scholarly journals Anti-hyperglycemic Effect of Stephania Glabra Tubers in Alloxan Induced Diabetic Mice

1970 ◽  
Vol 11 (1) ◽  
pp. 17-19 ◽  
Author(s):  
Deepak Kumar Semwal ◽  
Usha Rawat ◽  
Ruchi Badoni ◽  
Ravindra Semwal ◽  
Randhir Singh
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Key Words ◽  
Ethanolic Extract ◽  
Hypoglycemic Activity ◽  
Diabetic Mice ◽  
Antihyperglycemic Activity ◽  
Hypoglycemic Agent ◽  
Different Doses ◽  
Hyperglycemic Effect

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard. Key words: Stephania glabra, Menispermaceae, hydroxypalmatine, alloxan, glibenclamide, hypoglycemic activity DOI:10.3329/jom.v11i1.4262 J Medicine 2010: 11: 17-19

scholarly journals In vivo Neurological, Analgesic and In vitro Antioxidant and Cytotoxic Activities of Ethanolic Extract of Leaf and Stem Bark of Wedelia chinensis

2019 ◽  
Vol 22 (1) ◽  
pp. 18-26
Author(s):  
Sayema Khanum ◽  
Md Shahid Sarwar ◽  
Mohammad Safiqul Islam
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Pharmaceutical Journal ◽  
Stem Bark ◽  
Cytotoxic Activities

Wedelia chinensis is a widely used anti-inflammatory and hepatoprotective medicinal plant in Bangladesh. In this study, analgesic, neurological, antioxidant and cytotoxic activities of the ethanolic extract of leaf and stem bark of W. chinensis were investigated. Oral administration of the ethanolic extract of W. chinensis (200- and 300-mg/kg body weight) was investigated on animal model for neurological activity using open field test and hole cross test. Acetic acid induced writhing method was used to assess the analgesic activity. DPPH (1,1-diphenyl, 2-picryl hydrazyl) radical scavenging assay was used for determining the antioxidant activity, while brine shrimp lethality bioassay was used for investigating cytotoxicity. The ethanol extract of the plant produced significant reduction (P<0.05) of locomotion in both doses (200- and 300-mg/kg body weight) indicating pronounced neurological activity. Oral administration of alcoholic leaves and stem extracts significantly (p < 0.05) inhibited writhing response in mice. The percentage of scavenging of DPPH free radical was found to be concentration dependent with IC50 value of 44.10 ± 0.65 and 38.96 ± 0.50 μg/ml for leaves and stem extracts, respectively. Our findings indicate that W. chinensis may be a source of natural antioxidant with potent analgesic, neurological and cytotoxic activities. Bangladesh Pharmaceutical Journal 22(1): 18-26, 2019

scholarly journals Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice

Dose-Response ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 155932581985250 ◽  
Author(s):  
Sodah Bint Mustafa ◽  
Muhammad Akram ◽  
Hafiz Muhammad Asif ◽  
Imran Qayyum ◽  
Asif Mehmood Hashmi ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Plant Extracts ◽  
Therapeutic Potential ◽  
Curcuma Longa ◽  
Diabetic Mice ◽  
Aegle Marmelos ◽  
Antihyperglycemic Activity ◽  
Lavandula Stoechas

Background: Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance, characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete hyperglycemia in patients with diabetes. The present study was conducted to explore the therapeutic potential of selected medicinal plants for the treatment of diabetes as an alternative to allopathic medicines. Method: In present study, hydroalcoholic extracts of Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and their polyherbal preparation (PHP) as compound drug were investigated for their antihyperglycemic potential in alloxan-induced diabetic mice. The study subjects (mice) were divided into different groups as normal control, diabetic control, pioglitazone treated (standard drug), test groups (plant extract treated 50, 100, and 150 mg/kg body weight), and PHP-treated group. Blood glucose concentration of all the study animals was determined by Glucose strip test. Qualitative phytochemical analysis of all the plant extracts was also performed following standard methods. Result: It was investigated that treatment of alloxan-induced diabetic mice with hydroalcoholic extracts of studied medicinal plants showed significant ( P < .05) effects on fasting blood glucose levels (from baseline to normal range) in a manner comparable to that of the reference drug, pioglitazone (1 mg/kg body weight intraperitoneal). The tested plant extracts significantly ( P < .05) reduced the glucose concentration in blood of diabetes-induced mice in a dose-dependent manner. Conclusion: It could be concluded that studied medicinal plants have antihyperglycemic activity. The study findings favor the use of traditional herbal medicinal practices for the management of diabetes that might due to the presence of bioactive phytoconstituents in plants. However, larger studies are required to identify, isolate, and characterize the bioactive phytoconstituents responsible for antihyperglycemic activity of studied medicinal plants.

