scholarly journals Study on Serum Vitamin B12 And Folic Acid in Patients of Ischaemic Stroke

1970 ◽  
Vol 19 (2) ◽  
pp. 115-117
Author(s):  
K Kirtania ◽  
S Ahmed ◽  
N Sultana ◽  
MZ Hossain ◽  
MM Rahman
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Ischaemic Stroke ◽  
Large Population ◽  
Serum Vitamin ◽  
Developed Countries ◽  
Control Group ◽  
Case Group ◽  
Key Words Ischaemic Stroke ◽  
The Mean

Context: Stroke is the third commonest cause of death in developed countries and is responsible for the physical disability of a large population. Of two types, ischaemic stroke covers 85% and haemorrhagic stroke is only 15%. Methods: A case control study was designed to see the association of serum vitamin B12 and folic acid level with ischemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age and sex matched healthy control. Results: The mean vitamin B12 and folic acid levels in case group were 231.02±10.81 pg/ml and 2.29±0.54 ng/ml respectively. For control group, the mean vitamin B12 and folic acid levels were 278.72±15.88 pg/ml and 7.24±2.19 ng/ml respectively. Conclusion: The study suggests that low levels of serum vitamin B12 and folic acid are associated with ischaemic stroke. Key words: Ischaemic stroke; vitamin B12; folic acid. DOI: 10.3329/jdmc.v19i2.7080J Dhaka Med Coll. 2010; 19(2) : 115-117

scholarly journals Relationship between Vitamin B9 (Folic Acid), Vitamin B12 (Cobalamin), and Peripheral Neuropathy in Children with Beta-Thalassemia Major

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Uni Gamayani ◽  
Titin Junaidi ◽  
Nushrotul Lailiyya ◽  
Nur Suryawan ◽  
Nanan Sekarwana
Keyword(s):  
Folic Acid ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Control Group ◽  
Case Group ◽  
Beta Thalassemia Major ◽  
Vitamin B9 ◽  
Significant Difference

Vitamin B9 (folic acid) and B12 (cobalamin) are essential vitamins that play roles in the process of hematopoiesis and maintaining the function of peripheral nerves. Therefore, these deficiencies may create a risk for peripheral neuropathy in beta-thalassemia major patients. The purpose of this study is to determine the relationship between vitamin B9 level, vitamin B12 level, and peripheral neuropathy in beta-thalassemia major children. It was an observational analytical study with a case-control design has been conducted at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, in May–July 2019. There were 47 beta-thalassemia major children with peripheral neuropathy (case) and 41 healthy children (control). All subjects completed a general demographic questionnaire, underwent neurological examination, and were tested for vitamin B9 and B12 serum levels. Data were then analyzed using the unpaired t test to compare the vitamin levels between both groups and Spearman’s rank correlation test to investigate the correlation between vitamin levels and the number of affected nerves in the case group. Comparison of folic acid levels in the case group (21.52±6.22 ng/mL) and the control group (23.81±7.51 ng/mL) showed no significant difference (p=0.19). In contrast, cobalamin in the case group (288.57±168.61 ng/mL) and the control group (385.95±197.48 ng/mL) showed a significant difference (p=0.01). In addition, there was a moderate correlation (p=0.004, r=0.41) between folic acid level and the number of motoric nerves affected in the case group. In conclusion, cobalamin level correlates with peripheral neuropathy in beta-thalassemia major patients, and folic acid level correlates with the number of affected nerves, especially motoric nerves. HUBUNGAN ANTARA VITAMIN B9 (ASAM FOLAT), VITAMIN B12 (KOBALAMIN), DAN NEUROPATI PERIFER PADA ANAK DENGAN TALASEMIA BETA MAYORVitamin B9 (asam folat) dan B12 (kobalamin) merupakan vitamin esensial yang berperan dalam proses hematopoiesis dan menjaga fungsi saraf tepi. Defisiensi vitamin ini dapat menimbulkan risiko neuropati perifer pada pasien talasemia beta mayor. Tujuan penelitian ini mengetahui hubungan antara kadar vitamin B9, vitamin B12, dan neuropati perifer pada anak talasemia beta mayor. Metode penelitian ini adalah analitik observasional dengan rancangan studi kasus kontrol yang dilakukan di RSUP Dr. Hasan Sadikin Bandung, Indonesia pada Mei–Juli 2019. Terdapat 47 anak talasemia beta mayor dengan neuropati perifer (kelompok kasus) dan 41 anak sehat (kelompok kontrol). Seluruh subjek penelitian mengisi kuesioner demografi umum, menjalani pemeriksaan fisis neurologis, serta dilakukan tes kadar vitamin B9 dan B12 serum. Uji t test tidak berpasangan digunakan untuk membandingkan kadar vitamin pada kedua kelompok dan uji korelasi Spearman untuk membandingkan kadar kedua vitamin tersebut dengan jumlah saraf yang terkena pada kelompok kasus. Perbandingan kadar asam folat kelompok kasus (21,52±6,22 ng/mL) dan kelompok kontrol (23,81±7,51 ng/mL) menunjukkan perbedaan yang tidak bermakna (p=0,19), sedangkan perbandingan kadar kobalamin kelompok kasus (288,57±168,61 ng/mL) dan kelompok kontrol (385,95±197,48 ng/mL) menunjukkan perbedaan yang bermakna (p=0,01). Selain itu, terdapat korelasi sedang (p=0,004; r=0,41) antara kadar asam folat dam jumlah saraf motorik yang terkena pada kelompok kasus. Kesimpulan, kadar kobalamin berhubungan dengan neuropati perifer pada penderita talasemia beta mayor dan kadar asam folat berhubungan dengan jumlah saraf yang terkena, terutama saraf motorik.

