scholarly journals REPARAÇÃO DO TENDÃO CALCÂNEO EM RATOS APÓS TENOTOMIA E TRATAMENTO POR ABELMOSCHUS ESCULENTUS LINN E ULTRASSOM TERAPÊUTICO

2019 ◽  
Vol 8 (1) ◽  
pp. 41-55
Author(s):  
Gabriel Martins de Barros ◽  
Monaliza Sousa dos Anjos ◽  
Antônio Luiz Martins Maia Filho ◽  
Wellington Dos Santos Alves ◽  
Valdiléia Teixeira Uchôa ◽  
...  
Keyword(s):  
Tendon Repair ◽  
Repair Process ◽  
Treated Group ◽  
Abelmoschus Esculentus ◽  
Control Group ◽  
Adjuvant Effect ◽  
Calcaneal Tendon ◽  
Significance Level ◽  
Male Wistar Rats ◽  
One Way Anova

Este estudo objetivou comparar o efeito da reparação tendínea por Abelmoschus esculentus Linn (AEL) e ultrassom terapêutico (US) em modelo experimental de tenotomia. Foram selecionados 40 ratos machos Wistar que passaram por uma tenotomia na pata direita sendo tratados durante 7 e 14 dias consecutivos, os animais foram divididos em grupos com tratamento de AEL por via tópica, US, conjunto das duas terapias, além do grupo controle. Após o tratamento os tendões foram removidos para análise histológica, sendo realizado a contagem de células inflamatórias e fibroblásticas. A análise estatística foi feita através da variação do número de células no respectivo grupo, utilizando a análise de One Way ANOVA seguido pelo teste de Newman-keuls com nível de significância de 5% (p0,05). Nos resultados foi visto a redução significativa (p0,05) de células polimorfonucleadas do grupo tratado com US + AEL em relação ao grupo controle no tempo de 14 dias. Em relação ao número de células fibroblásticas houve aumento significativo nos grupos tratados com sonoforese em relação ao grupo controle em 7 e 14 dias. Nos outros grupos não houve diferenças significativas. A terapia com US e AEL mostrou efeito adjuvante no processo de reparo do tendão, demostrando eficácia da sonoforese com AEL.Palavras-chave: Ratos Wistar. Tendinite. Quiabo. Terapia por Ultrassom. Fonoforese. REPAIR OF THE CALCANEAL TENDON IN RATS AFTER TENOTOMY AND TREATMENT BY ABELMOSCHUS ESCULENTUS LINN AND THERAPEUTIC ULTRASOUNDABSTRACT: This study aimed to compare the effect of tendon repair by Abelmoschus esculentus Linn (AEL) and therapeutic ultrasound (US) in an experimental model of tenotomy. A total of 40 male Wistar rats were submitted to a tenotomy in the right paw and were treated for 7 and 14 consecutive days. The animals were divided into groups with AEL treatment topical, US, all of the therapies, as well as the control group. After the treatment, the tendons were removed for histological analysis, counting inflammatory and fibroblast cells. Statistical analysis was done by varying the number of cells in the respective group, using One Way ANOVA followed by Newman-keuls test with significance level of 5% (p0.05). The results showed a significant reduction (p 0.05) in polymorphonucleated cells from the US + AEL treated group compared to the 14-day control group. In relation to the number of fibroblastic cells there was a significant increase in the groups treated with phonophoresis in relation to the control group in 7 and 14 days. There were no significant differences in the other groups. US and AEL therapy showed an adjuvant effect on the tendon repair process, demonstrating the efficacy of phonophoresis with AEL.Keywords: RatsWistar. Tendinopathy. Abelmoschus. Ultrasonic Therapy. Phonophoresis.

scholarly journals Amniotic membrane applied to burns healing: Pre-clinical study

2021 ◽  
Vol 10 (4) ◽  
pp. 38110414286
Author(s):  
Fernanda Cláudia Miranda Amorim ◽  
Emilia Ângela Loschiavo Arisawa ◽  
Luciana Barros Sant’Anna ◽  
Khetyma Moreira Fonseca ◽  
Davidson Ribeiro Costa ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Healing Process ◽  
Inflammatory Cells ◽  
Repair Process ◽  
Treated Group ◽  
Preclinical Study ◽  
Control Group ◽  
Human Amniotic Membrane ◽  
Significance Level ◽  
Kolmogorov Smirnov