scholarly journals Effect of garlic and ginger extracts on the levels of glucose and Peptide-c in diabetic mice: تأثير مستخلصي الثوم والزنجبيل في مستوى سكر الدم والببتيد c عند الفئران المستحدث عندها داء السكري

2021 ◽  
Vol 5 (4) ◽  
pp. 119-105
Author(s):  
Hiam Kamel Fadil, Kholoud Mostafa Sheikh Yousef Hiam Kamel Fadil, Kholoud Mostafa Sheikh Yousef
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Physiological Saline ◽  
Alcoholic Extract ◽  
Diabetic Mice ◽  
Physiological Control ◽  
Fourth Group ◽  
The Third ◽  
Hypoglycemic Agent

This study aimed to investigate the effect of the alcoholic extract of garlic and ginger together on the levels of glucose, peptide -c and body weight in diabetic white mice. The study included 40 male white mice, Balb/c strain, which were divided into four experimental groups (10 mice in each group). The first group was a physiological control that was injected with physiological saline (0.9%) until the end of the experiment. As for the second group, diabetes was induced with a dose of 200 mg/kg of Alloxan hydrate weight of the mouse only, while the third group developed diabetes, and then it was treated with alcoholic extract of garlic and ginger together at a dose of 500 mg/kg of mouse weight for 10 days. While the fourth group developed diabetes and was treated with Glibenclamide. At the end of the experiment, the animals were anesthetized and blood was drawn from them by cardiocentesis. The results showed the effectiveness of garlic and ginger extracts in reducing blood glucose concentration by 35.75% and returning Peptide-c levels to their normal levels, equivalent to Glibenclamide (glyburide), which is known as an oral hypoglycemic agent.

THE INFLUENCE OF GILT AGE ON THE ENDOCRINE AND OVULATORY RESPONSE TO DIFFERENT DOSES OF ESTRADIOL BENZOATE

1988 ◽  
Vol 68 (3) ◽  
pp. 979-982 ◽  
Author(s):  
R. N. KIRKWOOD ◽  
F. X. AHERNE
Keyword(s):  
Body Weight ◽  
Luteinizing Hormone ◽  
Key Words ◽  
Jugular Vein ◽  
Estradiol Benzoate ◽  
Blood Samples ◽  
Estrous Cyclicity ◽  
The Mean ◽  
Different Doses ◽  
Phasic Release

Fifty-five prepubertal Yorkshire × Landrace gilts were randomly assigned to one of six treatments involving the injection (i.m.) of estradiol benzoate (EB) at either 10 or 20 μg kg−1 body weight at gilt ages of 130, 150 or 170 d. Blood samples were taken by jugular vein puncture at 0, 24, and 36 h, and then at 6-h intervals until 84 h, after injection and assayed for plasma luteinizing hormone (LH) concentrations. The mean magnitude of the EB-induced LH peak was 6.1 ± 0.2 ng mL−1, and was not affected by treatment. Fifty-six percent of gilts ovulated in response to EB injection, and 34% had a subsequent ovulation. The initial ovulation rate was unaffected by EB dose, but was higher (P < 0.05) in 170 d (9.9 ± 1.0) compared to younger gilts (4.2 ± 1.1 and 5.5 ± 1.1 for 130-dand 150-d gilts, respectively). Subsequent ovulation rates were unaffected by treatment. It is concluded that EB treatment will usually induce a phasic release of LH from prepubertal gilts, but this release is not necessarily accompanied by normal estrous cyclicity. Key words: Estradiol, gilts, ovulation

scholarly journals The Antioxidant Effect of Medicago sativa L. (Alfalfa) Ethanolic Extract against Mercury Chloride (HgCl2) Toxicity in Rat Liver and Kidney: An In Vitro and In Vivo Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
M. Raeeszadeh ◽  
M. Moradi ◽  
P. Ayar ◽  
Abolfazl Akbari
Keyword(s):  
Body Weight ◽  
Medicago Sativa ◽  
Ethanolic Extract ◽  
The Body ◽  
Control Group ◽  
Mercury Chloride ◽  
Dependent Manner ◽  
Histopathological Evaluation ◽  
Medicago Sativa L ◽  
Different Doses

