scholarly journals Formulasi Granul Effervescent Ekstrak Pandan Laut (Pandanus tectorius Parkinson ex Du Roi) Sebagai Analgetik

2020 ◽  
Vol 6 (2) ◽  
pp. 60
Author(s):  
Framesti Frisma Sriarumtias
Keyword(s):  
Sodium Bicarbonate ◽  
Analgesic Activity ◽  
Test Results ◽  
Activity Test ◽  
Ethanolic Extracts ◽  
The Difference ◽  
Ethanol Extracts ◽  
Test Requirements ◽  
Pandanus Tectorius ◽  
Gravity Test

Sea pandanus plants are plants that are spread along the coast in Indonesia. Pandan sea fruit itself has never been used by the community, so it becomes waste on the beach. The purpose of this study was to make a formulation of effervescent granules from ethanolic extracts of sea pandanus (Pandanus tectorius) which has analgesic activity. The effervescent granule formula consists of ethanol extracts of sea pandanus, sodium bicarbonate, citric acid, tartaric acid, mannitol, lactose, PVP, aerosils and orange dyes. The difference of the three formulas are the ratio of the concentration of sodium bicarbonate which is 25%, 30% and 35%, respectively. The results show that the best formula is formula I, which fulfills the organoleptic test requirements, water content, rest angle, real specific gravity test, incompressible density test, compressibility, disperse time and pH. The analgesic activity test results using siegmund method known analgesic activity of formula I as the best formula with a dose of 125 mg / kg BW and aspirin as a comparison with a dose of 65 mg / kg body weight gives an anlgetic effect with protective power is 83.68%.

scholarly journals Assessment of Analgesic, Anti-Inflammatory And Anti-Pyretic Activities of Malva Neglecta Wallr. In Animal Model

2021 ◽  
Vol 50 (3) ◽  
pp. 577-583
Author(s):  
Rahma Hamayun ◽  
Muhammad Shahid Iqbal ◽  
Muhammad Imran Qadir
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Aqueous Ethanol ◽  
Mice Model ◽  
Hot Plate ◽  
Standard Drug ◽  
Antipyretic Activity ◽  
Ethanolic Extracts ◽  
Anti Inflammatory ◽  
Ethanol Extracts

Analgesic, anti-inflammatory and anti-pyretic activities of n-hexane and aqueous ethanolic extracts of Malva neglecta in Swiss albino mice was evaluated. For each activity, the mice were divided into 4 groups: Group 1 served as control, Groups 2 and 3 were given n-hexane and aqueous ethanol extracts, respectively whereas Group 4 was treated with the standard drug. Analgesic activity was evaluated against acetic acid induced writhing, Eddy's hot plate method, and Formalin induced paw licking. Anti-inflammatory activity was evaluated by carrageenan-induced paw edema. The extracts were also examined for their anti-pyretic activities against yeast-induced pyrexia. Results showed that the n-hexane (p < 0.05) and aqueous ethanolic (p < 0.005) extracts of M. neglecta exhibited analgesic activity by reducing acetic acid-induced writhing, mean reaction time on hot plate model and formalin-induced paw licking in mice as compared to the control. The n-hexane extract (p < 0.05) as well as aqueous ethanolic (p < 0.005) extracts produced significant antiinflammatory activity as compared to the control. Both the n-hexane and aqueous ethanolic extracts revealed significant antipyretic activity (p < 0.005 and p < 0.05, respectively) in mice model. The results of the present study demonstrated that the n-hexane and aqueous ethanol extracts of M. neglecta possess analgesic, antiinflammatory and anti-pyretic activities. Bangladesh J. Bot. 50(3): 577-583, 2021 (September)

scholarly journals Influence of Tool Length and Profile Errors on the Inaccuracy of Cubic-Machining Test Results

2021 ◽  
Vol 5 (2) ◽  
pp. 51
Author(s):  
Zongze Li ◽  
Hiroki Ogata ◽  
Ryuta Sato ◽  
Keiichi Shirase ◽  
Shigehiko Sakamoto
Keyword(s):  
Machine Tools ◽  
Test Accuracy ◽  
Test Results ◽  
Machining Error ◽  
Tool Profile ◽  
Machining Test ◽  
The Difference ◽  
Side Error ◽  
Profile Errors ◽  
Five Axis

A cubic-machining test has been proposed to evaluate the geometric errors of rotary axes in five-axis machine tools using a 3 × 3 zone area in the same plane with different tool postures. However, as only the height deviation among the machining zones is detected by evaluating the test results, the machining test results are expected to be affected by some error parameters of tool sides, such as tool length and profile errors, and there is no research investigation on how the tool side error influences the cubic-machining test accuracy. In this study, machining inaccuracies caused by tool length and tool profile errors were investigated. The machining error caused by tool length error was formulated, and an intentional tool length error was introduced in the simulations and actual machining tests. As a result, the formulated and simulated influence of tool length error agreed with the actual machining results. Moreover, it was confirmed that the difference between the simulation result and the actual machining result can be explained by the influence of the tool profile error. This indicates that the accuracy of the cubic-machining test is directly affected by tool side errors.