This preclinical study aimed to evaluate the tissue repair process of burns treated with human amniotic membrane (hAM) patches in rats. Twenty-four rats were subjected to superficial burns of partial thickness, and randomly allocated into two groups: Control and Treated Group, subdivided into two experimental periods of 7th and 14th days. The lesions were evaluated by digitalized images (macroscopy) and by the analysis of histological sections stained in H&E to quantify the number of inflammatory cells and fibroblasts present in the different experimental times (histomorphometry). The histomorphometric analyses were performed blindly. Statistical analysis employed Kolmogorov-Smirnov and Mann Whitney tests, with 95% confidence interval at 5% significance level (p <0.05). Macroscopically, the lesions of Treated group presented a crust formation before Control Group, and there were no signs of infection in both groups. Microscopically, the qualitative analysis showed a faster evolution in the healing process of the Treated groups compared to the Control, with reduction of the inflammatory infiltrate, intense fibroblasts proliferation and better organization of the collagen fibers. The quantitative analysis showed statistically significant results regarding the reduction of inflammatory cells (p<0.0001) at 7th and 14 th day and increased proliferation of fibroblasts at 14th day (p<0.0001) in lesions treated with hAM compared to Control group. The results of this preclinical study demonstrated that the application of hAM patches reduces the inflammatory process and accelerates the onset of the proliferative phase in burn injuries.

scholarly journals Effects of proportional high-protein/low-carbohydrate formulated diet consumption in diabetic rats: Beneficial impact on glycemic and weight control

2020 ◽  
Vol 20 (07) ◽  
pp. 16984-16996
Author(s):  
MMC Anyakudo ◽  
◽  
DO Adeniji ◽  
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Treated Group ◽  
Morphological Features ◽  
High Protein ◽  
Control Group ◽  
Formulated Diet ◽  
Low Carbohydrate ◽  
Male Wistar Rats ◽  
And Control

The metabolic response to nutrient ingestion and the rate of digestion and absorption of nutrient molecules in bowel physiology plays an important role in the metabolic control of some human chronic non-infectious diseases. This experimentally-controlled designed nutritional study which lasted eight weeks aimed to determine the effects of proportional high-protein/low-carbohydrate (HP/LC) formulated diet on glycemic tolerance, glycemic control, body weight, organ weight and organ morphometry in healthy and diabetic adult male Wistar rats. Twenty-four male Wistar rats purchased from a disease-free stock were randomly categorized into four groups (n = 6, each) after two weeks acclimatization period in raised stainless steel cages with 6 mm2mesh floor and replaceable numbered blotters papers placed under each cage in a well-ventilated animal house. Animal groups include: Healthy control group (HC), Healthy treated group (HT), Diabetic control group (DC) and Diabetic treated group (DT. The animals were fed according to the experimental design with water ad libitumfor eight weeks. Diabetes was inducted with freshly prepared alloxan monohydrate solution (150 mg/kg bw, intraperitoneally). Body weights and fasting blood sugar concentrations were measured twice weekly, while oral glucose tolerance test was conducted on the last day of the eighth-week study and subsequently followed by organs extraction after anesthesia for weight and gross assessment. Proportional high-protein/low-carbohydrate formulated diet caused significant reduction in mean body weight of treated diabetic (DT: 22.6%; P= .001) and healthy (HT: 5.8%; P= .007) rats while the control animals on control diet recorded significant (P< .05) increase in body weight gain (DC: 12.4%; HC: 11.2%). Glycemic tolerance and control improved significantly in diabetic treated rats over that of the healthy treated rats. Gross morphometry of the extracted organs (kidneys, liver, heart, lungs, spleen and testes) revealed sustained normal morphological features without any visible lesion. In conclusion, consumption of proportional high-protein/low-carbohydrate formulated diet enhanced body weight reduction and sustained normal organ morphological features with good glycemic tolerance and control in experimental rats, suggesting its dietary potentiality, safety and suitability to ameliorate obesity-related diabetes.

