽  
Prospective Observational Study ◽  
Event Rate ◽  
Newly Diagnosed ◽  
Impaired Glucose Metabolism ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
The Relationship

BACKGROUND: Diabetes is diagnosed in 10-20% of patients with acute coronary syndrome (ACS) not known to be diabetics. Elevated blood glucose is an independent risk factor for cardiac events, regardless of presence of diabetes.AIM: Evaluating the prevalence of new-diagnosed DM among patients with ACS, and assessing the relationship between stress glycaemia and new diagnosed DM with in-hospital cardiac events.METHODS: Prospective observational study, in patients with ACS, in whom we analyzed parameters of glycemic metabolism, clinical data, and in-hospital cardiac events. We comparatively analyzed patients according to the HgbA1C and known DM in five groups: non-DM (< 5.6%), new pre-DM (5.6-6.5%), new DM (≥ 6.5%), controlled (<7%) and uncontrolled (≥7%) known DM.RESULTS: 150 patients, (93 male and 57 female) were included. Impaired glucose metabolism was detected in 44.5% of patients, 7.9% of whom were newly-diagnosed DM. The highest levels of stress glycaemia were found in new and uncontrolled known DM. The in-hospital event rate was 20.7%, the mortality rate 7.3%, being the highest in new diagnosed and uncontrolled known DM patients.CONCLUSIONS: The prevalence of unknown DM was high among patients with ACS. Stress glycaemia and failure to achieve glycemic controlee, were an independent predictors of in-hospital cardiac events.

scholarly journals Myotrophin is a more powerful predictor of major adverse cardiac events following acute coronary syndrome than N-terminal pro-B-type natriuretic peptide

2007 ◽  
Vol 112 (4) ◽  
pp. 251-256 ◽  
Author(s):  
Sohail Q. Khan ◽  
Dominic Kelly ◽  
Paulene Quinn ◽  
Joan E. Davies ◽  
Leong L. Ng
Keyword(s):  
Acute Coronary Syndrome ◽  
Natriuretic Peptide ◽  
Proportional Hazards Model ◽  
Survival Curve ◽  
Systolic Heart Failure ◽  
Cox Proportional Hazards Model ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
Adverse Cardiac Events

Myotrophin is a 12 kDa protein initially isolated from hypertrophied hearts of spontaneously hypertensive rats and acts by modulating NF-κB (nuclear factor κB) activity. We have reported previously the presence of myotrophin in patients with human systolic heart failure; however, its role as a predictor of MACE (major adverse cardiac events) in patients with ACS (acute coronary syndrome) is unclear. In the present study, we sought to investigate this and compared myotrophin with NTproBNP (N-terminal pro-B-type natriuretic peptide), a marker of MACE. We studied 356 patients with ACS {276 men; mean age, 63.0±12.8 years; 80.6% STEMI [ST segment elevation MI (myocardial infarction)]; and 19.4% NSTEMI (non-STEMI)}. Blood measurement was made at 25–48 h after the onset of chest pain. The plasma concentration of myotrophin and NTproBNP was determined using in-house non-competitive immunoassays. Patients were followed-up for the combined end point of death, MI or need for urgent revascularization. Over the median follow-up period of 355 (range 0–645) days, there were 28 deaths, 27 non-fatal MIs and 73 patients required urgent revascularization. Myotrophin was raised in patients with MACE compared with survivors [510.7 (116.0–7445.6) fmol/ml compared with 371.5 (51.8–6990.4) fmol/ml respectively; P=0.001; values are medians (range)]. Using a Cox proportional hazards model, myotrophin {HR (hazard ratio), 1.64 [95% CI (confidence interval), 0.97–2.76]; P=0.05} and Killip class above 1 [HR, 1.52 (95% CI, 0.93–2.42); P=0.10] were the only independent predictors of MACE. A Kaplan–Meier survival curve revealed a significantly better clinical outcome in patients with myotrophin below the median compared with those with myotrophin above the median (log rank, 7.63; P=0.006). In conclusion, after an ACS, levels of myotrophin are more informative at predicting MACE than NTproBNP and may be useful to risk stratify patients.