scholarly journals Association of Hypertension and Smoking with Ischaemic Stroke

2013 ◽  
Vol 3 (1) ◽  
pp. 16-18
Author(s):  
K Kirtania ◽  
N Sultana ◽  
S Ahmed ◽  
A Khatun
Keyword(s):  
Cigarette Smoking ◽  
Ischaemic Stroke ◽  
Matched Control ◽  
Strong Relationship ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
Study Population ◽  
The Mean ◽  
Control Study

Hypertension is one of the most important modifiable risk factors for ischemic stroke. Cigarette smoking is a risk factor for atherosclerotic disease. There is a strong relationship between hypertension and cigarette smoking with ischaemic stroke. A case control study was undertaken to see the association of hypertension and cigarette smoking with ischaemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age-and sex-matched control subjects. It was found that 60% patients of case group and 20% respondents of control group were hypertensive and diffrence was significant. Study showed that 56.66% of cases and 53.33% of controls were smoker and the findings were insignificant. The mean duration of smoking was 27.41 ± 2.98 years in cases and 15.63 ± 2.85 years in controls which was significant. The study suggests that hypertension is significantly associated with ischaemic stroke and longer duration of smoking also associated with ischaemic stroke. DOI: http://dx.doi.org/10.3329/bjmb.v3i1.13802 Bangladesh J Med Biochem 2010; 3(1): 16-18

scholarly journals Vitamin D and Parathyroid Hormone Status in Female Garment Workers: A Case-Control Study in Bangladesh

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Shakil Mahmood ◽  
Matiur Rahman ◽  
Subrata Kumar Biswas ◽  
Shaikh Nazmus Saqueeb ◽  
Shiblee Zaman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Control Group ◽  
Case Group ◽  
Serum Vitamin D ◽  
Garment Workers ◽  
Significant Difference ◽  
The Status ◽  
The Mean

Despite the abundant sunlight, vitamin D deficiency is prevalent in South Asian countries including Bangladesh. Information on vitamin D level is insufficient in adults particularly in female garment workers in Bangladesh. This study was designed to evaluate the status of vitamin D, parathormone (PTH), calcium, and alkaline phosphatase (ALP) among the female garment workers in Bangladesh. Blood samples were collected from female garment workers (n=40, case group) and general female workers (n=40, control group) in Dhaka. Serum vitamin D, PTH, calcium, and ALP were measured by chemiluminescence microparticle immunoassay. The mean level of vitamin D was significantly (p<0.001) lower in case (14.2±2.6 ng/mL) than in the control (22.4±2.4 ng/mL) group. No significant difference was found at mean of PTH and calcium between case (33.9±17.2 pg/mL;9.1±0.6 mg/dL, resp.) and control (35.9±16.3 pg/mL;9.3±0.6 mg/dL, resp.) group. The mean ALP in case (117.2±14.4 U/L) group was significantly (p<0.001) higher than the control group (80.5±30.6 U/L). Overall, PTH level did not show significant correlation with vitamin D. However, calcium and ALP levels showed a significant positive (p<0.05) and negative (p<0.001) correlation with vitamin D, respectively. This study indicates a high prevalence of vitamin D deficiency in the female garment workers in Bangladesh.