scholarly journals Effect of Pistacia atlantica subsp. kurdica Gum in Experimental Periodontitis Induced in Wistar Rats by Utilization of Osteoclastogenic Bone Markers

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5819
Author(s):  
Shokhan H. Azeez ◽  
Shanaz M. Gaphor ◽  
Aram M. Sha ◽  
Balkees T. Garib
Keyword(s):  
Wistar Rats ◽  
Bone Markers ◽  
Inflammatory Cells ◽  
Treated Group ◽  
Surrounding Tissue ◽  
Control Group ◽  
Pistacia Atlantica ◽  
Male Wistar Rats ◽  
Experimental Periodontitis ◽  
Serum Rankl

The aim of this study was to assess the effect of local application of essential oil of Pistacia atlantica kurdica (EOK) gel in treatment of experimentally induced periodontitis in rats and its effect on osteoclastogenic bone markers. Twenty-four male Wistar rats of 250 to 350 g were used in this study and were allocated into four groups. Control negative (without induced periodontitis), control positive (induced experimental periodontitis left without treatment), treatment control (induced experimental periodontitis and treated with Chlorhexidine gel) and EOK treated group (induced experimental periodontitis treated with EOK gel). The animals were sacrificed after 30 days, and the mandibular central incisor and surrounding tissue were dissected from the mandible and further processed for preparing H&E slides. Inflammatory cells, osteoclast cells, and periodontal ligament (PDL) were examined and measured histologically. Finally, the mean concentrations of both markers, receptor activator of nuclear factor kappa-Β ligand (RANKL) and (Interleukin-1β) IL-1β, were analyzed by ELISA. A significant reduction of inflammatory reaction and osteoclast numbers with improvement of PDL and low mean concentrations of RANKL and IL-1β were seen in the EOK treated group in comparison to the control group and the chlorhexidine group as well. The extract showed a protective effect in the healing of periodontitis that had been induced in rats and decreased bone resorption by down regulation of serum RANKL and IL-1β markers.

scholarly journals Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Araceli Diaz-Ruiz ◽  
Patricia Vacio-Adame ◽  
Antonio Monroy-Noyola ◽  
Marisela Méndez-Armenta ◽  
Alma Ortiz-Plata ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Frontal Cortex ◽  
Neurological Deficit ◽  
Neuroprotective Effect ◽  
Treated Group ◽  
Neurological Deficits ◽  
Control Group ◽  
Ischemia And Reperfusion ◽  
Male Wistar Rats ◽  
Neuroprotective Treatment

After transient cerebral ischemia and reperfusion (I/R), damaging mechanisms, such as excitotoxicity and oxidative stress, lead to irreversible neurological deficits. The induction of metallothionein-II (MT-II) protein is an endogenous mechanism after I/R. Our aim was to evaluate the neuroprotective effect of MT-II after I/R in rats. Male Wistar rats were transiently occluded at the middle cerebral artery for 2 h, followed by reperfusion. Rats received either MT (10 μg per rat i.p.) or vehicle after ischemia. Lipid peroxidation (LP) was measured 22 h after reperfusion in frontal cortex and hippocampus; also, neurological deficit was evaluated after ischemia, using the Longa scoring scale. Infarction area was analyzed 72 hours after ischemia. Results showed increased LP in frontal cortex (30.7%) and hippocampus (26.4%), as compared to control group; this effect was fully reversed by MT treatment. Likewise, we also observed a diminished neurological deficit assessed by the Longa scale in those animals treated with MT compared to control group values. The MT-treated group showed a significant (P<0.05) reduction of 39.9% in the infarction area, only at the level of hippocampus, as compared to control group. Results suggest that MT-II may be a novel neuroprotective treatment to prevent ischemia injury.

scholarly journals Neurotoxic Effects of Stanozolol on Male Rats‘ Hippocampi: Does Stanozolol cause apoptosis?