scholarly journals Experimental Study of the Space–Time Effect of a Double-Pipe Frozen Curtain Formation with Different Groundwater Velocities

Energies ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3830
Author(s):  
Shicheng Sun ◽  
Chuanxin Rong ◽  
Hua Cheng ◽  
Bin Wang ◽  
Xiaogang Jiang ◽  
...  
Keyword(s):  
Freezing Temperature ◽  
Physical Model Test ◽  
Sand Layer ◽  
Test Results ◽  
Groundwater Velocity ◽  
Test Platform ◽  
The Difference ◽  
Freezing Test ◽  
Double Pipe ◽  
Thermal Physical Properties

Groundwater velocity has significant effects on the formation of a frozen curtain during freezing. In order to study the influence of the velocity on a frozen curtain, a large physical model test platform was established for double-pipe freezing. Based on this platform, freezing tests for different velocities were carried out. Quartz sand was selected as a similar material. The freezing temperature of the saturated sand layer was found by analyzing the results of the nuclear magnetic resonance (NMR). Based on the study of the thermal physical properties of the sand layer, the freezing test results were analyzed, and the results showed that the flow led to the differential development of the temperature between the upstream and downstream sections of the freezing pipes. Moreover, the larger the velocity, the greater the difference. The flow prolonged the overlapping time of the frozen curtains. Additionally, the flow slowed down the development of the frozen curtain area and the frozen curtain thickness. The larger the flow velocity, the greater the inhibition of the flow on the development of the frozen curtain. The test results can provide more references for the design and construction of freezing engineering with flowing groundwater.

Influence of Collagen Status on Microstructures of Porous Collagen/TCP Composites

2007 ◽  
Vol 330-332 ◽  
pp. 495-498
Author(s):  
Chao Zou ◽  
Wen Jian Weng ◽  
Xu Liang Deng ◽  
Kui Cheng ◽  
Pi Yi Du ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Growth ◽  
Tricalcium Phosphate ◽  
Freeze Drying ◽  
Alkali Treatment ◽  
Test Results ◽  
Collagen Matrices ◽  
The Difference ◽  
Porous Composites ◽  
Better Than

Two starting collagens, sponge and floc collagen, were used to prepare collagen/tricalcium phosphate (TCP) composites. The resulting composites were porous and had 200μm pore size. However, there was a difference in the microstructure of the pore walls for the composites derived from the two collagens, the pore walls in sponge collagen/TCP composite were still porous and had 200 nm micropores size, TCP particles were trapped in collagen matrices. While floc collagen/TCP composite had smooth and dense walls in which TCP particles were embedded. The difference could be attributed to the starting collagen with different status. Sponge collagen has a soft structure, which easily becomes disassembled fibrils during alkali treatment, the disassembled fibrils are integrated again to form a dense morphology for pore walls after freeze-drying. While floc collagen has already a low disassembly degree, the alkali treatment could not be able to separate the fibrils, this remains as micropores in pore walls after freeze-drying. Both porous composites are significant in bone tissue engineering or regeneration. MTT test results showed the two composites had good cytocompatibility, and sponge collagen/TCP composite was somewhat better than floc collagen/TCP composite, which could result from that micropores derived roughness in pore walls of sponge collagen/TCP composite is suitable for cell growth.

Reply to comments of D. H. Zeuch

1992 ◽  
Vol 7 (7) ◽  
pp. 1959-1960
Author(s):  
Hu Gengxiang ◽  
Chen Shipu ◽  
Wu Xiaohua ◽  
Chen Xiaofu
Keyword(s):  
Compression Test ◽  
Compression Testing ◽  
Width Ratio ◽  
Test Results ◽  
Specimen Length ◽  
The Difference

Compression test results of our research on Al3Ti-base alloys are reported. It is evident that the specimen length-to-width ratio we used for compression testing can significantly reflect the difference in ductility of different alloys. Thus the tests fulfilled the aim of our present research.