scholarly journals Folic acid deficiency related to hyperhomocystinemia has less correlation with Gestational Diabetes Mellitus (GDM)

2016 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Shamim Ara Begum ◽  
Ibrahim Khalil ◽  
Chanchal Kumar Mandal ◽  
Md Moynul Hasan ◽  
Mohammad Ali Kawsar
Keyword(s):  
Diabetes Mellitus ◽  
Folic Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Metabolic Enzyme ◽  
Control Group ◽  
Case Group ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
The Mean

Gestational diabetes mellitus (GDM) is a different degree of the glucose intolerance that begins during pregnancy. GDM affects maternal and child health and is associated with a potential for preeclampsia, caesarean delivery due to macrosomic baby and type 2 diabetes in the mother, and with higher rates of perinatal mortally and many abnormalities in the infant. Homocysteine is a naturally occurring amino acid. Hyperhomocysteinemia(Hcy) is increased homocysteine levels which are associated folic acid deficiency. Hcy is regulated by several factors including genetically determined metabolic enzyme alteration, nutritional status, underlying disease, certain medication, age and pregnancy. A total of (40 case+40control) 80 patients are included in this study, it was observed that majority 21(52.5%) patients were age belonged to 31-35 years in case group and 17(42.5%) patients were age belonged to 31-35 years in control group. The mean age was found 30.5±4.2 years in case group and 29.05±4.2 years in control group. Majority 19(47.5%) patients had 3rd gravida in case group and 20(50.0%) patients had 3rd gravida in control group. Majority patients BMI belonged to 25-29.9 kg/m2 (over weight) in both groups which was 21(52.5%) in case and 32(80.0%) in control group. The mean BMI was found 28.9±3.4 kg/m2 in case and 28.53±2.9 kg/m2 in control group. The difference was not statistically significant (p>0.05) between two groups. Studies have shown that folate deficiency is associated with increased homocysteine levels in blood.Update Dent. Coll. j: 2016; 6 (1): 01-07

scholarly journals Vitamin B 12: the hidden ingredient of stroke

2020 ◽  
Vol 8 (2) ◽  
pp. 644
Author(s):  
Mehul Prajapati ◽  
Labani M. Ghosh
Keyword(s):  
Risk Factors ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Case Group ◽  
Cerebral Stroke ◽  
Chi Square ◽  
Median Serum ◽  
Increased Risk

Background: Study aimed to evaluate the relationship between vitamin B12 and acute cerebral stroke in this study.Methods: Blood samples drawn within 24 hours after the stroke from hospitalized patients (n=100) and from 100 control cases matched for age, sex and other modifiable risk factors of stroke were analyzed. With a competitive, ECLIA, serum levels of vitamin B12 were measured. The quantitative data of the groups was compared using Analysis of Varience and Tukeys HSD post hoc test for comparison. Chi-square tests were used.Results: Median serum vitamin B12 levels were significantly lower in the patients than in the control subjects, 188.71 and 256.25 pg/ml respectively (p=0.0001). This difference was independent from other risk factors. The mean age in case group was 62.49 (SD: 12.45 years) and 56.62 (SD: 13.05 years) in control group with p=0.001. Therefore, prevalence of stroke is more between 6th and 7th decade of life. Mean serum vitamin B12 levels were lower in males (201.8pg/ml) than the females (268.pg/ml) in the case group.Conclusions: Low vitamin B12 is associated with an increased risk of stroke, and its relationship is independent from the other known modifiable stroke risk factors.

scholarly journals Serum Homocysteine, Vitamin B12, Folic Acid Levels and Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism in Vitiligo