2019 ◽  
Vol 10 (1) ◽  
pp. 73-81
Author(s):  
Faezeh Nemati Karimooy ◽  
Alireza Ebrahimzadeh Bideskan ◽  
Abbas Mohammadi Pour ◽  
Seyed Mahmoud Hoseini
Keyword(s):  
Histopathological Examination ◽  
Apoptotic Cell ◽  
Cell Formation ◽  
Treated Group ◽  
Male Rats ◽  
Control Group ◽  
Cell Detection ◽  
Apoptotic Effect ◽  
Male Wistar Rats ◽  
The Mean

AbstractStanozolol is an anabolic-androgenic steroid which is commonly abused by athletes for improved energy, appearance, and physical size. It has been previously shown to cause changes in behaviour and has various physical effects. Studies have previously been conducted on its neurotoxic effect on the central nervous system (CNS), which are typically psychological in nature. This study was performed to investigate the apoptotic effect of stanozolol on different parts of the rat hippocampus. Sixteen male Wistar rats were divided randomly into two groups (experimental and control). The experimental group received subcutaneous injections of stanozolol (5mg/kg/day) for consecutive 28 days, whereas the control group received saline using the same dosing schedule and administration route. After routine procedures, coronal sections of rat brain were stained with Toluidine blue and TUNEL for pre-apoptotic and apoptotic cell detection, respectively. In order to compare groups, the mean number of TUNEL-positive and pre-apoptotic neurons per unit area were calculated and analysed. Histopathological examination revealed that the mean number of pre-apoptotic and apoptotic neurons in the CA1, CA2, CA3 and DG areas of the hippocampus were significantly increased in the stanozolol treated group. In conclusion, stanozolol abuse may induce pre-apoptotic and apoptotic cell formation in different regions of the hippocampus.

scholarly journals Impact of synbiotic diets including inulin, Bacillus coagulans and Lactobacillus plantarum on intestinal microbiota of rat exposed to cadmium and mercury

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Dornoush Jafarpour ◽  
Seyed Shahram Shekarforoush ◽  
Hamid Reza Ghaisari ◽  
Saeid Nazifi ◽  
Javad Sajedianfard
Keyword(s):  
Heavy Metals ◽  
Intestinal Microbiota ◽  
Anaerobic Bacteria ◽  
Bacillus Coagulans ◽  
Treated Group ◽  
Inhibitory Effect ◽  
Control Group ◽  
Standard Diet ◽  
Male Wistar Rats ◽  
Group 1

The aim of this study was to investigate the efficacy of two probiotics and a prebiotic (inulin) on intestinal microbiota of rats exposed to cadmium and mercury. Fifty-four male Wistar rats were randomly divided into nine groups. All groups except control group were fed standard rat chow with 5% inulin and treated as follows: i) control (standard diet), ii) <em>Lactobacillus</em> <em>plantarum</em>- treated group (1×109 CFU/day), iii) <em>Bacillus</em> <em>coagulans</em>-treated group (1×109 spores/day), iv) cadmium-treated group (200 μg/rat/day), v) L. plantarum and cadmium-treated group, vi) <em>B. coagulans</em> and cadmium-treated group, vii) mercury-treated group (10 μg/rat/day), viii) <em>L. plantarum</em> and mercurytreated group, ix) <em>B. coagulans</em> and mercurytreated group. Cadmium, mercury and probiotics were daily gavaged to individual rats for 42 days. Treatment effects on intestinal microbiota composition of rats were determined. Data showed that cadmium and mercury accumulation in rat intestine affected the gastrointestinal tract and had a reduction effect on all microbial counts (total aerobic bacteria, total anaerobic bacteria, total Lactic acid bacteria, <em>L. plantarum</em> and <em>B. coagulans</em> counts) compared to the control group. It was also observed that application of synbiotics in synbiotic and heavy metals-treated groups had a significant effect and increased the number of fecal bacteria compared to the heavy metals groups. Based on our study, it can be concluded that <em>L. plantarum</em> and <em>B. coagulans</em> along with prebiotic inulin play a role in protection against cadmium and mercury inhibitory effect and have the potential to be a beneficial supplement in rats’ diets.