Heavy metals such as mercury are some of the environmental pollutants and can induce toxicity by bioaccumulation and oxidative damage. This study aimed to investigate the effect of ethanolic extract of Medicago sativa L. (Alfalfa) on mercury damage in the kidney and liver of rats. Thirty Wistar rats were randomly divided into five groups, the control group, S group (2 mg/kg mercury chloride), and T1, T2, and T3 groups that, in addition to mercury, received doses of 250, 500, and 750 mg/kg of the alfalfa extract. On the last day, blood samples were taken, and the serum was separated to measure biochemical and oxidative stress parameters in the kidney and liver. A part of the kidney and liver was also used for histopathological evaluation. Total phenols and flavonoids were 40.45 ± 2.12 and 14.36 ± 0.45 mg/g, respectively, whereas IC50 was 245.18 ± 19.76 μg/ml. The body weight significantly decreased in the S group compared to other groups, while treatment with different doses of alfalfa extract increased the body weight. Mercury concentration in the kidney was higher than that in the liver. The serum levels of urea, creatinine, alanine aminotransferase (ALT), and alkaline phosphatase (ALP) significantly increased in the S group compared to the control group, while treatment with different doses of alfalfa extract increased their levels. Moreover, an increase in malondialdehyde (MDA) and a decrease in glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activity were observed in the S group. The level of these parameters significantly improved in the groups receiving the extract compared to the S group. Furthermore, the histopathological evaluation showed glomerular and tubular damage and hepatic necrosis in the S group and that these conditions improved in the T3 group. The findings of this study showed that the ethanolic extract of alfalfa in a dose-dependent manner has potentially unique protective effects against mercury poisoning in the kidney and liver.

scholarly journals Antidiabetic Activities of Hydromethanolic Leaf Extract of Calpurnia aurea (Ait.) Benth. Subspecies aurea (Fabaceae) in Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Yaschilal Muche Belayneh ◽  
Eshetie Melese Birru
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Leaf Extract ◽  
The Body ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Diabetic Dyslipidemia ◽  
Dose Administration ◽  
Antihyperglycemic Activity ◽  
Daily Dose

Diabetes mellitus is one of the largest global health problems demanding preventive and new therapeutic interventions. Currently, there is a need for safe, effective, and less costly antidiabetic medications, and investigating medicinal plants for new antidiabetic medication is an interesting research area. Thus, the present study was done to evaluate the antidiabetic activities of 80% methanolic leaf extract of Calpurnia aurea (Ait.) Benth. subspecies aurea (Fabaceae) in mice. Hypoglycemic and antihyperglycemic activity of the three doses (100mg/kg, 200 mg/kg, and 400 mg/kg) of crude hydromethanolic leaf extract was studied on normoglycemic, oral glucose loaded, and streptozotocin-induced diabetic mice models. The effect of the extract on body weight and diabetic dyslipidemia was also studied on streptozotocin-induced diabetic mice. Glibenclamide (5 mg/kg) was used as a standard drug in all cases. A glucose meter and an automated chemistry analyzer were used to measure blood glucose and serum lipid level respectively. Data were analyzed using one-way analysis of variance followed by Tukey’s post hoc multiple comparison test. All the three doses of the plant extract (100mg/kg, 200 mg/kg, and 400 mg/kg) showed a significant (p<0.05) antihyperglycemic activity in the diabetic mice at the 7th and 14th day of repeated daily dose administration as compared to the negative diabetic control. But, the extract did not show significant blood glucose lowering activity in normoglycemic, oral glucose loaded, and diabetic mice after single dose administration, and it did not significantly improve the body weight loss and diabetic dyslipidemia of diabetic mice after repeated daily dose administration for 14 days. This study revealed that the hydromethanolic extract of Calpurnia aurea leaves possesses significant antihyperglycemic activity justifying the traditional use of the plant for diabetes.