Outcome of patients with prior coronary bypass surgery admitted with an acute coronary syndrome

Heart ◽  
2021 ◽  
pp. heartjnl-2020-318047
Author(s):  
Ilan Marcuschamer ◽  
Oren Zusman ◽  
Z Iakobishvili ◽  
Abid R Assali ◽  
Hanah Vaknin-Assa ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Temporal Trends ◽  
Coronary Bypass ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Urgent Revascularisation ◽  
Time Periods

BackgroundPatients with prior coronary artery bypass graft surgery (CABG) are at increased risk for recurrent cardiovascular ischaemic events. Advances in management have improved prognosis of patients with acute coronary syndrome (ACS), yet it is not known whether similar trends exist in patients with prior CABG.AimExamine temporal trends in the prevalence, treatment and clinical outcomes of patients with prior CABG admitted with ACS.MethodsTime-dependent analysis of patients with or without prior CABG admitted with an ACS who enrolled in the ACS Israeli Surveys between 2000 and 2016. Surveys were divided into early (2000–2008) and late (2010–2016) time periods. Outcomes included 30 days major adverse cardiac events (30d MACE) (death, myocardial infarction, stroke, unstable angina, stent thrombosis, urgent revascularisation) and 1-year mortality.ResultsAmong 15 152 patients with ACS, 1506 (9.9%) had a prior CABG. Patients with prior CABG were older (69 vs 63 years), had more comorbidities and presented more with non-ST elevation-ACS (82% vs 51%). Between time periods, utilisation of antiplatelets, statins and percutaneous interventions significantly increased in both groups (p<0.001 for each). The rate of 30d MACE decreased in patients with (19.1%–12.4%, p=0.001) and without (17.4%–9.5%, p<0.001) prior CABG. However, 1-year mortality decreased only in patients without prior CABG (10.5% vs 7.4%, p<0.001) and remained unchanged in patients with prior CABG. Results were consistent after propensity matching.ConclusionsDespite an improvement in the management and prognosis of patients with ACS in the last decade, the rate of 1-year mortality of patients with prior CABG admitted with an ACS remained unchanged.

scholarly journals C-Reactive Protein in Patients with NSTEMI Acute Coronary Syndrome

2013 ◽  
Vol 1 (1) ◽  
pp. 10-14 ◽  
Author(s):  
RK Dubey ◽  
N Dhakal ◽  
BKL Das ◽  
NK Pandey ◽  
N Baral ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Serum Levels ◽  
C Reactive Protein ◽  
St Segment Elevation ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
Group I ◽  
St Segment ◽  
Group Ii ◽  
Serum Crp

Background: C- reactive protein (CRP) is an acute phase inflammatory mediator that has been implicated as a risk factor for cardiovascular disease (CVD). The clinical presentation of acute coronary syndrome (ACS) ranges from unstable angina (UA) to non ST- segment elevation myocardial infarction (NSTEMI) and ST- segment elevation myocardial infarction (STEMI). Although, elevated levels of serum CRP have been reported in patients with CVD, the serum levels of CRP in patients with NSTEMI ACS is unknown. The purpose of the study was to determine whether the serum levels of CRP are higher in patients with NSTEMI ACS as compared to healthy controls. Methods: The study subjects consisted of two groups. Group I: (controls) twenty- five age-matched healthy men and Group II: Forty- five NSTEMI ACS patients. Fasting blood samples were collected and serum levels of CRP were measured by using highly sensitivity immunoassay rate method technology. Results: The serum levels of CRP in Group I and Group II were 3.2 ± 0.25 and 11.32 ± 2.1 mg/L, respectively and these values were significantly different from each other (p< 0.05). Group II showed a 253% higher level of CRP as compared to Group I subjects. Conclusion: The results demonstrate that the serum levels of CRP are higher in patients with NSTEMI ACS as compared to controls. Serum CRP levels are elevated in patients with NSTEMI ACS and may contribute to the inflammation and thrombosis associated with acute coronary syndrome. DOI: http://dx.doi.org/10.3126/jucms.v1i1.8416   Journal of Universal College of Medical Sciences Vol.1(1) 2013:  10-14

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