scholarly journals Toxicology of Lapachol in rats: embryolethality

2001 ◽  
Vol 61 (1) ◽  
pp. 171-174 ◽  
Author(s):  
M. de O. GUERRA ◽  
A. S. B. MAZONI ◽  
M. A. F. BRANDÃO ◽  
V. M. PETERS
Keyword(s):  
Therapeutic Potential ◽  
Treated Group ◽  
Vehicle Group ◽  
Control Group ◽  
Corpora Lutea ◽  
Water Control ◽  
Chi Square ◽  
Significance Level ◽  
Chi Square Test ◽  
Teratogenic Potential

Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, l5 and 21 and food intake on days 2, 6, 15 and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were analyzed by ANOVA-one way, Dunnett test and the chi square test. Significance level test alpha = 0.05. Results have shown that mothers were unaffected but there were a 99.2% of fetus mortality, indicative of a strong abortifacient effect of Lapachol in rats.

scholarly journals Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level

2020 ◽  
Vol 3 (1) ◽  
pp. 172-177
Author(s):  
Hesty Wahyuningsih ◽  
Andina Putri Aulia
Keyword(s):  
Liver Injury ◽  
Brassica Oleracea ◽  
Control Group ◽  
Drug Induced ◽  
Red Cabbage ◽  
Drug Induced Liver Injury ◽  
Post Test ◽  
Male Wistar Rats ◽  
Post Hoc ◽  
One Way Anova

Red cabbage (Brassica oleracea var. Capitata f. Rubra) is a vegetable widely used in Indonesian cuisine. Red cabbage is rich in anthocyanins to reduce SGPT levels in drug-induced liver injury (DILI). This study aims to determine the effect of red cabbage juice on SGPT levels in acetaminophen-induced liver injury. In this post-test, only the control group study, male Wistar rats (300g), were randomly divided into 5 groups (K1-K2-K3-K4-K5). Acetaminophen was given to induce liver injury in rats. The rats were treated with the cabbage juice (at the dose of 0.5g/ml or 0.7g/ml or 0.9g/ ml. Data were analyzed using One way ANOVA and LSD post hoc test. Mean SGPT levels for K1, K2, K3, K4, K5 was 58.43 ± 7.18 UI / L, 71.20 ± 9.13 UI/L, 55.73 ± 9.51 UI / L, 72.80 ± 3.47 UI /L, 72.63 ± 3.01 UI /L, respectively. One way ANOVA resulted in p=0.00 (p <0.05). The post hoc LSD test showed significant differences (P <0.05) between all groups except between groups K1-K3, K2-K4, and K2-K5 (p> 0.05). Red cabbage juice can reduce SGPT in acetaminophen-induced liver injury in rats. The most effective dose was 0.5 g/ml.

scholarly journals Study of Hyperbaric Oxygen Theraphy and Gold sea Cucumber (Stichopus Hermanii) 3% for Collagen Density of Rat’s with Diabetes Mellitus Induced by Porphyromonas Gingivalis Bactery

DENTA ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 73
Author(s):  
Dyah Lestarining R ◽  
Dian Mulawarmanti ◽  
Widyastuti Widyastuti
Keyword(s):  
Hyperbaric Oxygen ◽  
Periodontal Ligament ◽  
Healing Process ◽  
Control Group ◽  
Therapeutic Effects ◽  
Chi Square ◽  
Significance Level ◽  
Male Wistar Rats ◽  
Collagen Density ◽  
Ligament Healing