HYPOGLYCEMIC ACTIVITY OF ETHANOLIC EXTRACT OF SAURAUIA VULCANI KORTH. LEAVES

2018 ◽  
Vol 11 (13) ◽  
pp. 35 ◽  
Author(s):  
Panal Sitorus ◽  
Rosidah Rosidah ◽  
Rosidah Rosidah ◽  
Rosidah Rosidah ◽  
Denny Satria ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Leaf Powder

 Objective: The aim of this study was to investigate the hypoglycemic activity of ethanol extract of Saurauia vulcani Korth. leaves.Methods: S. vulcani Korth. leaf powder was extracted by maceration method with ethanol 96%. Hypoglycemic activity was examined on rats which is induced with streptozotocin 40 mg/Kg body weight (BW) at dose of 50; 100; and 200 mg/Kg BW.Results: Hypoglycemic activity of the extract in diabetic rats showed a significant reduction in blood glucose levels (p<0.001) at dosage 50 mg/Kg BW.Conclusion: The results reveal that ethanol extract of S. vulcani Korth. leaves has hypoglycemic activity. Our further study is to assess mechanism action as antidiabetic.

scholarly journals Anti-hyperglycemic activity of Heliotropium strigosum (Boraginaecae) whole plant extract in alloxan-induced diabetic mice

2017 ◽  
Vol 16 (10) ◽  
pp. 2425-2430
Author(s):  
Huma Aslam ◽  
Arif-ullah Khan ◽  
Najeeb-ur- Rehman ◽  
Fawad Ali ◽  
Humaira Nadeem ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Whole Plant ◽  
Hyperglycemic Effect

Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce the blood glucose level of alloxan-induced diabetic mice.Methods: Preliminary phytochemical analysis was carried out using standard  procedures. Diabetes was induced in Balb/c mice by injecting alloxan (200 mg/kg i.p.). The crude methanol extract of Heliotropium strigosum (Hs.Cr, 30, 100 and 300 mg/kg doses) was administered daily to alloxan-induced diabetic mice for 15 days and its effect on fasting blood glucose levels, body weight and oral glucose tolerancewas evaluated. Two control groups (non-diabetic control and diabetic control)  received normal saline (0.2 ml). Metformin (500 mg/kg) was used as reference standard.Results: Heliotropium strigosum showed positive for the presence of alkaloids, tannins and flavonoids. The extract (30, 100 and 300 mg/kg) caused significant reduction in the fasting blood glucose level of alloxan-induced diabetic mice on days 5, 10 and 15 compared to diabetic control (p < 0.001). In this regard, the  anti-hyperglycemic effect compared to the reference (metformin). The extract also timedependently decreased the body weight of the treated animals as well as improved tolerance of the oral glucose overload.Conclusion: These results indicate that Heliotropium strigosum possesses  anti-hyperglycemic effect, reduces body weight and enhances the tolerance of  glucose overload in mice. Further studies are therefore required to determine its  feasiilty as an alternate herbal medicine in the management of diabetes in humans.Keywords: Heliotropium strigosum, Anti-hyperglycemic, Alloxan-induced diabetic mice, Blood glucose, Oral glucose tolerance, Body weight

scholarly journals Hepatoprotective effects of ethanol extract of Caesalpiniabonduc against carbon tetrachloride induced hepatotoxicity in Albino Rats

2016 ◽  
Vol 20 (2) ◽  
pp. 396-401
Author(s):  
A.E. Ubhenin ◽  
I Igbe ◽  
F.A. Adamude ◽  
A Falodun
Keyword(s):  
Body Weight ◽  
Carbon Tetrachloride ◽  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Serum Marker ◽  
Albino Rats ◽  
Different Doses

The present study was carried out to evaluate the Acute toxicity, hepatoprotective and in-vivo antioxidant activities of ethanolic extract of Caesalpinia bonduc leaf on carbon tetrachloride (CCl4) induced liver damage using Swiss albino rats . The ethanolic extract of the plant of C. bonduc were suspended in 5 % tragacanth and then administered orally at doses of 250 and 500 mg/kg body weight for fourteen days before intraperitoneally injection of Carbon tetrachloride (CCl4) at dose of 2 mL/kg body weight. The plant extracts at 250 and 500mg/kg b.wt showed a remarkable hepatoprotective and invivo antioxidant activities against carbon tetrachloride CCl4 – induced hepatotoxity judged from the serum marker enzymes .The CCl4 induced significant increase in aspartate amino transferase( AST), alanine amino transferase (ALT), alkaline phophatase (ALP), total bilirubin, and malondyaldehyde (MDA) with a reduction of total protein, catalase, and glutathione peroxidase . Treatment of rats with different doses of plant extract (250 and 500 mg/kg b.wt.) significantly (P< 0.001) altered serum maker enzymes and antioxidant levels to near normal levels. The study suggests that C. Bonduc specifically chloroform and ethyl acetate fraction may be good sources of natural antioxidant and hepatoprotective substance.Keywords: Ceasalpiniabonduc, hepatoprotective, intraperitoneally , antioxidant

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