Two important bridges protected from earthquake by extremely big sliding pendulum isolators

2021 ◽  
Author(s):  
Agostino Marioni ◽  
Roberto Dalpedri ◽  
Marco Banfi ◽  
Carla Cai
Keyword(s):  
Load Capacity ◽  
Special Focus ◽  
South East Asia ◽  
Vertical Load ◽  
Test Results ◽  
Surface Type ◽  
Total Length ◽  
Padma River ◽  
The Difference ◽  
Under Construction

<p>The Padma Bridge is a multipurpose road-rail bridge across the Padma River currently under construction in Bangladesh and is one of the most important projects in the whole south east Asia with a total length of 6150 m. The maximum design vertical load reaches 98725 kN.</p><p>The Holtekamp Bridge is a steel road bridge with 2 main spans of 150 m and 2 lateral spans of 75 for a total length of 450 m. The bridge is isolated by use of sliding pendulum isolators having a maximum vertical load capacity at ULS of 54915 kN.</p><p>In both cases the isolators are double sliding surface type but with a different approach about the central articulation. The paper aims to put in evidence the difference in behaviour of the 2 types of pendulum, analysing both the theoretical approach and the test results with a special focus over the adopted solution for perform the test on a device which exceed the capacity of aby existing laboratory.</p>

Moving to e-bidding

2019 ◽  
Vol 24 (1) ◽  
pp. 2-18 ◽  
Author(s):  
Djoen San Santoso ◽  
Nuttapon Bourpanus
Keyword(s):  
Wilcoxon Test ◽  
Test Results ◽  
Public Infrastructure ◽  
Senior Managers ◽  
Content Type ◽  
Thai Government ◽  
Infrastructure Project ◽  
The Difference ◽  
Public Money ◽  
Mean Differences

Purpose This study aims to examine the influences of shifting the bidding system of Thai public infrastructure projects from e-auction to e-bidding. Design/methodology/approach A questionnaire survey was conducted with owners or senior managers with direct responsibility in deciding the mark-up of 72 small and medium-sized contractor firms. Five senior professionals were interviewed to provide insights into and to strengthen the discussion of the findings. The Wilcoxon test was applied to analyze the difference in the importance of the factors between e-auction and e-bidding. Findings The results revealed a shift in the importance of the factors, from those related to the financial aspects in the e-auction to the situational aspects in the e-bidding. The comparison test results also suggested that the majority of factors become significantly less important in the e-bidding system, with “identity of competitors” and “general expense of the bidding process” having the most apparent mean differences. The interview results supported by data on winning prices and estimations strongly indicated that bid collusions likely exist in the e-auction. By shifting to e-bidding, the data also show that the Thai Government can save public money in its infrastructure project development. Originality/value The study provides an analysis from the perspectives of contractor firms on how e-auction and e-bidding options influence bid mark-up decisions. Many studies have focused on the issues and advantages provided by the e-procurement mainly from the owner (government)’s perspective but how the change influences the contractor’s attitude has been less explored.

scholarly journals FORMULATION, STABILTY TEST AND ENZYME ACTIVITY TEST TYROSINASE OF CREAM PEPARATIONS FROM HERENDONG FRUIT EXTRACT(Melastoma affine D. Don)

2020 ◽  
Vol 5 (2) ◽  
pp. 149-173
Author(s):  
Zuraida Sagala ◽  
Kurnia Telaumbanua
Keyword(s):  
Enzyme Inhibitors ◽  
Enzyme Inhibitor ◽  
Mechanical Test ◽  
Ethanol Extract ◽  
Activity Test ◽  
Irritation Test ◽  
Ic50 Values ◽  
Tyrosinase Enzyme ◽  
Ethanol Extracts ◽  
The Stability

One way to prevent or inhibit melanin formation is by inhibiting tyrosinase activity (Lloyd,2011). Tyrosinase enzyme is an enzyme that plays a role in the formation of skin pigments or known as melanogenesis. In the process of melanogenesis, the enzyme tyrosinase acts as a catalyst in two different reactions, namely the hydroxylation process of tyrosine to dihydroxy-phenylalanine (L-DOPA) and oxidation of L-DOPA to quinone DOPA. Tyrosinase in skin tissue is activated by solar UV radiation so that it accelerates the process of melanin production (Fais et al.  2009).  This  study  was  conducted  to  determine  the  stability,  effectiveness  of  cream preparations from ethanol extracts of Harendong fruit (Melastoma affine D. Don) as tyrosinase enzyme inhibitors so it can be used as a cosmetic ingredient for whitening or skin lightening. Results Cream with variants of Harendong (Melastoma affine D. Don) ethanol extract was physically stable and formulated with organoleptic test, homogeneity, viscosity, mechanical test, pH, cycling test, and irritation test. Type M / A cream preparations from ethanol extract of Harendong fruit (Melastoma affine D. Don) have a strong / moderate tyrosinase enzyme inhibitor activity with IC50 values of F1 (1%) of 526,192 ppm, F2 (1.5%) ) amounted to 317,534 ppm and F3  (2%)  amounted  to  128,523  ppm.  Keywords: Foemulation,  stability test, activity test, tyrosinase enzyme, herenong fruit (Melastoma affine G.Don)

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