2012 ◽  
Vol 33 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Ali Yasar ◽  
Kamer Gunduz ◽  
Ece Onur ◽  
Mehmet Calkan
Keyword(s):  
Folic Acid ◽  
Gene Polymorphism ◽  
Vitamin B12 ◽  
Significant Relationship ◽  
Gene Polymorphisms ◽  
Serum Vitamin ◽  
Mthfr Gene ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Mthfr Gene Polymorphism

The aim of this study was to determine serum vitamin B12, folic acid and homocysteine (Hcy) levels as well as MTHFR (C677, A1298C) gene polymorphisms in patients with vitiligo, and to compare the results with healthy controls. Forty patients with vitiligo and 40 age and sex matched healthy subjects were studied. Serum vitamin B12 and folate levels were determined by enzyme-linked immunosorbent assay. Plasma Hcy levels and MTHFR polymorphisms were determined by chemiluminescence and real time PCR methods, respectively. Mean serum vitamin B12 and Hcy levels were not significantly different while folic acid levels were significantly lower in the control group. There was no significant relationship between disease activity and vitamin B12, folic acid and homocystein levels. No significant difference in C677T gene polymorphism was detected. Heterozygote A1298C gene polymorphism in the patient group was statistically higher than the control group. There was no significant relationship between MTHFR gene polymorphisms and vitamin B12, folic acid and homocysteine levels. In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.

Serum Vitamin B12 and Folic Acid Levels in Hyperthyroidism

1979 ◽  
Vol 18 (06) ◽  
pp. 278-282 ◽  
Author(s):  
Matina Kesse-Elias ◽  
D. Koutras ◽  
P. Pandos ◽  
S. Papazoglou ◽  
S. Moulopoulos ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Mean Value ◽  
Clinical Index ◽  
The Mean ◽  
The Difference ◽  
Serum Folic Acid ◽  
Hyperthyroid Patients ◽  
Normal Controls

SummarySerum vitamin B12 and folic acid levels were measured in 48 hyperthyroid patients and in a group of euthyroid controls. The levels of vitamin B12 ranged from 120-900 pg/ml with a mean of 429.3 ± 30.9 pg/ml (SE). The mean serum vitamin B ? level was lower in hyperthyroid patients than in normal controls, the difference being statistically significant (t = 2.584, p < 0.025). Serum vitamin B12 levels showed a statistically significant negative correlation with the clinical index of Grooks et al. (r = 0.344, p < 0.05). The findings, although not excluding the involvement of auto-immune gastritis in patients with low serum vitamin B12 levels, suggest a direct action of increased thyroid hormone concentrations. Serum folic acid levels ranged from 0.5- 13.8 ng/ml with a mean of 6.8 ± 0.46 ng/ml (SE). The mean serum folic acid levels were higher in the hyperthyroid patients than in normal controls but the difference was not statistically significant (t = 1.2, p > 0.2). The serum folic acid levels did not show any statistically significant correlation with the clinical index of Grooks et al. The fact that no statistically significant difference was found between the mean value in hyperthyroid patients and the mean value in normal controls is probably due to the high folic acid intake in Greece.

scholarly journals Serum vitamin B12 and folic acid status in Autism spectrum disorder children

2020 ◽  
Vol 14 (2) ◽  
pp. 43-47
Author(s):  
Syeda Nusrat Mahruba ◽  
Shelina Begum ◽  
Shorifa Shahjadi ◽  
Sharmin Afroz ◽  
Umme Raihan Siddiqi ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Neurodevelopmental Disorder ◽  
Serum Vitamin ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Control Group ◽  
P Value ◽  
Healthy Children

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. The etiology of ASD involves gene-environmental interaction. Vitamin B12 and folic acid have important roles as methyl donor in many biosynthetic pathways, protein synthesis and formation of myelin sheath throughout the central nervous system. Therefore, deficiency of vitamin B12 and folic acid may act as environmental risk factor for ASD. Objective: To evaluate serum vitamin B12 and folic acid levels in ASD children. Methods: This cross-sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, from 2018 to 2019. Total 100 children 3-10 years of age were enrolled for this study.Among them fifty (50) diagnosed children with ASD were included in the study group. Fifty (50) healthy children constituted the control group. ASD children were selected from the Parent’s Forum for autistic children. No children were included receiving any vitamin supplementation or had acute illness. For this study, serum level of vitamin B12 and folic acid were measured by automated analyzer.For statistical analysis unpaired “t” test and chi square test were done. Result: The mean values of vitamin B12 and folic acid were significantly lower in ASD children than those of control group (p value <0.05). In addition 4% ASD children had vitamin B12 deficiency. Conclusion: Low serum vitamin B12 and folic acid was associated with ASD. J Bangladesh Soc Physiol. 2019, December; 14(2): 43-47