<p><strong><em>Background:</em></strong><em> Periodontitis is complication of DM in chronic state. Periodontitis susceptibility increase threefold in patient DM compared non-DM. Debridement with SRP alone is less effective in DM</em><em>. Hyperbaric Oxygen Therapy (HBO) has the effect of increasing insulin sensitivity and synthesis of collagen. Collagen is the largest extracellular matrix supporting periodontal tissue. Stchopus hermanii contains condrotin sulfate serves to inhibit the formation of mixed periodontopatogen bacteri. <strong>Purpose:</strong> To determine the therapeutic effects of  HBO 2,4 ATA 3x3’ interval 5’ 7 days and stichopus hermanii against periodontal ligament collagen density in the healing process of periodontitis with DM. <strong>Materials and Methods:</strong></em><em>The experiment design is factorial design. Rats are inducted with STZ 65 mg/kgBB to make them suffer DM and are inducted with P.gingivalis </em><em>1x10<sup>9</sup>sel/ml for 5 days straight to make them suffer periodontitis</em><em>,</em><em> 20 male Wistar rats were divided into 4 groups. K0 (control group), K1(STZ+P. gingivalis), K2(STZ+P. gingivalis+Stichopus hermanii), K3(STZ+P. gingivalis+HBO), and K4(STZ+P.gingivalis+stichopus hermanii HBO) after treatment on day 52, all groups were sacrificed and done making preparations for the HPA of the mandible bone. <strong>Results:</strong> Data were analyzed using chi-square, Kruskal wallis, and Mann Whitney U with 95% significance level (p = 0.05). increase level of collagen significantly</em> K1<em>(1 ± 0.00)</em> - K2<em>(2±0.00)</em>, dan K1<em>(1 ± 0.00)</em> - K4<em>(2.5 ± 0.289)</em><em>.<strong>Conclution</strong></em><strong><em>:</em></strong><em>Therapy  HBO combination of 2.4 ATA 3 x 30 </em><em>with 5 minutes air breaks for 7 days</em><em> and gel Stichopus hermanii3% effective on the Densityof collagen in the periodontal ligament healing process periodontitis with DM. <br /> <br /> </em></p><p><strong><em>Keywords:</em></strong><em>OHB, Stichopus hermanii, periodontitis with DM, collagen</em></p><p><strong><em> </em></strong></p><strong><em>Correspondence: </em></strong><em>Dian Mulawarmanti, Department of Oral Biology, Faculty of Dentistry, Hang Tuah University,Arif Rahman Hakim 150, Surabaya,Phone 031-5945864, Email: </em><a href="mailto:[email protected]"><em>[email protected]</em></a>

scholarly journals Chronic Administration of Quercetin Induces Biomechanical and Pharmacological Remodeling in the Rat Coronary Arteries

2017 ◽  
pp. 591-599 ◽  
Author(s):  
A. MONORI-KISS ◽  
F. KISS ◽  
J. M. RESTIFO ◽  
E. MONOS ◽  
G. L. NADASY
Keyword(s):  
Ex Vivo ◽  
Nitrogen Monoxide ◽  
Wall Stress ◽  
Chronic Administration ◽  
Vascular Wall ◽  
Treated Group ◽  
Control Group ◽  
Spontaneous Tone ◽  
Male Wistar Rats ◽  
Coronary Arterioles

Acute dilation brought about by the dietary flavonoid quercetin in coronary arterioles has been described earlier, but no information is available on its chronic effects. Male Wistar rats (body weight about 190 g) were divided to two groups: the quercetin-treated group (n=22) had quercetin supplementation of approximately 30 mg/kg/day, whereas the control group (n=20) had none. After eight weeks of treatment, intramural coronary arterioles with identical passive diameters (178±14 µm and 171±9 µm) were prepared and their biomechanics and pharmacological reactivities were tested using pressure arteriography ex vivo. The spontaneous tone of quercetin-treated arteries was higher (16.5±1.9 % vs. 12.9±0.9 %), which resulted in a reduced lumen size (144±9 μm vs. 167±12 μm), thicker vascular wall (22.6±1.8 μm vs. 17.4±1.6 μm) and decreased tangential wall stress (16.8±1.1 kPa vs. 20.5±1.6 kPa) in supplemented animals (in spontaneous tone at 50 mm Hg, p<0.01 in all these comparisons). Elevated basal NO release resulted in increased endothelial dilation in quercetin-treated animals, especially at higher intraluminal pressures (10.8±2.5 % vs. 5.7±1.3 % at 70 mm Hg, p<0.01). We found remodeling of the geometry of coronary arterioles to ensure higher dilatory reserve and nitrogen monoxide production, as well as lowered elastic stress of the vessel wall.

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