scholarly journals MRONJ and VIT D insufficiency

2021 ◽  
Author(s):  
Gholamreza Shirani ◽  
Arghavan Tonkaboni ◽  
Mina Mazani ◽  
Babak Mirzashahi ◽  
Abel Garcia Garcia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Osteonecrosis Of The Jaw ◽  
Control Group ◽  
Case Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Sex Type ◽  
The Mean

Background: medication related osteonecrosis of the jaw (MRONJ) is a chronic condition of the oral cavity resulting in mucosal ulceration and exposure of underlying necrotic bone, and the ensuing secondary complications. The aim of this study was to evaluate the relationship between vitamin D deficiency and osteonecrosis of the jaw related to bisphosphonates. Materials and methods: This was a case-control study. The samples were 20 patients taking bisphosphonates, that 10 of them were with MRONJ and 10 were non-MRONJ. Clinical examination of patients was performed to diagnose jaw osteonecrosis. Demographic data of the patients were recorded including age, sex, type of drug, duration and cause of drug intake, and measurement of serum vitamin D levels. Data were analyzed using SPSS software. Results: In the patients without MRONJ, the mean age was 60.60 (±14.975) years, and in the patients with MRONJ, the mean age was 68.30 (69.92) years. As a whole, of the 16 female patients in this study, 10 cases (62.5%) were non- MRONJ and 6 cases (37.5%) were suffered by MRONJ. All of the male patients presented with MRONJ. In control group mean of vitamin D was 63.990 ng/ml (±29.796) and in case group mean of vitamin D was 29.510 ng/ml (±23.723). The serum level of vitamin D (25-OHD) was significantly higher in control group than in the case group (p=0.010). Conclusion: According to our result, there were statistically significant relationship between age, sex, type of drug, vitamin D level, and MRONJ (p>0.05).

scholarly journals EVALUATING SERUM VITAMIN B12 LEVEL AS THE RISK FACTORS FOR STROKE: A PROSPECTIVE STUDY

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Shailendra Singh ◽  
Chetan Mathur ◽  
Hritu Singh ◽  
Shahid Abbas
Keyword(s):  
Vitamin B12 ◽  
Smoking Status ◽  
Serum Vitamin ◽  
General Medicine ◽  
General Information ◽  
Control Group ◽  
Case Group ◽  
Mixed Diet ◽  
Diabetes Status ◽  
A Prospective Study

Background: Hyperhomocysteinemia has been reported to be an independent risk factor for the development of stroke. Vitamin B12 is an important element of homocysteine metabolism. Aims and Objective: To compare the vitamin B12 level among the groups and compare it with the presence of hypertension, diabetes and smoking status. Materials and Methods: Ninety subjects were studied in the Department of General Medicine at Sri Aurobindo Medical College and PGI, Indore (M. P.) for one and half year from June-2015 to March-2016 after dividing them in to Cases (n=45; patients of ischemic stroke) and Control (n=45; subjects with no documented stroke). After recording general information on smoking/alcohol habit, hypertension and diabetes status, serum vitamin B12 level was assessed in all the subjects. Results: Vitamin B12 level (184.98±46.41 picomol/L) was greater in Case group as compared to Control group (639.62±157.43μmol/L) (p<0.001). Amongst those who had a stroke but had a habit of smoking/tobacco, had hypertension and diabetes diagnosed with very lowered vitamin B12 level (199.00±0.00 picomol/L, 176.00±31.21 picomol/L and 152.00±11.31 picomol/L) as compared to those without stroke. Tthose who had a stroke but had mixed diet had much lowered vitamin B12 level (188.71±54.63 picomol/L) as compared to control (592.69±143.71 picomol/L). Conclusion: Patients with stroke had lower level of vitamin B12 mainly in those with had a habit of smoking/tobacco, had hypertension, diabetes and had mixed diet as compared to those without stroke. Keywords: vitamin B12, stroke, hypertension, diabetes, smoking

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